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Third Generation Anti-Pseudomonal Cephalosporins

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1. Third Generation Anti-Pseudomonal Cephalosporins

Third Generation Anti-Pseudomonal Cephalosporins Third Generation Anti-Pseudomonal Cephalosporins Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Third Generation Anti-Pseudomonal Cephalosporins Third Generation Anti-Pseudomonal Cephalosporins Aka: Third Generation Anti-Pseudomonal Cephalosporins , Ceftazidime From Related Chapters II. Coverage Pseudomonas (Main indication) poorly covered No coverage III. Preparations: Ceftazidime (Fortaz) Adult: 1-2 grams IM or IV every 8 to 12 hours Child: 30-50 mg/kg IV every 8 hours IV. Disadvantages Most expensive Limited spectrum Images: Related links to external sites (from Bing) These images

2018 FP Notebook

2. Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis. (PubMed)

participants) comparing a single anti-pseudomonal agent to a combination of the same antibiotic and one other, were included.There was a wide variation in the individual antibiotics used in each trial. In total, the trials included seven comparisons of a beta-lactam antibiotic (penicillin-related or third generation cephalosporin) with a beta-lactam-aminoglycoside combination and three comparisons of an aminoglycoside with a beta-lactam-aminoglycoside combination. These two groups of trials were analysed (...) Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis. Choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of action, possible synergy and reduction of resistant organisms; advantages of monotherapy include lower cost, ease of administration

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2016 Cochrane

3. Emergence of the third-generation cephalosporin-resistant hypervirulent Klebsiella pneumoniae due to the acquisition of a self-transferable blaDHA-1-carrying plasmid by an ST23 strain (PubMed)

Emergence of the third-generation cephalosporin-resistant hypervirulent Klebsiella pneumoniae due to the acquisition of a self-transferable blaDHA-1-carrying plasmid by an ST23 strain 29683780 2018 09 17 2018 11 14 2150-5608 9 1 2018 12 31 Virulence Virulence Emergence of the third-generation cephalosporin-resistant hypervirulent Klebsiella pneumoniae due to the acquisition of a self-transferable bla DHA-1 -carrying plasmid by an ST23 strain. 838-844 10.1080/21505594.2018.1456229 Xie Yingzhou Y (...) Jiao Tong University , Shanghai , China. f Shanghai Key Laboratory of Veterinary Biotechnology , School of Life Sciences & Biotechnology, Shanghai Jiao Tong University , Shanghai , China. eng Letter Research Support, Non-U.S. Gov't United States Virulence 101531386 2150-5594 0 Anti-Bacterial Agents 0 Cephalosporins EC 3.5.2.6 beta-Lactamases IM Virulence. 2018 Dec 31;9(1):1000 29768087 Animal Structures Animals Anti-Bacterial Agents pharmacology Bacterial Load Cephalosporins pharmacology Disease

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2018 Virulence

4. Identification of Gut Microbiome Biomarkers Associated to Acquisition of Enterobacteriae Highly Resistant to Third Generation Cephalosporines Following Ceftriaxone Treatment.

Identification of Gut Microbiome Biomarkers Associated to Acquisition of Enterobacteriae Highly Resistant to Third Generation Cephalosporines Following Ceftriaxone Treatment. Identification of Gut Microbiome Biomarkers Associated to Acquisition of Enterobacteriae Highly Resistant to Third Generation Cephalosporines Following Ceftriaxone Treatment. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information (...) . Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Identification of Gut Microbiome Biomarkers Associated to Acquisition of Enterobacteriae Highly Resistant to Third Generation Cephalosporines Following Ceftriaxone Treatment. (ARCMI) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study

2018 Clinical Trials

5. Community Epidemiology and Typology of Third-generation Cephalosporins Resistant Enterobacteriaceae in Reunion Island

Community Epidemiology and Typology of Third-generation Cephalosporins Resistant Enterobacteriaceae in Reunion Island Community Epidemiology and Typology of Third-generation Cephalosporins Resistant Enterobacteriaceae in Reunion Island - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Community Epidemiology and Typology of Third-generation Cephalosporins Resistant Enterobacteriaceae in Reunion Island (AB-RUN) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03226314 Recruitment Status : Active

2017 Clinical Trials

6. Third Generation Anti-Pseudomonal Cephalosporins

Third Generation Anti-Pseudomonal Cephalosporins Third Generation Anti-Pseudomonal Cephalosporins Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer (...) Administration 4 Third Generation Anti-Pseudomonal Cephalosporins Third Generation Anti-Pseudomonal Cephalosporins Aka: Third Generation Anti-Pseudomonal Cephalosporins , Ceftazidime From Related Chapters II. Coverage Pseudomonas (Main indication) poorly covered No coverage III. Preparations: Ceftazidime (Fortaz) Adult: 1-2 grams IM or IV every 8 to 12 hours Child: 30-50 mg/kg IV every 8 hours IV. Disadvantages Most expensive Limited spectrum Images: Related links to external sites (from Bing) These images

2015 FP Notebook

7. PipEracillin Tazobactam Versus mERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae (PETERPEN)

BSI due to E. coli or Klebsiella spp. in one or more blood cultures associated with evidence of infection. The microorganism will have to be non-susceptible to third generation cephalosporins (ceftriaxone and ceftazidime) and susceptible to both PTZ and meropenem (see microbiological methods). Both community and hospital-acquired bacteremias will be included. We will permit the inclusion of bacteremias due to E. coli or Klebsiella spp. with concomitant growth in blood of skin commensals considered (...) MeSH terms: Layout table for MeSH terms Infection Communicable Diseases Bacterial Infections Bacteremia Enterobacteriaceae Infections Sepsis Systemic Inflammatory Response Syndrome Inflammation Pathologic Processes Gram-Negative Bacterial Infections Meropenem Tazobactam Piperacillin Piperacillin, Tazobactam Drug Combination Cephalosporins Anti-Bacterial Agents Anti-Infective Agents beta-Lactamase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action

2018 Clinical Trials

8. Antimicrobial stewardship: changing risk-related behaviours in the general population

Antimicrobial stewardship: changing risk-related behaviours in the general population Antimicrobial stewardship: changing risk- Antimicrobial stewardship: changing risk- related beha related behaviours in the gener viours in the general al population population NICE guideline Published: 25 January 2017 nice.org.uk/guidance/ng63 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility (...) and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with complying with those duties. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Antimicrobial stewardship: changing risk-related behaviours in the general population (NG63) © NICE 2019. All rights reserved. Subject

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

9. Is Spontaneous Bacterial Peritonitis Still Responding to 3rd Generation Cephalosporins?

, 2015 Last Update Posted : June 20, 2017 See Sponsor: Tanta University Information provided by (Responsible Party): Sherief Abd-Elsalam, Tanta University Study Details Study Description Go to Brief Summary: Current European and most other international guidelines recommend the use of a third-generation cephalosporin as the first choice, or amoxicillin-clavulanate acid or fluoroquinolones as an alternative choice . These recommendations are based mainly on clinical trials that were very often (...) conducted a decade or more ago, and on the assumption that E. coli would be involved in nearly half of the cases. The microbial etiology of SBP remains relatively constant; however, the antibiotic resistance rate especially for third-generation cephalosporins (including cefotaxime and ceftazidime), ciprofloxacin, and ofloxacin increased dramatically . Condition or disease Intervention/treatment Phase Primary Bacterial Peritonitis Drug: Cefotaxime Drug: ceftriaxone Phase 3 Detailed Description

2015 Clinical Trials

10. The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis)

The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail (...) Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Value of Post-operative Antibiotic Therapy After Laparoscopic Appendectomy for Complicated Acute Appendicitis (Other Than for Generalized Peritonitis) (ABAP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal

2018 Clinical Trials

11. General Principles of Fracture Care (Follow-up)

fracture management. Time to antibiotic administration has been shown to be the most important factor in reduction of infection risk in open fractures; therefore, antibiotics should be given immediately. For type I and type II fracture injuries, a first-generation cephalosporin (eg, cefazolin) is adequate. If the wound is severely contaminated (type III), an aminoglycoside (eg, gentamicin, tobramycin) is commonly added to complement treatment. If the injury is a "barnyard injury" (contaminated (...) cases, osteomyelitis and systemic infection in the form of sepsis. Early recognition of a local infection may prevent the development of sepsis and, thus, decrease patient morbidity. The most common pathogen is Staphylococcus aureus. Other pathogens include group A streptococci, coagulase-negative staphylococci, and enterococci. Appropriate antibiotics should be administered if an infection is suspected. A 2-week course of first-generation cephalosporins, such as cephalexin, is generally sufficient

2014 eMedicine Surgery

12. General Principles of Fracture Care (Treatment)

fracture management. Time to antibiotic administration has been shown to be the most important factor in reduction of infection risk in open fractures; therefore, antibiotics should be given immediately. For type I and type II fracture injuries, a first-generation cephalosporin (eg, cefazolin) is adequate. If the wound is severely contaminated (type III), an aminoglycoside (eg, gentamicin, tobramycin) is commonly added to complement treatment. If the injury is a "barnyard injury" (contaminated (...) cases, osteomyelitis and systemic infection in the form of sepsis. Early recognition of a local infection may prevent the development of sepsis and, thus, decrease patient morbidity. The most common pathogen is Staphylococcus aureus. Other pathogens include group A streptococci, coagulase-negative staphylococci, and enterococci. Appropriate antibiotics should be administered if an infection is suspected. A 2-week course of first-generation cephalosporins, such as cephalexin, is generally sufficient

2014 eMedicine Surgery

13. Cephalosporin

resistance to β-lactamases than the third-generation cephalosporins. Many can cross the and are effective in . They are also used against . [ ] 5 has been described as "fifth-generation" cephalosporin, though acceptance for this terminology is not universal. Ceftobiprole has powerful anti characteristics and appears to be less susceptible to development of resistance. has also been described as "fifth-generation" cephalosporin, but does not have the antipseudomonal or VRE coverage of ceftobiprole (...) activity. The classification of cephalosporins into "generations" is commonly practised, although the exact categorization is often imprecise. For example, the fourth generation of cephalosporins is not recognized as such in Japan. [ ] In Japan, cefaclor is classed as a first-generation cephalosporin, though in the United States it is a second-generation one; and cefbuperazone, cefminox, and cefotetan are classed as second-generation cephalosporins. Cefmetazole and cefoxitin are classed as third

2012 Wikipedia

14. Cough (acute): antimicrobial prescribing

(for example, sepsis, a pulmonary embolism or lung cancer). T T reatment reatment 1.1.5 Give general advice to people about: the usual course of acute cough (lasts up to 3 or 4 weeks) how to manage their symptoms with self-care (see the recommendations on self-care) when to seek medical help, for example if symptoms worsen rapidly or significantly, do not improve after 3 to 4 weeks, or the person becomes systemically very unwell. 1.1.6 Do not offer the following treatments to people for an acute cough (...) difference in the number of people with adverse events which led to withdrawal (0.5% versus 1.0%; very low quality evidence). Based on 2 systematic reviews and meta-analyses, Wagner et al. (2015) and Timmer et al. (2013), in adults, young people or children with an acute cough or acute bronchitis. Non-ster Non-steroidal anti-inflammatory drugs (NSAIDs) oidal anti-inflammatory drugs (NSAIDs) NSAIDs (naproxen or ibuprofen) were not significantly different to placebo for a cumulative cough score at follow

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

15. Sore throat (acute): antimicrobial prescribing

). Statistically significant differences were seen for some comparisons but the absolute differences between antibiotic classes was small. There was no significant difference in adverse events for cephalosporins, macrolides or sulfonamides compared with phenoxymethylpenicillin in 1 systematic review (van Driel et al. 2016). The other systematic review (Altamimi et al. 2012) found that a shorter course of late- generation (broader spectrum) antibiotics was associated with significantly more adverse events (...) prescribing (NG84) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 5 of 241.1.7 As well as the general advice in recommendation 1.1.4, give advice about: an antibiotic not being needed seeking medical help if symptoms worsen rapidly or significantly, do not start to improve after 1 week, or the person becomes systemically very unwell. See the evidence and committee discussion on no antibiotic. P People who ma eople who

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

16. Prostatitis (acute): antimicrobial prescribing

. Where fluoroquinolone resistance is a concern, other antibiotics that can reach therapeutic prostate levels include third-generation cephalosporins (such as ceftriaxone), carbapenems (such as imipenem or ertapenem), some aminoglycosides, aztreonam, piperacillin, minocycline, doxycycline, erythromycin, clindamycin and trimethoprim (Lipsky et al. 2010). In acute prostatitis, where there is intense inflammation of the prostate gland, antibiotic penetration can be better than in chronic prostatitis (...) of antibiotics for treating acute prostatitis. The committee was aware of several guidelines, which reflect current practice, that make recommendations based on expert consensus and overviews of the literature on pharmacokinetics and antimicrobial resistance patterns. Based on experience, the committee agreed that treating acute prostatitis requires high doses of fluoroquinolones, second- or third-generation cephalosporins or broad-spectrum penicillins (possibly combined with an aminoglycoside

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

17. Pyelonephritis (acute): antimicrobial prescribing

in clinical effectiveness between different antibiotics compared in the studies (third- and fourth-generation cephalosporins, aminoglycosides, co-amoxiclav and co-trimoxazole; very low to moderate quality evidence). Safety of antibiotics Safety of antibiotics Antibiotic-associated diarrhoea occurs in 2 to 25% of people taking antibiotics, depending on the antibiotic used (NICE clinical knowledge summary on diarrhoea – antibiotic associated). About 10% of the general population claim to have a penicillin (...) ). The studies included various different antibiotics, which may not reflect those chosen in UK practice. The committee discussed the evidence for a benefit of the intravenous third- generation cephalosporins, ceftolozane/tazobactam or ceftazidime, over an intravenous fluoroquinolone, but this was mainly limited to a benefit for composite cure (which included clinical cure, microbiological eradication and microbiological cure) and the absolute benefits were small. The committee agreed, based on experience

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

18. Optimisation of RIZIV – INAMI lump sums for incontinence

Incontinence 1 ? TABLE OF CONTENTS LIST OF FIGURES 8 LIST OF TABLES 10 LIST OF ABBREVIATIONS 13 ? SCIENTIFIC REPORT 16 1 GENERAL INTRODUCTION 16 1.1 AIM OF THE STUDY 16 1.2 SCOPE 17 1.3 REPORT OUTLINE 17 2 INCONTINENCE: PATIENTS, DIAGNOSIS AND TREATMENTS 18 2.1 INTRODUCTION 18 2.1.1 Chapter outline 18 2.1.2 Methods 18 2.1.3 PICO 18 2.1.4 Medline search 19 2.1.5 Cochrane search 19 2.1.6 Embase search 20 2.1.7 Grey literature search and websites incontinence societies 20 2.1.8 Results from search: retrieved (...) -PTNS Transcutaneous posterior tibial nerve stimulation TURP Transurethral resection of the prostate TVT Tension-free vaginal tape TVT-O Tension-free vaginal tape obturator UTI Urine tract infection UUI Urgency urinary incontinence UI Urinary Incontinence VC Vaginal cones WHO World Health Organisation 16 Incontinence KCE Report 304 ? SCIENTIFIC REPORT 1 GENERAL INTRODUCTION 1.1 Aim of the study Under specific conditions, persons suffering from incontinence can benefit from a grant for incontinence

2019 Belgian Health Care Knowledge Centre

19. Diagnosis and management of gonorrhoea and syphilis

AND DECLARATION OF INTEREST 25 2 METHODOLOGY 26 2.1 THE GUIDELINE DEVELOPMENT GROUP 26 2.2 INTERNATIONAL COLLABORATION 26 2.3 GENERAL APPROACH AND CLINICAL RESEARCH QUESTIONS 26 General approach 26 Research questions 28 2.4 SEARCH FOR GUIDELINES AND QUALITY APPRAISAL 34 2 Diagnosis and management of gonorrhoea and syphilis KCE Report 310 Databases and date limits 34 Search strategy 34 Quality appraisal 36 2.5 ADDITIONAL LITERATURE SEARCH: DIAGNOSTIC TESTS FOR GONORRHOEA 36 Diagnostic tests of choice (...) in pregnant women 101 Recommendation for treatment of gonorrhoea in pregnant women 104 Treatment of gonorrhoea in pregnant women: Good practice statements 104 3.9 TREATMENT OF GONORRHOEA: TREATMENT CHOICE IN PEOPLE WITH AN ALLERGY TO CEPHALOSPORIN 105 Background cephalosporin allergy 105 Recommendations from international guidelines 105 Recommendations from national guides 106 Additional literature search: Treatment of gonorrhoea in people with an allergy to cephalosporin 106 Treatment of gonorrhoea

2019 Belgian Health Care Knowledge Centre

20. British Association for Sexual Health and HIV national guideline for the management of infection with Neisseria gonorrhoeae

because of allergy, needle phobia or other absolute or relative contraindications. In patients with pencillin allergy there is ample evidence to allow the safe use of all but a few early generation cephalosporins (e.g. cephalexin, cefaclor and cefadroxil), and third- generation cephalosporins such as cefixime and ceftriaxone show negligible cross-allergy with penicillins. 80 ,81 Therefore, in penicillin-allergic patients ceftriaxone and cefixime are suitable treatment options, unless (...) ) and medical literature since its publication. A MEDLINE search of published articles in English language for the years 2009–18 was done using the subject headings ‘gonorrhoea’ OR ‘gonorrhea’ OR ‘Neisseria gonorrhoeae’ AND ‘therapy’ OR ‘treatment’ OR ‘therapeutics’ OR ‘resistance’ OR ‘anti-bacterial agents’ OR ‘antibiotics’ OR ‘failure’ OR ‘toxicity’. All entries in the English language or with abstracts in English were viewed because of the paucity of ‘clinical trials’ or ‘reviews’. 4 The Cochrane

2019 British Association for Sexual Health and HIV

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