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Thrombin Hemostatic

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181. Models for thrombin generation and risk of disease. Full Text available with Trip Pro

studies to understand thrombin dynamics on a mechanistic basis. The translation of an individual's specific coagulation factor composition data using these models into an integrated assessment of hemostatic status may provide a route for advancing the long-term goal of individualized medicine. This review details the integrated approaches to understanding: (i) What is normal thrombin generation in individuals? (ii) What is the effect of normal range plasma composition variation on thrombin generation (...) in pathologic states? (iii) Can disease progression or anticoagulation be followed by understanding the boundaries of normal thrombin generation defined by plasma composition? (iv) What are the controversies and limitations of current computational approaches? Progress in these areas can bring us closer to developing models that can be used to aid in identifying hemostatic risk. © 2013 International Society on Thrombosis and Haemostasis.

2013 Journal of Thrombosis and Haemostasis

182. Thrombin Generation and Gestational Outcome

generation- pregnancy First Posted: May 15, 2014 Last Update Posted: March 1, 2018 Last Verified: February 2018 Additional relevant MeSH terms: Layout table for MeSH terms Thrombophilia Hematologic Diseases Thrombin Hemostatics Coagulants (...) Thrombin Generation and Gestational Outcome Thrombin Generation and Gestational Outcome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thrombin Generation and Gestational Outcome The safety and scientific

2013 Clinical Trials

183. Safety and Efficacy of Topical Thrombin (Human) Grifols as an Adjunct to Hemostasis During Open Surgeries

. ( Instituto Grifols, S.A. ): Vascular surgery Hepatic surgery Soft tissue surgery Spinal surgery Additional relevant MeSH terms: Layout table for MeSH terms Hemostatics Thrombin Coagulants (...) Safety and Efficacy of Topical Thrombin (Human) Grifols as an Adjunct to Hemostasis During Open Surgeries Safety and Efficacy of Topical Thrombin (Human) Grifols as an Adjunct to Hemostasis During Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2013 Clinical Trials

184. Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation?

Pain Thrombophilia Avitaminosis Deficiency Diseases Malnutrition Nutrition Disorders Pain Neurologic Manifestations Signs and Symptoms Hematologic Diseases Vitamin D Thrombin Vitamins Micronutrients Nutrients Growth Substances Physiological Effects of Drugs Bone Density Conservation Agents Hemostatics Coagulants (...) Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation? Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation? - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2013 Clinical Trials

185. Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia

table for MeSH terms Bacteremia Bacterial Infections Sepsis Infection Systemic Inflammatory Response Syndrome Inflammation Pathologic Processes Dabigatran Argatroban Antithrombins Thrombin Serine Proteinase Inhibitors Protease Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Anticoagulants Hemostatics Coagulants Platelet Aggregation Inhibitors (...) Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia Direct Thrombin Inhibitors Versus LMWH in Staphylococcus Aureus Bacteraemia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Direct

2013 Clinical Trials

186. Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index. (Abstract)

Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index. To evaluate hemostatic markers in women with polycystic ovary syndrome (PCOS) compared with healthy controls matched for age and body mass index.Cross-sectional study.Tertiary teaching hospital.Forty-five women with PCOS and 45 controls paired for age (±2 years) and body mass index (±2 kg/m(2)).Clinical evaluation and venipuncture.Thrombin activatable (...) fibrinolysis inhibitor, D-dimer, plasminogen activator inhibitor-1, and the thrombin generation test.Thrombin generation lag-time was significantly shorter in women with PCOS compared with controls. The other hemostatic parameters were similar in both groups.Thrombin generation is faster in young and overweight women with PCOS, suggesting a greater risk of hypercoagulability.Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

2013 Fertility and Sterility

187. Dabigatran attenuates thrombin generation to a lesser extent than warfarin: could this explain their differential effects on intracranial hemorrhage and myocardial infarction? (Abstract)

into the RE-LY trial. Warfarin suppresses thrombin generation more efficiently than dabigatran. Greater suppression of normal hemostatic mechanisms in the brain and pathological thrombosis at sites of atherosclerotic plaque disruption may explain the higher rate of intracranial bleeding and lower rate of myocardial infarction with warfarin compared with dabigatran. (...) Dabigatran attenuates thrombin generation to a lesser extent than warfarin: could this explain their differential effects on intracranial hemorrhage and myocardial infarction? Compared with warfarin, dabigatran is associated with less intracranial hemorrhage, but an increased risk of myocardial infarction. To explore these phenomena, we compared their effects on thrombin generation. Thrombin generation in plasma from 10 patients taking therapeutic doses of warfarin (mean INR 2.6) was compared

2013 Journal of thrombosis and thrombolysis Controlled trial quality: uncertain

188. [Gelatin-thrombin matrix-mediated hemostasis: application in tonsillectomy]. (Abstract)

[Gelatin-thrombin matrix-mediated hemostasis: application in tonsillectomy]. To assess the feasibility of omitting thermal coagulation following cold knife tonsillectomy, we compared the use of a local thrombin hemostat (FloSeal®, FS) to bipolar electrocautery (EK).A total of 181 patients with chronic tonsillitis or tonsillar hypertrophy were stratified in terms of patient characteristics and randomized before undergoing tonsillectomy. The follow-up period continued until postoperative day 20

2013 HNO Controlled trial quality: uncertain

189. The Stabilization of Thrombin in Plasma: Development of a Simple Two-Stage Method for the Determination of Prothrombin Full Text available with Trip Pro

The Stabilization of Thrombin in Plasma: Development of a Simple Two-Stage Method for the Determination of Prothrombin 20258290 2010 03 18 2018 12 01 0007-1021 28 3 1947 Jun British journal of experimental pathology Br J Exp Pathol The stabilization of thrombin in plasma; development of a simple two-stage method for the determination of prothrombin. 168-77 STERNBERGER L A LA eng Journal Article England Br J Exp Pathol 0372543 0007-1021 0 Hemostatics 9001-26-7 Prothrombin EC 3.4.21.5 Thrombin OM (...) Blood Hemostatics Humans Plasma Prothrombin Thrombin 4713:942q BLOOD/prothrombin 2010 3 19 6 0 1947 6 1 0 0 2014 8 13 6 0 ppublish 20258290 PMC2073021

1947 British journal of experimental pathology

190. Reduced thrombin binding and aggregation in Bernard-Soulier platelets. Full Text available with Trip Pro

explain the hemostatic defect in these patients. In addition, the identical ratios of high affinity and low affinity binding sites in normals and in patients (0.37 and 0.36, and 0.36, respectively) supports the idea of a single class of binding sites for thrombin on the platelet surface. (...) Reduced thrombin binding and aggregation in Bernard-Soulier platelets. Platelets from two patients with Bernard-Soulier disease showed a reduction in their ability to bind human thrombin. Thrombin binding studies in the high affinity range showed 1,500 sites for the Bernard-Soulier platelets as against 4,000 for normal controls. However, the dissociation constant was the same for both normals and patients (4.4 nM) indicating identical affinity for thrombin at the available sites. In the low

1978 Journal of Clinical Investigation

191. Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187 Full Text available with Trip Pro

Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187 Prostacyclin (PGI(2)) is an unstable prostaglandin which inhibits platelet aggregation and serotonin release and causes vasodilation. The PGI(2) activity produced by monolayers of cultured human endothelial cells and fibroblasts was measured by the ability of their supernates to inhibit platelet aggregation in platelet-rich plasma, or to inhibit thrombin-induced [(14)C]serotonin release from (...) aspirin-treated, washed platelet suspensions. Monolayers of cultured human endothelial cells, stimulated with sodium arachidonate, thrombin, the ionophore A 23187, or trypsin, secreted PGI(2) into the supernatant medium. Monolayers of fibroblasts produced PGI(2) activity only when stimulated by arachidonate. "Resting," intact monolayers did not produce detectable PGI(2), nor did monolayers treated with ADP or epinephrine. Production of PGI(2) activity was abolished by treatment of the monolayers

1978 Journal of Clinical Investigation

192. Topical Hemostatic Agent

Topical Hemostatic Agent Topical Hemostatic Agent Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Topical Hemostatic Agent Topical (...) Hemostatic Agent Aka: Topical Hemostatic Agent , Hemostatic Agents II. Mechanism Topical Hemostatic Agents III. Indications Significant Bleeding Indicated for rapid non-extremity bleeding not controlled with direct manual pressure IV. Precautions Newer agents (Chitosan, and mineral dressings) are not widely available Primarily found in military and large s as of 2013 Risk of wound contamination with hemostatic agent (may require later debridement) V. Preparations: Agent Types Factor Concentrators (drying

2015 FP Notebook

193. Direct Thrombin Inhibitor

Direct Thrombin Inhibitor Direct Thrombin Inhibitor Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Direct Thrombin Inhibitor Direct (...) Thrombin Inhibitor Aka: Direct Thrombin Inhibitor , Antithrombin , Hirudin , Lepirudin , Refludan , Bivalirudin , Angiomax , Desirudin , Ipravask , Argatroban , Acova From Related Chapters II. Indications Thrombus prophylaxis, treatment or and III. Dosing: Hirudins (bivalent peptide derivatives from Salivary Gland of medicinal leaches) Lepirudan (Refludan) See other references for dosing Bivalirudin (Angiomax) Used in if contraindicated Coadminister with Initial: 0.75 mg/kg IV bolus Later: 1.75 mg/kg

2015 FP Notebook

194. Fibrinogen as a hemostatic agent. (Abstract)

Fibrinogen as a hemostatic agent. Coagulation factor I (fibrinogen) plays an essential role in the hemostatic system by bridging activated platelets and being the key substrate for thrombin in establishing a consolidating fibrin network. Fibrinogen is synthesized in the liver and the plasma concentration is 1 to 5-4.0 g/L. During recent 10 years, fibrinogen has been recognized to play an important role in controlling hemorrhage. Dilutional coagulopathy induced by colloid plasma expanders (...) is characterized by fibrinogen deficiency and dysfunctional fibrin polymerization. Trauma and use of extracorporeal circulation is also known to reduce levels of fibrinogen. A series of laboratory experiments and experimental animal studies have suggested fibrinogen as a potent hemostatic agent. These data are supported by retrospective surveys as well as a series of prospective proof of principal clinical trials. This article provides a description of the biochemistry and mechanisms of fibrinogen as well

2012 Seminars In Thrombosis And Hemostasis

195. Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox. (Abstract)

Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox. The hemostat, sealant, and adhesive components of the surgical toolbox continue to evolve and enter clinical practice at a rapid rate. The goal of this comprehensive, sequential review is to update these components to include those now available (February 2012) as well as to explore cost and regulatory factors that impact the development and use (...) of these materials. A unique system of definitions for organizing these components based on group, category, and class is used as a means of improving the understanding and appropriate use of these materials. The system will be used here to present the most recent additions to the toolbox, which are evaluated based on safety, efficacy, usability, and cost. These new additions include pooled human plasma fibrinogen and thrombin embedded in an equine collagen patch for cardiac surgical hemostasis, polyethylene

2012 Transfusion

196. Pocket related complications in 163 patients receiving anticoagulation or dual antiplatelet therapy: D-Stat Hemostat versus standard of care. (Abstract)

Pocket related complications in 163 patients receiving anticoagulation or dual antiplatelet therapy: D-Stat Hemostat versus standard of care. Pocket hematoma is a common complication after cardiac rhythm device implantation (CRDI) in patients receiving anticoagulation or dual antiplatelet therapy (DAPT). We sought to assess the safety and effectiveness of D-Stat Flowable Hemostat ([D-Stat]-a mixture of thrombin and collagen) in these patients.We conducted a prospective case control study

2012 International journal of cardiology

197. A Premarket, Prospective, Randomized, Single-Blind Study to Compare the Veriset™ Hemostatic Patch to TachoSil® as an Adjunct to Hemostasis in Subjects Undergoing Cardiovascular Surgery

A Premarket, Prospective, Randomized, Single-Blind Study to Compare the Verisetâ„¢ Hemostatic Patch to TachoSil® as an Adjunct to Hemostasis in Subjects Undergoing Cardiovascular Surgery A Premarket, Prospective, Randomized, Single-Blind Study to Compare the Veriset™ Hemostatic Patch to TachoSil® as an Adjunct to Hemostasis in Subjects Undergoing Cardiovascular Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration (...) or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Premarket, Prospective, Randomized, Single-Blind Study to Compare the Veriset™ Hemostatic Patch to TachoSil® as an Adjunct to Hemostasis in Subjects Undergoing Cardiovascular Surgery The safety and scientific validity of this study is the responsibility of the study sponsor

2012 Clinical Trials

198. A biocompatible cardiopulmonary bypass strategy to reduce hemostatic and inflammatory alterations: a randomized controlled trial. (Abstract)

A biocompatible cardiopulmonary bypass strategy to reduce hemostatic and inflammatory alterations: a randomized controlled trial. Cardiopulmonary bypass (CPB) systems without a venous reservoir rarely are adopted clinically. The effects of a biocompatible CPB system with a venous reservoir were evaluated on the activation of the coagulation and inflammatory systems.A prospective, randomized controlled trial.A university hospital (single center).Eighty-three coronary artery bypass graft (CABG (...) fragment 1-2 (PF-1.2, a marker of thrombin generation), plasmin-antiplasmin complex (PAP, a marker of fibrinolysis), and platelet factor 4 (PF4, a marker of platelet activation) were measured. The DNA binding activity of proinflammatory transcription factor NF-κB was quantified in the isolated lymphomonocyte cells. Surgery caused changes of all plasma biomarkers. This reaction was attenuated strongly in the Physio group; PF-1.2, PAP, and PF4 all were decreased significantly. In the Physio group

2012 Journal of cardiothoracic and vascular anesthesia Controlled trial quality: uncertain

199. Hemostatic techniques reduce hospital stay following multilevel posterior cervical spine surgery. (Abstract)

Hemostatic techniques reduce hospital stay following multilevel posterior cervical spine surgery. Despite meticulous hemostasis, persistent postoperative drain output following posterior cervical spine procedures often necessitates a prolonged length of hospital stay. We sought to determine if thrombin-soaked absorbable gelatin compressed sponge can decrease postoperative drain output and the length of hospital stay after multilevel posterior cervical spine surgery.We performed a retrospective (...) was soaked in thrombin and applied over the exposed spine before wound closure. A subfascial drain was used in all patients. Total drain output, time for the drainage to decrease to <30 mL per eight-hour shift (at which point the drain was discontinued), the length of stay, the number of readmissions, and postoperative complications were analyzed.Total drain output averaged 93 mL in the study group and 204 mL in the control group (p < 0.0001). The average time for the drainage to decrease to <30 mL per

2012 The Journal of Bone and Joint Surgery. American Volume

200. Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report. (Abstract)

of tryptase, total IgE, porcine, and bovine gelatin-specific IgE. The patient was counseled to avoid gelatin-containing products. At 6-month follow-up, his instrumented spine was radiographically fused and he reported no further allergic issues.Anaphylaxis may occur because of animal gelatin components of topical hemostatic agents. Previous reports have focused on the thrombin components. Care should be taken in the administration of these products, particularly in the atopic individual.Copyright © 2012 (...) Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report. The use of topical hemostatic agents is widespread and has been shown to reduce bleeding during a wide variety of surgical procedures. Nonetheless, as biologically active agents, there is potential for allergic reactions to these products.This is a report of intraoperative anaphylaxis to gelatin associated with the use of two topical hemostatic agents.Case report. There is no outside

2012 The Spine Journal

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