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Thrombin Hemostatic

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221. "Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy

"Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy "Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . "Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy (SPOTLIGHT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01359202 Recruitment Status : Completed First Posted : May 24, 2011 Last Update Posted : October 5, 2018 Sponsor: Dr. David Gladstone Collaborator: Canadian

2011 Clinical Trials

222. Use of fibrin sealant as a hemostatic agent in expanded polytetrafluoroethylene graft placement surgery. (Abstract)

Use of fibrin sealant as a hemostatic agent in expanded polytetrafluoroethylene graft placement surgery. The low thrombogenicity, porosity, and limited elasticity of expanded polytetrafluoroethylene (ePTFE) vascular grafts, although beneficial, may exacerbate the problem of suture-line bleeding at vascular anastomoses and consequently lead to increased operating times. The overall objective of this prospective, randomized, controlled, subject-blinded, multicenter phase 2 study was to evaluate (...) the efficacy and safety of a fibrin sealant containing 500 IU/mL thrombin and synthetic aprotinin (FS; marketed in the United States under the name TISSEEL) for hemostasis in subjects undergoing vascular surgery and receiving prosthetic ePTFE vascular grafts.FS was compared with manual compression with surgical gauze pads, a standard of care for hemostasis in vascular surgery. Two FS polymerization/setting times (60 and 120 seconds) were investigated to evaluate influence on the efficacy results. Patients

2011 Annals of vascular surgery Controlled trial quality: uncertain

223. Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta-analyzes. (Abstract)

Association between circulating hemostatic measures and dementia or cognitive impairment: systematic review and meta-analyzes. Hemostasis and thrombosis may be important contributors to cognitive decline and dementia. Certain blood markers may assist in diagnosis or management.To collate evidence for the association of circulating hemostatic variables and dementia or cognitive impairment.A systematic review of studies describing blood markers of hemostatic function and cognition/dementia (...) : 0.36; 95% CI: 0.15-0.56) and VWF (SMD: 0.31; 95% CI: 0.11-0.51). For specific cognitive domains, significant (P < 0.001) positive correlations were fibrinogen and speed of processing (0.76; 95% CI: 0.67-0.84), verbal memory (0.69; 95% CI: 0.59-0.79) and non-verbal reasoning (0.57; 95% CI: 0.49-0.65).The present results suggest a modest association between hemostasis and vascular dementia including increased levels of thrombin generation markers (D-dimer and prothrombin fragment 1 + 2

2011 Journal of thrombosis and haemostasis : JTH

224. Surgical hemostatic agents: assessment of drugs and medical devices. (Abstract)

Surgical hemostatic agents: assessment of drugs and medical devices. Surgical hemostatic agents are indicated to improve hemostasis when conventional techniques (compression, sutures or electrocoagulation) are inadequate. The National French Authority for Health (Haute Autorité de santé [HAS]) set out to assess these products (medical devices and agents) to determine their optimal utility. This evaluation included one class of products containing some form of human fibrinogen and thrombin (...) and eight classes of medical devices and automated devices to prepare autologous fibrin. The assessment was based on a systematic review of the literature and expert opinion of health care professionals. The main measures of effectiveness of hemostatic agents were the success rate as expressed in terms of the time necessary to obtain adequate hemostasis, the volume of intra and/or postoperative blood loss, the need for blood transfusions, complication rate, duration of operations and hospital stay

2011 Journal of visceral surgery

225. Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery

by Turku University Hospital: RCT Gelatin matrix thrombin idiopathic scoliosis Surgery Additional relevant MeSH terms: Layout table for MeSH terms Scoliosis Spinal Curvatures Spinal Diseases Bone Diseases Musculoskeletal Diseases Thrombin Hemostatics Coagulants (...) Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2011 Clinical Trials

226. Study of Thrombin Generation During the 3 First Cycles of Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma

Myeloma Newly diagnosed Thrombin generation TFPI Tissue Factor pathway inhibitor Protein S Thrombosis Chemotherapy Additional relevant MeSH terms: Layout table for MeSH terms Multiple Myeloma Neoplasms, Plasma Cell Neoplasms by Histologic Type Neoplasms Hemostatic Disorders Vascular Diseases Cardiovascular Diseases Paraproteinemias Blood Protein Disorders Hematologic Diseases Hemorrhagic Disorders Lymphoproliferative Disorders Immunoproliferative Disorders Immune System Diseases Thrombin Hemostatics (...) Study of Thrombin Generation During the 3 First Cycles of Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma Study of Thrombin Generation During the 3 First Cycles of Chemotherapy in Patients With Newly Diagnosed Multiple Myeloma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2011 Clinical Trials

227. Thrombin Generation and Thrombus Degradation in Cerebral Venous Thrombosis : Clinical and Radiological Correlations

Vascular Diseases Cardiovascular Diseases Thrombin Hemostatics Coagulants (...) Thrombin Generation and Thrombus Degradation in Cerebral Venous Thrombosis : Clinical and Radiological Correlations Thrombin Generation and Thrombus Degradation in Cerebral Venous Thrombosis : Clinical and Radiological Correlations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2011 Clinical Trials

228. Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding. (Abstract)

Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding. Bleeding after cardiopulmonary bypass (CPB) is a major cause of morbidity and mortality and consumes large amounts of blood. Identifying patients at increased risk of bleeding secondary to hemostatic impairment may improve clinical outcomes by allowing early intervention.This present study recruited 77 patients undergoing CPB and measured coagulation (...) screens, coagulation factors, TEG(®), Rotem(®) and thrombin generation (TG) before surgery and 30 min after heparin reversal. The tests were analyzed to investigate whether they identified patients at increased risk of excess bleeding (defined as > 1000 mL) in the first 24 h postoperatively.Patients who bled > 1000 mL had a lower: platelet count (P < 0.02), factors (F)IX, X and XI (P < 0.005), endogenous thrombin potential (ETP) and an initial rate of TG (P < 0.02) and higher activated partial

2011 Journal of Thrombosis and Haemostasis

229. Effects of enoxaparin preparations on thrombin generation and their correlation with their anti-FXa activity. (Abstract)

Effects of enoxaparin preparations on thrombin generation and their correlation with their anti-FXa activity. Anticoagulant effect of LMWHs is monitored by anti-factor Xa (anti-FXa) activity assay. Since this test has several limitations, the aim of this study was to explore the activity of two LMWHs by thrombin generation assay (TG, which presents an overall picture of hemostatic balance) and its correlation with their anti-FXa activity.In an open-label, randomized cross-over study, 40  mg (...) of two enoxaparins, the original branded formulation (R) and another one, also marketed in Argentina (T), were daily injected subcutaneously, for 7 days, to 20 healthy volunteers, with a 7-day washout interval. Blood samples were collected before treatment and 180  minutes after the injection on days 3 and 7. TG in platelet-poor plasma activated with tissue factor was assessed by lag time (LT), time to peak (TTP), peak (PTG), and endogenous thrombin potential (ETP). Anti-FXa and anti-FIIa activities

2011 Current medical research and opinion Controlled trial quality: uncertain

230. Human fibrinogen/thrombin-coated collagen patch to control intraoperative severe pulmonary hemorrhage and air leakage after correction of a ruptured thoracic aortic aneurysm. (Abstract)

Human fibrinogen/thrombin-coated collagen patch to control intraoperative severe pulmonary hemorrhage and air leakage after correction of a ruptured thoracic aortic aneurysm. Lung erosion represents a dreadful complication in patients affected by thoracic aortic aneurysms. Intraoperative occurrence of severe bleeding and extensive air leakage from the pulmonary erosion is usually quite particularly dangerous and challenging because of fragile lung tissue to be repaired, hypo-coagulative state (...) , and the need for full mechanical ventilation. We report the case of a patient who had uncontrollable pulmonary bleeding and marked air leakage from an aortic aneurysm-induced lung erosion and laceration, which were effectively treated with a hemostatic patch (Tachosil, Nycomed, Linz, Austria) after unsuccessful conventional surgical approaches.Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

2011 Annals of Thoracic Surgery

231. Recombinant human thrombin: safety and immunogenicity in pediatric burn wound excision. (Abstract)

Recombinant human thrombin: safety and immunogenicity in pediatric burn wound excision. Previous studies of recombinant human thrombin (rThrombin) enrolled adult and adolescent patients. This phase 4, open-label, single-group study was conducted in pediatric patients undergoing synchronous burn wound excision and skin grafting to provide information regarding the safety and immunogenicity of rThrombin (primary and secondary endpoints) in this population.Topical rThrombin was applied (...) as a hemostatic aid during a surgical procedure (day 1). Adverse events and clinical laboratory abnormalities were recorded during the study. Immunogenicity samples were collected on days 1 and 29 (study end). Study results were summarized with descriptive statistics.Thirty patients enrolled and 28 completed the study. Mean age was 6.9 years (range, 0.9-17.8 years); 40.0% of patients were girls. Flame and scald were the most common burn types (33.3% each, n = 10/30). Mean graft size was 3.6% total body

2011 Journal of Pediatric Surgery

232. Enhanced thrombin generation after cardiopulmonary bypass surgery. (Abstract)

Enhanced thrombin generation after cardiopulmonary bypass surgery. Thrombin generation has a key role in the pathophysiology of hemostasis. Research has focused on the intraoperative course of hemostasis, while little is known about postoperative hemostatic activation. Thrombin generation assays quantify the potential for thrombin generation ex vivo and may be useful for determining hypercoagulability. The thrombin dynamics test (TDT) assesses the initial kinetics of thrombin formation. We (...) hypothesized that there would be an increase in thrombin generation as well as thrombin capacity after cardiac surgery.Two hundred twenty patients undergoing primary coronary artery bypass grafting or aortic valve replacement (AVR) surgery were prospectively enrolled. Patients undergoing AVR received warfarin beginning on the second postoperative day. In addition to prothrombin fragment (F(1+2)), TDT, d-dimer, and troponin T were assessed. Blood samples were obtained preoperatively, at the end

2011 Anesthesia and analgesia Controlled trial quality: uncertain

233. Comparison of purified plant polysaccharide (HemoStase) versus gelatin-thrombin matrix (FloSeal) in controlling bleeding during sinus surgery: a randomized controlled trial. (Abstract)

Comparison of purified plant polysaccharide (HemoStase) versus gelatin-thrombin matrix (FloSeal) in controlling bleeding during sinus surgery: a randomized controlled trial. Purified plant polysaccharide (HemoStase) is a plant-derived hemostatic agent that has not previously been used in sinus surgery. This study was conducted to evaluate the effectiveness of this novel agent in the control of nasal bleeding during endoscopic sinus surgery. The volume of bleeding during endoscopic sinus surgery (...) was hypothesized to not be statistically significantly different between a control group (gelatin-thrombin matrix; FloSeal) and an experimental group (purified plant polysaccharide; HemoStase).Eighteen patients with a history of chronic rhinosinusitis in whom maximal medical therapy failed who underwent endoscopic sinus surgery were randomized into one of two groups (control FloSeal group or experimental HemoStase group). In the control group, sites in the nose that were actively bleeding during the operation

2011 The Annals of otology, rhinology, and laryngology Controlled trial quality: uncertain

234. A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt

Congenital Abnormalities Thrombin Hemostatics Coagulants (...) A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt A Pilot Study of Thrombin Generation Changes in Neonates Undergoing Placement of a Blalock-Taussig Shunt - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2011 Clinical Trials

235. Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass

: November 20, 2013 Last Verified: November 2013 Keywords provided by Nina Guzzetta, M.D., Emory University: Neonates Additional relevant MeSH terms: Layout table for MeSH terms Thrombin Hemostatics Coagulants (...) Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thrombin Generation

2011 Clinical Trials

236. Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma

: Other Study ID Numbers: 99-OVZ-09-024 First Posted: June 28, 2011 Last Update Posted: March 22, 2013 Last Verified: March 2013 Keywords provided by University Hospital Ostrava: Deep Burn Trauma Dermo-Epidermal Graft Platelet Rich Plasma Concentrate (PRP) Vancouver Scar Score Scarring Hypertrophic Scarring Additional relevant MeSH terms: Layout table for MeSH terms Burns Wounds and Injuries Thrombin Hemostatics Coagulants (...) Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma Autologous Platelets Concentrate and Autologous Thrombin for the Treatment of Deep Burn Trauma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2011 Clinical Trials

237. Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) activation in acquired hemostatic dysfunction: a diagnostic challenge (Full text)

Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) activation in acquired hemostatic dysfunction: a diagnostic challenge 21253418 2011 07 14 2018 11 13 2092-9129 45 4 2010 Dec The Korean journal of hematology Korean J Hematol Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) activation in acquired hemostatic dysfunction: a diagnostic challenge. 215-6 10.5045/kjh.2010.45.4.215 Kim Hyun Kyung HK Department of Laboratory Medicine, Seoul National University College

2010 The Korean journal of hematology PubMed abstract

238. Kidney Pre-biopsy medication: Antiplatelet and anticoagulant agents

). UNGRADED SUGGESTIONS FOR CLINICAL CARE ? We suggest all patients stop taking: o Adenosine diphosphate (ADP) inhibitors (clopidogrel, prasugrel, ticagrelor) 5 to 7 days before the renal biopsy o Warfarin 5 days before the renal biopsy o Direct thrombin inhibitors (dabigatran) and factor Xa inhibitors (rivaroxaban, apixaban) 48- 72 hours before the renal biopsy o Unfractionated heparin 4-6 hours before the renal biopsy o Low molecular weight heparin 24 hours before the renal biopsy ? We suggest (...) (e.g. warfarin), heparin (e.g. unfractionated, low molecular weight), direct thrombin inhibitors (e.g. dabigatran, argatroban, bivalirudin), and factor Xa inhibitors (e.g. apixaban, rivaroxaban). The anticoagulant effect of warfarin is mediated by antagonism of the production of vitamin K-dependent extrinsic pathway clotting factors and protein C and S in the liver. Unfractionated and low molecular weight heparin accelerate inhibition of factor X, potentiating the action of anti-thrombin III

2020 KHA-CARI Guidelines

240. Disorders of the Hepatic and Mesenteric Circulation (Full text)

dissolution ( ). Alterations in the hemostatic pathways in cirrhosis The deficit of liver-derived procoagulant factors in cirrhosis is well known, but the deficit of liver-derived anticoagulants such as PC and the increases in endothelial-derived factors such as factor VIII and vWF are less well appreciated. The magnitude of deficient PC in cirrhosis has become evident through studies of thrombin (factor II) generation in the presence of the endothelial-derived cofactor thrombomodulin. Together (...) that hemostatic pathways in compensated cirrhosis are largely intact, but in a precarious balance that can shift in either direction ( ). Increased clotting risk is evidenced by portal vein thrombosis (PVT) and peripheral deep venous thrombosis. Bleeding risk seems to be due to accelerated intravascular coagulation and fibrinolysis (AICF) involving premature clot dissolution. However, more common forms of bleeding such as variceal hemorrhage have only a tenuous relationship to the clotting cascade being

2020 American College of Gastroenterology PubMed abstract

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