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Thrombin Hemostatic

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161. [Modified polyurethane foam as a local hemostatic agent after dental extractions]. (PubMed)

socket a commercially available gelatin foam was applied. In the collagen group, a PU was applied in 1 socket, and a collagen wadding in the other. All hemostats were removed after 2 minutes, after which the degree of coagulation was measured using a thrombin/antithrombin test and a fibrinogen test. This study suggests that polyurethane foam has hemostatic capacity. Large scale clinical research is needed to confirm this finding, and should indicate whether this hemostatic capacity is clinically (...) [Modified polyurethane foam as a local hemostatic agent after dental extractions]. In this split mouth experiment, the feasibility ofpolyurethane foam as a local hemostatic agent after dental extractions was studied. Ten healthy patients underwent 2 extractions ofa dental element in 1 treatment session. The 10 patients were subsequently randomly divided in a gelatin group and a collagen group. In the gelatin group, a polyurethane foam (PU) was applied in 1 extraction socket, while in the other

2013 Nederlands tijdschrift voor tandheelkunde Controlled trial quality: uncertain

162. Novel thrombin and factor Xa inhibitors: challenges to reversal of their anticoagulation effects. (PubMed)

Novel thrombin and factor Xa inhibitors: challenges to reversal of their anticoagulation effects. Warfarin has been the sole oral anticoagulant used in the management of thromboembolic disorders for over 60 years. Target-specific oral anticoagulants (TSOAs) have recently emerged as alternatives to warfarin, because they do not require laboratory monitoring. Nevertheless, with the rising use of TSOAs, there is growing concern among clinicians regarding management of bleeding in patients taking (...) them. Unlike warfarin, there is no antidote or reversal agent for TSOAs. This review summarizes recent developments and attempts to provide a systematic approach to patients on TSOAs presenting with bleeding complications.Currently, data involving clinical management of TSOAs are limited and primarily based on ex-vivo or animal models using hemostatic agents with uncertain implications in bleeding patients. There is a pressing need for randomized clinical trials evaluating the safety and efficacy

2013 Current Opinion in Hematology

163. Gelatin-Thrombin Matrix for Intraoperative Hemostasis in Abdomino-Pelvic Surgery: A Systematic Review. (PubMed)

Gelatin-Thrombin Matrix for Intraoperative Hemostasis in Abdomino-Pelvic Surgery: A Systematic Review. Different hemostatic methods are available for mild to moderate intraoperative bleeding during open and laparoscopic abdomino-pelvic surgery, but topical hemostats have gained popularity. We sought to review evidence on the use of a gelatin-thrombin matrix (FloSeal®) in elective abdominal and pelvic surgery. A systematic search of PubMed, EMBASE, and Cochrane databases was conducted (...) . The primary endpoints were intraoperative bleeding and number of transfusions. Secondary endpoints included operative time, postoperative complications, re-operation for bleeding, mortality, and duration of hospitalization. Of five controlled trials, only three were prospective, randomized-controlled studies. The first, in open myomectomy, showed that hemostatic matrix dramatically reduced intraoperative bleeding and transfusion rates compared with conventional hemostatic measures. Hemostatic matrix also

2013 Surgical technology international

164. Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index. (PubMed)

Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index. To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index.Cross-sectional study.Tertiary teaching hospital.Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (±2 kg/m(2)).Clinical evaluation and venipuncture.Thrombin activatable (...) fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test.Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups.Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability.Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

2013 Fertility and Sterility

165. Thrombin Generation and Gestational Outcome

generation- pregnancy First Posted: May 15, 2014 Last Update Posted: March 1, 2018 Last Verified: February 2018 Additional relevant MeSH terms: Layout table for MeSH terms Thrombophilia Hematologic Diseases Thrombin Hemostatics Coagulants (...) Thrombin Generation and Gestational Outcome Thrombin Generation and Gestational Outcome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thrombin Generation and Gestational Outcome The safety and scientific

2013 Clinical Trials

166. Safety and Efficacy of Topical Thrombin (Human) Grifols as an Adjunct to Hemostasis During Open Surgeries

. ( Instituto Grifols, S.A. ): Vascular surgery Hepatic surgery Soft tissue surgery Spinal surgery Additional relevant MeSH terms: Layout table for MeSH terms Hemostatics Thrombin Coagulants (...) Safety and Efficacy of Topical Thrombin (Human) Grifols as an Adjunct to Hemostasis During Open Surgeries Safety and Efficacy of Topical Thrombin (Human) Grifols as an Adjunct to Hemostasis During Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2013 Clinical Trials

167. Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation. (PubMed)

Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation. Red blood cell-derived microparticles (RMPs) are small phospholipid vesicles shed from RBCs in blood units, where they accumulate during storage. Because microparticles are bioactive, it could be suggested that RMPs are mediators of posttransfusion complications or, on the contrary, constitute a potential hemostatic agent.This study was performed to establish the impact on coagulation (...) of RMPs isolated from blood units. Using calibrated automated thrombography, we investigated whether RMPs affect thrombin generation (TG) in plasma.We found that RMPs were not only able to increase TG in plasma in the presence of a low exogenous tissue factor (TF) concentration, but also to initiate TG in plasma in absence of exogenous TF. TG induced by RMPs in the absence of exogenous TF was neither affected by the presence of blocking anti-TF nor by the absence of Factor (F)VII. It was significantly

2013 Transfusion

168. Models for thrombin generation and risk of disease. (PubMed)

studies to understand thrombin dynamics on a mechanistic basis. The translation of an individual's specific coagulation factor composition data using these models into an integrated assessment of hemostatic status may provide a route for advancing the long-term goal of individualized medicine. This review details the integrated approaches to understanding: (i) What is normal thrombin generation in individuals? (ii) What is the effect of normal range plasma composition variation on thrombin generation (...) in pathologic states? (iii) Can disease progression or anticoagulation be followed by understanding the boundaries of normal thrombin generation defined by plasma composition? (iv) What are the controversies and limitations of current computational approaches? Progress in these areas can bring us closer to developing models that can be used to aid in identifying hemostatic risk. © 2013 International Society on Thrombosis and Haemostasis.

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2013 Journal of Thrombosis and Haemostasis

169. Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation?

Pain Thrombophilia Avitaminosis Deficiency Diseases Malnutrition Nutrition Disorders Pain Neurologic Manifestations Signs and Symptoms Hematologic Diseases Vitamin D Thrombin Vitamins Micronutrients Nutrients Growth Substances Physiological Effects of Drugs Bone Density Conservation Agents Hemostatics Coagulants (...) Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation? Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2013 Clinical Trials

170. Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia

table for MeSH terms Bacteremia Bacterial Infections Sepsis Infection Systemic Inflammatory Response Syndrome Inflammation Pathologic Processes Dabigatran Argatroban Antithrombins Thrombin Serine Proteinase Inhibitors Protease Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Anticoagulants Hemostatics Coagulants Platelet Aggregation Inhibitors (...) Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Direct

2013 Clinical Trials

171. Thrombin inhibitory activity of some polyphenolic compounds (PubMed)

Thrombin inhibitory activity of some polyphenolic compounds Thrombin, also known as an active plasma coagulation factor II, belongs to the family of serine proteases and plays a crucial role in blood coagulation process. The process of thrombin generation is the central event of the hemostatic process and regulates blood coagulant activity. For this reason, thrombin inhibition is key to successful novel antithrombotic pharmacotherapy. The aim of our present study was to examine the effects (...) of the well-known polyphenolic compounds on the activity of thrombin, by characterization of its interaction with selected polyphenols using different biochemical methods and biosensor BIAcore analyses. Only six compounds, cyanidin, quercetin, silybin, cyanin, (+)-catechin and (-)-epicatechin, of all examined in this study polyphenols caused the inhibition of thrombin amidolytic activity. But only three of the six compounds (cyanidin, quercetin and silybin) changed thrombin proteolytic activity. BIAcore

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2013 Medicinal Chemistry Research

172. The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation (PubMed)

platelet proteins associated with Rac1, a Rho GTPase family member, and actin regulatory protein essential for platelet hemostatic function. Mass spectrometry analysis revealed that upon platelet activation with thrombin, Rac1 associates with a set of effectors of the p21-activated kinases (PAKs), including GIT1, βPIX, and guanine nucleotide exchange factor GEFH1. Platelet activation by thrombin triggered the PAK-dependent phosphorylation of GIT1, GEFH1, and other PAK effectors, including LIMK1 (...) The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation Regulation of the platelet actin cytoskeleton by the Rho family of small GTPases is essential for the proper maintenance of hemostasis. However, little is known about how intracellular platelet activation from Rho GTPase family members, including Rac, Cdc42, and Rho, translate into changes in platelet actin structures. To better understand how Rho family GTPases coordinate platelet activation, we identified

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2013 American Journal of Physiology - Cell Physiology

173. [Gelatin-thrombin matrix-mediated hemostasis: application in tonsillectomy]. (PubMed)

[Gelatin-thrombin matrix-mediated hemostasis: application in tonsillectomy]. To assess the feasibility of omitting thermal coagulation following cold knife tonsillectomy, we compared the use of a local thrombin hemostat (FloSeal®, FS) to bipolar electrocautery (EK).A total of 181 patients with chronic tonsillitis or tonsillar hypertrophy were stratified in terms of patient characteristics and randomized before undergoing tonsillectomy. The follow-up period continued until postoperative day 20

2013 HNO Controlled trial quality: uncertain

174. Dabigatran attenuates thrombin generation to a lesser extent than warfarin: could this explain their differential effects on intracranial hemorrhage and myocardial infarction? (PubMed)

into the RE-LY trial. Warfarin suppresses thrombin generation more efficiently than dabigatran. Greater suppression of normal hemostatic mechanisms in the brain and pathological thrombosis at sites of atherosclerotic plaque disruption may explain the higher rate of intracranial bleeding and lower rate of myocardial infarction with warfarin compared with dabigatran. (...) Dabigatran attenuates thrombin generation to a lesser extent than warfarin: could this explain their differential effects on intracranial hemorrhage and myocardial infarction? Compared with warfarin, dabigatran is associated with less intracranial hemorrhage, but an increased risk of myocardial infarction. To explore these phenomena, we compared their effects on thrombin generation. Thrombin generation in plasma from 10 patients taking therapeutic doses of warfarin (mean INR 2.6) was compared

2013 Journal of thrombosis and thrombolysis Controlled trial quality: uncertain

175. Hemostatic techniques reduce hospital stay following multilevel posterior cervical spine surgery. (PubMed)

Hemostatic techniques reduce hospital stay following multilevel posterior cervical spine surgery. Despite meticulous hemostasis, persistent postoperative drain output following posterior cervical spine procedures often necessitates a prolonged length of hospital stay. We sought to determine if thrombin-soaked absorbable gelatin compressed sponge can decrease postoperative drain output and the length of hospital stay after multilevel posterior cervical spine surgery.We performed a retrospective (...) was soaked in thrombin and applied over the exposed spine before wound closure. A subfascial drain was used in all patients. Total drain output, time for the drainage to decrease to <30 mL per eight-hour shift (at which point the drain was discontinued), the length of stay, the number of readmissions, and postoperative complications were analyzed.Total drain output averaged 93 mL in the study group and 204 mL in the control group (p < 0.0001). The average time for the drainage to decrease to <30 mL per

2012 The Journal of Bone and Joint Surgery. American Volume

176. Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report. (PubMed)

of tryptase, total IgE, porcine, and bovine gelatin-specific IgE. The patient was counseled to avoid gelatin-containing products. At 6-month follow-up, his instrumented spine was radiographically fused and he reported no further allergic issues.Anaphylaxis may occur because of animal gelatin components of topical hemostatic agents. Previous reports have focused on the thrombin components. Care should be taken in the administration of these products, particularly in the atopic individual.Copyright © 2012 (...) Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report. The use of topical hemostatic agents is widespread and has been shown to reduce bleeding during a wide variety of surgical procedures. Nonetheless, as biologically active agents, there is potential for allergic reactions to these products.This is a report of intraoperative anaphylaxis to gelatin associated with the use of two topical hemostatic agents.Case report. There is no outside

2012 The Spine Journal

177. In Vitro Hemostatic Properties of French Lyophilized Plasma. (PubMed)

In Vitro Hemostatic Properties of French Lyophilized Plasma. French lyophilized plasma (FLyP) is used routinely by the French Armed Forces in war settings. The authors compared concentrations of coagulation proteins and global in vitro hemostatic properties in FLyP and in the same plasma before lyophilization to assess the impact of lyophilization on coagulation properties.Twenty-four batches of plasma before and after lyophilization were tested for coagulation proteins. Thrombin generation (...) time, thrombin antithrombin concentration, prothrombin fragment 1 + 2, and thromboelastography were assessed. Finally, the efficiencies of FLyP and plasma before lyophilization were compared on a hemorrhagic shock hemodilution model and tested on TEG(Haemoscope Corporation, Glenview, IL).Prothrombin time ratio (1.1 ± 0.1 vs. 1.2 ± 0.1) and activated partial thromboplastin time (35 ± 1.3 vs. 39 ± 2.4 s) were significantly increased in FLyP (8 ± 3%, P < 0.05 and 11 ± 5%, P < 0.001, respectively

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2012 Anesthesiology

178. Comparative study on hemostatic, cytotoxic and hemolytic activities of different species of Paris L. (PubMed)

Comparative study on hemostatic, cytotoxic and hemolytic activities of different species of Paris L. The rhizoma of Paris polyphylla var. yannanensis or P. polyphylla var. chinensis called Rhizoma Paridis as a traditional Chinese medicine has an effect of heat-clearing and detoxicating, detumescence and acesodyne in folk for a long time. The increasing application of Rhizoma Paridis resulted in the shortage of wildlife resources. Here, we compared the major activities of other species of genus (...) Paris to find the replacement plants.Six species (P. polyphylla var. yunnanensis, P. delavayi var. delavayi, P. fargesii var. Fargesii, P. bashanensis Wang et Tang, P. polyphyllar var. minora, and P. polyphylla var. pseudothibetical) were collected from three Provinces in China, and compared the hemostatic, cytotoxic and hemolytic activities by different assays.For the hemostatic activity, all the plants except Paris fargesii var. Fargesii could significantly shorten the tail bleeding time and blood

2012 Journal of Ethnopharmacology

179. Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox. (PubMed)

Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox. The hemostat, sealant, and adhesive components of the surgical toolbox continue to evolve and enter clinical practice at a rapid rate. The goal of this comprehensive, sequential review is to update these components to include those now available (February 2012) as well as to explore cost and regulatory factors that impact the development and use (...) of these materials. A unique system of definitions for organizing these components based on group, category, and class is used as a means of improving the understanding and appropriate use of these materials. The system will be used here to present the most recent additions to the toolbox, which are evaluated based on safety, efficacy, usability, and cost. These new additions include pooled human plasma fibrinogen and thrombin embedded in an equine collagen patch for cardiac surgical hemostasis, polyethylene

2012 Transfusion

180. Pocket related complications in 163 patients receiving anticoagulation or dual antiplatelet therapy: D-Stat Hemostat versus standard of care. (PubMed)

Pocket related complications in 163 patients receiving anticoagulation or dual antiplatelet therapy: D-Stat Hemostat versus standard of care. Pocket hematoma is a common complication after cardiac rhythm device implantation (CRDI) in patients receiving anticoagulation or dual antiplatelet therapy (DAPT). We sought to assess the safety and effectiveness of D-Stat Flowable Hemostat ([D-Stat]-a mixture of thrombin and collagen) in these patients.We conducted a prospective case control study

2012 International journal of cardiology

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