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1. Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite (PubMed)

Using curcumin to prevent structural impairments of testicles in rats induced by sodium metabisulfite Sodium metabisulfite (Na-MBS) is a disinfectant and preservative agent. Some organ including testicle would be in danger in the case of Na-MBS consumption. Curcumin (CUR) is the constituent of turmeric with protective properties. The effect of CUR on testicles in rats exposed to Na-MBS evaluated using stereological methods. Sprague-Dawley rats were divided into eight groups. The rats in groups (...) I to VIII received the following respectively: distilled water, CUR (100 mg/kg/day), low (0.7 mg/kg/day: acceptable daily intake), intermediate (7 mg/ kg/day), and high (70 mg/kg/day) doses of Na-MBS, and low, intermediate, and high doses of Na-MBS plus CUR. After 7 weeks, the testicles were analyzed. The volume of seminiferous tubule, tubular epithelium and tubule length reduced (25-40 %) on average in the rats that received intermediate and high doses of Na-MBS, while the connective tissue

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2017 EXCLI journal

2. Acute scrotum – Torsion of the third testicle! (PubMed)

Acute scrotum – Torsion of the third testicle! 30101075 2019 02 26 2214-4420 20 2018 Sep Urology case reports Urol Case Rep Acute scrotum - Torsion of the third testicle! 92-93 10.1016/j.eucr.2018.07.010 Kealey Joshua J Department of Urology, The Alfred Hospital, Melbourne, Australia. Yao Henry H I HHI Department of Urology, The Alfred Hospital, Melbourne, Australia. Grummet Jeremy J Department of Urology, The Alfred Hospital, Melbourne, Australia. eng Case Reports 2018 07 23 United States

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2018 Urology case reports

3. A Potential Link: Cross-fused Renal Ectopia With Concomitant Absent Left Testicle (PubMed)

A Potential Link: Cross-fused Renal Ectopia With Concomitant Absent Left Testicle Cross-fused renal ectopia (CFRE) is a rare congenital anomaly in which both kidneys are located on a unilateral side of the retroperitoneal space. The ureter of the ectopic kidney is seen to pass over the midline to insert in its normal anatomic position. Frequently this anomaly goes undetected until there is radiologic screening for other purposes or when other genitourinary issues are investigated. Although (...) frequently isolated, this condition has been reported to be associated with other congenital anomalies, genetic disorders, and various urogenital anomalies more than 50% of the time. However, we found no cases linking CFRE with a solitary testicle. This is a case of a 30-year-old man with left-to-right CFRE with concomitant absent left testicle and obstructing distal calculus.

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2018 Reviews in urology

4. Age at presentation of undescended testicles: a single-center study in Saudi Arabia (PubMed)

Age at presentation of undescended testicles: a single-center study in Saudi Arabia The undescended testis (UDT) is the most common genital anomaly encountered in pediatrics with an estimated incidence of 1% to 4% in full-term and 1% to 45% in preterm newborn boys. Over the years, studies on progressive histological deterioration and cancer risk has led to a change in recommendations for when orchidopexy should be done.Determine age at presentation of patients for UDT to a specialist in Saudi

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2018 Annals of Saudi Medicine

5. Patient Decision-Making and Predictors of Genital Satisfaction Associated with Testicular Prostheses after Radical Orchiectomy: a Questionnaire-Based Study of Men with Germ Cell Tumors of the Testicle. (PubMed)

Patient Decision-Making and Predictors of Genital Satisfaction Associated with Testicular Prostheses after Radical Orchiectomy: a Questionnaire-Based Study of Men with Germ Cell Tumors of the Testicle. To better understand patient decision-making and genital satisfaction associated with postorchiectomy testicular prosthesis (TP) implantation in patients with germ cell tumors of the testicle.An electronic survey to assess TP decision-making and genital satisfaction was distributed to patients

2018 Urology

6. Effect of Heat Stress on Sperm DNA: Protamine Assessment in Ram Spermatozoa and Testicle (PubMed)

Effect of Heat Stress on Sperm DNA: Protamine Assessment in Ram Spermatozoa and Testicle Sperm DNA fragmentation is considered one of the main causes of male infertility. The most accepted causes of sperm DNA damage are deleterious actions of reactive oxygen species (ROS), defects in protamination, and apoptosis. Ram sperm are highly prone to those damages due to the high susceptibility to ROS and to oxidative stress caused by heat stress. We aimed to evaluate the effects of heat stress

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2018 Oxidative medicine and cellular longevity

7. A Systematic Review of Testicle Survival Time After a Torsion Event. (PubMed)

A Systematic Review of Testicle Survival Time After a Torsion Event. The time window for possible salvage and survival of a torsed testicle is commonly thought to be 6 to 8 hours. However, survival of torsed testicles with or without subsequent atrophy is known to occur outside that critical time window. In this article, we performed a systematic review of the English literature to provide a more accurate understanding of reported time frames of testicle survival after a torsion event.The (...) primary research question was to determine the relationship between time to treatment and the rate of survival for testicles of male patients presenting with testicular torsion (TT).A systematic review of the literature was performed and structured according to PRISMA guidelines. An exhaustive library search was performed after search strategies were developed for multiple databases that included PubMed, Cochrane library, Ovid MEDLINE, Web of Science, and ProQuest Theses and Dissertations. Two

2017 Pediatric Emergency Care

8. Testicle-sparing surgery versus radical orchiectomy in the management of Leydig cell tumors: results from a multicenter study. (PubMed)

Testicle-sparing surgery versus radical orchiectomy in the management of Leydig cell tumors: results from a multicenter study. To compare the oncological outcomes of testicle-sparing surgery (TSS) and radical orchiectomy (RO) in patients with Leydig cell tumor (LCT) of the testis.A multicenter retrospective clinical study was conducted in 12 centers in France. All the patients with histologically proven LCT were included and analyzed according to treatment (organ-sparing surgery or radical (...) group, but three patients (8.6%) in the RO group died from other diseases without evidence of relapse. One patient (4.8%) in the TSS group versus five (14.3%) in the RO group were lost to follow-up.Long-term follow-up suggests that testicle-sparing surgery does not compromise relapse-free survival in the treatment of Leydig cell tumor of the testis.

2017 World journal of urology

9. Serous carcinoma of the testicle and paratesticular tissue: Case Report and Literature Review. (PubMed)

Serous carcinoma of the testicle and paratesticular tissue: Case Report and Literature Review. Ovarian-type epithelial lesions of the testicle and the paratesticular tissue are uncommon, especially invasive serous adenocarcinoma with only 18 cases reported in the literature. Although the majority of these tumors occur in adults with an age range from 16 to 87 years, only 1 patient was less than 10 years old. Herein, we report only the second case of invasive serous adenocarcinoma occurring (...) in the first decade of life, that of a 7-year-old boy. Additionally, clinical presentation, imaging, histopathology, immunohistochemistry, and clinical follow-up of invasive serous adenocarcinoma of the testicle are discussed, along with a review of the literature.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 Urology

10. Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review (PubMed)

Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. The tumor is composed of predominantly lobulated cellular nodules separated by hyalinized fibrous stroma and they expressed CD10, β-catenin (nuclear), and cyclin D1 (...) . Molecular analysis identified a point mutation (c.110C>G) in exon 3 of CTNNB1. The histopathological features, immunohistochemistry profiles, and molecular analysis of this tumor were consistent with MCST of the ovary. Therefore, a diagnosis of MCST of the right testicle was determined. To the best of our knowledge, this is the first case of MCST occurring in the testicles. The study may provide new insights to the tumor biology of MCST and a better understanding of this rare entity.

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2017 Cancer research and treatment : official journal of Korean Cancer Association

11. Advantage of early orchiopexy for undescended testis: Analysis of testicular growth percentage ratio in patients with unilateral undescended testicle (PubMed)

Advantage of early orchiopexy for undescended testis: Analysis of testicular growth percentage ratio in patients with unilateral undescended testicle This study reports the experience of our tertiary referral center and proposes a new indicator, the growth percentage ratio (GPR), for determining the optimal timing of surgical intervention. A retrospective review of boys who underwent orchiopexy for undescended testis from 2001 to 2013 was conducted. We analyzed testicular volumes in different (...) age groups using the UDT to normally descended testis ratio and testicular GPR. A total of 134 boys with unilateral undescended testicle underwent regular ultrasonography follow-up examinations for more than a mean of 3.9 years. Forty-five (33.4%) of them underwent orchiopexy before the age of one year. Orchiopexy at this age resulted in a GPR (2.02 ± 0.40) that was significantly higher than the GPRs in the second (1 < age ≤ 2 years, 1.25 ± 0.13, p = 0.004) and third (age > 2 years, 1.24 ± 0.14 p

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2017 Scientific reports

12. Juvenile Granulosa Cell Tumor of the Testicle – Report of a Neonatal Case with Positive Alpha-fetoprotein Immunohistochemical Staining (PubMed)

Juvenile Granulosa Cell Tumor of the Testicle – Report of a Neonatal Case with Positive Alpha-fetoprotein Immunohistochemical Staining We report on a case of juvenile granulosa cell tumor of the testicle in a neonate, a rare testicular tumor in children. No genital ambiguity, anatomic abnormalities, nor sex chromosome aneuploidy was noted in this patient. In our case, despite positive staining for alpha-fetoprotein which is most consistent with yolk sac tumors, all clinical, gross anatomic

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2017 Urology case reports

13. Surgical excision of perineal nodular induration: A cyclist’s third testicle (PubMed)

Surgical excision of perineal nodular induration: A cyclist’s third testicle Perineal nodular induration (PNI), or biker's nodule, is a rare, bothersome, pseudotumour. Herein, we describe the surgical technique used to treat a healthy cyclist who developed an enlarging PNI for five years that grew into a perineal mass. The mass prevented him from cycling due to worsening discomfort and heaviness. The PNI-associated mass was successfully removed by wide surgical excision and a local

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2017 Canadian Urological Association Journal

14. Cystic Dysplasia of the Testis in an Intraabdominal Undescended Testicle (PubMed)

Cystic Dysplasia of the Testis in an Intraabdominal Undescended Testicle Cystic dysplasia of the testis is a rare, benign pathologic finding. We present two recent cases of cystic dysplasia of the testis to our practice. The first case involves an 11 month old male presenting with a non-palpable, intra-abdominal left testis. The second case involves a 7 year old male with left scrotal swelling and a history of left renal agenesis. After review of the literature, the first case represents (...) the first report of cystic dysplasia of the testis in an undescended, intra-abdominal testicle.

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2017 Urology case reports

15. Shear Wave Sonoelastography Findings of Testicles in Chronic Kidney Disease Patients Who Undergo Hemodialysis (PubMed)

Shear Wave Sonoelastography Findings of Testicles in Chronic Kidney Disease Patients Who Undergo Hemodialysis Chronic kidney disease (CKD) is known to cause significant deterioration in the function of the testicles and sexual dysfunction in male patients who undergo hemodialysis. The aim of this study was to show the changes in the testicles that occur as a result of hypogonadism secondary to CKD and to analyze the elasticity of the parenchyma by shear wave sonoelastography.In our study we (...) included 28 male patients who undergo dialysis three times per week and 25 healthy volunteers. Firstly, B-mode ultrasonographic evaluation was performed in both testicles for structural analysis and to detect the presence of focal lesions. Afterward, the stiffness of the parenchyma was measured in kilopascals by shear wave sonoelastography.The CKD group had lower right, left, and mean testicular volumes (p<0.001). The CKD group also displayed greater right, left, and mean testicular parenchymal

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2017 The Eurasian journal of medicine

16. A Unique Case of Testicular Compromise in a Patient with Ovotesticular Disorder of Sexual Development and a Solitary Testicle (PubMed)

A Unique Case of Testicular Compromise in a Patient with Ovotesticular Disorder of Sexual Development and a Solitary Testicle Ovotesticular disorder of sexual development (OT-DSD), previously true hermaphroditism, is a condition in which one or both gonads contain testicular and ovarian tissue. A 23-year-old OT-DSD male patient presented with continuous pain in his right testicle which had been previously intermittent over the past five days. The patient had a prior history of left ovotestis (...) removal with prosthesis placement, a right undescended testicle with aberrant anatomy, and hypospadias repair, all of which were corrected shortly after birth. A lack of blood flow to the testicle on Doppler ultrasound warranted immediate surgical intervention. Intraoperatively, an aberrant tunica vaginalis space with a compressive hematoma secondary to epididymal abscess rupture was identified as the causation for testicular compromise. Return of vascular flow to the testicle was confirmed

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2017 Case reports in urology

17. Primary Malignancy in a Supernumerary Testicle Presenting as a Large Pelvic Mass (PubMed)

Primary Malignancy in a Supernumerary Testicle Presenting as a Large Pelvic Mass Supernumerary testis, also known as polyorchidism, is a condition characterized by the presence of more than two testes. Another condition of the testes is seminoma, a common cause of testicular germ cell tumor. A 35-year-old male was transferred to our hospital with a diagnosis of abdominal mass causing abdominal pain. On physical exam, he had a palpable undescended left testicle in the left inguinal canal, which (...) was determined to be seminoma. The mass was surgically removed, and the patient underwent chemotherapy. The report discusses his workup, treatment, and outcome. This case illustrates an unusual presentation of supernumerary testis with the extra testis harboring a seminoma. When presented with a case of testicular cancer with no tumor noted in the palpable testes, malignancy in an extranumerary testicle should be considered in the differential.

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2017 Case reports in urology

18. A bilobed testicle diagnosed with ultrasound in an 18-year-old boy (PubMed)

A bilobed testicle diagnosed with ultrasound in an 18-year-old boy Bilobed testicle is a very rare congenital malformation with an unknown etiology. Herein, we report an 18-year-old boy presented with a right-bilobed testicle mimicking a testicular tumor. The present case highlights the importance of considering bilobed testicle as a valuable differential diagnosis of testicular mass to prevent unnecessary surgery. Furthermore, the case could provide more information about presentation (...) and management of bilobed testicle.

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2016 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

19. New discovery of cryptorchidism: Decreased retinoic acid in testicle (PubMed)

New discovery of cryptorchidism: Decreased retinoic acid in testicle This study focuses on investigation of cryptorchidism induced by flutamide (Flu) and its histopathological damage, and detects retinoic acid concentration in testicle tissue, in order to find a new method for clinical treatment to infertility caused by cryptorchidism. Twenty SD (Sprague Dawley) pregnant rats were randomly divided into Flu cryptorchidism group (n = 10) and normal control group (n = 10). HE stained for observing (...) normal group in sperm quantity and quality. The observation by TEM showed a loose structure of tight junctions between Sertoli cells. Immunohistochemistry, western blot, and Q-PCR showed that cryptorchidism group was significantly lower than normal group in the expression of Stra8. HPLC showed that retinoic acid content was significantly lower in cryptorchid testis than in normal testis. In the cryptorchidism model, retinoic acid content in testicular tissue has a significant reduction; testicles

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2016 Saudi Pharmaceutical Journal : SPJ

20. Analysis of Transposon Control Pathways in Germinal Cancers of the Testicle

Analysis of Transposon Control Pathways in Germinal Cancers of the Testicle Analysis of Transposon Control Pathways in Germinal Cancers of the Testicle - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Analysis of Transposon Control Pathways in Germinal Cancers of the Testicle (SEMINOMES) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02873793 Recruitment Status : Unknown Verified July 2016 by Centre Hospitalier Universitaire Dijon. Recruitment status was: Recruiting First Posted : August 22, 2016

2016 Clinical Trials

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