How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,111 results for

Testosterone Supplementation

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Testosterone Treatment in Adult Men with Age-Related Low Testosterone Full Text available with Trip Pro

contributions to the supplemental rapid review on values and preferences of men treated with testosterone. Financial Support: Financial support for the development of this guideline comes exclusively from the ACP operating budget. Disclosures: Dr. Horwitch is a fiduciary officer for the Washington State Medical Association. Dr. Lin is an employee of Kaiser Permanente. Dr. McLean is an employee of Northeast Medical Group. Authors not named here have disclosed no conflicts of interest. Authors followed (...) . Summary of the ACP guideline on testosterone treatment in adult men with age-related low testosterone. ACP = American College of Physicians. A downloadable version of this figure is available as a at . PDF Supplement 1. Supplemental Appendices (Supplement 1) and Evidence to Decision Tables (Supplement 2) PDF Supplement. Summary of the ACP guideline on testosterone treatment in adult men with age-related low testosterone This feature is available only to Registered Users 2 Comments B Patrick Harpole MD

2020 American College of Physicians

2. Testosterone Imposters: An Analysis of Popular Online Testosterone Boosting Supplements. Full Text available with Trip Pro

Testosterone Imposters: An Analysis of Popular Online Testosterone Boosting Supplements. Testosterone-boosting supplements (T-Boosters) are prominently featured on Amazon.com, with numerous dedicated pages and claims that they "naturally" increase testosterone levels.To evaluate the highest rated and frequently reviewed T-Boosters on Amazon.com to facilitate patient counseling regarding marketing myths, T-Booster formulations, and evidence for efficacy and safety.The Amazon marketplace (...) the availability of highly effective therapies approved by the Food and Drug Administration. Balasubramanian A, Thirumavalavan N, Srivatsav A, et al. Testosterone Imposters: An Analysis of Popular Online Testosterone Boosting Supplements. J Sex Med 2019;16:203-212.Copyright © 2019 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

2019 Journal Of Sexual Medicine

3. Suspected Testosterone-Producing Tumor in a Patient Taking Biotin Supplements Full Text available with Trip Pro

Suspected Testosterone-Producing Tumor in a Patient Taking Biotin Supplements A perimenopausal woman presented with palpitations, hirsutism, and inability to lose weight. Laboratory tests revealed an unusual endocrine hormonal profile including pituitary hormones (TSH, ACTH, and prolactin) below reference intervals and gonadal (testosterone) and adrenal (cortisol) hormones above reference intervals. Ultimately, after a comprehensive workup including a scheduled surgical procedure, abnormal (...) , but also in tests for gonadal steroids, adrenal, and pituitary hormones. Falsely high as well as falsely low results can be ascribed to biotin. Competitive immunoassays (Fig. 1A)- in this case, tests used initially for serum cortisol and testosterone- can demonstrate falsely high results. Interference falsely lowers the immunometric "sandwich" immunoassay (Fig. 1B)-in this case, TSH. Biotin effect on our patient's endocrine testing led to decidedly abnormal findings, unnecessary medical referrals

2018 Journal of the Endocrine Society

4. Therapist-Assisted Progressive Resistance Training, Protein Supplements, and Testosterone Injections in Frail Older Men with Testosterone Deficiency: Protocol for a Randomized Placebo-Controlled Trial Full Text available with Trip Pro

Therapist-Assisted Progressive Resistance Training, Protein Supplements, and Testosterone Injections in Frail Older Men with Testosterone Deficiency: Protocol for a Randomized Placebo-Controlled Trial Fall accidents are a major cause of mortality among the elderly and the leading cause of traumatic brain injury. After a fall, many elderly people never completely recover and need help in coping with everyday life. Due to the increasing older population in the world, injuries, disabilities (...) -blind trial in which frail older men with testosterone deficiency are treated with testosterone supplemental therapy and therapist-assisted progressive resistance training for 20 weeks, with the possibility to continue treatment for 1 year. Four study arms of 48 participants each are provided based on factorial assignment to testosterone supplemental therapy and progressive resistance training. The 4 groups are as follows: controls given placebo injections without physical exercise for 20 weeks

2018 JMIR Research Protocols Controlled trial quality: predicted high

5. Cardiovascular and Metabolic Consequences of Testosterone Supplements in Young and Old Male Spontaneously Hypertensive Rats: Implications for Testosterone Supplements in Men Full Text available with Trip Pro

Cardiovascular and Metabolic Consequences of Testosterone Supplements in Young and Old Male Spontaneously Hypertensive Rats: Implications for Testosterone Supplements in Men The safety of testosterone supplements in men remains unclear. In the present study, we tested the hypothesis that in young and old male spontaneously hypertensive rats (SHR), long-term testosterone supplements increase blood pressure and that the mechanism is mediated in part by activation of the renin-angiotensin (...) system.In untreated males, serum testosterone exhibited a sustained decrease after 5 months of age, reaching a nadir by 18 to 22 months of age. The reductions in serum testosterone were accompanied by an increase in body weight until very old age (18 months). Testosterone supplements were given for 6 weeks to young (12 weeks-YMSHR) and old (21-22 months-OMSHR) male SHR that increased serum testosterone by 2-fold in young males and by 4-fold in old males. Testosterone supplements decreased body weight

2017 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

6. The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats. Full Text available with Trip Pro

The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats. The present study aimed to estimate the effect of endurance training, two doses of testosterone, and the combination of these stimuli on the level of the endothelial proteins claudin, occludin, JAM-1, VE-cadherin, ZO-1, ZO-2, and P-glycoprotein in rat spinal cords. Adult male Wistar rats were trained using a motor-driven treadmill for 6 weeks (40-60 min, 5 times per (...) week) and/or were treated for 6 weeks with two doses of testosterone (i.m.; 8 mg/kg or 80 mg/kg body weight). Spinal cords were collected 48 hours after the last training cycle and stored at -80°C. The levels of selected proteins in whole tissue lysates of the spinal cord were measured by western blot. Testosterone-treated trained rats had significantly lower claudin levels than vehicle-treated trained rats. High doses of testosterone resulted in a significant decrease in claudin-5 in untrained

2019 PLoS ONE

7. Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial. Full Text available with Trip Pro

Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial. Severe energy deficits during military operations, produced by significant increases in exercise and limited dietary intake, result in conditions that degrade lean body mass and lower-body muscle function, which may be mediated by concomitant reductions in circulating (...) ). Supplemental testosterone had no effect on lower-body muscle function or health-related biomarkers.Findings suggest that supplemental testosterone may increase lean body mass during short-term severe energy deficit in non-obese, young men, but it does not appear to attenuate lower-body functional decline.Collaborative Research to Optimize Warfighter Nutrition projects I and II, Joint Program Committee-5, funded by the US Department of Defence.Copyright © 2019. Published by Elsevier B.V.

2019 EBioMedicine Controlled trial quality: predicted high

8. Effects of Testosterone Supplementation on Separate Cognitive Domains in Cognitively Healthy Older Men: A Meta-analysis of Current Randomized Clinical Trials. (Abstract)

Effects of Testosterone Supplementation on Separate Cognitive Domains in Cognitively Healthy Older Men: A Meta-analysis of Current Randomized Clinical Trials. An increasing body of literature suggests a positive, neuroprotective effect for testosterone on cognition in older men. However, randomized clinical trials (RCTs) examining the effects of testosterone supplementation (TS) on cognitive function have been inconclusive.To investigate the potential for TS to prevent cognitive decline (...) versus treatment groups pre- and postsupplementation showed improvements in the treatment group in executive function (g (11) = 0.14, 95% confidence interval [CI]: 0.03-0.26, z = 0.56, p = 0.011). However, it was noted that two studies in our sample did not report a significant increase in mean serum total testosterone (TT) levels in the treatment group after supplementation. Following exclusion of these studies, analysis indicated improvement in the treatment group for the overall cognitive

2019 The American Journal of Geriatric Psychiatry

9. Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pARser81 and CDK1 signaling: biological implications for men treated with testosterone replacement Full Text available with Trip Pro

Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pARser81 and CDK1 signaling: biological implications for men treated with testosterone replacement Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains (...) controversial. The effects of continuous or pulsed T stimulation were tested in vitro and in vivo on androgen-sensitive Pca cell lines in order to assess the differential biological properties of these two treatment modalities. Pulsed T treatment resulted in a greater inhibition than continuous T supplementation of tumor growth in vitro and in vivo. The effects of pulsed T treatment on tumor growth inhibition, G0/G1 cell cycle arrest, and tumor senescence was more pronounced than those obtained upon

2017 Oncotarget

10. Acute Effects of 24-h Sleep Deprivation on Salivary Cortisol and Testosterone Concentrations and Testosterone to Cortisol Ratio Following Supplementation with Caffeine or Placebo Full Text available with Trip Pro

Acute Effects of 24-h Sleep Deprivation on Salivary Cortisol and Testosterone Concentrations and Testosterone to Cortisol Ratio Following Supplementation with Caffeine or Placebo Caffeine has become a popular ergogenic aid amongst athletes and usage to improve athletic performance has been well documented. The effect of caffeine on anabolic and catabolic hormones in a sleep-deprived s tate has had little investigation to date. The purpose of the current study was to investigate the potential (...) of caffeine to offset the effects, if any, of short-term sleep deprivation and exercise on an athlete's testosterone and cortisol concentrations via salivary technique. Eleven competitive male athletes volunteered to be part of this prospective double-blinded study. Three test days were scheduled for each athlete; one non-sleep deprived, one sleep-deprived with caffeine supplementation (6 mg.kg-1) and one sleep-deprived with placebo ingestion. Sleep deprivation was defined as 24-h without sleep. Each test

2017 International journal of exercise science Controlled trial quality: uncertain

11. Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial. (Abstract)

Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial. Cholecalciferol and/or calcium supplementation might increase skeletal muscle strength and serum testosterone in young adult males.We performed a randomized control trial assessing the effect of cholecalciferol/calcium on skeletal muscle strength and serum testosterone in vitamin D deficient young males.Two-by-two factorial RCT.Two-hundred and twenty (...) similar results. The mean serum testosterone decreased significantly at 6 months; however, delta change was similar in 4 groups. Change in handgrip strength and other outcomes was similar in 4 groups with and without adjustment for delta testosterone and FAI.Six months of cholecalciferol/calcium supplementation had no significant effect on skeletal muscle strength and serum testosterone in young adult males.© 2017 John Wiley & Sons Ltd.

2018 Clinical endocrinology Controlled trial quality: uncertain

12. Vitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trial. (Abstract)

Vitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trial. Observational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed to investigate whether vitamin D supplementation has beneficial effects on T indices (...) termination, there were no between-group differences in TT (P = 0.612), SHBG (P = 0.393), fT (P = 0.861), or BAT (P = 0.960).In male patients with advanced HF and low 25OHD concentrations, a daily vitamin D3 supplement of 4000 IU for 3 years did not prevent the decline in testosterone indices.

2018 European journal of nutrition Controlled trial quality: predicted high

13. Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial. Full Text available with Trip Pro

Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial. It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline.The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 (...)  at the endocrine outpatient clinic at the Medical University of Graz, Austria. One-hundred healthy men with serum TT levels < 10.4 nmol/l and 25-hydroxyvitamin D [25(OH)D] levels < 75 nmol/l participated in the trial. Subjects were randomized to receive 20,000 IU of vitamin D3/week (n = 50) or placebo (n = 50) for 12 weeks. Primary outcome was TT measured using mass spectrometry. Secondary outcomes were free testosterone, free androgen index, sex hormone-binding globulin, estradiol, follicle-stimulating

2018 European journal of nutrition Controlled trial quality: predicted high

14. Long-Term Testosterone Supplementation in Older Men Attenuates Age-Related Decline in Aerobic Capacity. Full Text available with Trip Pro

Long-Term Testosterone Supplementation in Older Men Attenuates Age-Related Decline in Aerobic Capacity. Testosterone increases skeletal muscle mass and strength, but long-term effects of testosterone supplementation on aerobic capacity, or peak oxygen uptake (V̇O2peak), in healthy older men with low testosterone have not been evaluated.To determine the effects of testosterone supplementation on V̇O2peak during incremental cycle ergometry.A double-blind, randomized, placebo-controlled, parallel (...) -group trial (Testosterone's Effects on Atherosclerosis Progression in Aging Men).Exercise physiology laboratory.Healthy men aged ≥ 60 years with total testosterone levels of 100 to 400 ng/dL (3.5 to 13.9 nmol/L) or free testosterone levels < 50 pg/mL (174 pmol/L).Randomization to 1% transdermal testosterone gel adjusted to achieve serum levels of 500 to 950 ng/dL or placebo applied daily for 3 years.Change in V̇O2peak.Mean (±SD) baseline V̇O2peak was 24.2 ± 5.2 and 23.6 ± 5.6 mL/kg/min

2018 Journal of Clinical Endocrinology and Metabolism Controlled trial quality: predicted high

15. Effects of testosterone supplement treatment in hypogonadal adult males with T2DM: a meta-analysis and systematic review. (Abstract)

Effects of testosterone supplement treatment in hypogonadal adult males with T2DM: a meta-analysis and systematic review. Testosterone supplement treatment (TST) is a classic therapy for hypogonadal men with type 2 diabetes mellitus (T2DM), but the effects of TST in different studies are inconsistent. We conducted this meta-analysis to evaluate the precise role of TST in hypogonadal men with T2DM.PubMed, Embase, Cochrane Library and Web of Science were searched to identify qualified randomized

2018 World journal of urology

16. Supplement Study: Strength, Testosterone, Sexual Function, Quality of Life

Supplement Study: Strength, Testosterone, Sexual Function, Quality of Life Supplement Study: Strength, Testosterone, Sexual Function, Quality of Life - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Supplement Study: Strength, Testosterone, Sexual Function, Quality of Life The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03457740 Recruitment Status : Completed First Posted : March 8, 2018 Last Update Posted : May 4, 2018 Sponsor: Appalachian State University Collaborator: Purity Products Information

2018 Clinical Trials

17. Testosterone Full Text available with Trip Pro

a systematic review of the risks of major cardiovascular events (MACE) from testosterone replacement therapy (TRT). The objectives are: 1 2016 4. Testosterone supplementation therapy for older men: potential benefits and risks Testosterone supplementation therapy for older men: potential benefits and risks Testosterone supplementation therapy for older men: potential benefits and risks Gruenewald D A, Matsumoto A M CRD summary This review assessed the effects of testosterone supplementation for men older (...) than 60 without severe illness. The authors concluded that supplementation may be helpful for men with low testosterone levels (...) with or without hypogonadism. The review found only a few studies and the stated inclusion criteria were not consistently followed; hence, the conclusions should be interpreted with caution. Authors' objectives To assess the effect of testosterone supplementation therapy in older men. Searching MEDLINE was searched from 1966 to October 2001; the search terms were

2018 Trip Latest and Greatest

18. Testosterone replacement in menopause

out the Free Androgen Index = Total Testosterone x 100 / SHBG. 7 Testosterone assays – interpretation of results Although it is not mandatory to perform testosterone level estimation prior to or for monitoring treatment, it can be useful. A low FAI < 1.0% in women with symptoms of low sexual desire and arousal, supports the use of testosterone supplementation. Repeat estimation at the 2-3 month follow up visit can be performed to demonstrate if there has been an increase in levels, though clinical (...) Testosterone replacement in menopause BRITISH MENOPAUSE SOCIETY T ool for clinicians Information for GPs and other health professionals 1 of 4 1 How much and where does it come from? Testosterone is an important female hormone. Healthy young women produce approximately 100 – 400 mcg per day. This represents three to four times the amount of estrogen produced by the ovaries. Approximately half of endogenous testosterone and precursors are derived from the ovaries e.g. androstenedione and half

2019 British Menopause Society

19. What Is Andropause? Is Testosterone Supplementation the Answer in Older Men?

What Is Andropause? Is Testosterone Supplementation the Answer in Older Men? What Is Andropause? Is Testosterone Supplementation the Answer in Older Men? – Clinical Correlations Search What Is Andropause? Is Testosterone Supplementation the Answer in Older Men? September 20, 2012 5 min read By Kylie Birnbaum Faculty Peer Reviewed Women have long bemoaned menopause and its physiological, psychological, and sexual effects. Fortunately, hormone replacement therapy has provided relief (...) for symptomatic women. Less attention is paid to men, who also experience declines in their sex hormones. Decreased testosterone may explain many symptoms experienced by elderly men, such as poor sexual function and libido, decreased bone mineral density, fatigue, and decreased muscle mass and strength. Should physicians treat elderly men with testosterone replacement therapy? Late-onset hypogonadism, or “andropause,” is the gradual decline in testosterone levels in aging men. It differs from menopause

2012 Clinical Correlations

20. Effects of testosterone supplementation therapy on lipid metabolism in hypogonadal men with T2DM: a meta-analysis of randomized controlled trials. Full Text available with Trip Pro

Effects of testosterone supplementation therapy on lipid metabolism in hypogonadal men with T2DM: a meta-analysis of randomized controlled trials. Testosterone supplementation may be effective for the treatment of hypogonadism in men with type 2 diabetes mellitus (T2DM), but the evidence from randomized controlled trials (RCTs) is inconclusive. We aimed to systematically summarize results from intervention studies and assess the effects of testosterone supplementation therapy (TST) on lipid

2017 Andrology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>