How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,189 results for

Thrombin Hemostatic

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

81. Topical Hemostatic Agent

Topical Hemostatic Agent Topical Hemostatic Agent Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Hemostatic Agent Topical (...) Hemostatic Agent Aka: Topical Hemostatic Agent , Hemostatic Agents II. Mechanism Topical Hemostatic Agents III. Indications Significant Bleeding Indicated for rapid non-extremity bleeding not controlled with direct manual pressure IV. Precautions Newer agents (Chitosan, and mineral dressings) are not widely available Primarily found in military and large s as of 2013 Risk of wound contamination with hemostatic agent (may require later debridement) V. Preparations: Agent Types Factor Concentrators (drying

2018 FP Notebook

82. Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study (PubMed)

single cohort study was conducted. Results from the CBC, coagulation tests (prothrombin, activated partial thromboplastin and thrombin times, fibrinogen, fibrin(ogen) degradation products, and D-dimer concentrations), rotational thromboelastometry (TEM), signalment, hemorrhagic diatheses, occurrence of disseminated intravascular coagulation (DIC) at admission, and survival to discharge were recorded.The most common hematologic and hemostatic abnormalities were anemia (30/35), thrombocytopenia (21/35 (...) Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study Leptospirosis in dogs is occasionally associated with a hemorrhagic syndrome, the pathophysiology of which is not fully understood.To characterize hematologic, hemostatic, and thromboelastometric abnormalities in dogs with leptospirosis and to study their association with hemorrhagic diatheses and outcomes.Thirty-five client-owned dogs.A prospective observational

Full Text available with Trip Pro

2016 Journal of Veterinary Internal Medicine

83. Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women. (PubMed)

levels were inversely associated with thrombin generation.Background Oral use of exogenous estrogen/progestin alters hemostatic factor levels. The influence of endogenous hormones on these levels is incompletely characterized. Objectives Our study aimed to test whether, among postmenopausal women, high levels of estradiol (E2), estrone (E1), testosterone (T), dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), and androstenedione, and low levels of sex hormone-binding globulin (...) Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women. Essentials Endogenous hormone levels' influence on hemostatic factor levels is not fully characterized. We tested for associations of endogenous hormone with hemostatic factor levels in postmenopause. Estrone levels were inversely associated with the natural anticoagulant, protein S antigen. Dehydroepiandrosterone sulfate

Full Text available with Trip Pro

2016 Journal of Thrombosis and Haemostasis

84. A new anti-fibrinolytic hemostatic compound 8-O-acetyl shanzhiside methylester extracted from Lamiophlomis rotata. (PubMed)

A new anti-fibrinolytic hemostatic compound 8-O-acetyl shanzhiside methylester extracted from Lamiophlomis rotata. Fibrinolysis prevents blood clots from growing and becoming problematic. Antifibrinolytics are used as inhibitors of fibrinolysis. Aprotinin was doubted after identification of major side effects, especially on kidney. Lysine analogues has their own defects and whether they are adequate substitutes for aprotinin is still under doubt. Lamiophlomis rotata (Benth.) Kudo. was previous (...) found to have hemostatic activity. But the active compound in L. rotata and its hemostatic mechanism were unknown.To find the major hemostatic compound in L. rotata and identify its haemostasis mechanism.Traumatic hemorrhage model and coagulant activity assays were monitored in mice and platelets in drug treatment group and control group. Hyperfibrinolysis model was established by intravenous administration of urokinase in mice. Capillary blood clotting time (CBCT), activated partial thromboplastin

2016 Journal of Ethnopharmacology

85. Dynamics of Thrombin Generation and Flux from Clots during Whole Human Blood Flow over Collagen/Tissue Factor Surfaces (PubMed)

coating became less efficient on a per μm2 basis, likely due to distal boundary layer depletion of platelets. Overall, thrombin is robustly generated within clots by the extrinsic pathway followed by late-stage FXIa contributions, with fibrin localizing thrombin via its antithrombin-I activity as a potentially self-limiting hemostatic mechanism.© 2016 by The American Society for Biochemistry and Molecular Biology, Inc. (...) Dynamics of Thrombin Generation and Flux from Clots during Whole Human Blood Flow over Collagen/Tissue Factor Surfaces Coagulation kinetics are well established for purified blood proteases or human plasma clotting isotropically. However, less is known about thrombin generation kinetics and transport within blood clots formed under hemodynamic flow. Using microfluidic perfusion (wall shear rate, 200 s-1) of corn trypsin inhibitor-treated whole blood over a 250-μm long patch of type I fibrillar

Full Text available with Trip Pro

2016 The Journal of biological chemistry

86. Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass

Hematologic Diseases Vascular Diseases Cardiovascular Diseases Hemorrhagic Disorders Thrombin Hemostatics Coagulants (...) Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2016 Clinical Trials

87. Age-dependency of Thrombin Generation Using a New Standardized Assay

ClinicalTrials.gov Identifier: Other Study ID Numbers: PO16107 First Posted: January 2, 2017 Last Update Posted: February 13, 2018 Last Verified: February 2018 Additional relevant MeSH terms: Layout table for MeSH terms Thrombin Hemostatics Coagulants (...) Age-dependency of Thrombin Generation Using a New Standardized Assay Age-dependency of Thrombin Generation Using a New Standardized Assay - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Age-dependency

2016 Clinical Trials

88. Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum

Individual Participant Data (IPD) Sharing Statement: Plan to Share IPD: Yes Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Varicose Ulcer Varicose Veins Vascular Diseases Cardiovascular Diseases Leg Ulcer Skin Ulcer Skin Diseases Thrombin Hemostatics Coagulants (...) Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety

2016 Clinical Trials

89. Rapid hemostasis in a sheep model using particles that propel thrombin and tranexamic acid. (PubMed)

Rapid hemostasis in a sheep model using particles that propel thrombin and tranexamic acid. Bleeding during endoscopic sinus surgery and open surgeries can easily obstruct the surgeons' field of view and increase morbidity and risk of intraoperative complications. Intraoperative bleeding could potentially be addressed by a hemostatic agent that safely disperses itself through the escaping blood. We tested the safety and efficacy of a self-propelling formulation of thrombin and tranexamic acid

2016 Laryngoscope

90. Haemostasis in Thyroid Surgery: Collagen-Fibrinogen-Thrombin Patch versus Cellulose Gauze—Our Experience (PubMed)

Haemostasis in Thyroid Surgery: Collagen-Fibrinogen-Thrombin Patch versus Cellulose Gauze—Our Experience Purpose. Postoperative hemorrhage is fortunately uncommon but potentially life-threatening complication of thyroid surgery that increases the postoperative morbidity and the hospital stay. In this study we compare the efficacy of collagen patch coated with human fibrinogen and human thrombin (CFTP) (group C) and oxidized regenerated cellulose gauze (group B) versus traditional hemostatic

Full Text available with Trip Pro

2016 Surgery research and practice

91. Direct Thrombin Inhibitor

Direct Thrombin Inhibitor Direct Thrombin Inhibitor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Direct Thrombin Inhibitor Direct (...) Thrombin Inhibitor Aka: Direct Thrombin Inhibitor , Antithrombin , Hirudin , Lepirudin , Refludan , Bivalirudin , Angiomax , Desirudin , Ipravask , Argatroban , Acova From Related Chapters II. Indications Thrombus prophylaxis, treatment or and III. Dosing: Hirudins (bivalent peptide derivatives from Salivary Gland of medicinal leaches) Lepirudan (Refludan) See other references for dosing Bivalirudin (Angiomax) Used in if contraindicated Coadminister with Initial: 0.75 mg/kg IV bolus Later: 1.75 mg/kg

2018 FP Notebook

92. TGA (Thrombin Generation Assay) and Prophylaxis in Haemophilia

assay factor VIII prophylactic therapy Additional relevant MeSH terms: Layout table for MeSH terms Hemophilia A Blood Coagulation Disorders, Inherited Blood Coagulation Disorders Hematologic Diseases Coagulation Protein Disorders Hemorrhagic Disorders Genetic Diseases, Inborn Factor VIII Thrombin Coagulants Hemostatics (...) TGA (Thrombin Generation Assay) and Prophylaxis in Haemophilia TGA (Thrombin Generation Assay) and Prophylaxis in Haemophilia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. TGA (Thrombin Generation Assay

2016 Clinical Trials

93. Does the Thrombin Generation Test Performed During the Pharmacokinetic Profile of the Substitutive Factor VIII Bring Benefits to the Personalized Treatment of Pediatric Patients and Adult Hemophilia A Patients Under Prophylaxis ?

Hospital Information provided by (Responsible Party): Dr Anne Demulder, Brugmann University Hospital Study Details Study Description Go to Brief Summary: In the context of hemophilia, it is well know that the level of factor VIII alone does not reflect the clinical phenotype of the patients in an accurate way. At equal factor VIII levels, certain patients will bleed more than others. The thrombin generation test (TGT) is a test that seems to provide a better prediction of the overall hemostatic status (...) for MeSH terms Hemophilia A Blood Coagulation Disorders, Inherited Blood Coagulation Disorders Hematologic Diseases Coagulation Protein Disorders Hemorrhagic Disorders Genetic Diseases, Inborn Factor VIII Thrombin Coagulants Hemostatics

2016 Clinical Trials

94. Patients Referred for Bleeding Symptoms of Unknown Cause: Does Evaluation of Thrombin Generation Contribute to Diagnosis? (PubMed)

Patients Referred for Bleeding Symptoms of Unknown Cause: Does Evaluation of Thrombin Generation Contribute to Diagnosis? Patients with mild to moderate bleeding symptoms referred for coagulation investigation sometimes never receive a definitive diagnosis. Bleed assessment tools have been developed and validated to assess the severity of symptoms. Global coagulation assays, e.g., the thrombin generation test (thrombogram) have a potential to identify hemostatic defects that are not detected (...) in specific assays.One hundred and eighty-five patients referred to our centre because of bleeding symptoms were evaluated using the bleeding assessment tool (BAT) described by Tosetto and colleagues in 2006. Blood samples were investigated for thrombin generation (TG) capacity (Technoclone), in platelet poor (PPP) plasma, and specific clotting factors, i.e., von Willebrand factor, factor VIII and IX, as well as INR, APTT, platelet count, and platelet adhesion.Of the 185 patients, five women were

Full Text available with Trip Pro

2016 Mediterranean journal of hematology and infectious diseases

95. Thrombin Generation in Zebrafish Blood (PubMed)

Thrombin Generation in Zebrafish Blood To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemostasis and thrombosis, as the hemostatic system proved to be similar to that in man. Their small size however, has been a hurdle for more widespread use in hemostasis related research. In this study we developed (...) a method that enables the measurement of thrombin generation in a single drop of non-anticoagulated zebrafish blood. Pre-treatment of the fish with inhibitors of FXa and thrombin, resulted in a dose dependent diminishing of thrombin generation, demonstrating the validity of the assay. In order to establish the relationship between whole blood thrombin generation and fibrin formation, we visualized the resulting fibrin network by scanning electron microscopy. Taken together, in this study we developed

Full Text available with Trip Pro

2016 PloS one

96. Improved bleeding scores using Gelfoam® Powder with incremental concentrations of bovine thrombin in a swine liver lesion model (PubMed)

Improved bleeding scores using Gelfoam® Powder with incremental concentrations of bovine thrombin in a swine liver lesion model Topical hemostatic agents are used intra-operatively to prevent uncontrolled bleeding. Gelfoam(®) Powder contains a hemostatic agent prepared from purified pork skin gelatin, the efficacy of which is increased when combined with thrombin. However, the effect of increasing concentrations of thrombin on resultant hemostasis is not known. This study sought to evaluate (...) system; comparison of bleeding scores was performed using ANOVA with the post hoc Tukey test. The bleeding scores with thrombin concentrations at 770 IU/mL were significantly lower than at 250 and 375 IU/mL at all four time points. The percentage of biopsies with a clinically acceptable bleeding score rose from 37.9, 46.6, and 71.2 % at 3 min to 55.2, 69.0, and 88.1 % at 12 min in the 250, 375, and 770 IU/mL thrombin groups, respectively. The study showed that the hemostatic response to thrombin

Full Text available with Trip Pro

2016 Journal of thrombosis and thrombolysis

97. Coagulation and non-coagulation effects of thrombin. (PubMed)

Coagulation and non-coagulation effects of thrombin. Thrombin is a multifunctional serine protease produced from prothrombin, and is a key regulator in hemostatic and non-hemostatic processes. It is the main effector protease in primary hemostasis by activating platelets, and plays a key role in secondary hemostasis. Besides its well-known functions in hemostasis, thrombin also plays a role in various non-hemostatic biological and pathophysiologic processes, predominantly mediated through (...) pathways, the exact mechanism behind the dichotomy of thrombin is yet still unknown. In this review, we highlight the hemostatic and non-hemostatic functions of thrombin, and specifically focus on the non-hemostatic dual role of thrombin under various conditions and in relation to cardiovascular disease.© 2016 International Society on Thrombosis and Haemostasis.

Full Text available with Trip Pro

2016 Journal of Thrombosis and Haemostasis

98. Hemostatic Therapy in Experimental Intracerebral Hemorrhage Associated With the Direct Thrombin Inhibitor Dabigatran. (PubMed)

Hemostatic Therapy in Experimental Intracerebral Hemorrhage Associated With the Direct Thrombin Inhibitor Dabigatran. Dabigatran-etexilate (DE) recently has been approved for stroke prevention in atrial fibrillation. However, lack of effective antagonists represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model of ICH associated with dabigatran, and to test the efficacy of different hemostatic factors in preventing

Full Text available with Trip Pro

2011 Stroke

99. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies (PubMed)

Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies Hemostatic defects are treated using coagulation factors; however, clot formation also requires a procoagulant phospholipid (PL) surface. Here, we show that innate immune cell-derived enzymatically oxidized phospholipids (eoxPL) termed hydroxyeicosatetraenoic acid-phospholipids (HETE-PLs) restore hemostasis in human and murine conditions of pathological bleeding. HETE-PLs abolished blood loss

Full Text available with Trip Pro

2018 JCI insight

100. The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin.

Identifier: Other Study ID Numbers: thrombingeneration- anemia First Posted: May 2, 2014 Last Update Posted: December 18, 2018 Last Verified: December 2015 Keywords provided by Elias mazen, HaEmek Medical Center, Israel: Anemias Iron-Deficiency thrombin Additional relevant MeSH terms: Layout table for MeSH terms Anemia Anemia, Iron-Deficiency Deficiency Diseases Hematologic Diseases Anemia, Hypochromic Iron Metabolism Disorders Metabolic Diseases Malnutrition Nutrition Disorders Thrombin Hemostatics (...) The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin. The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin. - Full

2014 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>