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Tetany

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1. Comparative pathogenomics of Clostridium tetani. (PubMed)

Comparative pathogenomics of Clostridium tetani. Clostridium tetani and Clostridium botulinum produce two of the most potent neurotoxins known, tetanus neurotoxin and botulinum neurotoxin, respectively. Extensive biochemical and genetic investigation has been devoted to identifying and characterizing various C. botulinum strains. Less effort has been focused on studying C. tetani likely because recently sequenced strains of C. tetani show much less genetic diversity than C. botulinum strains (...) and because widespread vaccination efforts have reduced the public health threat from tetanus. Our aim was to acquire genomic data on the U.S. vaccine strain of C. tetani to better understand its genetic relationship to previously published genomic data from European vaccine strains. We performed high throughput genomic sequence analysis on two wild-type and two vaccine C. tetani strains. Comparative genomic analysis was performed using these and previously published genomic data for seven other C. tetani

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2017 PLoS ONE

2. Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls (PubMed)

Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls The presence of botulinum neurotoxin-producing Clostridia (BPC) in food sources is a public health concern. In favorable environmental conditions, BPC can produce botulinum neurotoxins (BoNTs) outside or inside the vertebrate host, leading to intoxications or toxico-infectious forms of botulism, respectively. BPC in food are almost invariably (...) of a Clostridium tetani strain that produces tetanus neurotoxins (TeNTs) with the above-mentioned characteristics: lethal for mice, heat-labile and neutralized by botulinum antitoxin type B. Notably, neutralization occurred with two different commercially available type B antitoxins, but not with type A, C, D, E and F antitoxins. Although TeNT and BoNT fold very similarly, evidence that antitoxin B antiserum can neutralize the neurotoxic effect of TeNT in vivo has not been documented before. The presence of C

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2018 Toxins

3. Dengue fever manifesting with tetany as the first presentation of primary hypoparathyroidism: a case report (PubMed)

Dengue fever manifesting with tetany as the first presentation of primary hypoparathyroidism: a case report Primary hypoparathyroidism is associated with diverse variety of symptomatology of hypocalcemia including seizures and tetany. We report a case of previously undiagnosed asymptomatic primary hypoparathyroidism with extensive basal ganglia calcifications presenting for the first time with hypocalcemic tetany during acute dengue infection. Although hypocalcemia is known to occur in dengue (...) infection symptomatic hypocalcemia is very infrequent.A 32 year old male with short stature who has undergone bilateral cataract surgery 2 years ago but who was otherwise healthy, presented with fever and generalized body aches of 3 days duration and carpal spasms/tetany occurring on the third day of the illness. He was diagnosed to have acute dengue fever along with severe hypocalcemia. Subsequent workup confirmed that the patient had primary hypoparathyroidism with extensive basal ganglia

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2018 BMC research notes

4. Camurati-Engelmann disease-a rare cause of tetany identified on bone scintigraphy: A case report. (PubMed)

Camurati-Engelmann disease-a rare cause of tetany identified on bone scintigraphy: A case report. Camurati-Engelmann disease (i.e., progressive diaphyseal dysplasia) is an extremely rare autosomal dominant bone disorder. The most common clinical manifestations were chronic skeletal pain, waddling gait, muscular weakness.We described that a 27-year-old male with a 1-year history of intermittent tetany was referred for bone scintigraphy. The whole body bone scan images showed abnormal increased

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2017 Medicine

5. Hypokalemia, hypomagnesemia, hypocalciuria, and recurrent tetany: Gitelman syndrome in a Chinese pedigree and literature review (PubMed)

Hypokalemia, hypomagnesemia, hypocalciuria, and recurrent tetany: Gitelman syndrome in a Chinese pedigree and literature review Gitelman syndrome is an autosomal recessive disease mostly associated with loss-of-function mutations of the SLC12A3 gene and featured by clinical hypokalemia, hypomagnesemia, hypocalciuria, and histologically hypertrophy of the juxtaglomerular apparatus. A novel homozygous mutation (p.Arg399Pro) at the extracellular domain of SLC12A3 was found and correlated

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2017 Clinical Case Reports

6. Tetany

Tetany Tetany Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tetany Tetany Aka: Tetany , Chvostek's Sign II. Pathophysiology Lowered (...) muscular excitability threshold Results in involuntary spasms Diffuse muscles involved in severe, spontaneous Tetany Laryngeal Death may occur III. Causes IV. Symptoms Muscle spasms Spasm may be preceded by lip, arm, leg s V. Signs Rigid, unyielding muscles Chvostek's Sign Tap against bone just anterior to ear Positive sign produces ipsilateral facial contraction Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Tetany." Click

2018 FP Notebook

7. 2D DIGE Does Not Reveal all: A Scotopic Report Suggests Differential Expression of a Single “Calponin Family Member” Protein for Tetany of Sphincters! (PubMed)

2D DIGE Does Not Reveal all: A Scotopic Report Suggests Differential Expression of a Single “Calponin Family Member” Protein for Tetany of Sphincters! Using 2D differential gel electrophoresis (DIGE) and mass spectrometry (MS), a recent report by Rattan and Ali (2015) compared proteome expression between tonically contracted sphincteric smooth muscles of the internal anal sphincter (IAS), in comparison to the adjacent rectum [rectal smooth muscles (RSM)] that contracts in a phasic fashion

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2015 Frontiers in medicine

8. Clostridium tetani Osteitis without Tetanus (PubMed)

Clostridium tetani Osteitis without Tetanus 25152389 2015 07 06 2018 11 13 1080-6059 20 9 2014 Sep Emerging infectious diseases Emerging Infect. Dis. Clostridium tetani osteitis without tetanus. 1571-3 10.3201/eid2009.131579 Levy Pierre-Yves PY Fournier Pierre-Edouard PE Lotte Laurène L Million Matthieu M Brouqui Philippe P Raoult Didier D eng Case Reports Letter Research Support, Non-U.S. Gov't United States Emerg Infect Dis 9508155 1080-6040 0 Anti-Bacterial Agents 0 Tetanus Toxoid IM Adult (...) Amputation Anti-Bacterial Agents therapeutic use Clostridium tetani genetics isolation & purification Humans Male Osteitis diagnosis drug therapy microbiology surgery Radiography Tetanus Toxoid administration & dosage Tibial Fractures complications diagnostic imaging 2014 8 26 6 0 2014 8 26 6 0 2015 7 7 6 0 ppublish 25152389 10.3201/eid2009.131579 PMC4178411 Orthop Traumatol Surg Res. 2012 Oct;98(6):696-705 22951052 BMJ Case Rep. 2009;2009:null 21686979 Intern Med. 2009;48(15):1311-3 19652437 J Clin

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2014 Emerging Infectious Diseases

9. Genome of a chronic osteitis-causing Clostridium tetani (PubMed)

Genome of a chronic osteitis-causing Clostridium tetani We sequenced the genome of a Clostridium tetani strain that caused chronic tibial osteitis without any clinical sign of tetanus in a 26-year-old man previously vaccinated against this disease. The genome contained a plasmid that harboured the tetX-tetR tetanospasmin operon, and was highly similar to that of a tetanus-causing strain.

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2014 New Microbes and New Infections

10. Novel RNA structural features of an alternatively splicing group II intron from Clostridium tetani (PubMed)

Novel RNA structural features of an alternatively splicing group II intron from Clostridium tetani Group II introns are ribozymes in bacterial and organellar genomes that function as self-splicing introns and as retroelements. Previously, we reported that the group II intron C.te.I1 of Clostridium tetani alternatively splices in vivo to produce five distinct coding mRNAs. Accurate fusion of upstream and downstream reading frames requires a shifted 5' splice site located 8 nt upstream

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2014 RNA

11. Magnesium therapy in neonatal tetany. (PubMed)

Magnesium therapy in neonatal tetany. 104 infants with symptomatic hypocalcaemia were randomly allocated to treatment with calcium gluconate, phenobarbitone, or magnesium sulphate. Infants treated with magnesium sulphate had higher plasma-calcium concentrations after 48 hours' treatment and fewer convulsions during and after the treatment period. Magnesium sulphate is recommended as the treatment of choice in symptomatic neonatal tetany whether or not there is hypomagnesaemia.

1977 Lancet

12. OBSERVATIONS ON TETANY IN DOGS : RELATION OF THE PARATHYROIDS TO THE THYROID; RELATION OF TETANY TO AGE, AMOUNT OF PARATHYROID TISSUE REMOVED, ACCESSORY PARATHYROIDS, PREGNANCY, LACTATION, RICKETS, SULPHUR, AND DIET; RELATION OF PARATHYROIDS TO SUGAR TOLE (PubMed)

OBSERVATIONS ON TETANY IN DOGS : RELATION OF THE PARATHYROIDS TO THE THYROID; RELATION OF TETANY TO AGE, AMOUNT OF PARATHYROID TISSUE REMOVED, ACCESSORY PARATHYROIDS, PREGNANCY, LACTATION, RICKETS, SULPHUR, AND DIET; RELATION OF PARATHYROIDS TO SUGAR TOLE Accessory parathyroid tissue unassociated with the thyroid lobes is present in 5 to 6 per cent. of dogs. For the determination of the presence of accessory parathyroid tissue there are two tests: (1) the anatomical, often entailing serial (...) sections of the neck and upper thoracic structures, and (2) the biological, consisting of the daily use of some calcium salt for two to three weeks. The latter is more easily carried out and more accurate. In the absence of all parathyroid tissue calcium salts will not save the animal's life, while in the presence of active parathyroid tissue calcium will save it. Many factors other than the amount of parathyroid tissue removed influence the onset of tetany, among which are age, pregnancy, lactation

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1914 The Journal of experimental medicine

13. A Note on “Sensory Tetany,” “Vasomotor Tetany,” Acroparaesthesia, and Raynaud's Symptoms (PubMed)

A Note on “Sensory Tetany,” “Vasomotor Tetany,” Acroparaesthesia, and Raynaud's Symptoms 20765475 2011 03 29 2018 11 13 0007-1447 1 2617 1911 Feb 25 British medical journal Br Med J A Note on "Sensory Tetany," "Vasomotor Tetany," Acroparaesthesia, and Raynaud's Symptoms. 434-5 Weber F P FP eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1911 2 25 0 0 1911 2 25 0 1 ppublish 20765475 PMC2333172 Proc R Soc Med. 1909;2(Sect Study Dis Child):218-21 19973991

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1911 British medical journal

14. A COMPARATIVE STUDY OF THE EFFECTS OF VARIOUS TREATMENTS ON THE CALCIUM AND PHOSPHORUS METABOLISM IN TETANY: I. Chronic Juvenile Tetany (PubMed)

A COMPARATIVE STUDY OF THE EFFECTS OF VARIOUS TREATMENTS ON THE CALCIUM AND PHOSPHORUS METABOLISM IN TETANY: I. Chronic Juvenile Tetany 16693791 2006 05 31 2018 11 13 0021-9738 5 2 1928 Feb The Journal of clinical investigation J. Clin. Invest. A COMPARATIVE STUDY OF THE EFFECTS OF VARIOUS TREATMENTS ON THE CALCIUM AND PHOSPHORUS METABOLISM IN TETANY: I. Chronic Juvenile Tetany. 259-76 Liu S H SH Department of Medicine, Peking Union Medical College, Peking, China. eng Journal Article United

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1928 Journal of Clinical Investigation

15. A COMPARATIVE STUDY OF THE EFFECTS OF VARIOUS TREATMENTS ON THE CALCIUM AND PHOSPHORUS METABOLISM IN TETANY: II. Chronic Adult Idiopathic Tetany (PubMed)

A COMPARATIVE STUDY OF THE EFFECTS OF VARIOUS TREATMENTS ON THE CALCIUM AND PHOSPHORUS METABOLISM IN TETANY: II. Chronic Adult Idiopathic Tetany 16693792 2006 05 31 2018 11 13 0021-9738 5 2 1928 Feb The Journal of clinical investigation J. Clin. Invest. A COMPARATIVE STUDY OF THE EFFECTS OF VARIOUS TREATMENTS ON THE CALCIUM AND PHOSPHORUS METABOLISM IN TETANY: II. Chronic Adult Idiopathic Tetany. 277-84 Liu S H SH Department of Medicine, Peking Union Medical College, Peking, China. eng Journal

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1928 Journal of Clinical Investigation

16. Localised normocalcaemic tetany secondary to dehydration in an individual with Gitelman syndrome (PubMed)

Localised normocalcaemic tetany secondary to dehydration in an individual with Gitelman syndrome Dehydration is a common presentation to any emergency department with symptoms ranging from lethargy, confusion, oliguria as well as those specific to the underlying cause. In this case we describe a young patient who following a short history of vomiting and abdominal pain developed carpopedal spasm and distal parasthesia on a background of Gitelman syndrome. Biochemical blood analysis showed (...) a marked hypokalaemia, hypomagnesaemia and mild metabolic alkalosis in addition to a prolonged QTc interval of 592 ms seen on ECG. Following fluid replacement and electrolyte correction his clinical symptoms resolved along with QTc normalisation. This case demonstrates a patient with a rare and interesting renal disorder who presented with typical biochemical and ECG abnormalities in addition to tetany in the presence of normal plasma calcium.

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2013 BMJ case reports

17. Tetany due to hypoparathyroidism as the initial manifestation of autoimmune polyendocrine syndrome type-2: A case report (PubMed)

Tetany due to hypoparathyroidism as the initial manifestation of autoimmune polyendocrine syndrome type-2: A case report Hypoparathyroidism is most commonly isolated and idiopathic. Hypoparathyroidism in autoimmune polyendocrine syndrome type-2 (APS-2) is extremely rare with few isolated reports and usually presents late. We present perhaps for the first time, hypoparathyroidism being the initial manifestation of APS-2 which was diagnosed in a 32 year lady with tingling of the extremities along (...) with hypocalcemic tetany for 15 years. She also had generalized acral and mucosal hyperpigmentation of 2 years duration. Investigations were significant for low calcium (7.1mg/dl), elevated phosphorus (4.8mg/dl), vitamin-D insufficiency (27.4ng/ml), low intact parathyroid hormone (2.3pg/ml), low basal (4.7mcg/dl) and stimulated serum cortisol (9.2mcg/dl at half hour, 11.4mcg/dl at 1 hour post synacthen), elevated triiodothyronine (2.1ng/ml) and free tetraiodothyronine (2.4ng/dl) along with suppressed TSH

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2012 Indian journal of endocrinology and metabolism

18. Tetany

Tetany Tetany Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tetany Tetany Aka: Tetany , Chvostek's Sign II. Pathophysiology Lowered (...) muscular excitability threshold Results in involuntary spasms Diffuse muscles involved in severe, spontaneous Tetany Laryngeal Death may occur III. Causes IV. Symptoms Muscle spasms Spasm may be preceded by lip, arm, leg s V. Signs Rigid, unyielding muscles Chvostek's Sign Tap against bone just anterior to ear Positive sign produces ipsilateral facial contraction Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Tetany." Click

2015 FP Notebook

19. Anorexia Nervosa: Russell’s Sign with Concurrent Tetany (PubMed)

Anorexia Nervosa: Russell’s Sign with Concurrent Tetany 21279458 2011 10 27 2018 11 13 1525-1497 26 6 2011 Jun Journal of general internal medicine J Gen Intern Med Anorexia nervosa: Russell's sign with concurrent tetany. 668 10.1007/s11606-010-1613-5 Young Janet J Department of Internal Medicine, University of California Davis Medical Center, Sacramento, CA 95616, USA. Henderson Mark C MC Thompson George R GR 3rd eng Case Reports Journal Article 2011 01 29 United States J Gen Intern Med (...) 8605834 0884-8734 IM Adult Anorexia Nervosa complications diagnosis therapy Female Hand pathology Humans Tetany diagnosis etiology therapy 2010 06 06 2010 12 13 2011 2 1 6 0 2011 2 1 6 0 2011 10 28 6 0 ppublish 21279458 10.1007/s11606-010-1613-5 PMC3101975 Psychol Med. 1979 Aug;9(3):429-48 482466 Dermatology. 2001;203(4):314-7 11752819

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2011 Journal of General Internal Medicine

20. Anterior tibial compartment syndrome following prolonged tetany (PubMed)

Anterior tibial compartment syndrome following prolonged tetany A patient developed a persistent, disabling, bilateral anterior tibial compartment syndrome after salicylate self-poisoning. Prolonged tetany is postulated as the probable mechanism.

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1976 Journal of neurology, neurosurgery, and psychiatry

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