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Thrombocytosis

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1. Essential thrombocytosis

Essential thrombocytosis Essential thrombocytosis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Essential thrombocytosis Last reviewed: February 2019 Last updated: March 2018 Summary Essential thrombocytosis (primary thrombocythaemia) is a myeloproliferative disorder associated with an increase in number and size of circulating platelets. Half of all patients are asymptomatic, but clinical presentations include (...) are alternative treatments. The life expectancy for people with essential thrombocytosis is usually similar to that for people without the disease. Patients need FBCs on a regular follow-up basis. Definition Essential thrombocytosis is also known as primary thrombocythaemia. It is a chronic myeloproliferative disorder associated with sustained dysregulated megakaryocyte proliferation, increasing the number of circulating platelets. It is associated with thrombosis and bleeding. History and exam

2018 BMJ Best Practice

3. Anemia with thrombocytosis in an elderly male: a case of myelodysplastic syndrome-myeloproliferative neoplasm with ringed sideroblasts and thrombocytosis Full Text available with Trip Pro

Anemia with thrombocytosis in an elderly male: a case of myelodysplastic syndrome-myeloproliferative neoplasm with ringed sideroblasts and thrombocytosis 30370419 2019 02 26 2531-1387 40 4 2018 Oct-Dec Hematology, transfusion and cell therapy Hematol Transfus Cell Ther Anemia with thrombocytosis in an elderly male: a case of myelodysplastic syndrome-myeloproliferative neoplasm with ringed sideroblasts and thrombocytosis. 385-388 10.1016/j.htct.2018.02.005 Kumar Ashutosh A King George's Medical

2018 Hematology, Transfusion and Cell Therapy

4. Is thrombocytosis associated with a particular subtype of lung cancer? A systematic review and meta-analysis.

Is thrombocytosis associated with a particular subtype of lung cancer? A systematic review and meta-analysis. Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2020 PROSPERO

5. Artemisia vulgaris L. ethanolic leaf extract reverses thrombocytopenia/thrombocytosis and averts end-stage disease of experimental severe Plasmodium berghei murine malaria. (Abstract)

Artemisia vulgaris L. ethanolic leaf extract reverses thrombocytopenia/thrombocytosis and averts end-stage disease of experimental severe Plasmodium berghei murine malaria. Artemisinin isolated from Artemisia annua is the most potent antimalarial against chloroquine resistant Plasmodium falciparum malaria. We previously reported that the ethanolic leaf extract of Artemisia vulgaris, an invasive weed and the only Artemisia species in Sri Lanka, possess both potent and safe antimalarial activity (...) (in terms of antiparasitic properties) in a P. berghei murine malaria model. We report here a prototype study that investigated antidisease activities of A. vulgaris ethanolic leaf extract (AVELE) in a P. berghei ANKA murine malaria model that elicit pathogenesis similar to falciparum malaria. Profound thrombocytosis and thrombocytopenia in mice were detected in early-stage (Day 3), and at a later stage of infection (Day 6), respectively. Plasmodium berghei infected mice, 7 or 8 days post-infection

2020 Journal of Vector Borne Disease

6. Integrated micro/messenger RNA regulatory networks in essential thrombocytosis. Full Text available with Trip Pro

Integrated micro/messenger RNA regulatory networks in essential thrombocytosis. Essential thrombocytosis (ET) is a chronic myeloproliferative disorder with an unregulated surplus of platelets. Complications of ET include stroke, heart attack, and formation of blood clots. Although platelet-enhancing mutations have been identified in ET cohorts, genetic networks causally implicated in thrombotic risk remain unestablished. In this study, we aim to identify novel ET-related miRNA-mRNA regulatory

2018 PLoS ONE

7. Essential thrombocytosis with recurrent spontaneous abortion in the mid trimester: A case report. Full Text available with Trip Pro

Essential thrombocytosis with recurrent spontaneous abortion in the mid trimester: A case report. Essential thrombocytosis (ET) is a myeloproliferative neoplasm characterized by clonal proliferation of the megakaryocytic lineage within the bone marrow and phenotypically by an elevated platelet count in peripheral blood. Common vascular complications include thrombosis, microvascular disturbances, and hemorrhage. ET with recurrent spontaneous abortion as the primary symptom is rare.A 30-year-old

2019 Medicine

8. Reactive thrombocytosis in acute infectious diseases: Prevalence, characteristics and timing. (Abstract)

Reactive thrombocytosis in acute infectious diseases: Prevalence, characteristics and timing. Reactive thrombocytosis is known to occur in infectious, inflammatory and neoplastic diseases. However, the characteristics of its association with acute infections (ID) has not been systematically studied.A department of internal medicine in a general teaching hospital.Retrospective chart review of admitted patients with a confirmed diagnosis of community-acquired pneumonia (CAP), urinary tract (...) infection (UTI) or skin and soft tissue infection (SSTI). Key clinical and laboratory data were retrieved and patients with platelet counts >400 × 109/L who had no alternative cause of thrombocytosis were studied longitudinally and compared to patients with acute infections who had no thrombocytosis.Thirty two of 421 patients with acute infections (ID) had infection-associated thrombocytosis (7.6%): 11/125 patients with CAP (8.8%), 13/205 patients with UTI (6.3%) and 8/91 (8.8%) patients with SSTI

2019 European journal of internal medicine

9. Pretreatment thrombocytosis predict poor prognosis in patients with endometrial carcinoma: a systematic review and meta-analysis. Full Text available with Trip Pro

Pretreatment thrombocytosis predict poor prognosis in patients with endometrial carcinoma: a systematic review and meta-analysis. Several previous studies have confirmed that thrombocytosis was related to reduced survival in many solid tumors. However, the prognostic significance of thrombocytosis in endometrial carcinoma (EC) was still controversy. Therefore, we conducted this study to assess the prognostic value of thrombocytosis in EC.The database including PubMed, MEDLINE, EMBASE, and Web (...) of Science was searched to explore available literature. Above all, the hazard ratio (HR), odds ratios (OR) with 95% confidence intervals (CIs) was used to investigate the correlation between thrombocytosis and overall survival (OS) and disease-free survival (DFS). Moreover, the association between thrombocytosis and patient clinicopathological characteristics was explored. Publication bias and sensitivity analysis also were conducted in this study.Overall, 11 studies involving 3439 patients were

2019 BMC Cancer

10. Refractory Anemia with Ring Sideroblasts (RARS) and RARS with Thrombocytosis (RARS-T) - "2019 Update on Diagnosis, Risk-stratification, and Management". Full Text available with Trip Pro

Refractory Anemia with Ring Sideroblasts (RARS) and RARS with Thrombocytosis (RARS-T) - "2019 Update on Diagnosis, Risk-stratification, and Management". Ring sideroblasts (RS) are erythroid precursors with abnormal perinuclear mitochondrial iron accumulation. Two myeloid neoplasms defined by the presence of RS, include refractory anemia with ring sideroblasts (RARS), now classified under myelodysplastic syndromes with RS (MDS-RS) and RARS with thrombocytosis (RARS-T); now called myelodysplastic (...) /myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T).MDS-RS is a lower-risk MDS, with single or multilineage dysplasia (SLD/MLD), <5% bone marrow (BM) blasts and ≥ 15% BM RS (≥5% in the presence of SF3B1 mutations). MDS/MPN-RS-T, now a formal entity in the MDS/MPN overlap syndromes, has diagnostic features of MDS-RS-SLD, along with a platelet count ≥450 × 10(9)/L and large atypical megakaryocytes.Mutations in SF3B1 are seen in ≥80% of patients with MDS-RS-SLD and MDS/MPN-RS-T, and strongly

2019 American journal of hematology

11. Predictors of Reactive Thrombocytosis in Critically Ill Septic Patients

Predictors of Reactive Thrombocytosis in Critically Ill Septic Patients Predictors of Reactive Thrombocytosis in Critically Ill Septic Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Predictors (...) of Reactive Thrombocytosis in Critically Ill Septic Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03531515 Recruitment Status : Recruiting First Posted : May 21, 2018 Last Update Posted : May 21, 2018 See Sponsor

2018 Clinical Trials

12. Preoperative SCC-Ag and thrombocytosis as predictive markers for pelvic lymphatic metastasis of squamous cervical cancer in early FIGO stage Full Text available with Trip Pro

Preoperative SCC-Ag and thrombocytosis as predictive markers for pelvic lymphatic metastasis of squamous cervical cancer in early FIGO stage Objectives: To explore the clinical significance of squamous cell carcinoma antigen (SCC-Ag) and thrombocytosis to predict pelvic lymphatic metastasis (PLM) of squamous cervical cancer (SCC) in International Federation of Gynecology and Obstetrics (FIGO) stages IA-IIA. Methods: A retrospective clinicopathologic review of 782 patients of a primary cohort (...) in three Chinese hospitals from 2010 to 2015, and 407 patients of a validation cohort in another institution from 2015 to 2017. A receiver operating characteristic curve was used to determine the optimal SCC-Ag threshold to predict PLM in the groups. Univariate and multivariate logistic analyses for PLM were performed to assess differences in outcome. Results: In the primary and validation cohort, 15.6% (122/782) and 25.3% (103/407) patients were classified into the thrombocytosis group (platelet count

2018 Journal of Cancer

13. Evaluation of repeated progression of native coronary artery stenosis by optical frequency domain imaging in a patient with essential thrombocytosis Full Text available with Trip Pro

Evaluation of repeated progression of native coronary artery stenosis by optical frequency domain imaging in a patient with essential thrombocytosis Essential thrombocytosis (ET) is a myeloproliferative disorder with abnormal proliferation of the megakaryocytes and is manifested clinically by the overproduction of dysfunctional platelets, leading to thrombus formation. Therefore, the accurate evaluation of the morphological features for coronary stenosis and initiation of appropriate treatment (...) may be life-saving for ET patients. In this report, we describe a case of the rapid development of repeated stenosis in the native coronary artery in an ET patient, and optical frequency domain imaging confirmed the etiology of the stenoses. These findings may be helpful for consideration of etiology and therapeutic strategy for thrombotic complications in ET patients. thrombocytosis patients with particularly high platelet

2018 Journal of cardiology cases

14. Successful replantation of 2 digits in a patient with thrombocytosis after splenectomy: A case report: Erratum Full Text available with Trip Pro

Successful replantation of 2 digits in a patient with thrombocytosis after splenectomy: A case report: Erratum 29979453 2018 11 14 1536-5964 97 27 2018 Jul Medicine Medicine (Baltimore) Successful replantation of 2 digits in a patient with thrombocytosis after splenectomy: A case report: Erratum. e11515 10.1097/MD.0000000000011515 eng Journal Article United States Medicine (Baltimore) 2985248R 0025-7974 2018 7 7 6 0 2018 7 7 6 0 2018 7 7 6 0 ppublish 29979453 10.1097/MD.0000000000011515

2018 Medicine

15. Chronic Myeloid Leukemia with b3a3 (e14a3) Fusion: A Rare BCR/ABL Rearrangement Presenting with Thrombocytosis - Does MTHFR Polymorphism Matter Full Text available with Trip Pro

Chronic Myeloid Leukemia with b3a3 (e14a3) Fusion: A Rare BCR/ABL Rearrangement Presenting with Thrombocytosis - Does MTHFR Polymorphism Matter Fusion of b2a2 is the most common BCR/ABL rearrangement in CML; however, absent a2 exons are very rare. We describe a case with Philadelphia-positive chronic myeloid leukemia (CML) with a very rare b3a3 (e14a3) BCR/ABL junction. To our knowledge, only 15 such cases of CML have previously been reported. These uncommon transcripts may be under-reported (...) , since RT-PCR-based assays may fail to detect these fusions due to the location of the primers and probes used. We are reporting this case for the first time which presented with MTHFR mutation and significant thrombocytosis. There is very limited information on how this genotype expresses and responds to treatment, especially to tyrosine kinase inhibitors, as compared to classic CML. Also, the relationship between MTHFR mutation and CML is not clear, although studies have been done.

2018 Case reports in oncology

16. Spurious Thrombocytosis in the Setting of Hemolytic Anemia and Microcytosis Secondary to Extensive Burn Injury Full Text available with Trip Pro

Spurious Thrombocytosis in the Setting of Hemolytic Anemia and Microcytosis Secondary to Extensive Burn Injury 29391327 2018 12 18 2018 12 18 1308-5263 35 3 2018 08 03 Turkish journal of haematology : official journal of Turkish Society of Haematology Turk J Haematol Spurious Thrombocytosis in the Setting of Hemolytic Anemia and Microcytosis Secondary to Extensive Burn Injury 205-206 10.4274/tjh.2017.0466 Zahid Mohammad Faizan MF Temple University Hospital, Clinic of Internal Medicine (...) , Philadelphia, Pennsylvania, USA Alsammak Mohamed S. MS Temple University Hospital, Clinic of Pathology and Laboratory Medicine, Philadelphia, Pennsylvania, USA eng Case Reports Letter 2018 02 02 Turkey Turk J Haematol 9606065 1300-7777 IM Anemia, Hemolytic blood diagnosis etiology Burns blood complications diagnosis Erythrocytes, Abnormal pathology Humans Male Spherocytes pathology Thrombocytosis blood diagnosis etiology Spurious Thrombocytosis Burn Platelets Microcytosis 2018 2 3 6 0 2018 2 3 6 0 2018 12

2018 Turkish Journal of Hematology

17. Germline JAK2 L611S mutation in a child with thrombocytosis Full Text available with Trip Pro

Germline JAK2 L611S mutation in a child with thrombocytosis 29567786 2018 11 14 1592-8721 103 8 2018 Aug Haematologica Haematologica Germline JAK2 L611S mutation in a child with thrombocytosis. e372-e373 10.3324/haematol.2018.188995 Aral Bernard B Laboratoire de génétique chromosomique et moléculaire, Pôle Biologie, CHU de Dijon, France. Courtois Martine M Service d'Hématologie Biologique, Pôle Biologie, CHU de Dijon, France. Ragot Sylviane S Laboratoire de génétique chromosomique et

2018 Haematologica

18. Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome Full Text available with Trip Pro

Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome We describe a patient with MDS/MPN with ring sideroblasts and thrombocytosis who had deletions of long arm of chromosome 5 (5q-) and chromosome 20 (20q-). Molecular studies showed an exon 9, frame shift mutation in the calreticulin (CALR) gene, and absence of mutations in JAK2, MPL, SETBP1 or SF3B1. Treatment with lenalidomide resulted in durable clinical

2018 Leukemia research reports

19. Thrombocytosis as a Marker for Postoperative Complications in Colorectal Surgery Full Text available with Trip Pro

Thrombocytosis as a Marker for Postoperative Complications in Colorectal Surgery Blood platelet measurement is a widely available and inexpensive test that is performed routinely. Platelets are thought to act by inducing inflammation and play a role in clotting and antimicrobial defence. A postoperative rise in the platelet count (thrombocytosis) is often dismissed as an incidental finding, but there is growing evidence to suggest that it may act as an indicator to underlying pathology (...) . It correlates with significant pyogenic infections as well as multiple malignancies. In addition to this, recent research indicates that thrombocytosis may be a useful prognostic indicator for postoperative outcomes in patients with malignancies. In patients undergoing surgery for gastric cancer, a combination of platelet count and neutrophil-to-lymphocyte (NLR) ratio collected preoperatively was shown to correlate with postoperative survival.To evaluate whether there is a positive correlation between pre

2018 Gastroenterology research and practice

20. A cross-sectional retrospective study to analyze the underlying causes and clinical characteristics of children with reactive thrombocytosis at a Korean tertiary medical center Full Text available with Trip Pro

A cross-sectional retrospective study to analyze the underlying causes and clinical characteristics of children with reactive thrombocytosis at a Korean tertiary medical center Reactive thrombocytosis (RT) is a common condition among children, although no studies have examined the etiology or clinical characteristics of RT among Korean children.This retrospective study evaluated children with RT at a single Korean tertiary center during a 10-year period.RT accounted for 13.5% of children who

2018 Blood research

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