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Test Sensitivity

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121. Individual biological sensitivity to environmental influences: testing the differential susceptibility properties of the 5HTTLPR polymorphism in relation to depressive symptoms and delinquency in two adolescent general samples Full Text available with Trip Pro

Individual biological sensitivity to environmental influences: testing the differential susceptibility properties of the 5HTTLPR polymorphism in relation to depressive symptoms and delinquency in two adolescent general samples The gene-environment interaction research field in psychiatry has traditionally been dominated by the diathesis-stress framework, where certain genotypes are assumed to confer increased risk for adverse outcomes in a stressful environment. In later years, theories (...) of differential susceptibility, or biological sensitivity, suggest that candidate genes that interact with environmental events do not exclusively confer a risk for behavioural or psychiatric disorders but rather seem to alter the sensitivity to both positive and negative environmental influences. The present study investigates the susceptibility properties of the serotonin transporter-linked polymorphic region (5HTTLPR) in relation to depressive symptoms and delinquency in two separate adolescent community

2018 Journal of neural transmission

122. A Highly Sensitive Immunochromatographic Strip Test for Rapid and Quantitative Detection of Saikosaponin d Full Text available with Trip Pro

A Highly Sensitive Immunochromatographic Strip Test for Rapid and Quantitative Detection of Saikosaponin d A quantitative lateral-flow immunoassay using gold nanoparticles (AuNPs) conjugated with a monoclonal antibody (MAb) against saikosaponin d (SSd) was developed for the analysis of SSd. The AuNPs were prepared in our laboratory. The AuNPs were polyhedral, with an average diameter of approximately 18 nm. We used the conjugation between AuNPs and MAbs against SSd to prepare (...) immunochromatographic strips (ICSs). For the quantitative experiment, the strips with the test results were scanned using a membrane strip reader, and a detection curve (regression equation, y = -0.113ln(x) + 1.5451, R² = 0.983), representing the averages of the scanned data, was obtained. This curve was linear from 96 ng/mL to 150 μg/mL, and the IC50 value was 10.39 μg/mL. In this study, we bring the concept ofPOCT (point-of-care testing) to the measurement of TCM compounds, and this is the first report

2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

123. Sensitivity and specificity of point-of-care circulating Cathodic antigen test before and after praziquantel treatment in diagnosing Schistosoma mansoni infection in adult population co-infected with human immunodeficiency virus-1, North-Western Tanzania Full Text available with Trip Pro

Sensitivity and specificity of point-of-care circulating Cathodic antigen test before and after praziquantel treatment in diagnosing Schistosoma mansoni infection in adult population co-infected with human immunodeficiency virus-1, North-Western Tanzania The effect of Human Immunodeficiency Virus-1 (HIV-1) on CD4+ Th2 cells is hypothesized to affect parasitological diagnosis of Schistosoma mansoni using Kato Katz technique. Thus, the use of more sensitive technique such as Point-of-Care (...) Circulating Cathodic Antigen (POC-CCA) test is recommended. However, the sensitivity of this diagnostic test in diagnosing S.mansoni infection and the usefulness of it in monitoring efficacy of praziquantel drug in presence of HIV-1 co-infection remains inconclusive. The Primary objective of the present study was to assess accuracy of the POC-CCA test in diagnosing S.mansoni infection before and after praziquantel treatment in adult population co-infected with HIV -1.A prospective longitudinal study

2018 Archives of Public Health

124. The internal and external consistency of a speech reception threshold test for isiZulu speakers with normal hearing sensitivity Full Text available with Trip Pro

The internal and external consistency of a speech reception threshold test for isiZulu speakers with normal hearing sensitivity  This study investigated reliability, particularly the internal and external consistency, of a new isiZulu speech reception threshold (SRT) test. Methods: To examine internal consistency, 21 adult isiZulu speakers with normal hearing sensitivity completed the SRT test using the first and second halves of the SRT wordlist in the same test session. To examine external (...) consistency, a separate 23 adult isiZulu speakers with normal hearing sensitivity completed the SRT test, using the whole word list on two occasions 4 weeks apart. Consistency of SRT test scores in these test conditions was measured using intraclass correlation coefficient analyses (a measure of the consistency or reproducibility of different observations of the same quantity) and Bland and Altman analyses of agreement (a comparison of measurement error with the expected variation amongst subjects

2018 The South African Journal of Communication Disorders

125. Physician-diagnosed eczema is an independent risk factor for incident mouse skin test sensitization in adults. Full Text available with Trip Pro

Physician-diagnosed eczema is an independent risk factor for incident mouse skin test sensitization in adults. The disrupted skin barrier in eczema has been associated with an increased risk of immunoglobulin E (IgE) sensitization in childhood. However, it is unclear whether eczema, independent of atopy, is a risk factor for the development of allergic sensitization in adulthood.To determine if skin barrier dysfunction, independent of atopy, is a risk factor for incident sensitization in adult (...) the association between baseline physician-diagnosed eczema and incident mouse skin test sensitization and adjusted for potential confounders.The participants (N = 394) were followed up for a median of 24 months. Fifty-four percent were women, 89% were white, and 64% handled mice. At baseline, 7% of the participants reported physician-diagnosed eczema and 9% reported current asthma; 61% had at least one positive skin test result. At 30 months, 36% of those with eczema versus 14% of those without eczema had

2018 Allergy and Asthma Proceedings

126. Sensitive skin can be small fiber neuropathy: Results from a case-control quantitative sensory testing study. (Abstract)

Sensitive skin can be small fiber neuropathy: Results from a case-control quantitative sensory testing study. Sensitive skin syndrome (SSS) is defined as the occurrence of unpleasant sensations (itch, pain, burning, prickling) in response to stimuli that should not normally cause such sensations. Previous studies show that SSS could be a small fibre neuropathy, but quantitative sensory testing (QST) is lacking.Using QST, to determine the presence or absence of tactile sensitivity disorder

2018 British Journal of Dermatology

127. Poor Sensitivity of Commercial Rapid Diagnostic Tests for Hepatitis B e Antigen in Senegal, West Africa. Full Text available with Trip Pro

Poor Sensitivity of Commercial Rapid Diagnostic Tests for Hepatitis B e Antigen in Senegal, West Africa. Limited access to nucleic acid tests for hepatitis B virus (HBV) DNA is a significant barrier to the effective management of chronic HBV infection in resource-poor countries. Alternatively, HBV e antigen (HBeAg) may accurately indicate high viral replication. We assessed the diagnostic performance of three commercially available rapid diagnostic tests (RDTs) for HBeAg (SD Bioline, Insight (...) and OneStep) against a quantitative chemiluminescent immunoassay (CLIA, Architect). Using stored sera from adults with chronic HBV infection, we tested RDTs in three groups in Senegal (48 HBeAg-positive, 196 HBeAg-negative, and 117 cases with high HBV DNA (≥ 106 IU/mL)) and one group in France (17 HBeAg-positive East Asians). In Senegal, the sensitivity and specificity for HBeAg detection were 29.8% and 100% for SD Bioline, 31.1% and 100% for Insight, and 42.5% and 98.4% for OneStep, respectively

2018 American Journal of Tropical Medicine & Hygiene

128. Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer

Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information (...) . Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Direct Tumor Microinjection and FDG-PET in Testing Drug Sensitivity in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Stage IV Breast Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does

2018 Clinical Trials

129. Sensitive Troponin I and Stress Testing in the Emergency Department for the Early Management of Chest Pain Using 2-Hour Protocol. (Abstract)

Sensitive Troponin I and Stress Testing in the Emergency Department for the Early Management of Chest Pain Using 2-Hour Protocol. Despite improvements in identifying high-risk patients with non-ST segment ACS (acute coronary syndrome), low risk patients presenting with atypical chest pain and non-diagnostic Electrocardiogram (ECG) continued to undergo unnecessary admissions and testing. Since 1992, our chest pain protocol included using 4-hour serial biomarkers from ED admission in combination (...) with stress testing to evaluate these patients. Our study aimed at determining whether a new accelerated diagnostic protocol using sensitive cardiac troponin I (cTnI) 2 hours after admission to the ED followed by stress testing is safe and effective in emergency settings, allowing for appropriate triage, earlier discharge and reducing costs.We conducted a single center randomized trial at Presence St. Francis Hospital Chest pain center in Evanston, Illinois enrolling sixty-four consecutive patients

2018 Critical Pathways in Cardiology Controlled trial quality: uncertain

130. Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics. (Abstract)

Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics. 30578551 2019 02 19 1600-0536 2018 Dec 21 Contact dermatitis Contact Derm. Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics. 10.1111/cod.13202 Bennike Niels H NH https://orcid.org/0000-0001-8718-6140 National Allergy Research Centre, Department of Dermatology and Allergy, Copenhagen (...) patients contact allergy cyclamen aldehyde (CAS no. 103-95-7) fragrance allergy hexyl salicylate (CAS no. 6259-76-3) optimal concentration patch testing 2018 11 11 2018 12 17 2018 12 18 2018 12 24 6 0 2018 12 24 6 0 2018 12 23 6 0 aheadofprint 30578551 10.1111/cod.13202

2018 Contact Dermatitis

131. Ratiometric fluorescent test paper based on silicon nanocrystals and carbon dots for sensitive determination of mercuric ions Full Text available with Trip Pro

Ratiometric fluorescent test paper based on silicon nanocrystals and carbon dots for sensitive determination of mercuric ions Classical dye absorption-based pH test papers are widely used to measure the degree of acidity of media for quantification or semi-quantification by the observation of the naked eye on the variation of colour. However, it remains a challenging task to extend portable and cheap methods to a wide range of analytes for accurate quantification. Here, we report a dosage (...) -sensitive test paper for the assay of mercury ions (Hg2+) with wide colour evolution. The ratiometric fluorescent probe was prepared by mixing blue-emission silicon nanocrystals (Si NCs) and red-emission carbon dots (r-CDs). The Si NCs serve as the reaction site and the r-CDs as the internal reference. Upon the addition of Hg2+, the blue fluorescence of the Si NCs was quenched, while the red fluorescence of the r-CDs remained constant, resulting in the consecutive fluorescence colour changes from blue

2018 Royal Society Open Science

132. Is self-assessment of medical abortion using a low-sensitivity pregnancy test combined with a checklist and phone text messages feasible in South African primary healthcare settings? A randomized trial. Full Text available with Trip Pro

Is self-assessment of medical abortion using a low-sensitivity pregnancy test combined with a checklist and phone text messages feasible in South African primary healthcare settings? A randomized trial. To evaluate feasibility of self-assessment of medical abortion outcome using a low-sensitivity urine pregnancy test, checklist and text messages. The study assessed whether accurate self-assessment required a demonstration of the low-sensitivity urine pregnancy test or if verbal instructions (...) suffice.This non-inferiority trial enrolled 525 adult women from six public sector abortion clinics. Eligible women were undergoing medical abortion at gestations within 63 days. Consenting women completed a baseline interview, received standard care with mifepristone and home-administration of misoprostol. All were given a low-sensitivity urine pregnancy test and checklist for use 14 days later, sent text reminders, and asked to attend in-clinic follow-up after two weeks. Women were randomly assigned 1:1

2017 PLoS ONE Controlled trial quality: predicted high

133. A highly specific and sensitive massive parallel sequencer-based test for somatic mutations in non-small cell lung cancer. Full Text available with Trip Pro

A highly specific and sensitive massive parallel sequencer-based test for somatic mutations in non-small cell lung cancer. Molecular targeting therapy for non-small cell lung cancer (NSCLC) has clarified the importance of mutation testing when selecting treatment regimens. As a result, multiple-gene mutation tests are urgently needed. We developed a next-generation sequencer (NGS)-based, multi-gene test named the MINtS for investigating driver mutations in both cytological specimens and snap (...) -frozen tissue samples. The MINtS was used to investigate the EGFR, KRAS, BRAF genes from DNA, and the ERBB2, and the ALK, ROS1, and RET fusion genes from RNA. We focused on high specificity and sensitivity (≥0.99) and even included samples with a cancer cell content of 1%. The MINtS enables testing of more than 100 samples in a single run, making it possible to process a large number of samples submitted to a central laboratory, and reducing the cost for a single sample. We investigated 96

2017 PLoS ONE

134. Randomised controlled trial: The difference in sensitivity between HPV testing and cytology for detecting current and future CIN2+ increases over time

Randomised controlled trial: The difference in sensitivity between HPV testing and cytology for detecting current and future CIN2+ increases over time The difference in sensitivity between HPV testing and cytology for detecting current and future CIN2+ increases over time | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies (...) , please see our . Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here The difference in sensitivity between HPV testing and cytology for detecting current and future CIN2+ increases over

2014 Evidence-Based Medicine

135. Diagnostic accuracy of sensitive and high-sensitivity cardiac troponin assays used in serial testing to triage patients suspected of acute myocardial infarction: a systematic review protocol

Diagnostic accuracy of sensitive and high-sensitivity cardiac troponin assays used in serial testing to triage patients suspected of acute myocardial infarction: a systematic review protocol Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites (...) points). We will test the robustness of linear regression of time-to-treatment by performing stratified analysis (treatment pre-ischemia vs during vs post-ischemia). We will assess the effect of our decision to pool all reported scales for histological damage by re-running the analyses using only data from studies using the Jablonski scale. ">Sensitivity Example: For meta-analyses using the mean difference or risk ration as effect measure and containing at least 20 studies, we will produce funnel

2018 PROSPERO

136. Canadian Urological Association-Canadian Urologic Oncology Group guideline on metastatic castration-naive and castration-sensitive prostate cancer

)/CT, fluciclovine PET/CT, and prostate-specific membrane antigen (PSMA)- targeted PET/CT, appear to improve the sensitivity and specificity of conventional imaging; however, these tests are not universally available Canada, their clinical utility is not clear, and they are still considered investigational by Health Canada. Most importantly, all of the phase 3 trials in mCNPC/mCSPC used conventional imaging for staging and risk determination, and conclusion were based on these. Novel imaging (...) -6736(18)32486-3 16. Burdett S, Boeve LM, Ingleby FC, et al. Prostate radiotherapy for metastatic hormone-sensitive pros- tate cancer: A STOPCAP systematic review and meta-analysis. Eur Urol 2019;76:115-24. https://doi. org/10.1016/j.eururo.2019.02.003 17. Sooriakumaran P. Testing radical prostatectomy in men with prostate cancer and oligometastases to the bone: A randomized, controlled feasibility trial. BJU Int 2017;120:E8-E20. https://doi.org/10.1111/ bju.13925 18. Rexer H. [Metastatic, hormone

2020 Canadian Urological Association

137. Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer

, platinum-sensitive ovarian, fallopian tube and peritoneal cancer (TA528) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 17 of 22with further evidence, it may be possible to gain a more complete understanding of who would benefit most from treatment using somatic and other testing use in the NHS would allow collection of data on the duration of treatment in clinical practice. Nir Niraparib meets the criteria (...) Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer Nir Niraparib for maintenance treatment of aparib for maintenance treatment of relapsed, platinum-sensitiv relapsed, platinum-sensitive o e ovarian, varian, fallopian tube and peritoneal cancer fallopian tube and peritoneal cancer T echnology appraisal guidance Published: 4 July 2018 nice.org.uk/guidance/ta528 © NICE 2018. All rights reserved. Subject to Notice of rights (https

2018 National Institute for Health and Clinical Excellence - Technology Appraisals

138. Canadian Urological Association-Canadian Urologic Oncology Group guideline on metastatic castration-naive and castration-sensitive prostate cancer (Epub draft)

and visceral metastases. In patients with high risk disease, CT imaging of the chest may also be considered as lung metastases are the most common site of visceral metastases(7). Novel diagnostic imaging to stage PC including choline-based PET/CT, fluciclovine PET/CT and PSMA-targeted PET/CT, appear to improve the sensitivity and specificity of conventional imaging; however, these tests are not universally available Canada, their clinical utility is not clear and they are still considered investigational (...) Radiotherapy for Metastatic Hormone-sensitive Prostate Cancer: A STOPCAP Systematic Review and Meta-analysis. European urology. 2019;76(1):115-24. 17. Sooriakumaran P. Testing radical prostatectomy in men with prostate cancer and oligometastases to the bone: a randomized controlled feasibility trial. BJU Int. 2017;120(5B):E8-E20. 18. Rexer H. [Metastatic, hormone-naive prostate cancer interventional study : Multicenter, prospective, randomized study to evaluate the effect of standard drug therapy

2020 Canadian Urological Association

139. Non-invasive determination of the fetal rhesus factor to prevent maternal rhesus sensitization

assessment, systematic review Extract of final report D16-01 Version 1.0 Determination of fetal rhesus factor 20 March 2018 Institute for Quality and Efficiency in Health Care (IQWiG) - 1 - Key statement Research question The aim of the present investigation was the benefit assessment of non-invasive testing for the fetal rhesus factor in Rhesus D (RhD)-negative pregnant women in combination with indication for targeted anti-D prophylaxis to prevent maternal rhesus sensitization in the framework (...) sensitivity of 99.9% (95% confidence interval [CI] [99.5; 100]) and a very high specificity of 99.1% (95% CI [98.4; 99.5]). 10 of the 11 studies had a high risk of bias; the pooled estimation of the diagnostic accuracy from all studies was comparable with that of the study with low bias, however. Prenatal and postnatal testing for the rhesus factor can be considered equivalent. It was observed in the present subgroup analyses that the prenatal test before 8 or 11 weeks of gestation showed markedly lower

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

140. Rucaparib (Rubraca) - maintenance treatment of adult patients with platinum-sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer

Rucaparib (Rubraca) - maintenance treatment of adult patients with platinum-sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer 1 Published 9 March 2020 1 SMC2224 rucaparib 200mg, 250mg, 300mg film-coated tablets (Rubraca®) Clovis Oncology UK Ltd 7 February 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland (...) . The advice is summarised as follows: ADVICE: following a full submission assessed under the end of life and orphan medicine process rucaparib (Rubraca ® ) is accepted for restricted use within NHSScotland. Indication under review: As monotherapy for the maintenance treatment of adult patients with platinum-sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy. SMC restriction: to patients who

2020 Scottish Medicines Consortium

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