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Testicular Cancer

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1. Comparison of Tissue Stiffness Using Shear Wave Elastography in Men with Normal Testicular Tissue, Testicular Microlithiasis and Testicular Cancer (PubMed)

Comparison of Tissue Stiffness Using Shear Wave Elastography in Men with Normal Testicular Tissue, Testicular Microlithiasis and Testicular Cancer To compare elastography measurements in men with normal testicular tissue, testicular microlithiasis and testicular cancer.A total of 248 consecutive patients were included. All men provided written informed consent. Testicular stiffness was assessed using shear wave elastography (SWE). Three SWE velocity measurements were assessed in each testicle (...) . The patients were divided into three groups; men with normal testicular tissue (n=130), men with testicular microlithiasis (n=99) and men with testicular cancer (n=19).We found a higher mean velocity in the group of patients with testicular cancer (1.92 m/s (95% CI 1.82-2.03)) compared to both the group with normal tissue (0.76 m/s (95% CI: 0.75-0.78)) (p<0.001) and the group with testicular microlithiasis 0.79 m/s (95% CI: 0.77-0.81) (p<0.001).The presence of testicular microlithiasis increased stiffness

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2017 Ultrasound international open

4. Testicular cancer

Testicular cancer Testicular cancer - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Testicular cancer Last reviewed: February 2019 Last updated: January 2018 Summary Most commonly presents as a hard, painless nodule on one testis noticed by the patient or at a regular clinic examination. Elevated serum tumour markers can be used for disease diagnosis and aid in monitoring the treatment response. Ultrasound (...) extratesticular manifestation cryptorchidism gonadal dysgenesis family history of testicular cancer personal history of testicular cancer testicular atrophy white ethnicity HIV infection chemical carcinogens and low sperm count rural residence higher socioeconomic status inguinal hernia genetic abnormality of chromosome 12 Diagnostic investigations ultrasound (colour Doppler) of testis CT scan (abdomen and pelvis) serum beta-human chorionic gonadotrophin (beta-hCG) serum alpha-fetoprotein (AFP) serum lactate

2018 BMJ Best Practice

5. Testicular Cancer

Testicular Cancer Testicular Cancer | Uroweb › Testicular Cancer Testicular Cancer To access the pdfs & translations of individual guidelines, please as EAU member. Non-EAU members can view the web versions. To become an EAU member, click . M.P. Laguna (Chair), P. Albers, W. Albrecht, F. Algaba, C. Bokemeyer, J.L. Boormans, G. Cohn-Cedermark, K. Fizazi, H. Gremmels (Patient advocate), A. Horwich, D. Nichol, N. Nicolai, J. Oldenburg Guidelines Associates: J. Mayor de Castro, Ch. Fankhauser TABLE (...) OF CONTENTS REFERENCES 1. Albers, P., et al. Guidelines on Testicular Cancer: 2015 Update. Eur Urol, 2015. 68: 1054. 2. Guyatt, G.H., et al. What is “quality of evidence” and why is it important to clinicians? BMJ, 2008. 336: 995. 3. Guyatt, G.H., et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 2008. 336: 924. 4. Phillips B, et al. Oxford Centre for Evidence-based Medicine Levels of Evidence. Updated by Jeremy Howick March 2009. 1998. 5. Guyatt, G.H

2019 European Association of Urology

6. Diagnosis and Treatment of Early Stage Testicular Cancer

Diagnosis and Treatment of Early Stage Testicular Cancer Diagnosis and Treatment of Early Stage Testicular Cancer: AUA Guideline (2019) - American Urological Association advertisement Toggle navigation About Us About the AUA Membership AUA Governance Industry Relations Education AUAUniversity Education Products & Resources Normal Histology and Important Histo-anatomic Structures Urinary Bladder Prostate Kidney Renovascular Diseases Andrenal Gland Testis Paratesticular Tumors Penis (...) and Reimbursement Practice Managers' Network (PMN) Patient Safety and Quality of Care Accreditations and Reporting Patient Education Diagnosis and Treatment of Early Stage Testicular Cancer: AUA Guideline (2019) AUA Guideline Published 2019 [pdf] [pdf] Panel Members Andrew Stephenson, MD; Scott E. Eggener, MD; Eric B. Bass, MD, MPH; David M. Chelnick, BS; Siamak Daneshmand, MD; Darren Feldman, MD; Timothy Gilligan, MD; Jose A. Karam, MD; Bradley Leibovich, MD, FACS; Stanley L. Liauw, MD; Timothy A. Masterson

2019 American Urological Association

7. Testicular Cancer

Testicular Cancer Testicular Cancer | Uroweb › Testicular Cancer Testicular Cancer To access the pdfs & translations of individual guidelines, please as EAU member. Non-EAU members can view the web versions. To become an EAU member, click . M.P. Laguna (Chair), P. Albers, W. Albrecht, F. Algaba, C. Bokemeyer, J.L. Boormans, G. Cohn-Cedermark, K. Fizazi, H. Gremmels (Patient advocate), A. Horwich, D. Nichol, N. Nicolai, J. Oldenburg Guidelines Associates: J. Mayor de Castro, Ch. Fankhauser TABLE (...) OF CONTENTS REFERENCES 1. Albers, P., et al. Guidelines on Testicular Cancer: 2015 Update. Eur Urol, 2015. 68: 1054. 2. Guyatt, G.H., et al. What is “quality of evidence” and why is it important to clinicians? BMJ, 2008. 336: 995. 3. Guyatt, G.H., et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 2008. 336: 924. 4. Phillips B, et al. Oxford Centre for Evidence-based Medicine Levels of Evidence. Updated by Jeremy Howick March 2009. 1998. 5. Guyatt, G.H

2018 European Association of Urology

8. Sperm cryopreservation incidence in men with testicular cancer: towards a stabilization in testicular cancer incidence? Results from the CECOS network (PubMed)

Sperm cryopreservation incidence in men with testicular cancer: towards a stabilization in testicular cancer incidence? Results from the CECOS network Testicular cancer (TC) represents 1% of all new male cancer cases but remains the most frequent cancer in adolescents and young adults in industrialized countries. In this study, we assessed time trends in use of sperm cryopreservation by men with TC from 1990 to 2013 in France.We collected data from patients diagnosed with TC who underwent sperm

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2018 Basic and Clinical Andrology

9. Second cancers and causes of death in patients with testicular cancer in Sweden. (PubMed)

Second cancers and causes of death in patients with testicular cancer in Sweden. While treatment for testicular cancer (TC) has become standardized after the 1980s with an associated significant improvement in patient survival, this has been accompanied by an increased risk of second primary cancers (SPCs). Patients were identified from the Swedish Cancer Registry spanning the years from 1980 to 2015, including 8788 individuals with primary TC and their SPCs. Relative risks (RRs) for SPC were (...) calculated using the generalized Poisson regression model. SPCs were diagnosed in 9.4% of patients with TC and half of them were late onset cancers not common in the population in their 40s. Overall RR of SPCs (excluding second TC) was 1.30 (95%CI: 1.20-1.40), including high risks for seven solid cancers, non-Hodgkin lymphoma and leukemia. Second TC was the most common SPC and the RR of 17.19 (95%CI: 14.89-19.85) was the highest recorded. Cancers known to be fatal as first primary cancers were also fatal

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2019 PLoS ONE

10. ESMO Consensus Conference Guidelines on testicular germ cell cancer: diagnosis, treatment and follow-up

ESMO Consensus Conference Guidelines on testicular germ cell cancer: diagnosis, treatment and follow-up SPECIAL ARTICLE ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up F. Honecker 1,2 * , J. Aparicio 3 , D. Berney 4 , J. Beyer 5 , C. Bokemeyer 2 , R. Cathomas 6 , N. Clarke 7 , G. Cohn-Cedermark 8 , G. Daugaard 9 , K.-P. Dieckmann 10 , K. Fizazi 11 , S. Fossa ° 12 , J. R. Germa-Lluch 13 , P. Giannatempo 14 , J. A. Gietema 15 , S. Gillessen 16,17 , H (...) - meetingdiscussionsinwrittenform.Thismanuscriptpresentstheresultsoftheexpertpaneldiscussions,includingtheconsensus recommendationsandasummaryofevidencesupportingeachrecommendation.Allparticipantsapprovedthefinalmanuscript. Keywords: testicular germ cell cancer, consensus, diagnosis, treatment, quality of life, follow-up V C The Author(s) 2018. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com. Annals of Oncology 29: 1658–1686, 2018 doi:10.1093/annonc/mdy217

2018 European Society for Medical Oncology

11. Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia (PubMed)

Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia Onco-testicular sperm extraction is used to preserve fertility in patients with bilateral testicular tumors and azoospermia. We report the case of a testicular tumor in the solitary testis of a patient who had previously undergone successful contralateral orchiectomy and whose sperm was preserved by onco-testicular sperm extraction. A 35-year-old patient presented with swelling (...) of his right scrotum that had lasted for 1 month. His medical history included a contralateral orchiectomy during childhood. Ultrasonography revealed a mosaic echoic area in his scrotum, suggesting a testicular tumor. The lesion was palpated within the normal testicular tissue along its edge and semen analysis showed azoospermia. Radical inguinal orchiectomy and onco-testicular sperm extraction were performed simultaneously. Motile spermatozoa were extracted from normal seminiferous tubules under

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2018 Clinical and experimental reproductive medicine

12. Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report (PubMed)

Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report Although oncologic testicular sperm extraction (onco-TESE) has been increasingly practiced, the evidence of onco-TESE performed in patients with testicular cancer is insufficient. Furthermore, in bilateral testicular cancer, accounting for 0.5%-1% of testicular cancers, onco-TESE is more challenging and has been insufficiently reported.Here we report the case of a 25 (...) testicular cancer.

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2018 Basic and Clinical Andrology

13. Current controversies on the role of lymphadenectomy for testicular cancer for the journal: Urologic Oncology: Seminars and Original Investigations for the special seminars section on the role of lymphadenectomy for urologic cancers. (PubMed)

Current controversies on the role of lymphadenectomy for testicular cancer for the journal: Urologic Oncology: Seminars and Original Investigations for the special seminars section on the role of lymphadenectomy for urologic cancers. The role of surgery in the locoregional management of many solid tumors has long been established. For testicular cancer, the incorporation of lymphadenectomy has played an important part in generating long-term survival outcomes in excess of 90% for germ cell

2019 Urologic oncology

14. Family history of cancer and risk of paediatric and young adult's testicular cancer: A Norwegian cohort study. (PubMed)

Family history of cancer and risk of paediatric and young adult's testicular cancer: A Norwegian cohort study. The aim of this study was to examine the association of a family history of cancer with the risk of testicular cancer in young adults.This is a prospective cohort study including 1,974,287 males born 1951-2015, of whom 2686 were diagnosed with TC before the age of 30.A history of TC in male relatives was significantly associated with a diagnosis of TC among children and young adults (...) ). The risk of TC was also increased when fathers (11.1-fold), paternal (4.9-fold) and maternal uncles and aunts (4.6-fold) were diagnosed with malignant neuroepithelial-tumours.We found an increased risk of TC among children and young adults with a family history of TC, carcinoma, mesothelioma, sarcoma, malignant melanoma and malignant neuroepithelial tumours. Hereditary cancer syndromes might underlie some of the associations reported in this study.

2019 British Journal of Cancer

15. Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study. (PubMed)

Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study. Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk (...) was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.In this nationwide register study, all singletons born in Sweden 1994-2014 (n = 2,027,997) were included. Paternal TGCC diagnoses (n = 2,380), anti-neoplastic treatment, and offspring CMs were gathered from the Swedish Norwegian Testicular Cancer Group (SWENOTECA) and the Swedish Medical Birth Register. Children

2019 PLoS medicine

16. Treatment and Outcome of Patients with Stage IS Testicular Cancer: A Retrospective Study from the Spanish Germ Cell Cancer Group. (PubMed)

Treatment and Outcome of Patients with Stage IS Testicular Cancer: A Retrospective Study from the Spanish Germ Cell Cancer Group. Stage IS testicular cancer is defined by the persistence of elevated serum tumor markers, including α-fetoprotein and/or β-human chorionic gonadotropin, after orchiectomy without radiological evidence of metastatic disease. Current treatment recommendations include cisplatin based chemotherapy up front but the recommendations are based on limited single center (...) . At a median followup of 108 months 108 patients were alive and disease-free. Five and 10-year disease-free survival rates were 87% and 85%, respectively. The predominance of embryonal carcinoma in the primary tumor was the only factor associated with the probability of needing additional therapy.Stage IS testicular cancer is more commonly associated with elevated α-fetoprotein, an IGCCCG good prognosis and mixed nonseminomatous germ cell tumor. Treatment with cisplatin based chemotherapy leads to cure

2019 Journal of Urology

17. Testicular cancer in Geneva, Switzerland, 1970-2012: incidence trends, survival and risk of second cancer. (PubMed)

Testicular cancer in Geneva, Switzerland, 1970-2012: incidence trends, survival and risk of second cancer. This paper describes the testicular cancer trends for incidence, survival, socio-economic status (SES) disparities and second cancer occurrence in Geneva, Switzerland, a high-risk population.We included all testicular germ-cell tumors recorded in the population-based Geneva cancer registry during the period 1970-2012. Changes in incidence trends were assessed using Joinpoint regression (...) to calculate the annual percentage change (APC). Overall and cancer-specific survivals (OS, CSS) were estimated by Kaplan Meyer methods. To evaluate the risk of a second cancer we calculated the Standardized Incidence Ratios (SIR) using the Geneva population incidence rates.The average annual testicular cancer rate was 7.32/100 000 men, with a non-significant increasing trend during the study period. The highest rates were observed among men younger than 39 years. Despite a trend toward earlier diagnosis

2019 BMC Urology

18. Ultrasound Evaluation of Testicular Volume in Patients with Testicular Microlithiasis (PubMed)

Ultrasound Evaluation of Testicular Volume in Patients with Testicular Microlithiasis Ultrasonography is a useful tool to measure testicular volume. According to the European Society of Urogenital Radiology, the combination of testicular atrophy and testicular microlithiasis (TML) is a risk factor for testicular cancer. Testicular atrophy is defined as a volume of less than 12 ml. The aim of this study was to compare testicular volume in patients with TML to patients with normal testicular (...) tissue.From 2013 to 2015 we included a total of 91 adult patients with TML, and 91 adult patients with normal testicular tissue as a control group. All patients underwent scrotal B-mode ultrasound investigation including measurement of width, length and height in both testicles. Testicular volume was calculated using the formula π/6×length×height×width.The median age for patients with TML was 48 years (range: 19-94 years), and 48 years (range: 20-75 years) in patients with normal tissue. No statistically

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2018 Ultrasound international open

19. Non-risk-adapted Surveillance for Stage I Testicular Cancer: Critical Review and Summary

Non-risk-adapted Surveillance for Stage I Testicular Cancer: Critical Review and Summary Cancer-specific survival for men with clinical stage I testicular cancer (CSITC) is uniformly excellent. Non-risk-adapted active surveillance (NRAS) is a management strategy for CSITC to minimize overtreatment and avoid possible long-term side effects of adjuvant therapy.To review the evidence regarding oncologic outcomes for men with CSITC undergoing NRAS and discuss ongoing controversies in the management (...) with clinically localized (stage I) testicular cancer have an excellent prognosis, regardless of management. Non-risk-adapted active surveillance is an attractive management option where only patients destined to relapse will receive any treatment following orchiectomy. However, individual patient preferences should be discussed in selecting a management strategy.Copyright © 2018 European Association of Urology. Published by Elsevier B.V. All rights reserved.

2018 EvidenceUpdates

20. Testicular Tumour Size and Rete Testis Invasion as Prognostic Factors for the Risk of Relapse of Clinical Stage I Seminoma Testis Patients Under Surveillance: a Systematic Review by the Testicular Cancer Guidelines Panel. (PubMed)

Testicular Tumour Size and Rete Testis Invasion as Prognostic Factors for the Risk of Relapse of Clinical Stage I Seminoma Testis Patients Under Surveillance: a Systematic Review by the Testicular Cancer Guidelines Panel. Patients with clinical stage I (CS I) seminoma testis with large primary tumours and/or rete testis invasion (RTI) might have an increased risk of relapse. In recent years, these risk factors have frequently been employed to decide on adjuvant treatment.To systematically (...) . Furthermore, the evidence on the prognostic value of size and RTI has significant limitations, so prudency is warranted on their routine use in clinical practice.Primary testicular tumour size and rete testis invasion are considered to be important prognostic factors for the risk of relapse in patients with clinical stage I seminoma testis. We systematically reviewed all the literature on the prognostic value of these two postulated risk factors. The outcome is that the prognostic power of these factors

2017 European Urology

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