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Test Sensitivity

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41. Are drug intradermal tests dangerous to explore cross-reactivity and co-sensitization in DRESS? (Abstract)

Are drug intradermal tests dangerous to explore cross-reactivity and co-sensitization in DRESS? Drug Reaction with Eosinophilia and Systemic Symptoms syndrome (DRESS) is a severe Cutaneous Adverse drug Reaction, for which allergological explorations are poorly codified. Patch tests are usually well tolerated, and their sensitivity depends on the tested drug. Due to a potential risk of relapse during the tests, intradermal tests (IDTs) are contra-indicated in severe cutaneous drug adverse (...) reactions 1 . Consequently, results of IDTs in DRESS allergological work-up have been rarely reported. The objective of this retrospective monocentric study was to assess the value and tolerance of drug IDTs in patients who had a DRESS and negative patch tests with the same drugs. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

42. Recommendations for Institutions Transitioning to High-Sensitivity Troponin Testing: JACC Scientific Expert Panel. Full Text available with Trip Pro

Recommendations for Institutions Transitioning to High-Sensitivity Troponin Testing: JACC Scientific Expert Panel. High-sensitivity cardiac troponin (hs-cTn) I or T methods have been in use in certain regions for years but are now increasingly globally adopted, including in the United States. Accordingly, inevitable challenges are created for institutions transitioning from conventional cardiac troponin (cTn) assays. hs-cTn assays have higher analytic precision at lower concentrations, yielding (...) greater clinical sensitivity for myocardial injury and allowing accurate recognition of small changes in troponin concentration (rise or fall) within a short time frame. Although much of the knowledge regarding troponin biology that was applicable with older troponin assays still holds true, considerable education regarding the differences between conventional cTn and hs-cTn is needed before medical systems convert to the newer methods. This includes a basic understanding of how hs-cTn testing differs

2019 Journal of the American College of Cardiology

43. Contact sensitization to hair colors in acquired dermal macular hyperpigmentation: Results from a patch and photo patch-test study of 108 patients. (Abstract)

Contact sensitization to hair colors in acquired dermal macular hyperpigmentation: Results from a patch and photo patch-test study of 108 patients. Acquired dermal macular hyperpigmentation (ADMH) is an umbrella term including lichen planus pigmentosus, erythema dyschromicum perstans and pigmented contact/cosmetic dermatitis.To establish contact sensitization to hair colours as an aetiological factor for ADMH.Detailed clinical examination, skin biopsies, and patch and photo-patch testing (...) margins involvement (outer surface, helix and lobule of ear; temples and preauricular area), ill-defined lesions, epidermal atrophy and epidermal melanization extending >3 layers were significantly common in patch-test-positive patients. Well-defined lesions, perioral involvement and associated lichen planus were clinical pointers towards patch-test negativity.Index study exemplifies that patch-test results have distinct clinical and histopathological correlates in ADMH. Hair dye contact sensitization

2019 Journal of the European Academy of Dermatology and Venereology

44. How to Optimize Activated Partial Thromboplastin Time (APTT) Testing: Solutions to Establishing and Verifying Normal Reference Intervals and Assessing APTT Reagents for Sensitivity to Heparin, Lupus Anticoagulant, and Clotting Factors. (Abstract)

How to Optimize Activated Partial Thromboplastin Time (APTT) Testing: Solutions to Establishing and Verifying Normal Reference Intervals and Assessing APTT Reagents for Sensitivity to Heparin, Lupus Anticoagulant, and Clotting Factors. The activated partial thromboplastin time (APTT) assay is a very common coagulation test, used for several reasons. The test is conventionally used for assessing the contact factor (intrinsic) pathway of blood coagulation, and thus for screening deficiencies (...) of these separate uses is important to a given laboratory or clinician depends on the laboratory and the clinical context. For example, UFH sensitivity is important in hospital-based laboratories, where UFH therapy is used, but not in hospital-based laboratories where low-molecular-weight heparin (LMWH) is largely employed or where UFH may be assessed by anti-factor Xa testing, or in private/community laboratories not associated with a hospital system. High sensitivity to (low levels of) factors VIII, IX

2019 Seminars In Thrombosis And Hemostasis

45. Is a positive Christie-Atkinson-Munch-Peterson (CAMP) test sensitive enough for the identification of Streptococcus agalactiae? Full Text available with Trip Pro

Is a positive Christie-Atkinson-Munch-Peterson (CAMP) test sensitive enough for the identification of Streptococcus agalactiae? For a long time, the Christie-Atkinson-Munch-Peterson (CAMP) test has been a standard test for the identification of Streptococcus agalactiae, and a positive result for S.agalactiae has been considered sensitive enough.To confirm whether a positive CAMP test is a requirement for the identification of S.agalactiae, five suspected CAMP-negative S.agalactiae isolates from (...) two hospitals, confirmed as Gram-positive and catalase-negative streptococci, were verified by the CAMP test in three batches of plates from two manufacturers and identified by the Phoenix system, MALDI-TOF MS, the PCR assay and the 16S rDNA gene sequencing.All five suspected strains were S.agalactiae, four of which were CAMP-negative and one of which was not S.agalactiae by the PCR assay.A positive CAMP test was lacking sensitivity for the identification of S.agalactiae, and the question

2019 BMC Infectious Diseases

46. Correction to: Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood samples. Full Text available with Trip Pro

Correction to: Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood samples. Following publication of the original article [1], the authors flagged an error concerning a reference to a product in the Methods section.

2019 Malaria journal

47. Understanding the role of cutaneous allergy testing in anogenital dermatoses: a retrospective evaluation of contact sensitization in anogenital dermatoses. (Abstract)

Understanding the role of cutaneous allergy testing in anogenital dermatoses: a retrospective evaluation of contact sensitization in anogenital dermatoses. Patients with anogenital symptoms may delay before seeking medical attention. Attempted self-treatment with multiple topical preparations and excessive hygiene measures offer ideal conditions for sensitization. The aim of this study was to identify the common allergens detected on cutaneous allergy testing in patients presenting (...) with anogenital symptoms.A retrospective chart review of patients who underwent cutaneous allergy testing for perianal and/or genital symptoms over a 3-year period, January 2013 to December 2015, n = 99. Information was gathered from medical records, pretesting questionnaires, and cutaneous allergy testing records.At least one relevant allergen(s) was identified in 44/99 (45%) in our cohort, with allergic reactions to fragrances, Myroxylon pereirae, caine mix, sodium metabisulfite, and methylisothiazolinone

2019 International Journal of Dermatology

48. Baroreceptor activity and sensitivity: normal values in children and young adults using the head up tilt test. (Abstract)

Baroreceptor activity and sensitivity: normal values in children and young adults using the head up tilt test. Baroreceptor function in children and adolescents has not been well studied in the current literature, with a lack of agreed upon normal values. The authors hypothesize that there is a significant increase in the baroreceptor activity with a decrease in the sensitivity during the upright phase in comparison to the supine phases of the head upright tilt test (HUTT) protocol.Baroreceptor (...) evaluation was performed using the sequence method in 49 subjects ages 8-21 years, during the 3 phases of HUTT: supine, head up, and post-tilt supine positions. Baroreceptor Effectiveness Index (BEI) and the number and slope of baroreceptor events were recorded.On study of the events and slope values, there was a significant difference between the three phases of the HUTT with regard to the baroreceptor activity and sensitivity. No significant difference was found in BEI.Our study presents normal values

2019 Pediatric Research

49. Patient selection for high sensitivity cardiac troponin testing and diagnosis of myocardial infarction: prospective cohort study. Full Text available with Trip Pro

Patient selection for high sensitivity cardiac troponin testing and diagnosis of myocardial infarction: prospective cohort study. Objective To evaluate how selection of patients for high sensitivity cardiac troponin testing affects the diagnosis of myocardial infarction across different healthcare settings.Design Prospective study of three independent consecutive patient populations presenting to emergency departments.Setting Secondary and tertiary care hospitals in the United Kingdom (...) and United States.Participants High sensitivity cardiac troponin I concentrations were measured in 8500 consecutive patients presenting to emergency departments: unselected patients in the UK (n=1054) and two selected populations of patients in whom troponin testing was requested by the attending clinician in the UK (n=5815) and the US (n=1631). The final diagnosis of type 1 or type 2 myocardial infarction or myocardial injury was independently adjudicated.Main outcome measures Positive predictive value

2017 BMJ

50. Unexpected positive patch-test reactions to sesquiterpene lactones in patients sensitized to the glucose sensor FreeStyle Libre. (Abstract)

Unexpected positive patch-test reactions to sesquiterpene lactones in patients sensitized to the glucose sensor FreeStyle Libre. Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate, with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone mix (SLM) tested in the baseline series.To compile patch test results of subjects affected, and provide potential explanations for this association.53 Freestyle Libre (...) -allergic patients were patch-tested with isobornyl acrylate and/or SLM, and several also with the components of SLM. Chromatographic analyses were performed of the glucose sensor, isobornyl acrylate, and the components of SLM.Thirty-three patients reacted positively to SLM, and 11/27 patients tested positive to alantolactone, in particular. Gas-chromatographic and spectrometric (GC-MS) analyses did not detect these chemicals in the different parts of the glucose sensor, nor in isobornyl acrylate

2019 Contact Dermatitis

51. High-sensitive cardiac Troponin T and exercise stress test for evaluation of angiographically significant coronary disease. (Abstract)

High-sensitive cardiac Troponin T and exercise stress test for evaluation of angiographically significant coronary disease. Exercise stress test (EST) has a moderate precision for diagnosis of CAD and could potentially obtain improved accuracy if adding a reliable cardiac biomarker to the test.We aimed to investigate resting levels and change in hs-cTnT during EST in patients with and without angiographically significant CAD. Moreover, we intended to explore the additive value of hs-cTnT to EST

2019 International journal of cardiology

52. Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of "real-life" mixtures: the case of henna-based hair coloring products containing p-phenylenediamine. (Abstract)

Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of "real-life" mixtures: the case of henna-based hair coloring products containing p-phenylenediamine. Allergic contact dermatitis reported to henna-based hair coloring products (HPs) has been associated with adulteration of henna with p-phenylenediamine (PPD).To develop a testing approach based on in vitro techniques that address key events within the skin sensitization adverse outcome pathway (...) to evaluate allergenic potential of HPs.The following in vitro assays were used to test the sensitizing capacity of hair dye ingredients: micro-direct peptide reactivity assay (mDPRA); HaCaT keratinocytes-associated IL-18 assay; U937 cell line activation test (USENS)/IL-8 levels; blood monocyte-derived dendritic cell test; genomic allergen rapid detection (GARD skin). Those techniques with better human concordance were selected to evaluate the allergenic potential of ten HPs.Contrasting to the label's

2019 Contact Dermatitis

53. <i>Plasmodium falciparum</i> Parasitemia and Band Sensitivity of the SD Bioline Malaria Ag P.f/Pan Rapid Diagnostic Test in Madagascar. Full Text available with Trip Pro

Plasmodium falciparum Parasitemia and Band Sensitivity of the SD Bioline Malaria Ag P.f/Pan Rapid Diagnostic Test in Madagascar. Current malaria rapid diagnostic tests (RDTs) contain antibodies against Plasmodium falciparum-specific histidine-rich protein 2 (PfHRP2), Plasmodium lactate dehydrogenase (pLDH), and aldolase in various combinations. Low or high parasite densities/target antigen concentrations may influence the accuracy and sensitivity of PfHRP2-detecting RDTs. We analyzed (...) . Plasmodium falciparum-only infections were predominant (microscopy, 45.7%; LDR-FMA, 52.3%). In all, 16.3% of P. falciparum, 70% of P. vivax, and all of Plasmodium malariae, Plasmodium ovale, and mixed-species infections were submicroscopic. In 423 P. falciparum mono-infections, confirmed by microscopy and LDR-FMA, the parasitemia in those who were positive for both the PfHRP2 and pan-pLDH test bands was significantly higher than that in those who were positive only for the PfHRP2 band (P < 0.0001

2019 American Journal of Tropical Medicine & Hygiene

54. Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas. Full Text available with Trip Pro

Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas. Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have been identified in some sarcoma (...) with translocations.Soft tissue sarcoma cultures were established from patient biopsies with a success rate of 58%. The genomic profile and drug sensitivity testing on these samples helped to identify targeted inhibitors active on sarcomas. The cSrc inhibitor Dasatinib was identified as an active drug in sarcomas carrying chromosomal translocations. The drug sensitivity of the patient sarcoma cells ex vivo correlated with the response to the former treatment of the patient.Our results show that patient-derived sarcoma

2019 British Journal of Cancer

55. Resident Sensitive Processes of Care: the Impact of Surgical Residents on Inpatient Testing. (Abstract)

Resident Sensitive Processes of Care: the Impact of Surgical Residents on Inpatient Testing. Healthcare value is a national priority, and there are substantial efforts to reduce overuse of low-value testing. Residency training programs and teaching hospitals have been implicated in excessive testing. We evaluated the impact of surgery residents on the frequency of inpatient testing and investigated potential inter-resident variation.Inpatient laboratory and imaging orders placed on general (...) surgery services were extracted from an academic institution from 2014-2016 and linked to National Surgical Quality Improvement Program data. Using negative binomial mixed effects regression with unstructured covariance, we evaluated the frequency of testing orders compared to median utilization, accounting for case, patient, and attending-level variables.111,055 laboratory and 7,360 imaging orders were linked with 2,357 patients. Multivariable analysis demonstrated multiple significant predictors

2019 Journal of the American College of Surgeons

56. Rapid Tests for the Diagnosis of Group A Streptococcal Infection: A Review of Diagnostic Test Accuracy, Clinical Utility, Safety, and Cost-Effectiveness

-culture-based tests for the diagnosis of suspected group A strep infection? What is the safety of non-culture-based tests for the diagnosis of suspected group A strep infection? What is the cost-effectiveness of non-culture-based diagnostic tests for suspected group A strep infection? Key Message From systematic reviews and observational studies the sensitivity values ranged between 82% and 100% for molecular assays and between 55% and 94% for immunoassays. Specificities for the two test types were 91 (...) Rapid Tests for the Diagnosis of Group A Streptococcal Infection: A Review of Diagnostic Test Accuracy, Clinical Utility, Safety, and Cost-Effectiveness Rapid Tests for the Diagnosis of Group A Streptococcal Infection: A Review of Diagnostic Test Accuracy, Clinical Utility, Safety, and Cost-Effectiveness | CADTH.ca Find the information you need Rapid Tests for the Diagnosis of Group A Streptococcal Infection: A Review of Diagnostic Test Accuracy, Clinical Utility, Safety, and Cost-Effectiveness

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

57. What is the most accurate and cost-effective direct test (ELF test, hyaluronic acid, P3NP, Fibroscan or ARFI elastography) for detecting and staging liver fibrosis and/or cirrhosis in patients with diagnosed or suspected non-alcoholic fatty liver disease,

of interest had sensitivity =70% for detection of fibrosis and cirrhosis in patients with hepatitis C or non-alcoholic fatty liver disease (NAFLD). ? In a meta-analysis of 13 studies (n=1,163) the direct imaging tests Fibroscan® and ARFI elastography had similar sensitivity and specificity for the detection of significant fibrosis and cirrhosis. ? In a meta-analysis of four studies (n=612) Fibroscan® imaging was slightly more sensitive and more specific for diagnosing cirrhosis compared with the ELF test™ (...) . ? In a prospective diagnostic cohort study Fibroscan® had lower sensitivity and higher specificity for detection of significant fibrosis, and similar sensitivity with higher specificity for the detection of advanced fibrosis, compared with the ELF test™. A second prospective diagnostic study reported that Fibroscan® had statistically significantly higher sensitivity and specificity for the detection of cirrhosis compared with serum hyaluronic acid. ? The ELF test™ had higher sensitivity and lower specificity

2018 Evidence Notes from Healthcare Improvement Scotland

58. The Effect of a Diet Moderately High in Protein and Fiber on Insulin Sensitivity Measured Using the Dynamic Insulin Sensitivity and Secretion Test (DISST) Full Text available with Trip Pro

The Effect of a Diet Moderately High in Protein and Fiber on Insulin Sensitivity Measured Using the Dynamic Insulin Sensitivity and Secretion Test (DISST) Evidence shows that weight loss improves insulin sensitivity but few studies have examined the effect of macronutrient composition independently of weight loss on direct measures of insulin sensitivity. We randomised 89 overweight or obese women to either a standard diet (StdD), that was intended to be low in fat and relatively high (...) in carbohydrate (n = 42) or to a relatively high protein (up to 30% of energy), relatively high fibre (>30 g/day) diet (HPHFib) (n = 47) for 10 weeks. Advice regarding strict adherence to energy intake goals was not given. Insulin sensitivity and secretion was assessed by a novel method-the Dynamic Insulin Sensitivity and Secretion Test (DISST). Although there were significant improvements in body composition and most cardiometabolic risk factors on HPHFib, insulin sensitivity was reduced by 19.3% (95% CI

2017 Nutrients Controlled trial quality: uncertain

59. The Comparison of Sensitivity and Specificity of ELISA-based Microneutralization Test with Hemagglutination Inhibition Test to Evaluate Neutralizing Antibody against Influenza Virus (H1N1) Full Text available with Trip Pro

The Comparison of Sensitivity and Specificity of ELISA-based Microneutralization Test with Hemagglutination Inhibition Test to Evaluate Neutralizing Antibody against Influenza Virus (H1N1) The most common serological assay to measure anti-influenza antibodies is hemagglutination inhibition (HI) assay. Recently, neutralizing antibodies against influenza virus infection or vaccination can also be detected using microneutralization assays and occasionally, have greater sensitivity than (...) -ELISA assays. Correlation between methods was calculated by linear regression analysis.The linear correlation coefficient squares, R2, of microNT-ELISA and HI test was 0.61 (P<0.0001) and we observed a high index of coincidence between the two tests. According to McNemar's test, there was no statistically significant difference between these two assays (P>0.05).The sensitivity and specificity of microNT-ELISA assay were high (87% and 73%, respectively) and closely related to gold standard test

2017 Iranian journal of public health

60. Sensitivity of caloric test and video head impulse as screening test for chronic vestibular complaints Full Text available with Trip Pro

Sensitivity of caloric test and video head impulse as screening test for chronic vestibular complaints This study compared the results of the caloric test with those of the video head impulse test obtained during the same session and evaluated whether the former can be used to screen for non-acute vestibular dysfunction.A total of 157 participants complaining of dizziness with vestibular characteristics of varying durations and clinical courses completed the caloric test and video head impulse (...) test.Significantly more caloric test results than video head impulse test results were abnormal.The results of the caloric test and video head impulse test are distinct but complement each other. Within our sample, the caloric test was more sensitive for vestibular dysfunction. Therefore, the video head impulse test is not a suitable screening tool of the vestibular system in patients with chronic complaints.

2017 Clinics

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