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Thromboembolic Disease in Pregnancy

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181. Evaluation of Pulmonary Perfusion Heterogeneity in Patients With Chronic Thromboembolic Pulmonary Hypertension Using Functional PET Imaging

, 2017 Sponsor: Massachusetts General Hospital Information provided by (Responsible Party): Robert Scott Harris, M.D., Massachusetts General Hospital Study Details Study Description Go to Brief Summary: This study with evaluate blood flow in the lungs of patients prior to and after surgery for treatment. Condition or disease Chronic Thromboembolic Pulmonary Hypertension Detailed Description: Specifically, we will evaluate the length-scale or size of blood flow alterations using filtering techniques (...) Evaluation of Pulmonary Perfusion Heterogeneity in Patients With Chronic Thromboembolic Pulmonary Hypertension Using Functional PET Imaging Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2014 Clinical Trials

182. Follow-up in Rivaroxaban Patients in Setting of Thromboembolism

anticoagulants (heparins and warfarin); 2. there will be less bleeding than when patients are on conventional anticoagulants; 3. there will be a lower long-term incidence of morbidity from chronic thromboembolic pulmonary hypertension and post-thrombotic limb syndrome. Condition or disease Intervention/treatment Venous Thromboembolism Other: Non-interventional study Detailed Description: United Kingdom-only prospective, non-interventional, investigator-led, multi-centre, single cohort, registry (...) relevant MeSH terms: Layout table for MeSH terms Thromboembolism Venous Thromboembolism Embolism and Thrombosis Vascular Diseases Cardiovascular Diseases Rivaroxaban Factor Xa Inhibitors Antithrombins Serine Proteinase Inhibitors Protease Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Anticoagulants

2014 Clinical Trials

183. Prevention of Silent Cerebral Thromboembolism by Oral Anticoagulation With Dabigatran After Pulmonary Vein Isolation for Atrial Fibrillation

physician, ongoing drug or alcohol addiction (> 8 drinks/week) Pregnancy /breast feeding Severely impaired renal function, GFR < 30 ml/min Impaired liver function (ALT/AST transaminase count 3fold higher than normal values) or liver disease with reduced life expectancy <1 year Valvular AF (moderate- severe mitral insufficiency; relevant mitral steno-sis with a mean pressure gradient >5mmHg) Long standing persistent (>12 months) and permanent AF NSTEMI/STEMI/implantated drug eluting stent with indication (...) Hospital, Bonn ClinicalTrials.gov Identifier: Other Study ID Numbers: MED2-201301 2013-003492-35 ( EudraCT Number ) First Posted: February 20, 2014 Last Update Posted: September 3, 2018 Last Verified: August 2018 Additional relevant MeSH terms: Layout table for MeSH terms Atrial Fibrillation Thromboembolism Arrhythmias, Cardiac Heart Diseases Cardiovascular Diseases Pathologic Processes Embolism and Thrombosis Vascular Diseases Dabigatran Antithrombins Serine Proteinase Inhibitors Protease Inhibitors

2014 Clinical Trials

184. Apixaban for the Prevention of Venous Thromboembolism in Cancer Patients

will receive the study drug and 287 will receive an inactive substance. Analysis will be performed to assess the safety and the superiority of the study drug. Condition or disease Intervention/treatment Phase Venous Thromboembolism Cancer Drug: Apixaban Drug: Placebo drug Phase 2 Detailed Description: Patients holding a malignancy have a 7 to 28-fold higher risk for venous thromboembolism (VTE) than non-cancer patients(1). Since most cancer patients are currently treated in the outpatient setting, an acute (...) Thromboembolism Embolism and Thrombosis Vascular Diseases Cardiovascular Diseases Apixaban Factor Xa Inhibitors Antithrombins Serine Proteinase Inhibitors Protease Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Anticoagulants

2014 Clinical Trials

185. MERIT-2: Macitentan in thE tReatment of Inoperable Chronic Thromboembolic Pulmonary Hypertension (OL)

: NCT02060721 Recruitment Status : Active, not recruiting First Posted : February 12, 2014 Last Update Posted : December 20, 2018 Sponsor: Actelion Information provided by (Responsible Party): Actelion Study Details Study Description Go to Brief Summary: Long-term study to evaluate if macitentan is safe, tolerable and efficient enough to be used for treatment of inoperable chronic thromboembolic pulmonary hypertension (CTEPH) Condition or disease Intervention/treatment Phase Chronic Thromboembolic Pulmonary (...) of childbearing potential must have a negative pre-treatment serum pregnancy test, be advised on appropriate methods of contraception, and agree to use 2 reliable methods of contraception. Exclusion Criteria: Permanent discontinuation of DB study treatment due to an hepatic adverse event or liver aminotransferase abnormalities. Any known factor (e.g., drug or substance abuse) or disease (e.g., unstable psychiatric illness) that, in the opinion of the investigator, may interfere with treatment compliance

2014 Clinical Trials

186. Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. (PubMed)

Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. Recommendations for venous thromboembolism (VTE) prophylaxis in patients with inflammatory bowel disease (IBD) can be refined by incorporating patient-specific risk factors.To determine the risk of deep venous thrombosis (DVT) and pulmonary embolism (PE) in children and adults with Crohn's disease and ulcerative colitis and evaluate whether this risk varies by age (...) and/or presence of other risk factors.We performed a cohort study using Danish administrative data. Incidence rates of DVT and PE were calculated among patients with IBD and an age- and gender-matched comparison population and compared using Cox proportional hazards regression. We performed additional analyses stratifying by age, gender and disease type and restricting outcomes to unprovoked events (occurring without known malignancy, surgery, fracture/trauma or pregnancy). We next performed a nested case

2011 Gut

187. Development and validation of risk prediction algorithm (QThrombosis) to estimate future risk of venous thromboembolism: prospective cohort study. (PubMed)

years. Measures of calibration and discrimination undertaken in validation cohort.564 general practices in England and Wales contributing to the QResearch database.Patients aged 25-84 years, with no record of pregnancy in the preceding 12 months or any previous venous thromboembolism, and not prescribed oral anticoagulation at baseline: 2,314,701 in derivation cohort and 1,240,602 in validation cohort. Outcomes Incident cases of venous thromboembolism, either deep vein thrombosis or pulmonary (...) Development and validation of risk prediction algorithm (QThrombosis) to estimate future risk of venous thromboembolism: prospective cohort study. To derive and validate a new clinical risk prediction algorithm (QThrombosis, www.qthrombosis.org) to estimate individual patients' risk of venous thromboembolism.Prospective open cohort study using routinely collected data from general practices. Cox proportional hazards models used in derivation cohort to derive risk equations evaluated at 1 and 5

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2011 BMJ

188. Aortic Diseases

aortic event improve steadily, a speci?c section is dedicated for chronicAD andfollow-upof patients aftertheacutephaseof AAS. Special emphasis is put on genetic and congenital aortic diseases, becausepreventivemeasuresplayanimportantroleinavoidingsub- sequent complications. Aortic diseases of elderly patients often present as thromboembolic diseases or atherosclerotic stenosis. Thecalci?edaortacanbeamajorproblemforsurgicalorinterven- tionalmeasures.Thecalci?ed‘coralreef’aortahastobeconsidered (...) Aortic Diseases ESC GUIDELINES 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC) Authors/Task Force members: Raimund Erbel * (Chairperson) (Germany), Victor Aboyans * (Chairperson) (France), Catherine Boileau (France), Eduardo Bossone (Italy), Roberto Di Bartolomeo

2014 European Society of Cardiology

189. Management of Women with Obesity in Pregnancy

to women with a healthy pre-pregnancy weight, pregnant women with obesity are at increased risk of miscarriage, 6 gestational diabetes, 10 pre-eclampsia, 11 venous thromboembolism, 8,9 induced labour, 20 caesarean section, 17 anaesthetic complications 21,22 and wound infections, 10 and they are less likely to initiate or maintain breastfeeding. 18 Babies of obese mothers are at increased risk of stillbirth, 13 14 congenital anomalies, 7 prematurity, 23 macrosomia 10,15,20 and neonatal death. 14-16 (...) – 337.6) for antenatal venous thromboembolism (VTE) and 40.1 (95% CI 8.0–201.5) for postnatal VTE in women with a BMI =25 where there was evidence of immobilisation, compared with women with a BMI 40) (aOR 4.82, 95% CI 4.04–5.74). 15 Similar increases in risk have been reported for pregnancy induced hypertension and pre-eclampsia in an Australian cohort study, in which the incidence ranged from 2.4% in women with a BMI 19.8-26.0 to 14.5% (aOR 4.87, 95% CI 3.27– 7.24) in women with a BMI >40. 23

2010 Royal College of Obstetricians and Gynaecologists

190. Prevention of Thromboembolism in Spinal Cord Injury (Treatment)

cord injury, and following the cessation of prophylactic anticoagulation therapy, to be lower than during the first 3 months after the injury, measuring 1.25% (eight out of 640 patients). [ ] For patient education information, see , as well as and . See also , , , , , , , and . Next: Etiopathophysiology Patients with spinal cord injury (SCI) have a higher risk of thromboembolic disease related to the Virchow triad (ie, venous stasis, hypercoagulability, intimal injury). Stasis from paralyzed (...) other tests for detecting DVT of the calf muscle, has less sensitivity and specificity than Doppler ultrasonography, and is less sensitive to incomplete obstruction of a vein by DVT. In addition, extrinsic compression may give a positive result. Radiologic Studies The following imaging studies may be used in the diagnosis of thromboembolic disease: radiocontrast venography, Doppler ultrasonography, I-125 fibrinogen scintigraphy, and ventilation/perfusion scanning. Radiocontrast venography

2014 eMedicine.com

191. Prevention of Thromboembolism in Spinal Cord Injury (Overview)

cord injury, and following the cessation of prophylactic anticoagulation therapy, to be lower than during the first 3 months after the injury, measuring 1.25% (eight out of 640 patients). [ ] For patient education information, see , as well as and . See also , , , , , , , and . Next: Etiopathophysiology Patients with spinal cord injury (SCI) have a higher risk of thromboembolic disease related to the Virchow triad (ie, venous stasis, hypercoagulability, intimal injury). Stasis from paralyzed (...) other tests for detecting DVT of the calf muscle, has less sensitivity and specificity than Doppler ultrasonography, and is less sensitive to incomplete obstruction of a vein by DVT. In addition, extrinsic compression may give a positive result. Radiologic Studies The following imaging studies may be used in the diagnosis of thromboembolic disease: radiocontrast venography, Doppler ultrasonography, I-125 fibrinogen scintigraphy, and ventilation/perfusion scanning. Radiocontrast venography

2014 eMedicine.com

192. Prevention of Thromboembolism in Spinal Cord Injury (Follow-up)

cord injury, and following the cessation of prophylactic anticoagulation therapy, to be lower than during the first 3 months after the injury, measuring 1.25% (eight out of 640 patients). [ ] For patient education information, see , as well as and . See also , , , , , , , and . Next: Etiopathophysiology Patients with spinal cord injury (SCI) have a higher risk of thromboembolic disease related to the Virchow triad (ie, venous stasis, hypercoagulability, intimal injury). Stasis from paralyzed (...) other tests for detecting DVT of the calf muscle, has less sensitivity and specificity than Doppler ultrasonography, and is less sensitive to incomplete obstruction of a vein by DVT. In addition, extrinsic compression may give a positive result. Radiologic Studies The following imaging studies may be used in the diagnosis of thromboembolic disease: radiocontrast venography, Doppler ultrasonography, I-125 fibrinogen scintigraphy, and ventilation/perfusion scanning. Radiocontrast venography

2014 eMedicine.com

193. Thromboembolism (Diagnosis)

disease, a ventriculoatrial shunt, trauma (especially fractures), cancer, surgery, infection, dehydration, shock, estrogen-containing contraceptives, pregnancy, smoking, and . (See Etiology.) [ ] The diagnosis and treatment of thrombosis in children were initially based on standards of care for adults. However, since the early 1990s, pediatric data have emerged that stress differences in thromboembolism etiology, pathophysiology, and anticoagulant drug pharmacokinetics in children. (See Etiology (...) that in pediatric trauma patients, independent risk factors for venous thromboembolism include older age, blood transfusion, surgery, a higher Injury Severity Score, and a lower Glasgow Coma Scale score. [ ] Use of arterial catheters The use of arterial catheters is the most common risk factor for arterial thromboembolism in children. Cardiac catheterization through the femoral artery to manage congenital heart disease is a frequent cause. Prophylaxis with heparin (100-150 U/kg) during the procedure lowers

2014 eMedicine Pediatrics

194. Prevention of Thromboembolism in Spinal Cord Injury (Diagnosis)

cord injury, and following the cessation of prophylactic anticoagulation therapy, to be lower than during the first 3 months after the injury, measuring 1.25% (eight out of 640 patients). [ ] For patient education information, see , as well as and . See also , , , , , , , and . Next: Etiopathophysiology Patients with spinal cord injury (SCI) have a higher risk of thromboembolic disease related to the Virchow triad (ie, venous stasis, hypercoagulability, intimal injury). Stasis from paralyzed (...) other tests for detecting DVT of the calf muscle, has less sensitivity and specificity than Doppler ultrasonography, and is less sensitive to incomplete obstruction of a vein by DVT. In addition, extrinsic compression may give a positive result. Radiologic Studies The following imaging studies may be used in the diagnosis of thromboembolic disease: radiocontrast venography, Doppler ultrasonography, I-125 fibrinogen scintigraphy, and ventilation/perfusion scanning. Radiocontrast venography

2014 eMedicine.com

195. Thromboembolism (Follow-up)

In pregnancy, establishing a clear guideline for the treatment of thromboembolic disease is difficult from an evidence-based perspective. Heparin is the anticoagulant of choice, given its relative safety for the fetus. Heparin therapy should be discontinued immediately before delivery, and then both heparin and warfarin therapy can be started post partum. Pregnant women with a history of previous thromboembolic disease probably should receive some prophylaxis, as the estimated range of recurrence is 0-15 (...) on the factors and cofactors of the coagulation cascade. Patients with acute, massive (PE) causing hemodynamic instability may be treated initially with a thrombolytic agent (eg, streptokinase or tissue plasminogen activator [t-PA]). t-PA has increasingly been used as the first-choice thrombolytic agent. Antibodies to streptokinase may be developed, limiting its use. Surgical interventions for venous thromboembolic disorders include thrombectomy and venous interruption. Special considerations Pregnancy

2014 eMedicine Surgery

196. Thromboembolism (Treatment)

In pregnancy, establishing a clear guideline for the treatment of thromboembolic disease is difficult from an evidence-based perspective. Heparin is the anticoagulant of choice, given its relative safety for the fetus. Heparin therapy should be discontinued immediately before delivery, and then both heparin and warfarin therapy can be started post partum. Pregnant women with a history of previous thromboembolic disease probably should receive some prophylaxis, as the estimated range of recurrence is 0-15 (...) on the factors and cofactors of the coagulation cascade. Patients with acute, massive (PE) causing hemodynamic instability may be treated initially with a thrombolytic agent (eg, streptokinase or tissue plasminogen activator [t-PA]). t-PA has increasingly been used as the first-choice thrombolytic agent. Antibodies to streptokinase may be developed, limiting its use. Surgical interventions for venous thromboembolic disorders include thrombectomy and venous interruption. Special considerations Pregnancy

2014 eMedicine Surgery

197. Thromboembolism (Overview)

disease, a ventriculoatrial shunt, trauma (especially fractures), cancer, surgery, infection, dehydration, shock, estrogen-containing contraceptives, pregnancy, smoking, and . (See Etiology.) [ ] The diagnosis and treatment of thrombosis in children were initially based on standards of care for adults. However, since the early 1990s, pediatric data have emerged that stress differences in thromboembolism etiology, pathophysiology, and anticoagulant drug pharmacokinetics in children. (See Etiology (...) that in pediatric trauma patients, independent risk factors for venous thromboembolism include older age, blood transfusion, surgery, a higher Injury Severity Score, and a lower Glasgow Coma Scale score. [ ] Use of arterial catheters The use of arterial catheters is the most common risk factor for arterial thromboembolism in children. Cardiac catheterization through the femoral artery to manage congenital heart disease is a frequent cause. Prophylaxis with heparin (100-150 U/kg) during the procedure lowers

2014 eMedicine Pediatrics

198. Risk of thromboembolic disease in women taking oral contraceptives. A preliminary communication to the Medical Research Council by a Subcommittee. (PubMed)

Contraceptives, Oral adverse effects Coronary Disease chemically induced Female Humans Intracranial Embolism and Thrombosis chemically induced Middle Aged Phlebitis chemically induced Pregnancy Pulmonary Embolism chemically induced Retrospective Studies Thromboembolism chemically induced Thrombophlebitis chemically induced 1967 5 6 1967 5 6 0 1 1967 5 6 0 0 ppublish 6023133 PMC1841690 Br Med J. 1967 Mar 25;1(5542):726-9 6020089 Br Med J. 1965 Nov 13;2(5471):1164-6 5833621 (...) Risk of thromboembolic disease in women taking oral contraceptives. A preliminary communication to the Medical Research Council by a Subcommittee. 6023133 1967 06 23 2018 11 13 0007-1447 2 5548 1967 May 06 British medical journal Br Med J Risk of thromboembolic disease in women taking oral contraceptives. A preliminary communication to the Medical Research Council by a Subcommittee. 355-9 eng Journal Article England Br Med J 0372673 0007-1447 0 Contraceptives, Oral AIM IM Adolescent Adult

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1967 British medical journal

199. Oral contraceptives and thromboembolic disease. (PubMed)

Oral contraceptives and thromboembolic disease. 6023128 1967 06 23 2018 11 13 0007-1447 2 5548 1967 May 06 British medical journal Br Med J Oral contraceptives and thromboembolic disease. 327-8 eng Journal Article England Br Med J 0372673 0007-1447 0 Contraceptives, Oral AIM IM Adult Contraceptives, Oral adverse effects Female Humans Pregnancy Thromboembolism chemically induced 1967 5 6 1967 5 6 0 1 1967 5 6 0 0 ppublish 6023128 PMC1841739 Br Med J. 1966 May 28;1(5499):1327-8 5934376

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1967 British medical journal

200. Acute and recurrent thromboembolic disease: a new concept of etiology. (PubMed)

Acute and recurrent thromboembolic disease: a new concept of etiology. 5344031 1969 12 02 2018 11 13 0003-4932 170 4 1969 Oct Annals of surgery Ann. Surg. Acute and recurrent thromboembolic disease: a new concept of etiology. 547-58 Altemeier W A WA Hill E O EO Fullen W D WD eng Journal Article United States Ann Surg 0372354 0003-4932 9005-49-6 Heparin AIM IM Acute Disease Adult Aged Bacteroides Chronic Disease Female Fusobacterium Infections complications Heparin administration & dosage (...) therapeutic use Humans Infection microbiology L Forms pathogenicity Male Middle Aged Peptostreptococcus Pregnancy Pulmonary Embolism etiology Staphylococcal Infections complications Streptococcal Infections complications Thromboembolism etiology microbiology Thrombophlebitis etiology microbiology Varicose Veins complications 1969 10 1 1969 10 1 0 1 1969 10 1 0 0 ppublish 5344031 PMC1387770 Surgery. 1951 Aug;30(2):298-310 14855228 J Bacteriol. 1941 Mar;41(3):301-3 16560400 J Bacteriol. 1964 Dec;88:1805-7

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1969 Annals of Surgery

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