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Test Sensitivity

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141. Sensitivity of HIV rapid tests compared to fourth generation enzyme immunoassays or HIV RNA tests - a systematic review and meta-analysis. (PubMed)

Sensitivity of HIV rapid tests compared to fourth generation enzyme immunoassays or HIV RNA tests - a systematic review and meta-analysis. Determine the sensitivity of HIV rapid tests compared with fourth-generation enzyme immunoassays (EIA) or nucleic acid amplification tests (NAAT) in clinical settings.Systematic review and meta-analysis.Medline, PubMed, Embase, Cochrane Controlled Trials Register, Cochrane reviews and Cumulative Index to Nursing and Allied Health Literature were searched (...) until 14 July 2015 for studies of adults comparing point-of-care HIV rapid tests to fourth-generation HIV EIA antibody/p24 antigen or HIV NAAT.From 953 titles, 18 studies were included, involving 110 122 HIV rapid test results. Compared with EIA, the estimated sensitivity (random effects) of HIV rapid tests was 94.5% [95% confidence interval (CI): 87.4-97.7]. Compared with NAAT, the sensitivity of HIV rapid tests was 93.7% (95% CI: 88.7-96.5). The sensitivity of HIV rapid tests in high-income

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2016 AIDS (London, England)

142. The benefit of D-Dimer testing to decide on stopping anticoagulation after a first unprovoked VTE: a matter of sex or of test sensitivity? (PubMed)

The benefit of D-Dimer testing to decide on stopping anticoagulation after a first unprovoked VTE: a matter of sex or of test sensitivity? 26317262 2015 10 27 2015 08 31 0301-1526 44 5 2015 Sep VASA. Zeitschrift fur Gefasskrankheiten VASA The benefit of D-Dimer testing to decide on stopping anticoagulation after a first unprovoked VTE: a matter of sex or of test sensitivity? 399 10.1024/0301-1526/a000461 Czihal Michael M 1 Munich, Germany. Reinecke Holger H eng Journal Article Multicenter Study (...) Randomized Controlled Trial Switzerland Vasa 0317051 0301-1526 0 Anticoagulants 0 Fibrin Fibrinogen Degradation Products 0 fibrin fragment D IM Adult Anticoagulants therapeutic use Blood Coagulation Blood Coagulation Tests methods Female Fibrin Fibrinogen Degradation Products metabolism Germany epidemiology Humans Incidence Male Risk Factors Sex Factors Venous Thromboembolism blood epidemiology prevention & control 2015 8 29 6 0 2015 9 1 6 0 2015 10 28 6 0 ppublish 26317262 10.1024/0301-1526/a000461

2015 VASA. Zeitschrift fur Gefasskrankheiten Controlled trial quality: uncertain

143. Non-invasive determination of the fetal rhesus factor to prevent maternal rhesus sensitization

assessment, systematic review Extract of final report D16-01 Version 1.0 Determination of fetal rhesus factor 20 March 2018 Institute for Quality and Efficiency in Health Care (IQWiG) - 1 - Key statement Research question The aim of the present investigation was the benefit assessment of non-invasive testing for the fetal rhesus factor in Rhesus D (RhD)-negative pregnant women in combination with indication for targeted anti-D prophylaxis to prevent maternal rhesus sensitization in the framework (...) sensitivity of 99.9% (95% confidence interval [CI] [99.5; 100]) and a very high specificity of 99.1% (95% CI [98.4; 99.5]). 10 of the 11 studies had a high risk of bias; the pooled estimation of the diagnostic accuracy from all studies was comparable with that of the study with low bias, however. Prenatal and postnatal testing for the rhesus factor can be considered equivalent. It was observed in the present subgroup analyses that the prenatal test before 8 or 11 weeks of gestation showed markedly lower

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

144. Quantitative Sensory Testing in Subjects With Sensitive Skin or Not

Quantitative Sensory Testing in Subjects With Sensitive Skin or Not Quantitative Sensory Testing in Subjects With Sensitive Skin or Not - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Quantitative Sensory (...) Testing in Subjects With Sensitive Skin or Not (SENSISKIN) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03081403 Recruitment Status : Completed First Posted : March 16, 2017 Last Update Posted : October 19, 2017 Sponsor: University Hospital, Brest Information provided by (Responsible Party

2017 Clinical Trials

145. Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma

Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma (HYVES) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03063424 Recruitment Status : Unknown Verified February 2017 by Brian Grondin-Beaudoin, Université de Sherbrooke. Recruitment status was: Recruiting First Posted : February 24

2017 Clinical Trials

146. Influence of family history on the willingness of outpatients to undergo genetic testing for salt-sensitive hypertension: a cross-sectional study. (PubMed)

Influence of family history on the willingness of outpatients to undergo genetic testing for salt-sensitive hypertension: a cross-sectional study. It is unclear whether family medical history influences the willingness to undergo genetic testing. This study aimed to determine how family history affected the willingness to undergo genetic testing for salt-sensitive hypertension in patients with and without hypertension.Cross-sectional study using a self-administered questionnaire.Six primary (...) care clinics and hospitals in Japan.Consecutive 1705 outpatients aged >20 years, 578 of whom had hypertension.The primary outcome variable was the willingness to undergo genetic testing to determine the risk of salt-sensitive hypertension, and the secondary variables were age, sex, education level, family history and concerns about hypertension. Factors associated with a willingness to undergo genetic testing were evaluated in patients with and without hypertension using a logistic regression

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2017 BMJ open

147. Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. (PubMed)

Utility, reliability, sensitivity and validity of an online test system designed to monitor changes in cognitive function in clinical trials. The advent of long-term remotely conducted clinical trials requires assessments which can be administered online. This paper considers the utility, reliability, sensitivity and validity of an internet-based system for measuring changes in cognitive function which is being used in one such trial.The Platform for Research Online to investigate Genetics (...) and Cognition in Ageing is a 10-year longitudinal and entirely remote study launched in November 2015. The CogTrackTM System is being used to monitor changes in important aspects of cognitive function using tests of attention, information processing and episodic memory. On study entry, the participants performed CogTrackTM up to three times over seven days, and these data are evaluated in this paper.During the first six months of the study, 14 531 individuals aged 50 to 94 years enrolled and performed

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2017 International Journal of Geriatric Psychiatry

148. Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells. (PubMed)

Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells. Resistance to standard chemotherapy poses a major clinical problem in the treatment of ovarian cancer patients. Adult-type granulosa cell tumor (AGCT) is a unique ovarian cancer subtype for which efficient treatment options are lacking in advanced disease. To this end, systematic drug response and transcriptomics profiling were (...) performed to uncover new therapy options for AGCTs.The responses of three primary and four recurrent AGCTs to 230 anticancer compounds were screened in vitro using a systematic drug sensitivity and resistance testing (DSRT) platform, coupled with mRNA sequencing. The responses of the AGCTs were compared with those of human granulosa luteal cells and bone marrow mononuclear cells.Patient-derived AGCT cells showed selective sensitivity to the Src family tyrosine kinase inhibitor dasatinib. A combination

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2017 Gynecologic Oncology

149. Sensitivity and specificity of the lymphocyte transformation test in drug reaction with eosinophilia and systemic symptoms causality assessment. (PubMed)

Sensitivity and specificity of the lymphocyte transformation test in drug reaction with eosinophilia and systemic symptoms causality assessment. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe delayed hypersensitivity reaction. The determination of drug causality is complex. The lymphocyte transformation test (LTT) has been reported positive in more than 50% of DRESS cases. Nevertheless, the sensitivity and specificity of LTT specifically in DRESS have not yet been (...) in acute or recovery samples. A stimulation index (SI) ≥2 in at least one concentration except for beta-lactams (SI ≥3) and contrast media (SI ≥4) was considered positive. Contingency tables and ROC curves were used for analysis.Sensitivity and specificity of LTT in the recovery phase of DRESS were 73% and 82%, respectively, whereas in the acute phase, they were only 40% and 30%, respectively. Comparison of skin tests and LTT confirmed a higher sensitivity and specificity of LTT in DRESS. LTT showed

2017 Clinical and Experimental Allergy

150. International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests. (PubMed)

International survey to identify diagnostic needs to support malaria elimination: guiding the development of combination highly sensitive rapid diagnostic tests. In malaria elimination settings, the very low levels of transmission now being attained present challenges that demand new strategies to identify and treat low-density infections in both symptomatic and asymptomatic populations. Accordingly, passive case detection activities need to be supplemented by active case detection (ACD (...) ) strategies with more sensitive diagnostic tools. Malaria rapid diagnostic tests (RDTs) have provided low- and middle-income countries with unprecedented access to malaria diagnostics. Nevertheless, conventional RDTs miss a potentially important proportion of sub-microscopic infections. Therefore, new combination highly sensitive (HS-)RDTs, able to detect low parasite densities and identify all infected individuals, could support countries implementing ACD strategies for radical cure to accelerate malaria

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2017 Malaria journal

151. Fluoroquinolone Resistance Mutation Detection Is Equivalent to Culture-Based Drug Sensitivity Testing for Predicting Multidrug-Resistant Tuberculosis Treatment Outcome: A Retrospective Cohort Study. (PubMed)

Fluoroquinolone Resistance Mutation Detection Is Equivalent to Culture-Based Drug Sensitivity Testing for Predicting Multidrug-Resistant Tuberculosis Treatment Outcome: A Retrospective Cohort Study. Molecular diagnostics that rapidly and accurately predict fluoroquinolone (FQ) resistance promise to improve treatment outcomes for individuals with multidrug-resistant (MDR) tuberculosis (TB). Mutations in the gyr genes, though, can cause variable levels of in vitro FQ resistance, and some in vitro (...) with "intermediate-level" gyr mutations of 1.3 (0.6-3.1), which did not reach statistical significance. The gyr mutations were not different than culture-based FQ drug susceptibility testing in predicting the hazard of death or treatment failure and may be superior.FQ molecular-based diagnostic tests may better predict treatment response than traditional drug susceptibility testing and open avenues for personalizing TB therapy.© The Author 2017. Published by Oxford University Press for the Infectious Diseases

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2017 Clinical Infectious Diseases

152. High-Sensitivity Cardiac Troponin I as a Gatekeeper for Coronary Computed Tomography Angiography and Stress Testing in Patients with Acute Chest Pain. (PubMed)

High-Sensitivity Cardiac Troponin I as a Gatekeeper for Coronary Computed Tomography Angiography and Stress Testing in Patients with Acute Chest Pain. Most patients presenting to the emergency department (ED) with suspected acute coronary syndrome (ACS) undergo noninvasive cardiac testing with a low diagnostic yield. We determined whether a combination of high-sensitivity cardiac troponin I (hs-cTnI) and cardiovascular risk factors might improve selection of patients for cardiac testing.We (...) included patients from the Rule Out Myocardial Infarction/Ischemia Using Computer Assisted Tomography (ROMICAT) I and II trials who presented to the ED with acute chest pain and were referred for cardiac testing. Based on serial hs-cTnI measurements and cardiovascular risk factors, we derived and validated the criterion for no need of cardiac testing. We predicted the effect of this criterion on the effectiveness of patient management.A combination of baseline hs-cTnI (<4 ng/L) and cardiovascular risk

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2017 Clinical Chemistry

153. Comparison of two low-sensitivity urine pregnancy tests for confirming the success of early medical abortion. (PubMed)

Comparison of two low-sensitivity urine pregnancy tests for confirming the success of early medical abortion. We introduced a single-window low-sensitivity urine pregnancy test (LSPT) to replace a double-window LSPT (both 1000 IU hCG) for self-assessment of the outcome of early medical abortion (EMA) (≤63 days gestation) 2 weeks later. We wished to compare assessment of outcomes of EMA with each LSPT.A retrospective review of the outcomes of EMA during 10 months' use of the double-window LSPT (...) results occurred in 6 (1.2%) and 19 (3.4%) double- and single-window LSPT tests, respectively (P=0.0244). Invalid results were reported in 18 (3.6%) and 6 (1.1%) of double- and single-window LSPT groups, respectively (P=0.01).The introduction of the single-window LSPT has not impacted on the detection of ongoing pregnancy or on contact with the service due to a positive or invalid LSPT. Services could consider use of either LSPT but should also place emphasis on informing women about the clinical

2017 Journal of Family Planning and Reproductive Health Care

154. A novel chemotherapeutic sensitivity-testing system based on collagen gel droplet embedded 3D-culture methods for hepatocellular carcinoma. (PubMed)

A novel chemotherapeutic sensitivity-testing system based on collagen gel droplet embedded 3D-culture methods for hepatocellular carcinoma. Patients suffering from advanced stage hepatocellular carcinoma (HCC) often exhibit a poor prognosis or dismal clinical outcomes due to ineffective chemotherapy or a multi-drug resistance (MDR) process. Thus, it is urgent to develop a new chemotherapeutic sensitivity testing system for HCC treatment. The presence study investigated the potential application (...) of a novel chemotherapeutic sensitivity-testing system based on a collagen gel droplet embedded 3D-culture system (CD-DST).Primary cells were separating from surgical resection specimens and then tested by CD-DST. To identify whether HCC cell lines or cells separating from clinical specimens contain MDR features, the cells were treated with an IC 50 (half maximal inhibitory concentration) or IC max (maximal inhibitory concentration) concentration of antitumor agents, e.g., 5-furuolouracil (5-FU

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2017 BMC Cancer

155. The Effect of Testing Reliability on Visual Field Sensitivity in Normal Eyes: The Singapore Chinese Eye Study. (PubMed)

The Effect of Testing Reliability on Visual Field Sensitivity in Normal Eyes: The Singapore Chinese Eye Study. To quantitatively determine how the reliability indices in standard automated perimetry (SAP) affect the global indices of visual field (VF) results in nonglaucomatous eyes.Observational, cross-sectional study.A total of 830 adults aged 40 to 80 years, without visual impairment, glaucoma, significant cataract, and major eye diseases, were selected from the population-based Singapore (...) Chinese Eye Study (SCES).Study participants underwent a comprehensive and standardized ocular examination and VF assessment using a Humphrey Field Analyzer II (Carl Zeiss Meditec, Inc., Dublin, CA). The effects of the test reliability, as indicated by the false-negative (FN), false-positive (FP), and fixation loss (FL) rates, on global indices, as indicated by the mean deviation (MD) and pattern standard deviation (PSD), were analyzed with multivariable regression models.The MD and PSD.A total of 1828

2017 Ophthalmology

156. Performance of a High-Sensitivity Rapid Diagnostic Test for <i>Plasmodium falciparum</i> Malaria in Asymptomatic Individuals from Uganda and Myanmar and Naive Human Challenge Infections. (PubMed)

Performance of a High-Sensitivity Rapid Diagnostic Test for Plasmodium falciparum Malaria in Asymptomatic Individuals from Uganda and Myanmar and Naive Human Challenge Infections. Sensitive field-deployable diagnostic tests can assist malaria programs in achieving elimination. The performance of a new Alere™ Malaria Ag P.f Ultra Sensitive rapid diagnostic test (uRDT) was compared with the currently available SD Bioline Malaria Ag P.f RDT in blood specimens from asymptomatic individuals (...) in Nagongera, Uganda, and in a Karen Village, Myanmar, representative of high- and low-transmission areas, respectively, as well as in pretreatment specimens from study participants from four Plasmodium falciparum-induced blood-stage malaria (IBSM) studies. A quantitative reverse transcription PCR (qRT-PCR) and a highly sensitive enzyme-linked immunosorbent assay (ELISA) test for histidine-rich protein II (HRP2) were used as reference assays. The uRDT showed a greater than 10-fold lower limit of detection

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2017 American Journal of Tropical Medicine & Hygiene

157. Multiple and repeated sampling increases the sensitivity of direct immunofluorescence testing for the diagnosis of mucous membrane pemphigoid. (PubMed)

Multiple and repeated sampling increases the sensitivity of direct immunofluorescence testing for the diagnosis of mucous membrane pemphigoid. Mucous membrane pemphigoid (MMP) is an autoimmune disease characterized by the predominant blistering of mucosal surfaces and the linear deposition of complement, IgG, or IgA along the basement membrane detected by direct immunofluorescence (DIF) test.To assess the impact of multiple and repeated DIF sampling on establishing the diagnosis of MMP.We (...) findings in 11 patients. Overall, 74 of 78 patients (95%) had ≥1 positive result by DIF test. In the remaining 4 cases, the diagnosis was confirmed by the detection of circulating autoantibodies against BP180.This is a retrospective, single-center study.Our data demonstrate that multiple and repeated biopsies increase the sensitivity of the DIF test for MMP diagnosis. Negative DIF test findings in cases clinically suggestive of MMP should prompt repeat biopsies.Copyright © 2017 American Academy

2017 Journal of American Academy of Dermatology

158. A comparative study on basophil activation test, histamine release assay and passive sensitization histamine release assay in the diagnosis of peanut allergy. (PubMed)

A comparative study on basophil activation test, histamine release assay and passive sensitization histamine release assay in the diagnosis of peanut allergy. Allergy can be diagnosed using basophil tests. Several methods measuring basophil activation are available. This study aimed at comparing basophil activation test (BAT), histamine release assay (HR), and passive sensitization histamine release assay (passive HR) in the diagnosis of peanut allergy.BAT, HR, and passive HR were performed (...) on 11 peanut-allergic and 14 nonallergic subjects. Blood was incubated with peanut extract or anti-IgE and tests were performed as follows: BAT-CD63 upregulation was assessed by flow cytometry; HR-released histamine was quantified by a glass fiber-based fluorometric method; passive HR-IgE-stripped donor basophils were incubated with participants' serum and histamine release was quantified as HR.CDsens, a measure of basophil allergen sensitivity, was significantly higher for BAT (80.1±17.4) compared

2017 Allergy

159. Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling. (PubMed)

Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling. T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. The median survival of T-PLL patients is <2 years and clinical trials are difficult to execute. Here we systematically explored the diversity of drug responses in T-PLL patient samples (...) using an ex vivo drug sensitivity and resistance testing platform and correlated the findings with somatic mutations and gene expression profiles. Intriguingly, all T-PLL samples were sensitive to the cyclin-dependent kinase inhibitor SNS-032, which overcame stromal-cell-mediated protection and elicited robust p53-activation and apoptosis. Across all patients, the most effective classes of compounds were histone deacetylase, phosphoinositide-3 kinase/AKT/mammalian target of rapamycin, heat-shock

2017 Leukemia

160. Sensitivity and Specificity of Clinical and Laboratory Otolith Function Tests. (PubMed)

Sensitivity and Specificity of Clinical and Laboratory Otolith Function Tests. To evaluate clinic based and laboratory tests of otolith function for their sensitivity and specificity in demarcating unilateral compensated complete vestibular deficit from normal.Prospective cross-sectional study.Tertiary care hospital vestibular physiology laboratory.Control group-30 healthy adults, 20-45 years age; Case group-15 subjects post vestibular shwannoma excision or post-labyrinthectomy with compensated (...) unilateral complete audio-vestibular loss.Otolith function evaluation by precise clinical testing (head tilt test-HTT; subjective visual vertical-SVV) and laboratory testing (headroll-eye counterroll-HR-ECR; vesibular evoked myogenic potentials-cVEMP).Sensitivity and specificity of clinical and laboratory tests in differentiating case and control subjects.Measurable test results were universally obtained with clinical otolith tests (SVV; HTT) but not with laboratory tests. The HR-ECR test did

2017 Otology and Neurotology

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