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Thrombin Hemostatic

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181. Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox. (Abstract)

Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox. The hemostat, sealant, and adhesive components of the surgical toolbox continue to evolve and enter clinical practice at a rapid rate. The goal of this comprehensive, sequential review is to update these components to include those now available (February 2012) as well as to explore cost and regulatory factors that impact the development and use (...) of these materials. A unique system of definitions for organizing these components based on group, category, and class is used as a means of improving the understanding and appropriate use of these materials. The system will be used here to present the most recent additions to the toolbox, which are evaluated based on safety, efficacy, usability, and cost. These new additions include pooled human plasma fibrinogen and thrombin embedded in an equine collagen patch for cardiac surgical hemostasis, polyethylene

2012 Transfusion

182. Pocket related complications in 163 patients receiving anticoagulation or dual antiplatelet therapy: D-Stat Hemostat versus standard of care. (Abstract)

Pocket related complications in 163 patients receiving anticoagulation or dual antiplatelet therapy: D-Stat Hemostat versus standard of care. Pocket hematoma is a common complication after cardiac rhythm device implantation (CRDI) in patients receiving anticoagulation or dual antiplatelet therapy (DAPT). We sought to assess the safety and effectiveness of D-Stat Flowable Hemostat ([D-Stat]-a mixture of thrombin and collagen) in these patients.We conducted a prospective case control study

2012 International journal of cardiology

183. Fibrinogen as a hemostatic agent. (Abstract)

Fibrinogen as a hemostatic agent. Coagulation factor I (fibrinogen) plays an essential role in the hemostatic system by bridging activated platelets and being the key substrate for thrombin in establishing a consolidating fibrin network. Fibrinogen is synthesized in the liver and the plasma concentration is 1 to 5-4.0 g/L. During recent 10 years, fibrinogen has been recognized to play an important role in controlling hemorrhage. Dilutional coagulopathy induced by colloid plasma expanders (...) is characterized by fibrinogen deficiency and dysfunctional fibrin polymerization. Trauma and use of extracorporeal circulation is also known to reduce levels of fibrinogen. A series of laboratory experiments and experimental animal studies have suggested fibrinogen as a potent hemostatic agent. These data are supported by retrospective surveys as well as a series of prospective proof of principal clinical trials. This article provides a description of the biochemistry and mechanisms of fibrinogen as well

2012 Seminars In Thrombosis And Hemostasis

184. Hemostatic response to surgical neutering via ovariectomy and ovariohysterectomy in dogs. (Abstract)

. Plasma samples were subjected to thromboelastography after thawing. In addition, coagulation variables were measured, including concentrations of von Willebrand factor antigen, fibrinogen, antithrombin, and protein C; activity of factor VIII; activated partial thromboplastin time; prothrombin time; and thrombin time. The fibrinolytic response was assessed via concentrations of D-dimer, plasminogen, and α-2-antiplasmin (plasmin inhibitor).Substantial hemostatic and fibrinolytic activation was evident (...) Hemostatic response to surgical neutering via ovariectomy and ovariohysterectomy in dogs. To investigate the hemostatic response to surgery and compare the response for ovariohysterectomy with that for ovariectomy and to evaluate the usefulness of thromboelastography on plasma samples.42 female dogs.Dogs were assigned to undergo ovariohysterectomy or ovariectomy. Blood samples were collected immediately before and 1, 6, and 24 hours after surgery and stored at -80°C for subsequent analysis

2012 American journal of veterinary research Controlled trial quality: uncertain

185. A biocompatible cardiopulmonary bypass strategy to reduce hemostatic and inflammatory alterations: a randomized controlled trial. (Abstract)

A biocompatible cardiopulmonary bypass strategy to reduce hemostatic and inflammatory alterations: a randomized controlled trial. Cardiopulmonary bypass (CPB) systems without a venous reservoir rarely are adopted clinically. The effects of a biocompatible CPB system with a venous reservoir were evaluated on the activation of the coagulation and inflammatory systems.A prospective, randomized controlled trial.A university hospital (single center).Eighty-three coronary artery bypass graft (CABG (...) fragment 1-2 (PF-1.2, a marker of thrombin generation), plasmin-antiplasmin complex (PAP, a marker of fibrinolysis), and platelet factor 4 (PF4, a marker of platelet activation) were measured. The DNA binding activity of proinflammatory transcription factor NF-κB was quantified in the isolated lymphomonocyte cells. Surgery caused changes of all plasma biomarkers. This reaction was attenuated strongly in the Physio group; PF-1.2, PAP, and PF4 all were decreased significantly. In the Physio group

2012 Journal of cardiothoracic and vascular anesthesia Controlled trial quality: uncertain

186. Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report. (Abstract)

of tryptase, total IgE, porcine, and bovine gelatin-specific IgE. The patient was counseled to avoid gelatin-containing products. At 6-month follow-up, his instrumented spine was radiographically fused and he reported no further allergic issues.Anaphylaxis may occur because of animal gelatin components of topical hemostatic agents. Previous reports have focused on the thrombin components. Care should be taken in the administration of these products, particularly in the atopic individual.Copyright © 2012 (...) Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report. The use of topical hemostatic agents is widespread and has been shown to reduce bleeding during a wide variety of surgical procedures. Nonetheless, as biologically active agents, there is potential for allergic reactions to these products.This is a report of intraoperative anaphylaxis to gelatin associated with the use of two topical hemostatic agents.Case report. There is no outside

2012 The Spine Journal

187. In Vitro Hemostatic Properties of French Lyophilized Plasma. Full Text available with Trip Pro

In Vitro Hemostatic Properties of French Lyophilized Plasma. French lyophilized plasma (FLyP) is used routinely by the French Armed Forces in war settings. The authors compared concentrations of coagulation proteins and global in vitro hemostatic properties in FLyP and in the same plasma before lyophilization to assess the impact of lyophilization on coagulation properties.Twenty-four batches of plasma before and after lyophilization were tested for coagulation proteins. Thrombin generation (...) time, thrombin antithrombin concentration, prothrombin fragment 1 + 2, and thromboelastography were assessed. Finally, the efficiencies of FLyP and plasma before lyophilization were compared on a hemorrhagic shock hemodilution model and tested on TEG(Haemoscope Corporation, Glenview, IL).Prothrombin time ratio (1.1 ± 0.1 vs. 1.2 ± 0.1) and activated partial thromboplastin time (35 ± 1.3 vs. 39 ± 2.4 s) were significantly increased in FLyP (8 ± 3%, P < 0.05 and 11 ± 5%, P < 0.001, respectively

2012 Anesthesiology

188. Comparative study on hemostatic, cytotoxic and hemolytic activities of different species of Paris L. (Abstract)

Comparative study on hemostatic, cytotoxic and hemolytic activities of different species of Paris L. The rhizoma of Paris polyphylla var. yannanensis or P. polyphylla var. chinensis called Rhizoma Paridis as a traditional Chinese medicine has an effect of heat-clearing and detoxicating, detumescence and acesodyne in folk for a long time. The increasing application of Rhizoma Paridis resulted in the shortage of wildlife resources. Here, we compared the major activities of other species of genus (...) Paris to find the replacement plants.Six species (P. polyphylla var. yunnanensis, P. delavayi var. delavayi, P. fargesii var. Fargesii, P. bashanensis Wang et Tang, P. polyphyllar var. minora, and P. polyphylla var. pseudothibetical) were collected from three Provinces in China, and compared the hemostatic, cytotoxic and hemolytic activities by different assays.For the hemostatic activity, all the plants except Paris fargesii var. Fargesii could significantly shorten the tail bleeding time and blood

2012 Journal of Ethnopharmacology

189. Hemostatic techniques reduce hospital stay following multilevel posterior cervical spine surgery. (Abstract)

Hemostatic techniques reduce hospital stay following multilevel posterior cervical spine surgery. Despite meticulous hemostasis, persistent postoperative drain output following posterior cervical spine procedures often necessitates a prolonged length of hospital stay. We sought to determine if thrombin-soaked absorbable gelatin compressed sponge can decrease postoperative drain output and the length of hospital stay after multilevel posterior cervical spine surgery.We performed a retrospective (...) was soaked in thrombin and applied over the exposed spine before wound closure. A subfascial drain was used in all patients. Total drain output, time for the drainage to decrease to <30 mL per eight-hour shift (at which point the drain was discontinued), the length of stay, the number of readmissions, and postoperative complications were analyzed.Total drain output averaged 93 mL in the study group and 204 mL in the control group (p < 0.0001). The average time for the drainage to decrease to <30 mL per

2012 The Journal of Bone and Joint Surgery. American Volume

190. Direct Thrombin Inhibitor

Direct Thrombin Inhibitor Direct Thrombin Inhibitor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Direct Thrombin Inhibitor Direct (...) Thrombin Inhibitor Aka: Direct Thrombin Inhibitor , Antithrombin , Hirudin , Lepirudin , Refludan , Bivalirudin , Angiomax , Desirudin , Ipravask , Argatroban , Acova From Related Chapters II. Indications Thrombus prophylaxis, treatment or and III. Dosing: Hirudins (bivalent peptide derivatives from Salivary Gland of medicinal leaches) Lepirudan (Refludan) See other references for dosing Bivalirudin (Angiomax) Used in if contraindicated Coadminister with Initial: 0.75 mg/kg IV bolus Later: 1.75 mg/kg

2015 FP Notebook

191. [Treatment of upper gastrointestinal hemorrhage (portal hypertension excluded) by intragastric infusion of hemostatic solution. A controlled trial (author's transl)]. (Abstract)

Hilary P P Rouzaud P P Louis A A fre Clinical Trial Controlled Clinical Trial English Abstract Journal Article Randomized Controlled Trial Traitement hémostatique des hémorragies digestive hautes (hypertension portale exceptée) par perfusion gastrique. Résultats d'une étude contrôlée. France Gastroenterol Clin Biol 7704825 0399-8320 0 Hemostatics 0 Placebos 7C0697DR9I Atropine EC 3.4.21.5 Thrombin U6F3787206 Aminocaproic Acid IM Administration, Oral Aminocaproic Acid administration & dosage (...) therapeutic use Atropine therapeutic use Clinical Trials as Topic Double-Blind Method Drug Evaluation Gastrointestinal Hemorrhage drug therapy Hemostatics administration & dosage therapeutic use Humans Intubation, Gastrointestinal Peptic Ulcer Hemorrhage drug therapy Placebos Thrombin therapeutic use 1978 4 1 1978 4 1 0 1 1978 4 1 0 0 ppublish 352786

1978 Gastroenterologie clinique et biologique Controlled trial quality: uncertain

192. Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency. Full Text available with Trip Pro

Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency. The endoperoxide prostaglandin G2 (PGG2) induced platelet aggregation as well as the platelet release reaction (release of ADP and serotonin) when added to human platelet-rich plasma. Formation of a metabolite of PGG2 [8-(l-hydroxy-3-oxopropyl)-9,12L-dihydroxy-5,10-heptadecadienoic acid] and a lipoxygenase product [12L-hydroxy-5,8,10,14-eicosatetraenoic acid] accompanied (...) the release reaction caused by aggregating agents such as collagen, ADP, epinephrine, and thrombin. Indomethacin inhibited the release reaction and PGG2 formation induced by these agents but had no effect on PGG2-induced release reaction. The aggregating effect of PGG2 was abolished by furosemide, which is a competitive inhibitor of ADP-induced primary aggregation. These data indicate that the aggregating effect of PGG2 is due to release of ADP and that PGG2 synthesis is required for induction

1975 Proceedings of the National Academy of Sciences of the United States of America

193. Thrombin Generation Assay (TGA) as Predictive Test for Haemostatic. Effectiveness of FVIII Concentrates in Haemophiliac A With Inhibitors

: January 9, 2012 Last Update Posted: June 17, 2013 Last Verified: June 2013 Keywords provided by Grifols Italia S.p.A: Thrombin Hemophilia Inhibitors Immunotolerance Haemostatic FVIII Epitopes Moderately severe Hemophilia A with inhibitor Additional relevant MeSH terms: Layout table for MeSH terms Hemophilia A Blood Coagulation Disorders, Inherited Blood Coagulation Disorders Hematologic Diseases Coagulation Protein Disorders Hemorrhagic Disorders Genetic Diseases, Inborn Hemostatics Thrombin Factor (...) Thrombin Generation Assay (TGA) as Predictive Test for Haemostatic. Effectiveness of FVIII Concentrates in Haemophiliac A With Inhibitors Thrombin Generation Assay (TGA) as Predictive Test for Haemostatic. Effectiveness of FVIII Concentrates in Haemophiliac A With Inhibitors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study

2012 Clinical Trials

194. A Prospective, Randomized Trial of Histoacryl Injection Versus Thrombin in the Control of Acute Gastric Variceal Bleeding

/treatment Phase Ulcer, on Gastric Varices Rebleeding From Gastric Varices Drug: Thrombin Drug: Histoacryl Phase 3 Detailed Description: Previous studies have proven that the use of cyanoacrylate glue injection was superior to EIS or EVL in arresting acute gastric variceal bleeding. Endoscopic obturation with glue injection has gained worldwide popularity except the United States. The hemostatic rates of glue injection ranged from 87% to 100%, with rebleeding rates about 7% to 71%. Though histoacryl (...) 30, 2012 Last Update Posted: November 6, 2012 Last Verified: November 2012 Keywords provided by Gin-Ho Lo, E-DA Hospital: gastric varices, thrombin, histoacryl Additional relevant MeSH terms: Layout table for MeSH terms Varicose Veins Esophageal and Gastric Varices Vascular Diseases Cardiovascular Diseases Esophageal Diseases Gastrointestinal Diseases Digestive System Diseases Hypertension, Portal Liver Diseases Thrombin Hemostatics Coagulants

2012 Clinical Trials

195. Thrombin generation reveals high procoagulant potential in the plasma of sickle cell disease children. (Abstract)

Thrombin generation reveals high procoagulant potential in the plasma of sickle cell disease children. Changes in several components of the clotting system are well documented in sickle cell disease (SCD) patients. However, whether the global hemostatic potential of these patients is altered is still unclear. Calibrated automated thrombogram(®) method of thrombin generation (TG) was used to characterize the hemostatic potential of 83 SCD children (75 SS, 6 SC, and 2 Sβ (thal)) at steady-state (...) as compared with 50 controls of the same range of age. TG was triggered using 1 pM tissue factor and 4 μM phospholipids with and without thrombomodulin. Thirteen SCD children were also evaluated during vaso-occlusive crisis. Protein C activity, free protein S and D-dimers levels were measured in parallel. SCD patients showed higher rates of thrombin formation, higher thrombin peak height (with and without thrombomodulin), and higher endogenous thrombin potential (ETP) than controls in the presence

2012 American journal of hematology

196. Intact thrombin generation and decreased fibrinolytic capacity in patients with acute liver injury or acute liver failure. (Abstract)

Intact thrombin generation and decreased fibrinolytic capacity in patients with acute liver injury or acute liver failure. It has been well established that hemostatic potential in patients with chronic liver disease is in a rebalanced status due to a concomitant decrease in pro- and antihemostatic drivers. The hemostatic changes in patients with acute liver injury/failure (ALI/ALF) are similar but not identical to the changes in patients with chronic liver disease and have not been studied (...) in great detail.To assess thrombin generation and fibrinolytic potential in patients with ALI/ALF.We performed thrombin generation tests and clot lysis assays in platelet-poor plasma from 50 patients with ALI/ALF. Results were compared with values obtained in plasma from 40 healthy volunteers.The thrombin generation capacity of plasma from patients with ALI/ALF sampled on the day of admission to hospital was indistinguishable from that of healthy controls, provided thrombomodulin was added to the test

2012 Journal of Thrombosis and Haemostasis

197. Activated thrombin activatable fibrinolysis inhibitor (TAFIa) is associated with inflammatory markers in inflammatory bowel diseases TAFIa level in patients with IBD. (Abstract)

Activated thrombin activatable fibrinolysis inhibitor (TAFIa) is associated with inflammatory markers in inflammatory bowel diseases TAFIa level in patients with IBD. Thrombin activatable fibrinolysis inhibitor (TAFI) has been reported to be involved in the pathogenesis and progression of inflammatory bowel disease (IBD). Activated TAFI (TAFIa) attenuates fibrinolysis by cleaving C-terminal lysine residues thus down-regulating plasminogen activation. To date, no reports on TAFIa in IBD have (...) been published.Plasma levels of TAFIa were measured using a functional assay in 55 consecutive patients with ulcerative colitis (UC) and 50 with Crohn's disease (CD). Associations of TAFIa with disease activity, hemostatic variables and inflammatory markers were assessed.Plasma TAFIa was higher in CD patients than in those with UC. The disease activity correlated positively with TAFIa levels in the UC group, but not in the CD group. In UC patients, there were positive correlations of TAFIa

2012 Journal of Crohn's & colitis

198. Thrombin generation: what have we learned? (Abstract)

Thrombin generation: what have we learned? Thrombin is a pivotal player in the coagulation system. In clotting blood a transient wave of thrombin appears after a lag time. Clotting occurs at the start of the wave. The amount of thrombin formed reflects the function of the hemostatic system much better than the clotting time does: "The more thrombin the less bleeding but the more thrombosis, the less thrombin the more bleeding but the less thrombosis" has been shown to hold for congenital (...) and acquired tendencies to venous thrombosis and bleeding and under all variants of antithrombotic treatment. The situation with arterial thrombosis is less clear. Calibrated automated thrombinography (CAT) allows quantitative assessment of the thrombin generation (TG) curve in platelet poor as well as in platelet rich plasma. Procedures to measure TG in whole blood and at the point of care are under development. TG measurement in platelet rich plasma underlines the close cooperation between platelets

2012 Blood reviews

199. Crystal structure of Jararacussin-I: The highly negatively charged catalytic interface contributes to macromolecular selectivity in snake venom thrombin-like enzymes Full Text available with Trip Pro

Crystal structure of Jararacussin-I: The highly negatively charged catalytic interface contributes to macromolecular selectivity in snake venom thrombin-like enzymes Snake venom serine proteinases (SVSPs) are hemostatically active toxins that perturb the maintenance and regulation of both the blood coagulation cascade and fibrinolytic feedback system at specific points, and hence, are widely used as tools in pharmacological and clinical diagnosis. The crystal structure of a thrombin-like enzyme

2012 Protein science : a publication of the Protein Society

200. Whole Blood Thrombin Generation Monitored with a Calibrated Automated Thrombogram-Based Assay. Full Text available with Trip Pro

this knowledge we developed a whole blood CAT-based assay.We demonstrated that the whole blood CAT-based assay is a sensitive and rapid screening test to assess function of the hemostatic system under more nearly physiological conditions than the TG assay in plasma. Under conditions of low tissue factor concentration (0.5 pmol/L) and 50% diluted blood, the intraassay CV of the thrombogram parameters, endogenous thrombin potential and thrombin peak height, were 6.7% and 6.5%, respectively. The respective (...) Whole Blood Thrombin Generation Monitored with a Calibrated Automated Thrombogram-Based Assay. The calibrated automated thrombogram (CAT) assay in plasma is a versatile tool to investigate patients with hypo- or hypercoagulable phenotypes. The objective was to make this method applicable for whole blood measurements.Thin-layer technology and the use of a rhodamine 110-based thrombin substrate appear to be essential for a reliable thrombin generation (TG) assay in whole blood. Using

2012 Clinical Chemistry

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