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Thrombin Hemostatic

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61. Safety and Tolerability Study of E-WE Thrombin in Healthy Adult Subjects

and Thrombosis Vascular Diseases Cardiovascular Diseases Thrombin Hemostatics Coagulants (...) Safety and Tolerability Study of E-WE Thrombin in Healthy Adult Subjects Safety and Tolerability Study of E-WE Thrombin in Healthy Adult Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety

2018 Clinical Trials

62. A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin (Full text)

A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic (...) skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized. Skin test and specific immunoglobulin E test showed positive results for bovine thrombin and beef, respectively. During the second stage of operation (After 10 days from first stage of operation), bovine-derived thrombin powder was excluded and the operation was successful without any unexpected events. Therefore, bovine thrombin should be used with caution because

2018 Allergy, asthma & immunology research PubMed abstract

63. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies (Full text)

Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies Hemostatic defects are treated using coagulation factors; however, clot formation also requires a procoagulant phospholipid (PL) surface. Here, we show that innate immune cell-derived enzymatically oxidized phospholipids (eoxPL) termed hydroxyeicosatetraenoic acid-phospholipids (HETE-PLs) restore hemostasis in human and murine conditions of pathological bleeding. HETE-PLs abolished blood loss

2018 JCI insight PubMed abstract

64. Apixaban + DAPT in Lowering Platelet Reactivity and Thrombin Generation

Apixaban + DAPT in Lowering Platelet Reactivity and Thrombin Generation Apixaban + DAPT in Lowering Platelet Reactivity and Thrombin Generation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Apixaban (...) + DAPT in Lowering Platelet Reactivity and Thrombin Generation (SEARCH) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03746782 Recruitment Status : Recruiting First Posted : November 20, 2018 Last Update Posted

2018 Clinical Trials

65. Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs

. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Thrombosis Venous Thrombosis Embolism and Thrombosis Vascular Diseases Cardiovascular Diseases Thrombin Hemostatics Coagulants (...) Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2018 Clinical Trials

66. Comparison of Two Gelatin and Thrombin Combination Hemostats in a Porcine Liver Abrasion Model (Full text)

Comparison of Two Gelatin and Thrombin Combination Hemostats in a Porcine Liver Abrasion Model Surgical hemostasis is achieved using adjunctive hemostats when conventional methods fail.This study compares the effectiveness of two adjunctive gelatin-thrombin hemostats.To determine effectiveness, hemostats were compared in vivo, in vitro, and using scanning electron microscopy (SEM).In vivo, a heparinized porcine liver abrasion model was used to compare hemostatic success, degree of bleeding (...) , and blood loss at 2, 5, and 10 minutes post-treatment. In vitro, thrombin in the supernatant of each hemostat and Red Blood Cells (RBC'S) in the supernatant of clots formed by each was compared.Ultrastructure of one gelatin was smooth and the other stellate. In vivo, smooth gelatin provided superior hemostatic success at 5 (85% vs. 60%; OR: 5.3; 95% CI: 1.66 to 17.9) and 10 mins (72.5% vs. 47.5%; OR: 5.0; 95% CI: 1.55 to 16.1). Smooth gelatin had a statistically different degree of bleeding at 5 (0.58

2013 Journal of Investigative Surgery PubMed abstract

67. Hemostatic Matrix (FloSeal) as Treatment for Urethral Crush Injury After Failure of Traditional Hemostatic Technique. (Abstract)

Hemostatic Matrix (FloSeal) as Treatment for Urethral Crush Injury After Failure of Traditional Hemostatic Technique. We report a case of traumatic arterial hemorrhage from the posterior urethral artery, refractory to traditional hemostatic technique, and successfully managed with intraurethral thrombin hemostatic matrix (FloSeal [Baxter Healthcare Corporation, Deerfield, Illinois, US]). We believe that this demonstrates a safe, effective therapy for urethral hemorrhage that may be accomplished

2016 Annals of Emergency Medicine

68. Reversing Dabigatran Anticoagulation with Prothrombin Complex Concentrate versus Idarucizumab as Part of Multimodal Hemostatic Intervention in an Animal Model of Polytrauma. (Abstract)

Reversing Dabigatran Anticoagulation with Prothrombin Complex Concentrate versus Idarucizumab as Part of Multimodal Hemostatic Intervention in an Animal Model of Polytrauma. Although idarucizumab is the preferred treatment for urgent dabigatran reversal, it is not always available. Prothrombin complex concentrate (PCC) may be an alternative and, with bleeding in trauma, additional hemostatic therapy may be required. The authors investigated multimodal treatment in a preclinical polytrauma (...) ). Animals were monitored for 240 min after trauma, or until death.The degree of injury was similar in all animals before intervention. Control and TXA-FCH animals had the highest total postinjury blood loss (3,652 ± 601 and 3,497 ± 418 ml) and 100% mortality (mean survival time 96 and 109 min). Blood loss was significantly lower in the PCC50 (1,367 ± 273 ml) and IDA (986 ± 144 ml) groups, with 100% survival. Thrombin-antithrombin levels and thrombin generation were significantly elevated in the PCC50

2017 Anesthesiology

69. Factor XIII Co-Treatment with Hemostatic Agents in Hemophilia A Increases Fibrin α-Chain Crosslinking. (Full text)

, deficiency or inhibition of factor VIII. Bleeding is treated with hemostatic agents (FVIII, recombinant activated FVII [rFVIIa], anti-inhibitor coagulation complex [FEIBA], or recombinant porcine FVIII [rpFVIII]). Despite treatment, some patients have prolonged bleeding. FXIII-A2 B2 (FXIII) is a protransglutaminase. During clot contraction, thrombin-activated FXIII (FXIIIa) crosslinks fibrin and α2 -antiplasmin, which promotes red blood cell retention and increases clot stability and weight. We (...) hypothesized that FXIII cotreatment in hemophilia would accelerate FXIII activation, leading to increased fibrin crosslinking. Methods FVIII-deficient plasma and whole blood were clotted with or without hemostatic agents (FVIII, rFVIIa, FEIBA, or recombinant B-domain-deleted porcine FVIII [rpFVIII]) and/or FXIII. The effects on FXIII activation, thrombin generation, fibrin and α2 -antiplasmin crosslinking, clot formation and clot weight were measured by western blotting, calibrated automated thrombography

2017 Journal of Thrombosis and Haemostasis PubMed abstract

70. Orthostatic Challenge Shifts the Hemostatic System of Patients Recovered from Stroke toward Hypercoagulability (Full text)

to- and at the end of- standing in the upright position for 6 min. Hemostatic profiling was performed by determining thrombelastometry and calibrated automated thrombogram values, indices of thrombin generation, standard coagulation times, markers of endothelial activation, plasma levels of coagulation factors and copeptin, and hematocrit. Results: Orthostatic challenge caused a significant endothelial and coagulation activation in patients (Group 1) and healthy controls (Group 2): Plasma levels of prothrombin (...) Orthostatic Challenge Shifts the Hemostatic System of Patients Recovered from Stroke toward Hypercoagulability Aims: The objective of our study was to assess the effects of orthostatic challenge on the coagulation system in patients with a history of thromboembolic events and to assess how they compared with age-matched healthy controls. Methods: Twenty-two patients with histories of ischemic stroke and 22 healthy age-matched controls performed a sit-to-stand test. Blood was collected prior

2017 Frontiers in physiology PubMed abstract

71. Generation of Platelet Microparticles after Cryopreservation of Apheresis Platelet Concentrates Contributes to Hemostatic Activity (Full text)

Generation of Platelet Microparticles after Cryopreservation of Apheresis Platelet Concentrates Contributes to Hemostatic Activity In the last decade, substantial evidence has accumulated about the use of cryopreserved platelet concentrates, especially in trauma. However, little reference has been made in these studies to the morphological and functional changes of platelets. Recently platelets have been shown to be activated by cryopreservation processes and to undergo procoagulant membrane (...) changes resulting in the generation of platelet-derived microparticles (PMPs), platelet degranulation, and release of platelet-derived growth factors (PDGFs). We assessed the viabilities and the PMP and PDGF levels of cryopreserved platelets, and their relation with thrombin generation.Apheresis platelet concentrates (APCs) from 20 donors were stored for 1 day and cryopreserved with 6% dimethyl sulfoxide. Cryopreserved APCs were kept at -80 °C for 1 day. Thawed APCs (100 mL) were diluted with 20 mL

2017 Turkish Journal of Hematology PubMed abstract

72. Is the use of hemostatic matrix (Floseal) and alkylene oxide copolymer (Ostene) safe in spinal laminectomies? Peridural fibrosis assessment (Full text)

Is the use of hemostatic matrix (Floseal) and alkylene oxide copolymer (Ostene) safe in spinal laminectomies? Peridural fibrosis assessment Failed Back Syndrome (FBS) is unacceptable relief of pain or recurrence of symptoms in patients after spinal surgery, such as laminectomy. One possible cause of FBS is peridural fibrosis (PF). PF is the overproduction of scar tissue adjacent to the dura mater. Bleeding can cause PF after laminectomy. Ostene is an alkylene oxide copolymer material used (...) to stop bleeding from bony surfaces. Floseal is a gelatin thrombin matrix sealant used to assist fibrin formation and to promote coagulation.Total of 32 female Sprague-Dawley rats were evenly allotted to 4 experimental groups: laminectomy only, laminectomy + Ostene (Baxter International, Inc., Deerfield, IL, USA), laminectomy + Floseal (Baxter International, Inc., Deerfield, IL, USA), and laminectomy + Adcon-L (aap Implantate AG, Berlin, Germany). After performing total laminectomy, agents were placed

2017 Acta orthopaedica et traumatologica turcica PubMed abstract

73. The role of hemostatic agents in preventing complications in laparoscopic partial nephrectomy (Full text)

The role of hemostatic agents in preventing complications in laparoscopic partial nephrectomy Nephron-sparing surgery is currently the treatment of choice for renal cell carcinoma stage T1a. During the past years, several hemostatic agents (HA) have been developed in order to reduce surgical complications. We present the results of our series and the impact of the use of HA in the prevention of surgical complications in laparoscopic partial nephrectomies (LPNs).We retrospectively analyzed all (...) LPN performed in our center from 2005 to 2012. A total of 77 patients were included for analysis. Patients were divided into two groups: Group A (no use of HA) and Group B (use of HA). HA used included gelatin matrix thrombin (FloSeal) and oxidized regenerated cellulose (Surgicel). Demographics, perioperative variables, and complications were analyzed with a special interest in postoperative bleeding and urinary leakage.Median age was 57.17 years old (±12.1), 72.7% were male, most common

2017 Central European journal of urology PubMed abstract

74. The effect of hemostatic dressing prototypes for the uniformed services on selected blood coagulation parameters in pigs (Full text)

of hemostatic dressing prototypes on the porcine coagulation system.Fibrinogen and D-dimer concentrations were significantly higher in the experimental groups where hemostatic dressings were used in comparison with the control group. Considerable differences in antithrombin III activity and thrombin-antithrombin complex concentrations were also observed between groups.The hemostatic dressing comprising modified seton impregnated with 18.0 g/m2 of procoagulant was most effective in preserving (...) The effect of hemostatic dressing prototypes for the uniformed services on selected blood coagulation parameters in pigs Serious injuries accompanied by severe bleeding are life-threatening. Post-traumatic hemorrhage involves the risk of developing coagulopathy. Hemostatic dressings are widely used to minimize bleeding. The application of procoagulants in control of hemorrhage may lead to thrombosis or disseminated intravascular coagulation. The aim of this study was to evaluate the effect

2017 Acta veterinaria Scandinavica PubMed abstract

75. Hemostatic Profiles of Endocrine Therapies for Breast Cancer

Hemostatic Profiles of Endocrine Therapies for Breast Cancer Hemostatic Profiles of Endocrine Therapies for Breast Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Hemostatic Profiles of Endocrine (...) Hospital, Geneva Information provided by (Responsible Party): Marc Blondon, University Hospital, Geneva Study Details Study Description Go to Brief Summary: The aim of this prospective cohort study is to evaluate the modifications of the biological hemostatic profile associated with the use of endocrine therapy in women with breast cancer (tamoxifen or aromatase inhibitors). Condition or disease Breast Neoplasms Venous Thromboembolism Detailed Description: In this cohort study, women with breast cancer

2017 Clinical Trials

76. Thrombin Hemostatic

Thrombin Hemostatic Thrombin Hemostatic Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Thrombin Hemostatic Thrombin Hemostatic Aka (...) : Thrombin Hemostatic , Topical Thrombin , Topical Thrombin in Gelatin , Floseal II. Indications Control of minor bleeding (e.g. tongue ) in patients with prolonged INR (e.g. ) Used in combination with gelatins III. Mechanism Thrombin facilitates conversion to fibrin in the formation of clot IV. Preparations Bovine-derived thrombin (Thrombin-JMI) Contraindicated in cow allergies Human plasma-derived Thrombin (Evithrom) Recombinant human thrombin (rhThrombin) Topical Thrombin in Gelatin (Floseal) V

2015 FP Notebook

77. Evaluation of a Standardized Protocol for Thrombin Generation Assay

Diseases Coagulation Protein Disorders Hemorrhagic Disorders Genetic Diseases, Inborn Thrombin Hemostatics Coagulants (...) Evaluation of a Standardized Protocol for Thrombin Generation Assay Evaluation of a Standardized Protocol for Thrombin Generation Assay - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation

2017 Clinical Trials

78. Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management.

, Heparin, Protamine Additional relevant MeSH terms: Layout table for MeSH terms Heparin Calcium heparin Thrombin Protamines Anticoagulants Fibrinolytic Agents Fibrin Modulating Agents Molecular Mechanisms of Pharmacological Action Hemostatics Coagulants Heparin Antagonists (...) Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management. Thrombin Generation During Cardiopulmonary Bypass With Titrated Versus Conventional Anticoagulation Management. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

79. Thrombin Generation Values and Percutaneous Coronary Intervention Results.

Product: No Studies a U.S. FDA-regulated Device Product: No Product Manufactured in and Exported from the U.S.: No Keywords provided by HaEmek Medical Center, Israel: thrombin generation calibrated automated thrombogram ischemic heart disease Percutaneous Coronary Intervention Additional relevant MeSH terms: Layout table for MeSH terms Ischemia Heart Diseases Myocardial Ischemia Coronary Artery Disease Coronary Stenosis Blood Coagulation Disorders Hemostatic Disorders Pathologic Processes (...) Cardiovascular Diseases Vascular Diseases Coronary Disease Arteriosclerosis Arterial Occlusive Diseases Hematologic Diseases Hemorrhagic Disorders Thrombin Hemostatics Coagulants

2017 Clinical Trials

80. Thrombin Generation and Platelet Activation in CRS/HIPEC

Peritoneal Diseases Neoplasms, Cystic, Mucinous, and Serous Thrombin Hemostatics Coagulants (...) Thrombin Generation and Platelet Activation in CRS/HIPEC Thrombin Generation and Platelet Activation in CRS/HIPEC - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thrombin Generation and Platelet Activation

2017 Clinical Trials

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