How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,218 results for

Thrombin Hemostatic

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

81. Thrombin Generation and Platelet Activation in CRS/HIPEC

Peritoneal Diseases Neoplasms, Cystic, Mucinous, and Serous Thrombin Hemostatics Coagulants (...) Thrombin Generation and Platelet Activation in CRS/HIPEC Thrombin Generation and Platelet Activation in CRS/HIPEC - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thrombin Generation and Platelet Activation

2017 Clinical Trials

82. Evaluation of a Standardized Protocol for Thrombin Generation Assay

Diseases Coagulation Protein Disorders Hemorrhagic Disorders Genetic Diseases, Inborn Thrombin Hemostatics Coagulants (...) Evaluation of a Standardized Protocol for Thrombin Generation Assay Evaluation of a Standardized Protocol for Thrombin Generation Assay - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation

2017 Clinical Trials

83. Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management.

, Heparin, Protamine Additional relevant MeSH terms: Layout table for MeSH terms Heparin Calcium heparin Thrombin Protamines Anticoagulants Fibrinolytic Agents Fibrin Modulating Agents Molecular Mechanisms of Pharmacological Action Hemostatics Coagulants Heparin Antagonists (...) Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management. Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

84. Comparing Thrombin Generation in Patients with Hemophilia A and Patients on Vitamin K Antagonists. Full Text available with Trip Pro

to hear Dr Negrier's perspective on global assays for assessing coagulation SUMMARY: Background It is unknown whether patients with hemophilia A with atrial fibrillation require treatment with vitamin K antagonists (VKAs) to the same extent as the normal population. Objective To compare hemostatic potential in hemophilia patients and patients on VKAs using thrombin generation (TG). Methods In this cross-sectional study, TG, initiated with 1pM tissue factor, was measured in 133 patients with severe (...) Comparing Thrombin Generation in Patients with Hemophilia A and Patients on Vitamin K Antagonists. Essentials It is unknown if hemophilia patients with atrial fibrillation need anticoagulation. Endogenous thrombin potentials (ETP) in hemophilia patients and patients on coumarins were compared. Severe hemophilia patients had comparable ETP to therapeutic international normalized ratio (INR). In non-severe hemophilia, 33% had higher ETP than therapeutic INR and may need anticoagulation. Click

2017 Journal of Thrombosis and Haemostasis

85. Reduced Requirement for Prothrombin Complex Concentrate for the Restoration of Thrombin Generation in Plasma from Liver Transplant Recipients. (Abstract)

Reduced Requirement for Prothrombin Complex Concentrate for the Restoration of Thrombin Generation in Plasma from Liver Transplant Recipients. Plasma transfusion remains the mainstay hemostatic therapy during liver transplantation (LT) in most countries. However, a large volume is required for plasma to achieve clinically relevant factor increases. Prothrombin complex concentrate (PCC) is a low-volume alternative to plasma in warfarin reversal, but its efficacy has not been well studied (...) in LT.Blood samples were collected from 28 LT patients at baseline (T0) and 30 minutes after graft reperfusion (T1). Factor X and antithrombin levels were measured. Ex vivo effects of PCC (0.2 and 0.4 IU/mL) and 10% volume replacement with normal plasma were compared in LT and warfarin plasma by measuring lag time, thrombin peak, and endogenous thrombin potential (ETP) using thrombin generation (TG) assay.Coagulation status was worsened at T1 as international normalized ratio increased from 1.7 to 3.0

2017 Anesthesia and Analgesia

86. Concentrated lyophilized plasma used for reconstitution of whole blood leads to higher coagulation factor activity but unchanged thrombin potential compared with fresh-frozen plasma. Full Text available with Trip Pro

). The hemostatic capacity of each reconstituted whole blood sample was tested with blood cell counts, standard coagulation tests, factor activity, thrombin generation, and viscoelastic assays.Hematocrit, platelet counts, and fibrinogen levels of the three ratios were similar between FFP200 and LP200 units but were lower compared with the corresponding ratios in LP100 and LP50 units. The activity of procoagulant and anticoagulant factors increased linearly with the increasing plasmatic fraction and, at 1:1:2 (...) Concentrated lyophilized plasma used for reconstitution of whole blood leads to higher coagulation factor activity but unchanged thrombin potential compared with fresh-frozen plasma. During massive hemorrhage, it is recommended to transfuse red blood cells, platelet concentrate, and fresh-frozen plasma in a ratio close to 1:1:1. To avoid the thawing process of fresh frozen plasma, lyophilized plasma (LP) is increasingly used. Evidence is limited on the activity of coagulation factors

2017 Transfusion

87. Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent. Full Text available with Trip Pro

Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent. Essentials Cancer cachexia and cancer-associated thrombosis have not previously been mechanistically linked. We assessed thrombin generation and coagulation parameters in cachectic C26 tumor-bearing mice. C26 mice are hypercoagulable, partially corrected by blocking tumor derived interleukin-6. Coagulability and anti-inflammatory interventions may be clinically important in cancer (...) (F1 hybrid) mice with a C26 tumor we used modified calibrated automated thrombogram and fibrin generation (based on overall hemostatic potential) assays to assess the functional coagulation state, and also examined fibrinogen, erythrocyte sedimentation rate (ESR), platelet count, tissue factor pathway inhibitor (TFPI) and hepatic expression of coagulation factors by microarray. C26 mice were compared with non-cachectic NC26, pair-fed and sham control mice. IL-6 expression in C26 cells was knocked

2017 Journal of Thrombosis and Haemostasis

88. Thrombin Generation Values and Percutaneous Coronary Intervention Results.

Product: No Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: No Keywords provided by HaEmek Medical Center, Israel: thrombin generation calibrated automated thrombogram ischemic heart disease Percutaneous Coronary Intervention Additional relevant MeSH terms: Layout table for MeSH terms Ischemia Heart Diseases Myocardial Ischemia Coronary Artery Disease Coronary Stenosis Blood Coagulation Disorders Hemostatic Disorders Pathologic Processes (...) Cardiovascular Diseases Vascular Diseases Coronary Disease Arteriosclerosis Arterial Occlusive Diseases Hematologic Diseases Hemorrhagic Disorders Thrombin Hemostatics Coagulants

2017 Clinical Trials

89. Topical Hemostatic Agent

Topical Hemostatic Agent Topical Hemostatic Agent Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Hemostatic Agent Topical (...) Hemostatic Agent Aka: Topical Hemostatic Agent , Hemostatic Agents II. Mechanism Topical Hemostatic Agents III. Indications Significant Bleeding Indicated for rapid non-extremity bleeding not controlled with direct manual pressure IV. Precautions Newer agents (Chitosan, and mineral dressings) are not widely available Primarily found in military and large s as of 2013 Risk of wound contamination with hemostatic agent (may require later debridement) V. Preparations: Agent Types Factor Concentrators (drying

2018 FP Notebook

90. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XX. THE DEVELOPMENT OF FIBRIN FOAM AS A HEMOSTATIC AGENT AND FOR USE IN CONJUNCTION WITH HUMAN THROMBIN Full Text available with Trip Pro

CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XX. THE DEVELOPMENT OF FIBRIN FOAM AS A HEMOSTATIC AGENT AND FOR USE IN CONJUNCTION WITH HUMAN THROMBIN 16695138 2006 05 31 2018 11 13 0021-9738 23 4 1944 Jul The Journal of clinical investigation J. Clin. Invest. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XX. THE DEVELOPMENT OF FIBRIN FOAM AS A HEMOSTATIC AGENT AND FOR USE IN CONJUNCTION WITH HUMAN (...) THROMBIN. 586-90 Bering E A EA Department of Physical Chemistry, Harvard Medical School, Boston. eng Journal Article United States J Clin Invest 7802877 0021-9738 1944 7 1 0 0 1944 7 1 0 1 1944 7 1 0 0 ppublish 16695138 10.1172/JCI101527 PMC435376 J Clin Invest. 1944 Jul;23(4):417-32 16695119 J Clin Invest. 1944 Jul;23(4):557-65 16695133 J Clin Invest. 1944 Jul;23(4):591-6 16695139 Science. 1941 Apr 4;93(2414):328 17748329 Science. 1939 Jan 27;89(2300):86 17787747 Ann Surg. 1943 Jul;118(1):116-26

1944 Journal of Clinical Investigation

91. Direct Thrombin Inhibitor

Direct Thrombin Inhibitor Direct Thrombin Inhibitor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Direct Thrombin Inhibitor Direct (...) Thrombin Inhibitor Aka: Direct Thrombin Inhibitor , Antithrombin , Hirudin , Lepirudin , Refludan , Bivalirudin , Angiomax , Desirudin , Ipravask , Argatroban , Acova From Related Chapters II. Indications Thrombus prophylaxis, treatment or and III. Dosing: Hirudins (bivalent peptide derivatives from Salivary Gland of medicinal leaches) Lepirudan (Refludan) See other references for dosing Bivalirudin (Angiomax) Used in if contraindicated Coadminister with Initial: 0.75 mg/kg IV bolus Later: 1.75 mg/kg

2018 FP Notebook

92. The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin.

Identifier: Other Study ID Numbers: thrombingeneration- anemia First Posted: May 2, 2014 Last Update Posted: December 18, 2018 Last Verified: December 2015 Keywords provided by Elias mazen, HaEmek Medical Center, Israel: Anemias Iron-Deficiency thrombin Additional relevant MeSH terms: Layout table for MeSH terms Anemia Anemia, Iron-Deficiency Deficiency Diseases Hematologic Diseases Anemia, Hypochromic Iron Metabolism Disorders Metabolic Diseases Malnutrition Nutrition Disorders Thrombin Hemostatics (...) The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin. The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin. - Full

2014 Clinical Trials

93. Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature. Full Text available with Trip Pro

Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature. Essentials Methods were developed to image the hemostatic response in mouse femoral arteries in real time. Penetrating injuries produced thrombi consisting primarily of platelets. Similar to arterioles, a core-shell architecture of platelet activation occurs in the femoral artery. Differences from arterioles included slower platelet activation and reduced thrombin dependence.Background (...) platelet ADP P2Y12 receptors destabilized the shell and reduced thrombus size without affecting the core. Inhibiting thrombin with hirudin suppressed fibrin accumulation, but had little impact on thrombus size. Removing the platelet collagen receptor, glycoprotein VI, had no effect. Conclusions These results (i) demonstrate the feasibility of performing high-speed fluorescence imaging in larger vessels and (ii) highlight differences as well as similarities in the hemostatic response in the macro

2016 Journal of Thrombosis and Haemostasis

94. The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women. Full Text available with Trip Pro

presence and severity reported in the 4 weeks before WHI baseline, who were not using warfarin or hormone therapy and for whom the following baseline hemostatic parameters were measured within the WHI Cardiovascular Disease Biomarker Case-Control Study: antithrombin, plasminogen activator inhibitor-1, protein C antigen, total and free protein S antigen, total and free tissue factor pathway inhibitor, D-dimer, normalized activated protein C sensitivity ratio, and thrombin generation. Using multiple (...) The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women. Vasomotor symptoms (VMS) may be a marker of cardiovascular risk. We aimed to evaluate the cross-sectional association of VMS presence and severity with hemostatic parameter levels measured at baseline among Women's Health Initiative (WHI) Hormone Therapy trial postmenopausal participants.This cross-sectional analysis included 2,148 postmenopausal women with measures of VMS

2016 Menopause

95. Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women. Full Text available with Trip Pro

levels were inversely associated with thrombin generation.Background Oral use of exogenous estrogen/progestin alters hemostatic factor levels. The influence of endogenous hormones on these levels is incompletely characterized. Objectives Our study aimed to test whether, among postmenopausal women, high levels of estradiol (E2), estrone (E1), testosterone (T), dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), and androstenedione, and low levels of sex hormone-binding globulin (...) Cross-sectional association of endogenous steroid hormone, sex hormone-binding globulin, and precursor steroid levels with hemostatic factor levels in postmenopausal women. Essentials Endogenous hormone levels' influence on hemostatic factor levels is not fully characterized. We tested for associations of endogenous hormone with hemostatic factor levels in postmenopause. Estrone levels were inversely associated with the natural anticoagulant, protein S antigen. Dehydroepiandrosterone sulfate

2016 Journal of Thrombosis and Haemostasis

96. The hemostatic disturbance in patients with acute aortic dissection: A prospective observational study. Full Text available with Trip Pro

The hemostatic disturbance in patients with acute aortic dissection: A prospective observational study. Coagulopathy is still a frequent complication in the surgical treatment of acute aortic dissection. However, the physiopathology of surgically induced coagulopathy has never been systematically and comprehensively studied in patients with acute aortic dissection. The aim of the present study was to describe the perioperative hemostatic system in patients with acute aortic dissection.The 87 (...) patients who underwent aortic arch surgery for acute Stanford type A aortic dissection from January 2013 to September 2015 were enrolled in this study. The perioperative biomarkers of hemostatic system were evaluated using standard laboratory tests and enzyme-linked immunosorbent assays (ELISAs) at 5 time points: anesthesia induction (T1), lowest nasopharyngeal temperature (T2), protamine reversal (T3), 4 hours after surgery (T4), and 24 hours after surgery (T5).The ELISAs biomarkers revealed

2016 Medicine

97. Compression Socks Worn During Flight and Hemostatic Balance in Boston Marathon Runners on Oral Contraceptives. (Abstract)

Compression Socks Worn During Flight and Hemostatic Balance in Boston Marathon Runners on Oral Contraceptives. To investigate the effect of oral contraceptive (OC) use and compression socks on hemostatic activation in women flying cross-country to and from a marathon.Prospective study.2015 Boston Marathon.Women were divided into non-OC using (CONTROL; n = 12), OC-using (OC; n = 15), and OC-using plus compression sock (OC + SOCK; n = 14) groups.Women in OC + SOCK wore compression socks during (...) flights to and from the marathon.Venous blood samples were collected within 24 hours of arriving in Boston (EXPO), immediately after the marathon (RUN), and within 24 hours after a return flight home (Post-Flight) for analysis of thrombin-antithrombin complex (TAT), d-dimer, and tissue plasminogen activator (t-PA).TAT did not increase with exercise (P = 0.48) and was not affected by group (P = 0.08) or the interaction between these 2 factors (P = 0.80). Group, time, and their interaction were

2017 Clinical Journal of Sport Medicine Controlled trial quality: uncertain

98. Hemostatic Wound Dressing for Postinterventional Hemostasis in Large Femoral Artery Access Sites: An Initial Efficacy and Safety Study. Full Text available with Trip Pro

Hemostatic Wound Dressing for Postinterventional Hemostasis in Large Femoral Artery Access Sites: An Initial Efficacy and Safety Study. To present the results of a prospective single-center study that evaluated the safety and efficacy of a hemostatic dressing following femoral artery access.Within a 9-month period, 80 patients (mean age 68±14 years; 55 men) were treated with a hemostatic dressing patch (Hematrix Active Patch) containing aminocaproic acid, calcium chloride, and thrombin after

2016 Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

99. Preserved hemostatic status in patients with non-alcoholic fatty liver disease. (Abstract)

Preserved hemostatic status in patients with non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of thrombosis. However, it remains unclear if hypercoagulability contributes to this risk. We, therefore, determined an in-depth hemostatic profile in a cohort of well-defined patients with NAFLD.We drew blood samples from 68 patients with biopsy-proven NAFLD (simple steatosis n=24, NASH n=22, and NASH cirrhosis n=22), 30 lean controls (...) , 30 overweight controls (body mass index (BMI) >25kg/m2), and 15 patients with alcoholic (ASH) cirrhosis, and performed in-depth hemostatic profiling.Basal and agonist-induced platelet activation, plasma levels of markers of platelet activation, and plasma levels of the platelet adhesion regulators von Willebrand factor and ADAMTS13 were comparable between patients with non-cirrhotic NAFLD and controls. Agonist-induced platelet activation was decreased in patients with cirrhosis. Thrombomodulin

2016 Journal of Hepatology

100. Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study Full Text available with Trip Pro

single cohort study was conducted. Results from the CBC, coagulation tests (prothrombin, activated partial thromboplastin and thrombin times, fibrinogen, fibrin(ogen) degradation products, and D-dimer concentrations), rotational thromboelastometry (TEM), signalment, hemorrhagic diatheses, occurrence of disseminated intravascular coagulation (DIC) at admission, and survival to discharge were recorded.The most common hematologic and hemostatic abnormalities were anemia (30/35), thrombocytopenia (21/35 (...) Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study Leptospirosis in dogs is occasionally associated with a hemorrhagic syndrome, the pathophysiology of which is not fully understood.To characterize hematologic, hemostatic, and thromboelastometric abnormalities in dogs with leptospirosis and to study their association with hemorrhagic diatheses and outcomes.Thirty-five client-owned dogs.A prospective observational

2016 Journal of Veterinary Internal Medicine

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>