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Thrombin Hemostatic

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81. Thrombin Generation Values and Percutaneous Coronary Intervention Results.

Product: No Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: No Keywords provided by HaEmek Medical Center, Israel: thrombin generation calibrated automated thrombogram ischemic heart disease Percutaneous Coronary Intervention Additional relevant MeSH terms: Layout table for MeSH terms Ischemia Heart Diseases Myocardial Ischemia Coronary Artery Disease Coronary Stenosis Blood Coagulation Disorders Hemostatic Disorders Pathologic Processes (...) Cardiovascular Diseases Vascular Diseases Coronary Disease Arteriosclerosis Arterial Occlusive Diseases Hematologic Diseases Hemorrhagic Disorders Thrombin Hemostatics Coagulants

2017 Clinical Trials

82. Thrombin Generation and Platelet Activation in CRS/HIPEC

Peritoneal Diseases Neoplasms, Cystic, Mucinous, and Serous Thrombin Hemostatics Coagulants (...) Thrombin Generation and Platelet Activation in CRS/HIPEC Thrombin Generation and Platelet Activation in CRS/HIPEC - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thrombin Generation and Platelet Activation

2017 Clinical Trials

83. Meal-induced Thrombin Generation Before and After Gastric Bypass

terms: Layout table for MeSH terms Weight Loss Obesity, Morbid Body Weight Changes Body Weight Signs and Symptoms Obesity Overnutrition Nutrition Disorders Overweight Thrombin Hemostatics Coagulants (...) Meal-induced Thrombin Generation Before and After Gastric Bypass Meal-induced Thrombin Generation Before and After Gastric Bypass - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Meal-induced Thrombin

2017 Clinical Trials

84. Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent. Full Text available with Trip Pro

Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent. Essentials Cancer cachexia and cancer-associated thrombosis have not previously been mechanistically linked. We assessed thrombin generation and coagulation parameters in cachectic C26 tumor-bearing mice. C26 mice are hypercoagulable, partially corrected by blocking tumor derived interleukin-6. Coagulability and anti-inflammatory interventions may be clinically important in cancer (...) (F1 hybrid) mice with a C26 tumor we used modified calibrated automated thrombogram and fibrin generation (based on overall hemostatic potential) assays to assess the functional coagulation state, and also examined fibrinogen, erythrocyte sedimentation rate (ESR), platelet count, tissue factor pathway inhibitor (TFPI) and hepatic expression of coagulation factors by microarray. C26 mice were compared with non-cachectic NC26, pair-fed and sham control mice. IL-6 expression in C26 cells was knocked

2017 Journal of Thrombosis and Haemostasis

85. Reduced Requirement for Prothrombin Complex Concentrate for the Restoration of Thrombin Generation in Plasma from Liver Transplant Recipients. (Abstract)

Reduced Requirement for Prothrombin Complex Concentrate for the Restoration of Thrombin Generation in Plasma from Liver Transplant Recipients. Plasma transfusion remains the mainstay hemostatic therapy during liver transplantation (LT) in most countries. However, a large volume is required for plasma to achieve clinically relevant factor increases. Prothrombin complex concentrate (PCC) is a low-volume alternative to plasma in warfarin reversal, but its efficacy has not been well studied (...) in LT.Blood samples were collected from 28 LT patients at baseline (T0) and 30 minutes after graft reperfusion (T1). Factor X and antithrombin levels were measured. Ex vivo effects of PCC (0.2 and 0.4 IU/mL) and 10% volume replacement with normal plasma were compared in LT and warfarin plasma by measuring lag time, thrombin peak, and endogenous thrombin potential (ETP) using thrombin generation (TG) assay.Coagulation status was worsened at T1 as international normalized ratio increased from 1.7 to 3.0

2017 Anesthesia and Analgesia

86. Comparing Thrombin Generation in Patients with Hemophilia A and Patients on Vitamin K Antagonists. Full Text available with Trip Pro

to hear Dr Negrier's perspective on global assays for assessing coagulation SUMMARY: Background It is unknown whether patients with hemophilia A with atrial fibrillation require treatment with vitamin K antagonists (VKAs) to the same extent as the normal population. Objective To compare hemostatic potential in hemophilia patients and patients on VKAs using thrombin generation (TG). Methods In this cross-sectional study, TG, initiated with 1pM tissue factor, was measured in 133 patients with severe (...) Comparing Thrombin Generation in Patients with Hemophilia A and Patients on Vitamin K Antagonists. Essentials It is unknown if hemophilia patients with atrial fibrillation need anticoagulation. Endogenous thrombin potentials (ETP) in hemophilia patients and patients on coumarins were compared. Severe hemophilia patients had comparable ETP to therapeutic international normalized ratio (INR). In non-severe hemophilia, 33% had higher ETP than therapeutic INR and may need anticoagulation. Click

2017 Journal of Thrombosis and Haemostasis

87. Concentrated lyophilized plasma used for reconstitution of whole blood leads to higher coagulation factor activity but unchanged thrombin potential compared with fresh-frozen plasma. Full Text available with Trip Pro

). The hemostatic capacity of each reconstituted whole blood sample was tested with blood cell counts, standard coagulation tests, factor activity, thrombin generation, and viscoelastic assays.Hematocrit, platelet counts, and fibrinogen levels of the three ratios were similar between FFP200 and LP200 units but were lower compared with the corresponding ratios in LP100 and LP50 units. The activity of procoagulant and anticoagulant factors increased linearly with the increasing plasmatic fraction and, at 1:1:2 (...) Concentrated lyophilized plasma used for reconstitution of whole blood leads to higher coagulation factor activity but unchanged thrombin potential compared with fresh-frozen plasma. During massive hemorrhage, it is recommended to transfuse red blood cells, platelet concentrate, and fresh-frozen plasma in a ratio close to 1:1:1. To avoid the thawing process of fresh frozen plasma, lyophilized plasma (LP) is increasingly used. Evidence is limited on the activity of coagulation factors

2017 Transfusion

88. The Efficacy of a Thrombin-Based Hemostatic Agent in Unilateral Total Knee Arthroplasty: A Randomized Controlled Trial. (Abstract)

The Efficacy of a Thrombin-Based Hemostatic Agent in Unilateral Total Knee Arthroplasty: A Randomized Controlled Trial. Blood loss following total knee arthroplasty can lead to substantial morbidity and the need for blood transfusions. Hemostatic agents have been used to minimize blood loss and to decrease transfusion rates. Floseal is a thrombin-based hemostatic agent with unknown efficacy for achieving these goals in patients undergoing total knee arthroplasty.We performed a prospective (...) (two in each group) underwent knee manipulation under anesthesia to achieve improved knee motion. With the numbers available, there was no significant association between Floseal use and the occurrence of these adverse events.The present study showed that Floseal had no demonstrable effect on blood loss as measured through drain output following total knee arthroplasty. There were also no notable adverse events associated with its use. The usefulness of Floseal as a hemostatic agent in total knee

2012 The Journal of Bone and Joint Surgery. American Volume Controlled trial quality: uncertain

89. Topical Hemostatic Agent

Topical Hemostatic Agent Topical Hemostatic Agent Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Hemostatic Agent Topical (...) Hemostatic Agent Aka: Topical Hemostatic Agent , Hemostatic Agents II. Mechanism Topical Hemostatic Agents III. Indications Significant Bleeding Indicated for rapid non-extremity bleeding not controlled with direct manual pressure IV. Precautions Newer agents (Chitosan, and mineral dressings) are not widely available Primarily found in military and large s as of 2013 Risk of wound contamination with hemostatic agent (may require later debridement) V. Preparations: Agent Types Factor Concentrators (drying

2018 FP Notebook

90. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XX. THE DEVELOPMENT OF FIBRIN FOAM AS A HEMOSTATIC AGENT AND FOR USE IN CONJUNCTION WITH HUMAN THROMBIN Full Text available with Trip Pro

CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XX. THE DEVELOPMENT OF FIBRIN FOAM AS A HEMOSTATIC AGENT AND FOR USE IN CONJUNCTION WITH HUMAN THROMBIN 16695138 2006 05 31 2018 11 13 0021-9738 23 4 1944 Jul The Journal of clinical investigation J. Clin. Invest. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XX. THE DEVELOPMENT OF FIBRIN FOAM AS A HEMOSTATIC AGENT AND FOR USE IN CONJUNCTION WITH HUMAN (...) THROMBIN. 586-90 Bering E A EA Department of Physical Chemistry, Harvard Medical School, Boston. eng Journal Article United States J Clin Invest 7802877 0021-9738 1944 7 1 0 0 1944 7 1 0 1 1944 7 1 0 0 ppublish 16695138 10.1172/JCI101527 PMC435376 J Clin Invest. 1944 Jul;23(4):417-32 16695119 J Clin Invest. 1944 Jul;23(4):557-65 16695133 J Clin Invest. 1944 Jul;23(4):591-6 16695139 Science. 1941 Apr 4;93(2414):328 17748329 Science. 1939 Jan 27;89(2300):86 17787747 Ann Surg. 1943 Jul;118(1):116-26

1944 Journal of Clinical Investigation

91. Direct Thrombin Inhibitor

Direct Thrombin Inhibitor Direct Thrombin Inhibitor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Direct Thrombin Inhibitor Direct (...) Thrombin Inhibitor Aka: Direct Thrombin Inhibitor , Antithrombin , Hirudin , Lepirudin , Refludan , Bivalirudin , Angiomax , Desirudin , Ipravask , Argatroban , Acova From Related Chapters II. Indications Thrombus prophylaxis, treatment or and III. Dosing: Hirudins (bivalent peptide derivatives from Salivary Gland of medicinal leaches) Lepirudan (Refludan) See other references for dosing Bivalirudin (Angiomax) Used in if contraindicated Coadminister with Initial: 0.75 mg/kg IV bolus Later: 1.75 mg/kg

2018 FP Notebook

92. The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin.

Identifier: Other Study ID Numbers: thrombingeneration- anemia First Posted: May 2, 2014 Last Update Posted: December 18, 2018 Last Verified: December 2015 Keywords provided by Elias mazen, HaEmek Medical Center, Israel: Anemias Iron-Deficiency thrombin Additional relevant MeSH terms: Layout table for MeSH terms Anemia Anemia, Iron-Deficiency Deficiency Diseases Hematologic Diseases Anemia, Hypochromic Iron Metabolism Disorders Metabolic Diseases Malnutrition Nutrition Disorders Thrombin Hemostatics (...) The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin. The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin. - Full

2014 Clinical Trials

93. The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women. Full Text available with Trip Pro

presence and severity reported in the 4 weeks before WHI baseline, who were not using warfarin or hormone therapy and for whom the following baseline hemostatic parameters were measured within the WHI Cardiovascular Disease Biomarker Case-Control Study: antithrombin, plasminogen activator inhibitor-1, protein C antigen, total and free protein S antigen, total and free tissue factor pathway inhibitor, D-dimer, normalized activated protein C sensitivity ratio, and thrombin generation. Using multiple (...) The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women. Vasomotor symptoms (VMS) may be a marker of cardiovascular risk. We aimed to evaluate the cross-sectional association of VMS presence and severity with hemostatic parameter levels measured at baseline among Women's Health Initiative (WHI) Hormone Therapy trial postmenopausal participants.This cross-sectional analysis included 2,148 postmenopausal women with measures of VMS

2016 Menopause

94. Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women. Full Text available with Trip Pro

levels were inversely associated with thrombin generation.Background Oral use of exogenous estrogen/progestin alters hemostatic factor levels. The influence of endogenous hormones on these levels is incompletely characterized. Objectives Our study aimed to test whether, among postmenopausal women, high levels of estradiol (E2), estrone (E1), testosterone (T), dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), and androstenedione, and low levels of sex hormone-binding globulin (...) Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women. Essentials Endogenous hormone levels' influence on hemostatic factor levels is not fully characterized. We tested for associations of endogenous hormone with hemostatic factor levels in postmenopause. Estrone levels were inversely associated with the natural anticoagulant, protein S antigen. Dehydroepiandrosterone sulfate

2016 Journal of Thrombosis and Haemostasis

95. Preserved hemostatic status in patients with non-alcoholic fatty liver disease. (Abstract)

Preserved hemostatic status in patients with non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of thrombosis. However, it remains unclear if hypercoagulability contributes to this risk. We, therefore, determined an in-depth hemostatic profile in a cohort of well-defined patients with NAFLD.We drew blood samples from 68 patients with biopsy-proven NAFLD (simple steatosis n=24, NASH n=22, and NASH cirrhosis n=22), 30 lean controls (...) , 30 overweight controls (body mass index (BMI) >25kg/m2), and 15 patients with alcoholic (ASH) cirrhosis, and performed in-depth hemostatic profiling.Basal and agonist-induced platelet activation, plasma levels of markers of platelet activation, and plasma levels of the platelet adhesion regulators von Willebrand factor and ADAMTS13 were comparable between patients with non-cirrhotic NAFLD and controls. Agonist-induced platelet activation was decreased in patients with cirrhosis. Thrombomodulin

2016 Journal of Hepatology

96. The hemostatic properties of thawed pooled cryoprecipitate up to 72 hours. (Abstract)

at 24, 48, and 72 hours compared with the baseline; however, at all time points units met the UK specification for FVIII level. The peak thrombin, endogenous thrombin potential, and all ROTEM variables remained unchanged after 72 hours.The hemostatic properties of thawed pooled cryoprecipitate, maintained at ambient temperature, remain stable for up to 72 hours. Stocking a prethawed product may optimize inventory management, to ensure product availability for rapid transfusion. Further studies need (...) The hemostatic properties of thawed pooled cryoprecipitate up to 72 hours. There is increasing interest in replacing fibrinogen early for the treatment of major hemorrhage. In countries where cryoprecipitate is the main concentrated source of fibrinogen, the thawing process complicates the timely availability of cryoprecipitate for transfusion early during major bleeding. The aim of the study was to investigate the hemostatic quality of cryoprecipitate, thawed and held at 18 to 24°C for up

2016 Transfusion

97. A new anti-fibrinolytic hemostatic compound 8-O-acetyl shanzhiside methylester extracted from Lamiophlomis rotata. (Abstract)

A new anti-fibrinolytic hemostatic compound 8-O-acetyl shanzhiside methylester extracted from Lamiophlomis rotata. Fibrinolysis prevents blood clots from growing and becoming problematic. Antifibrinolytics are used as inhibitors of fibrinolysis. Aprotinin was doubted after identification of major side effects, especially on kidney. Lysine analogues has their own defects and whether they are adequate substitutes for aprotinin is still under doubt. Lamiophlomis rotata (Benth.) Kudo. was previous (...) found to have hemostatic activity. But the active compound in L. rotata and its hemostatic mechanism were unknown.To find the major hemostatic compound in L. rotata and identify its haemostasis mechanism.Traumatic hemorrhage model and coagulant activity assays were monitored in mice and platelets in drug treatment group and control group. Hyperfibrinolysis model was established by intravenous administration of urokinase in mice. Capillary blood clotting time (CBCT), activated partial thromboplastin

2016 Journal of Ethnopharmacology

98. Hemostatic Therapy Using Tranexamic Acid and Coagulation Factor Concentrates in a Model of Traumatic Liver Injury. (Abstract)

Hemostatic Therapy Using Tranexamic Acid and Coagulation Factor Concentrates in a Model of Traumatic Liver Injury. The potential clinical benefits of targeted therapy with coagulation factor concentrates (e.g., fibrinogen) and antifibrinolytic agents (e.g., tranexamic acid [TXA]) for the treatment of trauma-induced coagulopathy are increasingly recognized. We hypothesized that human fibrinogen concentrate (FC) and prothrombin complex concentrate (PCC), administered as combined therapy with TXA (...) , would provide additive effects for reducing blood loss in an animal trauma model.Thirty-six pigs were subjected to 2 consecutive blunt liver injuries, resulting in severe hemorrhagic shock and coagulopathy. Intervention comprised saline (control group); TXA (15 mg kg, TXA group); TXA and FC (90 mg kg, TXA-FC); or TXA, FC, and PCC (20 U kg, TXA-FC-PCC). Blood loss, thromboelastometry (ROTEM), measures of thrombin generation, platelet activation, and global coagulation variables were monitored for 4

2016 Anesthesia and Analgesia

99. Hemostatic Wound Dressing for Postinterventional Hemostasis in Large Femoral Artery Access Sites: An Initial Efficacy and Safety Study. Full Text available with Trip Pro

Hemostatic Wound Dressing for Postinterventional Hemostasis in Large Femoral Artery Access Sites: An Initial Efficacy and Safety Study. To present the results of a prospective single-center study that evaluated the safety and efficacy of a hemostatic dressing following femoral artery access.Within a 9-month period, 80 patients (mean age 68±14 years; 55 men) were treated with a hemostatic dressing patch (Hematrix Active Patch) containing aminocaproic acid, calcium chloride, and thrombin after

2016 Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

100. Compression Socks Worn During Flight and Hemostatic Balance in Boston Marathon Runners on Oral Contraceptives. (Abstract)

Compression Socks Worn During Flight and Hemostatic Balance in Boston Marathon Runners on Oral Contraceptives. To investigate the effect of oral contraceptive (OC) use and compression socks on hemostatic activation in women flying cross-country to and from a marathon.Prospective study.2015 Boston Marathon.Women were divided into non-OC using (CONTROL; n = 12), OC-using (OC; n = 15), and OC-using plus compression sock (OC + SOCK; n = 14) groups.Women in OC + SOCK wore compression socks during (...) flights to and from the marathon.Venous blood samples were collected within 24 hours of arriving in Boston (EXPO), immediately after the marathon (RUN), and within 24 hours after a return flight home (Post-Flight) for analysis of thrombin-antithrombin complex (TAT), d-dimer, and tissue plasminogen activator (t-PA).TAT did not increase with exercise (P = 0.48) and was not affected by group (P = 0.08) or the interaction between these 2 factors (P = 0.80). Group, time, and their interaction were

2017 Clinical Journal of Sport Medicine Controlled trial quality: uncertain

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