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1. Diphtheria, tetanus, acellular pertussis and inactivated poliomyelitis vaccine (dTaP/IPV) for pregnant women: patient group direction (PGD) template

Diphtheria, tetanus, acellular pertussis and inactivated poliomyelitis vaccine (dTaP/IPV) for pregnant women: patient group direction (PGD) template application/vnd.openxmlformats-officedocument.wordprocessingml.document

2019 Public Health England

2. Tetanus

Tetanus Tetanus - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Tetanus Last reviewed: February 2019 Last updated: July 2018 Summary Prevention includes appropriate management of tetanus-prone wounds and complete active immunisation, with passive immunisation administered when required. Diagnosis is based on clinical findings that include trismus, muscle rigidity, spasms, respiratory embarrassment, dysphagia (...) , or autonomic dysfunction. Management of clinical tetanus includes supportive care, wound debridement, antimicrobials, passive and active immunisation, control of muscle spasms, and management of autonomic dysfunction. Definition Tetanus is a life-threatening neurological syndrome characterised by tonic muscle spasms and hyperreflexia, caused by the exotoxin of Clostridium tetani , a gram-positive spore-forming obligate anaerobe. History and exam antecedent tetanus-prone injury tetanus immunisation status

2018 BMJ Best Practice

4. Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among men seeking medical circumcision services in Uganda. Full Text available with Trip Pro

Prevalence of protective tetanus antibodies and immunological response following tetanus toxoid vaccination among men seeking medical circumcision services in Uganda. Tetanus infection associated with men who had male circumcision has been reported in East Africa, suggesting a need for tetanus toxoid-containing vaccines (TTCV).To determine the prevalence of tetanus toxoid antibodies following vaccination among men seeking circumcision.We enrolled 620 consenting men who completed a questionnaire (...) and received TTCV at enrollment (day 0) prior to circumcision on day 28. Blood samples were obtained at day 0 from all enrollees and on days 14, 28 and 42 from a random sample of 237 participants. Tetanus toxoid (TT) IgG antibody levels were assayed using EUROIMMUN. Analyses included prevalence of TT antibodies at enrollment and used a mixed effects model to determine the immunological response.Mean age was 21.4 years, 65.2% had knowledge of tetanus, 56.6% knew how tetanus was contracted, 22.8% reported

2018 PLoS ONE

5. Correction: Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses. Full Text available with Trip Pro

Correction: Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses. [This corrects the article DOI: 10.1371/journal.pone.0169086.].

2018 PLoS ONE

6. VAXELIS, hexavalent vaccine against diphtheria, tetanus, poliomyelitis, pertussis, Haemophilus influenzae type b infections, hepatitis B

VAXELIS, hexavalent vaccine against diphtheria, tetanus, poliomyelitis, pertussis, Haemophilus influenzae type b infections, hepatitis B Haute Autorité de Santé - VAXELIS, vaccin hexavalent contre diphtérie, tétanos, poliomyélite, coqueluche, infections à Haemophilus influenzae type b, hépatite B Développer la qualité dans le champ sanitaire, social et médico-social Recherche Évaluation & Recommandation La HAS Accréditation & Certification Outils, Guides & Méthodes Agenda Avis sur les

2018 Haute Autorite de sante

7. Neonatal tetanus in eastern Uganda: improved outcome following the implementation of a neonatal tetanus protocol. (Abstract)

Neonatal tetanus in eastern Uganda: improved outcome following the implementation of a neonatal tetanus protocol. Neonatal tetanus remains a significant, yet avoidable, cause of neonatal death. Despite the 34,000 deaths that occur globally from neonatal tetanus every year, there has been little research into the management of neonatal tetanus. Until worldwide elimination of neonatal tetanus is achieved, the case management of this devastating illness needs to be improved. We describe (...) an improved outcome of neonatal tetanus following the introduction of a neonatal tetanus protocol including diazepam, magnesium sulphate, bubble continuous positive airway pressure and broad-spectrum antibiotics in a low-resource setting in eastern Uganda.

2019 Tropical Doctor

8. Update on Immunization and Pregnancy Tetanus Diphtheria and Pertussis Vaccination

Update on Immunization and Pregnancy Tetanus Diphtheria and Pertussis Vaccination Update on Immunization and Pregnancy Tetanus Diphtheria and Pertussis Vaccination - ACOG Menu ▼ Update on Immunization and Pregnancy Tetanus Diphtheria and Pertussis Vaccination Page Navigation ▼ Number 718, September 2017 (Replaces Committee Opinion 566, June 2013) Committee on Obstetric Practice Immunization and Emerging Infections Expert Work Group This Committee Opinion was developed by the Immunization (...) , or consequential damages, incurred in connection with this publication or reliance on the information presented. Update on Immunization and Pregnancy: Tetanus, Diphtheria, and Pertussis Vaccination ABSTRACT: The overwhelming majority of morbidity and mortality attributable to pertussis infection occurs in infants who are 3 months and younger. Infants do not begin their own vaccine series against pertussis until approximately 2 months of age. This leaves a window of significant vulnerability for newborns, many

2017 American College of Obstetricians and Gynecologists

9. Tetanus vaccines: WHO position paper – February 2017 = Note de synthèse: position de l’OMS sur les vaccins antitétaniques – février 2017

Tetanus vaccines: WHO position paper – February 2017 = Note de synthèse: position de l’OMS sur les vaccins antitétaniques – février 2017 Tetanus vaccines: WHO position paper – February 2017 = Note de synthèse: position de l’OMS sur les vaccins antitétaniques – février 2017 JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Tetanus vaccines: WHO position paper – February 2017 (...) = Note de synthèse: position de l’OMS sur les vaccins antitétaniques – février 2017 View/ Open View Statistics Altmetrics Share Citation World Health Organization = Organisation mondiale de la Santé . (‎2017)‎. Tetanus vaccines: WHO position paper – February 2017 = Note de synthèse: position de l’OMS sur les vaccins antitétaniques – février 2017. Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 92 (‎6)‎, 53 - 76. World Health Organization = Organisation mondiale de la Santé

2017 WHO

10. Validation of maternal and neonatal tetanus elimination in Equatorial Guinea, 2016 – Validation de l’élimination du tétanos maternel et néonatal en Guinée équatoriale, 2016

Validation of maternal and neonatal tetanus elimination in Equatorial Guinea, 2016 – Validation de l’élimination du tétanos maternel et néonatal en Guinée équatoriale, 2016 Validation of maternal and neonatal tetanus elimination in Equatorial Guinea, 2016 – Validation de l’élimination du tétanos maternel et néonatal en Guinée équatoriale, 2016 JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics (...) Related Links Validation of maternal and neonatal tetanus elimination in Equatorial Guinea, 2016 – Validation de l’élimination du tétanos maternel et néonatal en Guinée équatoriale, 2016 View/ Open View Statistics Altmetrics Share Citation World Health Organization = Organisation mondiale de la Santé . (‎2017)‎. Validation of maternal and neonatal tetanus elimination in Equatorial Guinea, 2016 – Validation de l’élimination du tétanos maternel et néonatal en Guinée équatoriale, 2016. Weekly

2017 WHO

11. Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses. Full Text available with Trip Pro

Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses. Despite widespread uses of tetanus toxoid (TT) as a vaccine, model antigen and protein carrier, TT epitopes have been poorly characterized. Herein we defined the human CD4+ T cell epitope repertoire by reevaluation of previously described epitopes and evaluation of those derived from prediction of HLA Class II binding. Forty-seven epitopes were

2017 PLoS ONE

12. Repeated vaccination with tetanus toxoid of plasma donors with pre-existing specific IgE transiently elevates tetanus-specific IgE but does not induce allergic symptoms. (Abstract)

Repeated vaccination with tetanus toxoid of plasma donors with pre-existing specific IgE transiently elevates tetanus-specific IgE but does not induce allergic symptoms. 29383792 2018 03 26 1365-2222 48 4 2018 Apr Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Clin. Exp. Allergy Repeated vaccination with tetanus toxoid of plasma donors with pre-existing specific IgE transiently elevates tetanus-specific IgE but does not induce allergic

2018 Clinical and Experimental Allergy

13. Vaccines for women for preventing neonatal tetanus. (Abstract)

Vaccines for women for preventing neonatal tetanus. Tetanus is an acute, often fatal, disease caused by an exotoxin produced by Clostridium tetani. It occurs in newborn infants born to mothers who do not have sufficient circulating antibodies to protect the infant passively, by transplacental transfer. Prevention may be possible by the vaccination of pregnant or non-pregnant women, or both, with tetanus toxoid, and the provision of clean delivery services. Tetanus toxoid consists (...) of a formaldehyde-treated toxin that stimulates the production of antitoxin.To assess the effectiveness of tetanus toxoid, administered to women of reproductive age or pregnant women, to prevent cases of, and deaths from, neonatal tetanus.We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 January 2015), CENTRAL (The Cochrane Library 2015, Issue 1), PubMed (1966 to 28 January 2015), EMBASE (1974 to 28 January 2015) and reference lists of retrieved studies.Randomised or quasi-randomised

2015 Cochrane

14. Tetanus. (Abstract)

Tetanus. Tetanus is a vaccine-preventable disease that still commonly occurs in many low-income and middle-income countries, although it is rare in high-income countries. The disease is caused by the toxin of the bacterium Clostridium tetani and is characterised by muscle spasms and autonomic nervous system dysfunction. Global vaccination initiatives have had considerable success but they continue to face many challenges. Treatment for tetanus aims to control spasms and reduce cardiovascular (...) instability, and consists of wound debridement, antitoxin, antibiotics, and supportive care. Recent research has focused on intravenous magnesium sulphate and intrathecal antitoxin administration as methods of spasm control that can avoid the need for ventilatory support. Nevertheless, without access to mechanical ventilation, mortality from tetanus remains high. Even with such care, patients require several weeks of hospitalisation and are vulnerable to secondary problems, such as hospital-acquired

2019 Lancet

15. Mapping diphtheria-pertussis-tetanus vaccine coverage in Africa, 2000-2016: a spatial and temporal modelling study. Full Text available with Trip Pro

Mapping diphtheria-pertussis-tetanus vaccine coverage in Africa, 2000-2016: a spatial and temporal modelling study. Routine childhood vaccination is among the most cost-effective, successful public health interventions available. Amid substantial investments to expand vaccine delivery throughout Africa and strengthen administrative reporting systems, most countries still require robust measures of local routine vaccine coverage and changes in geographical inequalities over time.This analysis (...) drew from 183 surveys done between 2000 and 2016, including data from 881 268 children in 49 African countries. We used a Bayesian geostatistical model calibrated to results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017, to produce annual estimates with high-spatial resolution (5 ×    5 km) of diphtheria-pertussis-tetanus (DPT) vaccine coverage and dropout for children aged 12-23 months in 52 African countries from 2000 to 2016.Estimated third-dose (DPT3) coverage

2019 Lancet

16. Vaxelis - diphtheria, tetanus, pertussis (acellular, component), hepatitis B (rDNA), poliomyelitis (inactivated) and Haemophilus type b conjugate vaccine (adsorbed)

Vaxelis - diphtheria, tetanus, pertussis (acellular, component), hepatitis B (rDNA), poliomyelitis (inactivated) and Haemophilus type b conjugate vaccine (adsorbed) 17 December 2015 EMA/CHMP/72003/2016 Committee for Medicinal Products for Human Use (CHMP) Assessment report Vaxelis Common name: diphtheria, tetanus, pertussis (acellular, component), hepatitis B (rDNA), poliomyelitis (inactivated) and haemophilus type b conjugate vaccine (adsorbed) Procedure No. EMEA/H/C/003982/0000 Note (...) Recommendation SDS-PAGE Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis T Tetanus TSE Transmissible Spongiform Encephalopathy USP United States Pharmacopeia vIPV Inactivated Vero Trivalent Poliomyelitis Vaccine bulk WCB Working Cell Bank WFI Water For Injection WHO World Health Organization WSL Working seed lot Assessment report EMA/CHMP/72003/2016 Page 6/140 1. Background information on the procedure 1.1. Submission of the dossier The applicant Sanofi Pasteur MSD SNC submitted on 17 December 2014

2016 European Medicines Agency - EPARs

17. Biophysical comparison of diphtheria and tetanus toxins with the formaldehyde-detoxified toxoids, the main components of diphtheria and tetanus vaccines Full Text available with Trip Pro

Biophysical comparison of diphtheria and tetanus toxins with the formaldehyde-detoxified toxoids, the main components of diphtheria and tetanus vaccines 28430538 2018 10 09 2018 11 13 2150-5608 8 8 2017 11 17 Virulence Virulence Biophysical comparison of diphtheria and tetanus toxins with the formaldehyde-detoxified toxoids, the main components of diphtheria and tetanus vaccines. 1880-1889 10.1080/21505594.2017.1321726 Alsarraf Husam H a Department of Microbiology and Infection Control (...) Vaccine Department , Statens Serum Institut , Copenhagen S. , Denmark. Jørgensen René R a Department of Microbiology and Infection Control , Statens Serum Institut , Copenhagen S. , Denmark. eng Comparative Study Journal Article Research Support, Non-U.S. Gov't 2017 05 16 United States Virulence 101531386 2150-5594 0 Diphtheria Toxin 0 Diphtheria Toxoid 0 Tetanus Toxin 0 Tetanus Toxoid 0 Toxoids 1HG84L3525 Formaldehyde IM Clostridium tetani genetics physiology Corynebacterium diphtheriae genetics

2017 Virulence

18. Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice. Full Text available with Trip Pro

Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice. Spaceflight affects the immune system, but the effects on the antibody repertoire, responsible for humoral immunity, has not been well explored. In particular, the complex gene assembly and expression process; including mutations, might make this process vulnerable. Complementarity determining region 3 (CDR3), composed of parts of the V-(D-)J-gene segments, is very important for antigen (...) binding and can be used as an important measure of variability. Skeletal unloading, and the physiological effects of it, parallel many impacts of space flight. Therefore, we explored the impact of skeletal unloading using the antiorthostatic suspension (AOS) model. Animals were experimentally challenged with tetanus toxoid (TT) and/or the adjuvant CpG. Blood was analyzed for anti-TT antibody and corticosterone concentrations. Whole spleen tissue was prepared for repertoire characterization. AOS

2019 PLoS ONE

19. Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder Full Text available with Trip Pro

Prenatal Tetanus, Diphtheria, Acellular Pertussis Vaccination and Autism Spectrum Disorder : media-1vid110.1542/5803567555001PEDS-VA_2018-0120Video Abstract BACKGROUND: Increasing vaccination of pregnant women makes it important to assess safety events potentially linked to prenatal vaccination. This study investigates the association between prenatal tetanus, diphtheria, acellular pertussis (Tdap) vaccination and autism spectrum disorder (ASD) risk in offspring.This is a retrospective cohort

2018 EvidenceUpdates

20. Vitamin C for preventing and treating tetanus. Full Text available with Trip Pro

Vitamin C for preventing and treating tetanus. Tetanus is a severe disease that can be prevented by vaccination. In developing countries vaccination coverage is not always high. Cases still occur also in developed countries, particularly in elderly people owing to their reduced immuno protection. There are about 1 million tetanus cases per year globally. In animal studies, vitamin C has protected against various infections and bacterial toxins. In a study with rats, vitamin C protected against (...) the purified tetanus toxin.To assess the prophylactic and therapeutic effect of vitamin C on tetanus.In May 2013 we searched the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations ); and Ovid EMBASE for this third update.Controlled trials of vitamin C as a prevention or treatment for tetanus, whether or not these were placebo controlled, in any language

2013 Cochrane

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