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Thrombin Hemostatic

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381. Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis Full Text available with Trip Pro

Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis To investigate serum omentin and vaspin levels in cirrhotic patients; and to assess the relationship of these levels with hemostatic parameters, metabolic abnormalities, cirrhosis severity and etiology.Fifty-one cirrhotic patients (17 with portal vein thrombosis) were analyzed. Serum omentin and vaspin levels were measured with commercially available direct enzyme-linked immunosorbent assays (ELISAs (...) ). To assess platelet activity, the following tests were performed using a MULTIPLATE®PLATELET FUNCTION ANALYZER: (1) an ADP-induced platelet activation test; (2) a cyclooxygenase dependent aggregation test (ASPI test); (3) a von Willebrand factor and glycoprotein Ib-dependent aggregation (using ristocetin) test (RISTO test); and (4) a test for thrombin receptor-activating peptide-6 induced activation of the thrombin receptor, which is sensitive to IIb/IIIa receptor antagonists.Omentin, but not vaspin

2017 World Journal of Gastroenterology

382. Is it necessary to alter anticoagulation therapy for tooth extraction in patients taking direct oral anticoagulants? Full Text available with Trip Pro

by gauze pads, moderate bleeding controlled by hemostatic agents and severe bleeding required hospitalization. Analysis of variance, chi square test and correlation analysis were used for statistical analysis of data.A total of 84 patients (48 male, 36 female) were included in this study. The mean age of patients was 57 (38-87) years. Mean AOB was 1388.6±913.0, 1909.29±1063.1, 3673±1415.4, 1593.33±672.5 mg for direct thrombin inhibitor, factor Xa inhibitor, warfarin and control groups respectively (...) without altering the anticoaguation therapy.The study consisted of four groups: Direct thrombin inhibitor group, factor Xa inhibitor group, warfarin group and a control group. A single tooth was extracted in each patient and routine coagulation test values were recorded prior to extraction. AOB was measured for 20 minutes after tooth extraction. The patients were evaluated on 2nd and 7th days after extraction for bleeding. Status of bleeding was classified as no bleeding, mild bleeding controlled

2017 Medicina oral, patología oral y cirugía bucal

383. Polyphosphate in Neonates: Less Shedding from Platelets and Divergent Prothrombotic Capacity Due to Lower TFPI Levels Full Text available with Trip Pro

Polyphosphate in Neonates: Less Shedding from Platelets and Divergent Prothrombotic Capacity Due to Lower TFPI Levels Background: The neonatal hemostatic system exhibits a fragile balance featuring lower levels of clotting factors as well as inhibitors. Neonatal platelets show in-vitro hypoaggregability, but neonates exhibit well-functioning primary and secondary hemostasis despite this impairment. Recently, polyphosphate shed by activated platelets has been shown to induce a prothrombotic (...) shift on the plasmatic coagulation system of adults. The impact of platelet derived polyphosphate might differ in neonates due to aforementioned peculiarities. Aims: We aimed to comparatively determine polyphosphate content and release from adult and neonatal platelets and to determine its impact on thrombin generation in plasma from adult and cord blood. Methods: Polyphosphate was extracted from adult and neonatal platelet lysates and releasates using silica spin-columns and quantified with a DAPI

2017 Frontiers in physiology

384. Recurrent mutations in a SERPINC1 hotspot associate with venous thrombosis without apparent antithrombin deficiency Full Text available with Trip Pro

control. These mutations were absent in a Caucasian cohort. Carriers of these mutations had normal antithrombin levels and anticoagulant activity, consistent with results obtained in a recombinant model. However, mutation carriers had a significantly increased endogenous thrombin potential. Our results suggest the existence in the Chinese population of a hotspot in SERPINC1 that significantly increases the risk of VTE by impairing the anticoagulant capacity of the hemostatic system. This effect

2017 Oncotarget

385. The Reversal of Direct Oral Anticoagulants in Animal Models Full Text available with Trip Pro

The Reversal of Direct Oral Anticoagulants in Animal Models Several direct oral anticoagulants (DOACs), including direct thrombin and factor Xa inhibitors, have been approved as alternatives to vitamin K antagonist anticoagulants. As with any anticoagulant, DOAC use carries a risk of bleeding. In patients with major bleeding or needing urgent surgery, reversal of DOAC anticoagulation may be required, presenting a clinical challenge. The optimal strategy for DOAC reversal is being refined (...) , and may include use of hemostatic agents such as prothrombin complex concentrates (PCCs; a source of concentrated clotting factors), or DOAC-specific antidotes (which bind their target DOAC to abrogate its activity). Though promising, most specific antidotes are still in development.Preclinical animal research is the key to establishing the efficacy and safety of potential reversal agents. Here, we summarize published preclinical animal studies on reversal of DOAC anticoagulation. These studies (n

2017 Shock (Augusta, Ga.)

386. Hemostasis in Overt and Subclinical Hyperthyroidism Full Text available with Trip Pro

Hemostasis in Overt and Subclinical Hyperthyroidism There are contradictory results on the effect of hyperthyroidism on hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). The present review focuses on hemostatic changes in overt and subclinical hyperthyroidism.A systematic literature search was conducted employing MEDLINE database. The following words were used for the search: Hyperthyroidism; thyrotoxicosis (...) such as factor (F) VIII, FX, FIX, von Willebrand F (vWF), and fibrinogen, while hypofibrinolysis by changes in coagulation parameters such as a decrease in plasmin and plasmin activator or an increase in α2-antiplasmin, plasminogen activator inhibitor-1 and thrombin activatable fibrinolysis inhibitor.Although many reports are in favor of a hypercoagulable state in overt hyperthyroidism but this finding at the biochemical level and its clinical implication, on the occurrence of VTE, has yet to be confirmed.

2017 International journal of endocrinology and metabolism

387. Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview Full Text available with Trip Pro

Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich

2017 The journal of venomous animals and toxins including tropical diseases

388. Blood Components Load in Post-operative Neurosurgical Patients Suspected with Disseminated Intravascular Coagulation Full Text available with Trip Pro

neurosurgery patients suspected with DIC and had at least one deranged haemostatic parameter namely platelet count, prothrombin time, partial thromboplastin time and thrombin time. Their blood components load was co-related with the outcome and with the hemostatic derangements. Twenty-eight patients died in our study group. 19/28 died patients had DIC. The red cell load was significantly more in patients who died compared to those who were alive (p = 0.041). On the other hand, load of PRP as well as FFP

2017 Indian Journal of Hematology & Blood Transfusion

389. Evaluation of procoagulant tissue factor expression in canine hemangiosarcoma cell lines Full Text available with Trip Pro

in factor VII-deficient plasma was abolished by incubation of cells with annexin V. Thrombin generation by SB-HSA cells was unaffected by the addition of corn trypsin inhibitor. CONCLUSIONS AND CLINICAL RELEVANCE Hemangiosarcoma cell lines expressed procoagulant TF in vitro. Further research is needed to determine whether TF can be used as a biomarker for hemostatic dysfunction in dogs with hemangiosarcoma. (...) by quantitative real-time PCR assay and flow cytometry, respectively. Thrombin generation was measured in canine plasma and in coagulation factor-replete or specific coagulation factor-deficient human plasma by calibrated automated thrombography. Corn trypsin inhibitor and annexin V were used to examine contributions of contact activation and membrane-bound phosphatidylserine, respectively, to thrombin generation. RESULTS All cell lines expressed TF mRNA and antigen, with significantly greater expression

2017 American journal of veterinary research

390. Prothrombotic State in Asthma Is Related to Increased Levels of Inflammatory Cytokines, IL-6 and TNFα, in Peripheral Blood Full Text available with Trip Pro

potential (β = 0.35 [95% CI, 0.28-0.42] and β = 0.15 [95% CI, 0.07-0.23], respectively) but not with CLT or platelet markers. However, TNFα predicted CLT in a multiple linear regression model. Periostin was not associated with any hemostatic parameters. Enhanced thrombin generation is driven in asthma by a systemic inflammatory state mediated by IL-6 and to a lesser extent TNFα, however, not periostin. TNFα might contribute to impaired fibrinolysis. (...) Prothrombotic State in Asthma Is Related to Increased Levels of Inflammatory Cytokines, IL-6 and TNFα, in Peripheral Blood Recently, we have reported that asthma is associated with enhanced plasma thrombin formation and impaired fibrinolysis. The mechanisms underlying the prothrombotic state in this disease are unknown. Our aim was to investigate whether prothrombotic alterations in asthmatics are associated with inflammation. We studied 164 adult, white, stable asthmatics and 72 controls

2017 Inflammation

391. STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units

are not considered exclusion. Hereditary or acquired haemorrhagic diathesis or coagulation factor deficiency. Use of heparin, low-molecular weight heparin, GPIIb/IIIa antagonist, or oral anticoagulation (e.g. warfarin, factor Xa inhibitor, thrombin inhibitor) within the previous 14 days, irrespective of laboratory values Pregnancy (women of childbearing potential must be tested) Planned surgery for ICH within 24 hours Concurrent or planned treatment with haemostatic agents (e.g. prothrombin complex concentrate (...) Brain Diseases Central Nervous System Diseases Nervous System Diseases Vascular Diseases Cardiovascular Diseases Tranexamic Acid Antifibrinolytic Agents Fibrin Modulating Agents Pharmacologic Actions Cardiovascular Agents Therapeutic Uses Hematologic Agents Hemostatics Contrast Media Angiography Cerebral Angiography Tomography, X-Ray Computed Additional relevant MeSH terms: Layout table for MeSH terms Hemorrhage Cerebral Hemorrhage Pathologic Processes Intracranial Hemorrhages Cerebrovascular

2017 Clinical Trials

392. To Compare TEG (Thrombelastography) and Conventional Tests in CKD Patients

provided by (Responsible Party): kelika Prakash, Institute of Liver and Biliary Sciences, India Study Details Study Description Go to Brief Summary: Background: Coagulopathy in chronic kidney disease is multifactorial. Both hypocoagulopathy and hypercoaguability are seen. Conventional tests of coagulation (CCTs) end at the formation of thrombin, and do not take into account the interaction of coagulation factors, platelets, RBC etc. By overcoming the above deficiencies, thromboelastography provides (...) relevant MeSH terms: Layout table for MeSH terms Kidney Diseases Kidney Failure, Chronic Blood Coagulation Disorders Hemostatic Disorders Urologic Diseases Renal Insufficiency, Chronic Renal Insufficiency Hematologic Diseases Vascular Diseases Cardiovascular Diseases Hemorrhagic Disorders

2017 Clinical Trials

393. Randomized Assessment of Devices Used to Prevent Post-operative Hemorrhagic Risk in Endonasal Surgery

-operative haemostasis in endonasal surgery. Device: Surgiflo using device during the endonasal surgery. Experimental: Floseal Using Floseal® (Absorbable Gelatin Hemostatic) containing human thrombin for the post-operative haemostasis in endonasal surgery Device: Floseal using device during the endonasal surgery. Experimental: Algosteril Using Algosteril® (Hemostatic Sterile Wick) for the post-operative haemostasis in endonasal surgery Device: Algosteril using device during the endonasal surgery (...) : Floseal Device: Algosteril Not Applicable Detailed Description: Surgiflo® is a matrix of haemostatic frost of porcine protein origin is the coverage of the post-operative bleeding of which one of the indications is in endonasal surgery. Floseal® is a haemostatic frost(gel) containing of the thrombin. Algosteril® is a lint tent of arginate of calcium. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 571 participants Allocation

2017 Clinical Trials

394. Recombinant Activated Factor VII in the Management of Massive Bleeding in Hospital Universiti Sains Malaysia

in Hospital Universiti Sains Malaysia (HUSM) Condition or disease Intervention/treatment Massive Hemorrhage Massive Blood Loss Massive Blood Transfusion; Thrombocytopenia Drug: NovoSeven Detailed Description: Effective hemostasis can be life-saving. However, there is still lack of an ideal hemostatic drug which is safe and effective. Recombinant activated factor VII (rFVIIa; Novo Nordisk, Bagsvaerd, Denmark) is a hemostatic agent originally developed for the management of bleeding in haemophilia A and B (...) patients with inhibitors to factor VIII or IX respectively. Recombinant FVIIa involves in extrinsic clotting pathway where it forms a complex with tissue factor which in the presence of calcium and phospholipids activates coagulation factor X which then initiates the conversion of prothrombin into thrombin at the site of injury (Figure 1). Formation of thrombin and clot stabilises platelet plug and form a tight fibrin structure which is resistant to lysis. Due to the efficient haemostatic property

2017 Clinical Trials

395. D-dimer to Guide Anticoagulation Therapy in Patients With Atrial Fibrillation

a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Wuhan Asia Heart Hospital: D-dimer Nonvalvular atrial fibrillation Direct thrombin inhibitor INR Additional relevant MeSH terms: Layout table for MeSH terms Atrial Fibrillation Hemorrhage Thrombosis Arrhythmias, Cardiac Heart Diseases Cardiovascular Diseases Pathologic Processes Embolism and Thrombosis Vascular Diseases Warfarin Dabigatran Fibrin fragment D Anticoagulants Antithrombins Serine (...) Proteinase Inhibitors Protease Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Antifibrinolytic Agents Fibrin Modulating Agents Hemostatics Coagulants

2017 Clinical Trials

396. A Clinical Study to Evaluate the Efficacy and Safety of Hemocoagulase Injection

, Respiratory Signs and Symptoms Thrombin Hemostatics Coagulants (...) Hemoptysis Drug: Snake venom thrombin (Treatment) Drug: Placebo Phase 4 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 100 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: A Multi-centre, Randomised, Double Blind, Placebo Controlled Clinical Study to Evaluate the Efficacy and Safety of Snake Venom Thrombin Injection

2017 Clinical Trials

397. The Effect of Application of TachoSil® in Pancreatoduodenectomy

Neoplasms Digestive System Neoplasms Neoplasms by Site Neoplasms Endocrine Gland Neoplasms Digestive System Diseases Pancreatic Diseases Endocrine System Diseases Thrombin Fibrin Tissue Adhesive Hemostatics Coagulants (...) Center Information provided by (Responsible Party): Jae Hoon Lee, Asan Medical Center Study Details Study Description Go to Brief Summary: Fibrinogen/thrombin-coated collagen patch (TachoSil®) is known to have the effect of strengthening tissue anastomosis and promoting suturing to prevent leakage. The purpose of this study is to compare the incidence of pancreatic fistula that is most crucial for surgical outcome and complications in pancreaticoduodenectomy with those of the control group

2017 Clinical Trials

398. Hemostasis Evolution During Fluid Loading in Abdominal Surgery. Effects of Fluid Choice: Saline Versus Hydroxyethyl Starch (HAEMO Study)

fluid volumes, which may contribute to poorer outcomes. In the surgical context, clinical trials and meta-analyses have shown that individualized goal-direct fluid administration can reduce postoperative morbidity. Although most GDT studies have used colloid solutions for fluid loading, the effects of the type of fluids are currently unknown and crystalloids are proposed for first-line therapy. Moreover conflicting results on hemostatic effects of HES have been reported. HES have been associated (...) with increased bleeding volume and transfusion requirements, especially in the ICU setting in septic patients. Perioperative use of HES was not associated with such findings. Biological effects of HES on hemostasis has barely been investigated and only by diluting plasma of healthy donors with HES. The proposed Haemo multicenter study will be conducted to assess if the use of HES or crystalloid solutions during an individualized GDT contribute to biological hemostatic differences in patients at moderate

2017 Clinical Trials

399. INR Comparison Testing in Cardiac Surgery

than or equal to 18 years of age. Patients undergoing elective surgery. Patients undergoing cardiac surgery. Patients to undergo general anesthesia with endotracheal intubation. Patients with well-controlled health disorders. Exclusion Criteria: Patients currently on Coumadin or other anticoagulants; including, direct thrombin inhibitors and direct Xa inhibitors. Patients who are under 18 years of age or pregnant. Patients undergoing emergency surgery. Patients with known coagulation disorders (...) relevant MeSH terms: Layout table for MeSH terms Blood Coagulation Disorders Hemostatic Disorders Hematologic Diseases Vascular Diseases Cardiovascular Diseases Hemorrhagic Disorders

2017 Clinical Trials

400. Cytokine Registry Database of Stroke Patients

110- 118: Subarachnoid hemorrhage grading scales). During the acute phase of focal cerebral ischemia, there is an elevation of thrombin activity and a decline in fibrinolytic activity. Moreover, the role of pro-inflammatory cytokines has been proven in the last few decades, as markers of inflammation have been closely studied in mice models; there are indications that elevated levels correlate with the extent of ischemic injury. Various interleukins were found to be elevated in most if not all (...) patients with acute ischemic stroke. Correlation of hemostatic (procoagulant and fibrinolytic markers) with inflammatory markers is under discussion, with no confirmed common marker identified as of yet. As new cytokines and tissue markers are established in scientific literature, stroke scientists are interested in evaluating the role of these markers in the pathophysiology of stroke. The role of glial cell markers has been of remarkable interest. Recently, an astrocyte marker S100B has shown

2017 Clinical Trials

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