How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,217 results for

Thrombin Hemostatic

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

221. Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery

by Turku University Hospital: RCT Gelatin matrix thrombin idiopathic scoliosis Surgery Additional relevant MeSH terms: Layout table for MeSH terms Scoliosis Spinal Curvatures Spinal Diseases Bone Diseases Musculoskeletal Diseases Thrombin Hemostatics Coagulants (...) Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2011 Clinical Trials

222. Study of Thrombin Generation During the 3 First Cycles of Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma

Myeloma Newly diagnosed Thrombin generation TFPI Tissue Factor pathway inhibitor Protein S Thrombosis Chemotherapy Additional relevant MeSH terms: Layout table for MeSH terms Multiple Myeloma Neoplasms, Plasma Cell Neoplasms by Histologic Type Neoplasms Hemostatic Disorders Vascular Diseases Cardiovascular Diseases Paraproteinemias Blood Protein Disorders Hematologic Diseases Hemorrhagic Disorders Lymphoproliferative Disorders Immunoproliferative Disorders Immune System Diseases Thrombin Hemostatics (...) Study of Thrombin Generation During the 3 First Cycles of Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma Study of Thrombin Generation During the 3 First Cycles of Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2011 Clinical Trials

223. Thrombin Generation and Thrombus Degradation in Cerebral Venous Thrombosis : Clinical and Radiological Correlations

Vascular Diseases Cardiovascular Diseases Thrombin Hemostatics Coagulants (...) Thrombin Generation and Thrombus Degradation in Cerebral Venous Thrombosis : Clinical and Radiological Correlations Thrombin Generation and Thrombus Degradation in Cerebral Venous Thrombosis : Clinical and Radiological Correlations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2011 Clinical Trials

224. Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding. (Abstract)

Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding. Bleeding after cardiopulmonary bypass (CPB) is a major cause of morbidity and mortality and consumes large amounts of blood. Identifying patients at increased risk of bleeding secondary to hemostatic impairment may improve clinical outcomes by allowing early intervention.This present study recruited 77 patients undergoing CPB and measured coagulation (...) screens, coagulation factors, TEG(®), Rotem(®) and thrombin generation (TG) before surgery and 30 min after heparin reversal. The tests were analyzed to investigate whether they identified patients at increased risk of excess bleeding (defined as > 1000 mL) in the first 24 h postoperatively.Patients who bled > 1000 mL had a lower: platelet count (P < 0.02), factors (F)IX, X and XI (P < 0.005), endogenous thrombin potential (ETP) and an initial rate of TG (P < 0.02) and higher activated partial

2011 Journal of Thrombosis and Haemostasis

225. Effects of enoxaparin preparations on thrombin generation and their correlation with their anti-FXa activity. (Abstract)

Effects of enoxaparin preparations on thrombin generation and their correlation with their anti-FXa activity. Anticoagulant effect of LMWHs is monitored by anti-factor Xa (anti-FXa) activity assay. Since this test has several limitations, the aim of this study was to explore the activity of two LMWHs by thrombin generation assay (TG, which presents an overall picture of hemostatic balance) and its correlation with their anti-FXa activity.In an open-label, randomized cross-over study, 40  mg (...) of two enoxaparins, the original branded formulation (R) and another one, also marketed in Argentina (T), were daily injected subcutaneously, for 7 days, to 20 healthy volunteers, with a 7-day washout interval. Blood samples were collected before treatment and 180  minutes after the injection on days 3 and 7. TG in platelet-poor plasma activated with tissue factor was assessed by lag time (LT), time to peak (TTP), peak (PTG), and endogenous thrombin potential (ETP). Anti-FXa and anti-FIIa activities

2011 Current medical research and opinion Controlled trial quality: uncertain

226. Human fibrinogen/thrombin-coated collagen patch to control intraoperative severe pulmonary hemorrhage and air leakage after correction of a ruptured thoracic aortic aneurysm. (Abstract)

Human fibrinogen/thrombin-coated collagen patch to control intraoperative severe pulmonary hemorrhage and air leakage after correction of a ruptured thoracic aortic aneurysm. Lung erosion represents a dreadful complication in patients affected by thoracic aortic aneurysms. Intraoperative occurrence of severe bleeding and extensive air leakage from the pulmonary erosion is usually quite particularly dangerous and challenging because of fragile lung tissue to be repaired, hypo-coagulative state (...) , and the need for full mechanical ventilation. We report the case of a patient who had uncontrollable pulmonary bleeding and marked air leakage from an aortic aneurysm-induced lung erosion and laceration, which were effectively treated with a hemostatic patch (Tachosil, Nycomed, Linz, Austria) after unsuccessful conventional surgical approaches.Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

2011 Annals of Thoracic Surgery

227. Recombinant human thrombin: safety and immunogenicity in pediatric burn wound excision. (Abstract)

Recombinant human thrombin: safety and immunogenicity in pediatric burn wound excision. Previous studies of recombinant human thrombin (rThrombin) enrolled adult and adolescent patients. This phase 4, open-label, single-group study was conducted in pediatric patients undergoing synchronous burn wound excision and skin grafting to provide information regarding the safety and immunogenicity of rThrombin (primary and secondary endpoints) in this population.Topical rThrombin was applied (...) as a hemostatic aid during a surgical procedure (day 1). Adverse events and clinical laboratory abnormalities were recorded during the study. Immunogenicity samples were collected on days 1 and 29 (study end). Study results were summarized with descriptive statistics.Thirty patients enrolled and 28 completed the study. Mean age was 6.9 years (range, 0.9-17.8 years); 40.0% of patients were girls. Flame and scald were the most common burn types (33.3% each, n = 10/30). Mean graft size was 3.6% total body

2011 Journal of Pediatric Surgery

228. Enhanced thrombin generation after cardiopulmonary bypass surgery. (Abstract)

Enhanced thrombin generation after cardiopulmonary bypass surgery. Thrombin generation has a key role in the pathophysiology of hemostasis. Research has focused on the intraoperative course of hemostasis, while little is known about postoperative hemostatic activation. Thrombin generation assays quantify the potential for thrombin generation ex vivo and may be useful for determining hypercoagulability. The thrombin dynamics test (TDT) assesses the initial kinetics of thrombin formation. We (...) hypothesized that there would be an increase in thrombin generation as well as thrombin capacity after cardiac surgery.Two hundred twenty patients undergoing primary coronary artery bypass grafting or aortic valve replacement (AVR) surgery were prospectively enrolled. Patients undergoing AVR received warfarin beginning on the second postoperative day. In addition to prothrombin fragment (F(1+2)), TDT, d-dimer, and troponin T were assessed. Blood samples were obtained preoperatively, at the end

2011 Anesthesia and analgesia Controlled trial quality: uncertain

229. Comparison of purified plant polysaccharide (HemoStase) versus gelatin-thrombin matrix (FloSeal) in controlling bleeding during sinus surgery: a randomized controlled trial. (Abstract)

Comparison of purified plant polysaccharide (HemoStase) versus gelatin-thrombin matrix (FloSeal) in controlling bleeding during sinus surgery: a randomized controlled trial. Purified plant polysaccharide (HemoStase) is a plant-derived hemostatic agent that has not previously been used in sinus surgery. This study was conducted to evaluate the effectiveness of this novel agent in the control of nasal bleeding during endoscopic sinus surgery. The volume of bleeding during endoscopic sinus surgery (...) was hypothesized to not be statistically significantly different between a control group (gelatin-thrombin matrix; FloSeal) and an experimental group (purified plant polysaccharide; HemoStase).Eighteen patients with a history of chronic rhinosinusitis in whom maximal medical therapy failed who underwent endoscopic sinus surgery were randomized into one of two groups (control FloSeal group or experimental HemoStase group). In the control group, sites in the nose that were actively bleeding during the operation

2011 The Annals of otology, rhinology, and laryngology Controlled trial quality: uncertain

230. A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt

Congenital Abnormalities Thrombin Hemostatics Coagulants (...) A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2011 Clinical Trials

231. Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass

: November 20, 2013 Last Verified: November 2013 Keywords provided by Nina Guzzetta, M.D., Emory University: Neonates Additional relevant MeSH terms: Layout table for MeSH terms Thrombin Hemostatics Coagulants (...) Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thrombin Generation

2011 Clinical Trials

232. Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma

: Other Study ID Numbers: 99-OVZ-09-024 First Posted: June 28, 2011 Last Update Posted: March 22, 2013 Last Verified: March 2013 Keywords provided by University Hospital Ostrava: Deep Burn Trauma Dermo-Epidermal Graft Platelet Rich Plasma Concentrate (PRP) Vancouver Scar Score Scarring Hypertrophic Scarring Additional relevant MeSH terms: Layout table for MeSH terms Burns Wounds and Injuries Thrombin Hemostatics Coagulants (...) Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2011 Clinical Trials

233. Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) activation in acquired hemostatic dysfunction: a diagnostic challenge Full Text available with Trip Pro

Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) activation in acquired hemostatic dysfunction: a diagnostic challenge 21253418 2011 07 14 2018 11 13 2092-9129 45 4 2010 Dec The Korean journal of hematology Korean J Hematol Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) activation in acquired hemostatic dysfunction: a diagnostic challenge. 215-6 10.5045/kjh.2010.45.4.215 Kim Hyun Kyung HK Department of Laboratory Medicine, Seoul National University College

2010 The Korean journal of hematology

235. Recommendation on the Use and Management of Emicizumab-kxwh (Hemlibra) for Hemophilia A with and without Inhibitors

differently. Some of the differences are: BLOOD, 7 DECEMBER 2017 - VOLUME 130, NUMBER 23 FVIIIa has multiple sites of interaction with FIXa, FX and the phospholipid surface whereas FVIII needs to be activated (thrombin mediated), emicizumab does not FVIII binds to VWF, emicizumab does not FVIII binds to phospholipid surface, emicizumab does not -> FVIII binding limits movement of the FX-activating complex more than emicizumab FVIIIa binds to surface on activated platelet, emicizumab probably does (...) the need for concomitant use of alternative hemostatic therapies. Due to the serious adverse events observed in the clinical trial program, we are reiterating below the previous interim guidance on management of breakthrough bleeding, surveillance for thromboembolic and TMA events, and recommendation on appropriate use of laboratory assays. No TMA or serious thrombotic events have been reported to date with adherence to these management principles after implementation within the global clinical trial

2020 National Hemophilia Foundation

236. Guideline on Laboratory aspects of assays used in haemostasis and thrombosis Full Text available with Trip Pro

of von Willebrand disease (VWD); measurement of factor replacement in haemophilia A and B; monitoring of anticoagulants [vitamin K antagonists (VKA) and direct oral anticoagulants (DOAC)]; and global assays of haemostasis (e.g. TEG, ROTEM, thrombin generation). Preanalytical variables Preanalytical errors account for the majority of errors in the haemostasis laboratory and it is essential that they are well understood and minimised. To produce accurate and meaningful results and increase quality (...) the presence of anticoagulants if this is not known from the clinical details provided. However the sensitivity of PT and APTT reagents to anticoagulants varies and these tests may not detect concentrations that can interfere with other assays; so if there is doubt about their presence an assay using specific calibrators (if known) should be performed. If indicated, the presence of a normal thrombin time (TT) effectively excludes the presence of a thrombin inhibitor or significant contamination

2020 British Committee for Standards in Haematology

237. Management of Bleeding in Patients on Oral Anticoagulants

¼ direct-acting oral anticoagulant; DTI¼ direct thrombin inhibitor; FXa¼ Factor Xa; h¼ hours; ICH¼ intracranial hemorrhage; INR¼ international normalized ratio; IV¼ intravenous; OAC¼ oral anticoagulant, including DOACs and VKAs; PCC¼ prothrombin complex concentrate; VKA¼ vitamin K antagonist. *Reversal/hemostatic agents include repletion strategies such as PCCs, plasma, vitamin K, and speci?c reversal agents for DOACs (e.g., idarucizumab for dabigatran;andexanetalfaforapixabanorrivaroxaban (...) Nonmajor Bleeds . 603 5.6. OAC Reversal/Hemostatic Strategies . 603 Figure 3. Considerations for Reversal/Hemostatic Agents 604 Table 4a: Estimated Drug Half-Life Based on CrCl .. 605 Table 4b: Suggested Duration for Withholding DOAC Based on Bleed Risk. 605 Table 5. Suggested Reversal/Hemostatic Strategy for OACs 606 5.6.1. Vitamin K Antagonists (Warfarin)... 605 5.6.2. Factor IIa Inhibitors (Dabigatran) ... 606 5.6.3. Factor Xa Inhibitors (Apixaban, Betrixaban, Edoxaban, and Rivaroxaban) 606 5.6.4

2020 American College of Cardiology

238. ERCP-related adverse events

against salvage pancreatic stenting in pa- tients with post-ERCP pancreatitis. Weak recommendation, low qualityevidence. 8ESGEsuggests temporaryplacementofabiliary fullycov- ered self-expandable metal stent for post-sphincterotomy bleeding refractory to standard hemostatic modalities. Weak recommendation, low qualityevidence. 9 ESGE suggests to evaluate patients with post-ERCP cholangitis by abdominal ultrasonography or computed tomography (CT) scan and, in the absence of improvement with conservative (...) %) and of re-bleeding (16% vs. 12%) [234]. After failed epinephrine therapy, hemostatic clips may be used, delivered through a cap-fitted forward-viewing endo- scope or a duodenoscope (the elevator often makes clip deliv- ery challenging). In two studies (67 patients with persistent PSB), clips provided hemostasis in 90%–100% of the cases [235, 236]. New clipsdesigned for delivery using the duodeno- scope may also be used [237]. A small prospective series re- ported PSB control by monopolar coagulation

2020 European Society of Gastrointestinal Endoscopy

239. Nosebleed (Epistaxis) Full Text available with Trip Pro

cautery; 41% had anterior packing alone; and 7% had anterior and posterior nasal packing performed. While the use of topical vasoconstriction and anterior nasal packing is accepted and used widely, questions remain about the types of topical agents, the method of packing, the specific packing materials employed, the duration of packing, and the aftercare for patients with nasal packing. Hemostatic aids, such as antifibrinolytic agents and hemostatic packing materials, provide additional options

2020 American Academy of Otolaryngology - Head and Neck Surgery

240. Disorders of the Hepatic and Mesenteric Circulation Full Text available with Trip Pro

dissolution ( ). Alterations in the hemostatic pathways in cirrhosis The deficit of liver-derived procoagulant factors in cirrhosis is well known, but the deficit of liver-derived anticoagulants such as PC and the increases in endothelial-derived factors such as factor VIII and vWF are less well appreciated. The magnitude of deficient PC in cirrhosis has become evident through studies of thrombin (factor II) generation in the presence of the endothelial-derived cofactor thrombomodulin. Together (...) that hemostatic pathways in compensated cirrhosis are largely intact, but in a precarious balance that can shift in either direction ( ). Increased clotting risk is evidenced by portal vein thrombosis (PVT) and peripheral deep venous thrombosis. Bleeding risk seems to be due to accelerated intravascular coagulation and fibrinolysis (AICF) involving premature clot dissolution. However, more common forms of bleeding such as variceal hemorrhage have only a tenuous relationship to the clotting cascade being

2020 American College of Gastroenterology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>