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Thrombin Hemostatic

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61. The role of hemostatic agents in preventing complications in laparoscopic partial nephrectomy (PubMed)

The role of hemostatic agents in preventing complications in laparoscopic partial nephrectomy Nephron-sparing surgery is currently the treatment of choice for renal cell carcinoma stage T1a. During the past years, several hemostatic agents (HA) have been developed in order to reduce surgical complications. We present the results of our series and the impact of the use of HA in the prevention of surgical complications in laparoscopic partial nephrectomies (LPNs).We retrospectively analyzed all (...) LPN performed in our center from 2005 to 2012. A total of 77 patients were included for analysis. Patients were divided into two groups: Group A (no use of HA) and Group B (use of HA). HA used included gelatin matrix thrombin (FloSeal) and oxidized regenerated cellulose (Surgicel). Demographics, perioperative variables, and complications were analyzed with a special interest in postoperative bleeding and urinary leakage.Median age was 57.17 years old (±12.1), 72.7% were male, most common

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2017 Central European journal of urology

62. Comparison of Two Gelatin and Thrombin Combination Hemostats in a Porcine Liver Abrasion Model (PubMed)

Comparison of Two Gelatin and Thrombin Combination Hemostats in a Porcine Liver Abrasion Model Surgical hemostasis is achieved using adjunctive hemostats when conventional methods fail.This study compares the effectiveness of two adjunctive gelatin-thrombin hemostats.To determine effectiveness, hemostats were compared in vivo, in vitro, and using scanning electron microscopy (SEM).In vivo, a heparinized porcine liver abrasion model was used to compare hemostatic success, degree of bleeding (...) , and blood loss at 2, 5, and 10 minutes post-treatment. In vitro, thrombin in the supernatant of each hemostat and Red Blood Cells (RBC'S) in the supernatant of clots formed by each was compared.Ultrastructure of one gelatin was smooth and the other stellate. In vivo, smooth gelatin provided superior hemostatic success at 5 (85% vs. 60%; OR: 5.3; 95% CI: 1.66 to 17.9) and 10 mins (72.5% vs. 47.5%; OR: 5.0; 95% CI: 1.55 to 16.1). Smooth gelatin had a statistically different degree of bleeding at 5 (0.58

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2013 Journal of Investigative Surgery

63. Thrombin Generation and Platelet Activation in CRS/HIPEC

Peritoneal Diseases Neoplasms, Cystic, Mucinous, and Serous Thrombin Hemostatics Coagulants (...) Thrombin Generation and Platelet Activation in CRS/HIPEC Thrombin Generation and Platelet Activation in CRS/HIPEC - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thrombin Generation and Platelet Activation

2017 Clinical Trials

64. Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent. (PubMed)

Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent. Essentials Cancer cachexia and cancer-associated thrombosis have not previously been mechanistically linked. We assessed thrombin generation and coagulation parameters in cachectic C26 tumor-bearing mice. C26 mice are hypercoagulable, partially corrected by blocking tumor derived interleukin-6. Coagulability and anti-inflammatory interventions may be clinically important in cancer (...) (F1 hybrid) mice with a C26 tumor we used modified calibrated automated thrombogram and fibrin generation (based on overall hemostatic potential) assays to assess the functional coagulation state, and also examined fibrinogen, erythrocyte sedimentation rate (ESR), platelet count, tissue factor pathway inhibitor (TFPI) and hepatic expression of coagulation factors by microarray. C26 mice were compared with non-cachectic NC26, pair-fed and sham control mice. IL-6 expression in C26 cells was knocked

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2017 Journal of Thrombosis and Haemostasis

65. Reduced Requirement for Prothrombin Complex Concentrate for the Restoration of Thrombin Generation in Plasma from Liver Transplant Recipients. (PubMed)

Reduced Requirement for Prothrombin Complex Concentrate for the Restoration of Thrombin Generation in Plasma from Liver Transplant Recipients. Plasma transfusion remains the mainstay hemostatic therapy during liver transplantation (LT) in most countries. However, a large volume is required for plasma to achieve clinically relevant factor increases. Prothrombin complex concentrate (PCC) is a low-volume alternative to plasma in warfarin reversal, but its efficacy has not been well studied (...) in LT.Blood samples were collected from 28 LT patients at baseline (T0) and 30 minutes after graft reperfusion (T1). Factor X and antithrombin levels were measured. Ex vivo effects of PCC (0.2 and 0.4 IU/mL) and 10% volume replacement with normal plasma were compared in LT and warfarin plasma by measuring lag time, thrombin peak, and endogenous thrombin potential (ETP) using thrombin generation (TG) assay.Coagulation status was worsened at T1 as international normalized ratio increased from 1.7 to 3.0

2017 Anesthesia and Analgesia

66. Concentrated lyophilized plasma used for reconstitution of whole blood leads to higher coagulation factor activity but unchanged thrombin potential compared with fresh-frozen plasma. (PubMed)

). The hemostatic capacity of each reconstituted whole blood sample was tested with blood cell counts, standard coagulation tests, factor activity, thrombin generation, and viscoelastic assays.Hematocrit, platelet counts, and fibrinogen levels of the three ratios were similar between FFP200 and LP200 units but were lower compared with the corresponding ratios in LP100 and LP50 units. The activity of procoagulant and anticoagulant factors increased linearly with the increasing plasmatic fraction and, at 1:1:2 (...) Concentrated lyophilized plasma used for reconstitution of whole blood leads to higher coagulation factor activity but unchanged thrombin potential compared with fresh-frozen plasma. During massive hemorrhage, it is recommended to transfuse red blood cells, platelet concentrate, and fresh-frozen plasma in a ratio close to 1:1:1. To avoid the thawing process of fresh frozen plasma, lyophilized plasma (LP) is increasingly used. Evidence is limited on the activity of coagulation factors

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2017 Transfusion

67. Comparing Thrombin Generation in Patients with Hemophilia A and Patients on Vitamin K Antagonists. (PubMed)

to hear Dr Negrier's perspective on global assays for assessing coagulation SUMMARY: Background It is unknown whether patients with hemophilia A with atrial fibrillation require treatment with vitamin K antagonists (VKAs) to the same extent as the normal population. Objective To compare hemostatic potential in hemophilia patients and patients on VKAs using thrombin generation (TG). Methods In this cross-sectional study, TG, initiated with 1pM tissue factor, was measured in 133 patients with severe (...) Comparing Thrombin Generation in Patients with Hemophilia A and Patients on Vitamin K Antagonists. Essentials It is unknown if hemophilia patients with atrial fibrillation need anticoagulation. Endogenous thrombin potentials (ETP) in hemophilia patients and patients on coumarins were compared. Severe hemophilia patients had comparable ETP to therapeutic international normalized ratio (INR). In non-severe hemophilia, 33% had higher ETP than therapeutic INR and may need anticoagulation. Click

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2017 Journal of Thrombosis and Haemostasis

68. Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management.

, Heparin, Protamine Additional relevant MeSH terms: Layout table for MeSH terms Heparin Calcium heparin Thrombin Protamines Anticoagulants Fibrinolytic Agents Fibrin Modulating Agents Molecular Mechanisms of Pharmacological Action Hemostatics Coagulants Heparin Antagonists (...) Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management. Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

69. Thrombin Generation Values and Percutaneous Coronary Intervention Results.

Product: No Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: No Keywords provided by HaEmek Medical Center, Israel: thrombin generation calibrated automated thrombogram ischemic heart disease Percutaneous Coronary Intervention Additional relevant MeSH terms: Layout table for MeSH terms Ischemia Heart Diseases Myocardial Ischemia Coronary Artery Disease Coronary Stenosis Blood Coagulation Disorders Hemostatic Disorders Pathologic Processes (...) Cardiovascular Diseases Vascular Diseases Coronary Disease Arteriosclerosis Arterial Occlusive Diseases Hematologic Diseases Hemorrhagic Disorders Thrombin Hemostatics Coagulants

2017 Clinical Trials

70. Evaluation of a Standardized Protocol for Thrombin Generation Assay

Diseases Coagulation Protein Disorders Hemorrhagic Disorders Genetic Diseases, Inborn Thrombin Hemostatics Coagulants (...) Evaluation of a Standardized Protocol for Thrombin Generation Assay Evaluation of a Standardized Protocol for Thrombin Generation Assay - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation

2017 Clinical Trials

71. Meal-induced Thrombin Generation Before and After Gastric Bypass

terms: Layout table for MeSH terms Weight Loss Obesity, Morbid Body Weight Changes Body Weight Signs and Symptoms Obesity Overnutrition Nutrition Disorders Overweight Thrombin Hemostatics Coagulants (...) Meal-induced Thrombin Generation Before and After Gastric Bypass Meal-induced Thrombin Generation Before and After Gastric Bypass - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Meal-induced Thrombin

2017 Clinical Trials

72. Thrombin Hemostatic

Thrombin Hemostatic Thrombin Hemostatic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Thrombin Hemostatic Thrombin Hemostatic Aka (...) : Thrombin Hemostatic , Topical Thrombin , Topical Thrombin in Gelatin , Floseal II. Indications Control of minor bleeding (e.g. tongue ) in patients with prolonged INR (e.g. ) Used in combination with gelatins III. Mechanism Thrombin facilitates conversion to fibrin in the formation of clot IV. Preparations Bovine-derived thrombin (Thrombin-JMI) Contraindicated in cow allergies Human plasma-derived Thrombin (Evithrom) Recombinant human thrombin (rhThrombin) Topical Thrombin in Gelatin (Floseal) V

2015 FP Notebook

73. The Efficacy of a Thrombin-Based Hemostatic Agent in Unilateral Total Knee Arthroplasty: A Randomized Controlled Trial. (PubMed)

The Efficacy of a Thrombin-Based Hemostatic Agent in Unilateral Total Knee Arthroplasty: A Randomized Controlled Trial. Blood loss following total knee arthroplasty can lead to substantial morbidity and the need for blood transfusions. Hemostatic agents have been used to minimize blood loss and to decrease transfusion rates. Floseal is a thrombin-based hemostatic agent with unknown efficacy for achieving these goals in patients undergoing total knee arthroplasty.We performed a prospective (...) (two in each group) underwent knee manipulation under anesthesia to achieve improved knee motion. With the numbers available, there was no significant association between Floseal use and the occurrence of these adverse events.The present study showed that Floseal had no demonstrable effect on blood loss as measured through drain output following total knee arthroplasty. There were also no notable adverse events associated with its use. The usefulness of Floseal as a hemostatic agent in total knee

2012 The Journal of Bone and Joint Surgery. American Volume Controlled trial quality: uncertain

74. Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers

not possible to determine the hemostatic status of a given patient. This instability of hemostatic system is not revealed by classical tests. Thus, a better characterization of hemostatic status could certainly improve patient care. This study aims at characterizing disorders of coagulation and fibrinolysis using "global" tests such as thrombin generation test or coagulolytic test. Furthermore, the association with biological markers of interest (such as microparticles, neutrophil elastase or histones (...) Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2016 Clinical Trials

75. Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature. (PubMed)

Hierarchical organization of the hemostatic response to penetrating injuries in the mouse macrovasculature. Essentials Methods were developed to image the hemostatic response in mouse femoral arteries in real time. Penetrating injuries produced thrombi consisting primarily of platelets. Similar to arterioles, a core-shell architecture of platelet activation occurs in the femoral artery. Differences from arterioles included slower platelet activation and reduced thrombin dependence.Background (...) platelet ADP P2Y12 receptors destabilized the shell and reduced thrombus size without affecting the core. Inhibiting thrombin with hirudin suppressed fibrin accumulation, but had little impact on thrombus size. Removing the platelet collagen receptor, glycoprotein VI, had no effect. Conclusions These results (i) demonstrate the feasibility of performing high-speed fluorescence imaging in larger vessels and (ii) highlight differences as well as similarities in the hemostatic response in the macro

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2016 Journal of Thrombosis and Haemostasis

76. The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women. (PubMed)

presence and severity reported in the 4 weeks before WHI baseline, who were not using warfarin or hormone therapy and for whom the following baseline hemostatic parameters were measured within the WHI Cardiovascular Disease Biomarker Case-Control Study: antithrombin, plasminogen activator inhibitor-1, protein C antigen, total and free protein S antigen, total and free tissue factor pathway inhibitor, D-dimer, normalized activated protein C sensitivity ratio, and thrombin generation. Using multiple (...) The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women. Vasomotor symptoms (VMS) may be a marker of cardiovascular risk. We aimed to evaluate the cross-sectional association of VMS presence and severity with hemostatic parameter levels measured at baseline among Women's Health Initiative (WHI) Hormone Therapy trial postmenopausal participants.This cross-sectional analysis included 2,148 postmenopausal women with measures of VMS

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2016 Menopause

77. Hemostatic Wound Dressing for Postinterventional Hemostasis in Large Femoral Artery Access Sites: An Initial Efficacy and Safety Study. (PubMed)

Hemostatic Wound Dressing for Postinterventional Hemostasis in Large Femoral Artery Access Sites: An Initial Efficacy and Safety Study. To present the results of a prospective single-center study that evaluated the safety and efficacy of a hemostatic dressing following femoral artery access.Within a 9-month period, 80 patients (mean age 68±14 years; 55 men) were treated with a hemostatic dressing patch (Hematrix Active Patch) containing aminocaproic acid, calcium chloride, and thrombin after

2016 Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

78. The hemostatic properties of thawed pooled cryoprecipitate up to 72 hours. (PubMed)

at 24, 48, and 72 hours compared with the baseline; however, at all time points units met the UK specification for FVIII level. The peak thrombin, endogenous thrombin potential, and all ROTEM variables remained unchanged after 72 hours.The hemostatic properties of thawed pooled cryoprecipitate, maintained at ambient temperature, remain stable for up to 72 hours. Stocking a prethawed product may optimize inventory management, to ensure product availability for rapid transfusion. Further studies need (...) The hemostatic properties of thawed pooled cryoprecipitate up to 72 hours. There is increasing interest in replacing fibrinogen early for the treatment of major hemorrhage. In countries where cryoprecipitate is the main concentrated source of fibrinogen, the thawing process complicates the timely availability of cryoprecipitate for transfusion early during major bleeding. The aim of the study was to investigate the hemostatic quality of cryoprecipitate, thawed and held at 18 to 24°C for up

2016 Transfusion

79. The hemostatic disturbance in patients with acute aortic dissection: A prospective observational study. (PubMed)

The hemostatic disturbance in patients with acute aortic dissection: A prospective observational study. Coagulopathy is still a frequent complication in the surgical treatment of acute aortic dissection. However, the physiopathology of surgically induced coagulopathy has never been systematically and comprehensively studied in patients with acute aortic dissection. The aim of the present study was to describe the perioperative hemostatic system in patients with acute aortic dissection.The 87 (...) patients who underwent aortic arch surgery for acute Stanford type A aortic dissection from January 2013 to September 2015 were enrolled in this study. The perioperative biomarkers of hemostatic system were evaluated using standard laboratory tests and enzyme-linked immunosorbent assays (ELISAs) at 5 time points: anesthesia induction (T1), lowest nasopharyngeal temperature (T2), protamine reversal (T3), 4 hours after surgery (T4), and 24 hours after surgery (T5).The ELISAs biomarkers revealed

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2016 Medicine

80. Preserved hemostatic status in patients with non-alcoholic fatty liver disease. (PubMed)

Preserved hemostatic status in patients with non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of thrombosis. However, it remains unclear if hypercoagulability contributes to this risk. We, therefore, determined an in-depth hemostatic profile in a cohort of well-defined patients with NAFLD.We drew blood samples from 68 patients with biopsy-proven NAFLD (simple steatosis n=24, NASH n=22, and NASH cirrhosis n=22), 30 lean controls (...) , 30 overweight controls (body mass index (BMI) >25kg/m2), and 15 patients with alcoholic (ASH) cirrhosis, and performed in-depth hemostatic profiling.Basal and agonist-induced platelet activation, plasma levels of markers of platelet activation, and plasma levels of the platelet adhesion regulators von Willebrand factor and ADAMTS13 were comparable between patients with non-cirrhotic NAFLD and controls. Agonist-induced platelet activation was decreased in patients with cirrhosis. Thrombomodulin

2016 Journal of Hepatology

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