How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

373 results for

Tertiary Syphilis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

2. Rapid progression to gummatous tertiary syphilis in a patient with HIV. (PubMed)

Rapid progression to gummatous tertiary syphilis in a patient with HIV. Co-infection with human immunodeficiency virus-1 (HIV) and syphilis is associated with rapid progression to tertiary syphilis. This case report describes the early development of gummatous skin disease and suspected neurosyphilis in a patient with untreated HIV and approaches to treatment.© 2018 The Australasian College of Dermatologists.

2018 Australasian Journal of Dermatology

3. Seroprevalence of transfusion-transmissible infections (HBV, HCV, syphilis and HIV) among prospective blood donors in a tertiary health care facility in Calabar, Nigeria; an eleven years evaluation. (PubMed)

Seroprevalence of transfusion-transmissible infections (HBV, HCV, syphilis and HIV) among prospective blood donors in a tertiary health care facility in Calabar, Nigeria; an eleven years evaluation. Provision of constant and safe blood has been a public health challenge in Sub-Saharan Africa with high prevalence of transfusion-transmissible infections (TTIs). This study was aimed at determining the trend and seroprevalence of HBV, HCV, syphilis and HIV across the years within study among (...) based kits.Out of the 24,979 screened prospective donors in the 2005-2016 study period, 3739 (14.96%) were infected with at least one infective agent. The overall prevalence of HBV, HCV, syphilis and HIV were 4.1, 3.6, 3.1 and 4.2%, respectively. During the period of study, the percentage of all transfusion-transmissible infections declined significantly with remarkable decline in HIV. The study showed male dominated donor pool (98.7%) with higher prevalence (4.2%) of transfusion-transmissible

Full Text available with Trip Pro

2018 BMC Public Health

4. Tertiary syphilis in the lumbar spine: a case report. (PubMed)

Tertiary syphilis in the lumbar spine: a case report. The incidence of tertiary syphilis involvement in the spinal column with destructive bone lesions is very rare. It is difficult to establish the correct diagnosis from radiographs and histological examination alone. Limited data are available on surgical treatment to tertiary syphilitic spinal lesions. In this article, we report a case of tertiary syphilis in the lumbar spine with osteolytic lesions causing cauda equina compression.A 44-year (...) radiographs showed absorption of the bone grafts and failure of instrumentation. A Charcot's arthropathy was formed between L4 and L5.It is challenging to diagnose the tertiary syphilis in the spine. Surgery is a reasonable auxiliary method to antibiotic therapy for patients who suffered with neuropathy. Charcot's arthropathy should be considered as an operative complication.

Full Text available with Trip Pro

2017 BMC Infectious Diseases

5. Double Morphology: Tertiary Syphilis and Acquired Immunodeficiency Syndrome—A Rare Association (PubMed)

Double Morphology: Tertiary Syphilis and Acquired Immunodeficiency Syndrome—A Rare Association Human immunodeficiency virus (HIV) and Treponema pallidum coinfection is relatively common and accounts for about 25% of primary and secondary syphilis. Tertiary syphilis in HIV-uninfected and HIV-infected patients is vanishingly rare. This is most likely due to early treatment of cases of primary and secondary syphilis. There is rapid progression to tertiary syphilis in HIV-infected patients.A 49 (...) -year-old woman diagnosed with HIV Type 1 infection and cluster of differentiation 4 (CD4) count of 482 presented with a four-week history of multiple crusted plaques, nodules, and ulcers on her face, arms, and abdomen. Her past history revealed red painful eyes six months prior to this presentation. She had generalized lymphadenopathy, no alopecia, and no palmar-plantar or mucosal lesions. There were no features suggestive of secondary syphilis. Neurological examination was normal. Her rapid plasma

Full Text available with Trip Pro

2017 Case reports in dermatological medicine

6. Late Neurosyphilis and Tertiary Syphilis in Guangdong Province, China: Results from a Cross-sectional Study (PubMed)

Late Neurosyphilis and Tertiary Syphilis in Guangdong Province, China: Results from a Cross-sectional Study Due to challenges in diagnosis and the need for complex laboratory tests, misdiagnosis of neurosyphilis and tertiary syphilis is common in China. We validated the diagnosis and examined the treatment of late neurosyphilis and tertiary syphilis in Guangdong Province, China. A cross-sectional study was conducted to collect data from late neurosyphilis and tertiary syphilis cases reported (...) between 2009 and 2014 in Guangdong, China. Descriptive analysis, bivariate analyses and multiple logistic regressions were performed to determine the structural factors associated with correct diagnosis and standard treatment of late neurosyphilis and tertiary syphilis. Among the 3805 respondents (3805/3936, 96.7%), 1,837 (48.3%) met the misdiagnosed criteria. The misdiagnosis rate decreased over the study period (54.2% in 2009 and 41.8% in 2014). Only 27.1% and 24.9% of the correctly diagnosed late

Full Text available with Trip Pro

2017 Scientific reports

7. Diagnosis and management of gonorrhoea and syphilis

% and reoccurrence of early secondary symptoms in 25% Up to 2 years after infection Late Latent • Asymptomatic Tertiary • In one-third of untreated cases: Gummatous disease (15% of patients); cardiovascular (10%) and late neurological complications (7%) 20-40 years after initial infection Note. Stages and symptoms of congenital syphilis were not reported in this table; ECDC: European Centre for Disease Prevention and Control 18 Diagnosis and management of gonorrhoea and syphilis KCE Report 310 Figure 2 (...) Diagnosis and management of gonorrhoea and syphilis 2019 www.kce.fgov.be KCE REPORT 310 DIAGNOSIS AND MANAGEMENT OF GONORRHOEA AND SYPHILIS 2019 www.kce.fgov.be KCE REPORT 310 GOOD CLINICAL PRACTICE DIAGNOSIS AND MANAGEMENT OF GONORRHOEA AND SYPHILIS VICKY JESPERS, SABINE STORDEUR, ANJA DESOMER, SERENA CARVILLE, CLARE JONES, SEDINA LEWIS, MARK PERRY, SAM CORDYN, TINE CORNELISSEN, TANIA CRUCITTI, CELINE DANHIER, IRITH DE BAETSELIER, ANNE-SOPHIE DE CANNIÈRE, WOUTER DHAEZE, ELS DUFRAIMONT, CHRIS

2019 Belgian Health Care Knowledge Centre

8. Syphilis in pregnancy

in the second year Latent · May be divided into 25,27 : o Early latent (infection for less than two years) o Late latent (infection for two years or more) o Syphilis of unknown duration · Characterised by reactive serology with no clinical manifestations · If untreated 15–40% develop tertiary infection Tertiary · Can affect any organ system 4,16 · Occurs in approximately one-third of untreated patients · Main manifestations are: o Neurological disease (neurosyphilis)—can occur at any stage of syphilis (...) Syphilis in pregnancy Maternity and Neonatal C linical G uideline Queensland Health Syphilis in pregnancy Queensland Clinical Guideline: Syphilis in pregnancy Refer to online version, destroy printed copies after use Page 2 of 31 Document title: Syphilis in pregnancy Publication date: December 2018 Document number: MN18.44-V1-R23 Document supplement: The document supplement is integral to and should be read in conjunction with this guideline. Amendments: Full version history is supplied

2019 Queensland Health

9. Tertiary Syphilis

Tertiary Syphilis Tertiary Syphilis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tertiary Syphilis Tertiary Syphilis Aka: Tertiary (...) Syphilis , Syphylitic Gumma , Gumma From Related Chapters II. Pathophysiology Low-level infection with strong immune response III. Types Late benign (50% of Tertiary Syphilis cases) Presents with gumma, granulomas and -like s May form 1 to 10 years after initial infection Destructive granulomatous lesions (fungating masses) affect any area Responds rapidly to treatment Typically involves s (especially ascending aortitis) Thoracic aneurysm (Occurs in 10% of untreated ) l penetration of the blood brain

2018 FP Notebook

10. Syphilis

). Syphilis MANAGEMENT SUMMARY FOLLOW-UP Infectious syphilis • Repeat serology at 3, 6 and 12 months • Serological cure is defined by consistent four-fold (2 dilutions) drop in RPR titre • Failure of RPR titre to decrease fourfold (2 dilutions) within 12 months indicates treatment failure – re-evaluation is necessary • A subsequent four-fold (2 dilution) rise in RPR titre is an indication of re-infection – re-evaluation is necessary Late latent syphilis and tertiary syphilis (excluding neurosyphilis (...) syphilis • Primary syphilis: 3 months plus duration of symptoms. Empiric treatment for syphilis is recommended, as serology may be negative • Secondary syphilis: 6 months plus duration of symptoms • Early latent syphilis and syphilis of unknown duration where RPR = 1:32: 12 months Late latent syphilis, syphilis of unknown duration with low RPR and tertiary syphilis • Serologic evaluation of current or last sexual contact and/or serologic evaluation of children if index case is female MANAGEMENT

2017 New Zealand Sexual Health Society

11. Canadian guidelines on sexually transmitted infections : interim syphilis treatment guidelines during the Bicillin L-A shortage

. Refer to tables 6 and 7 in the Syphilis chapter. Effective immediately it is recommended that the use of Bicillin L-A be restricted to: 1. Pregnant patients (all stages) Primary, secondary, early latent syphilis Benzathine penicillin G 2.4 m.u. IM as a single dose Late latent, latent of unknown duration, tertiary syphilis (not involving the central nervous system) Benzathine penicillin G 2.4 m.u. IM weekly x 3 doses Notes: • There is no satisfactory alternative to penicillin in pregnancy; strongly (...) in patients reporting anaphylactic reactions to penicillin. The following patients (including HIV infected) should be preferentially treated with oral doxycycline if adherence to treatment AND follow-up is expected. 1. Primary, secondary and early latent syphilis cases and their sexual contacts (non-pregnant adults) Doxycycline 100 mg PO BID x 14 days 2. Late latent, latent of unknown duration, tertiary syphilis (not involving the central nervous system) in non-pregnant adults Doxycycline 100 mg PO BID x

2016 CPG Infobase

12. WHO guideline on syphilis screening and treatment for pregnant women

testing, although plasma can be used in some non-treponemal serological tests. Cerebrospinal fluid is used to diagnose congenital and tertiary syphilis and when neurological symptoms are present.11 RAPID SYPHILIS TESTS (RSTS) In the past decade, a number of point-of-care rapid syphilis tests (RSTs) for treponemal antibodies in syphilis infection have been developed. RSTs provide treponemal antibody results in 10–15 minutes and can be performed on-site in any setting since they do not require (...) WHO guideline on syphilis screening and treatment for pregnant women WHO GUIDELINE ON Syphilis screening and treatment for pregnant women WHO GUIDELINE ON Syphilis screening and treatment for pregnant women WHO guideline on syphilis screening and treatment for pregnant women ISBN 978-92-4-155009-3 © World Health Organization 2017 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommer- cial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https

2017 World Health Organisation Guidelines

13. WHO guidelines for the treatment of Treponema pallidum (syphilis)

years and is divided into stages. Early syphilis consists of primary syphilis, secondary syphilis and early latent syphilis, while late syphilis consists of late latent syphilis and tertiary syphilis (neurosyphilis, cardiosyphilis and gumma). Primary syphilis classically presents as a solitary, painless chancre at the site of inoculation. However, the primary chancre may go unnoticed by patients. If untreated, the disease progresses to the secondary stage, characterized by generalized mucocutaneous (...) and is divided into stages. Early syphilis consists of primary syphilis, secondary syphilis and early latent syphilis, while late syphilis consists of late latent syphilis and tertiary syphilis. Primary syphilis classically presents as a solitary, painless chancre at the site of inoculation, usually in the vagina, penis or anus (but it may be extra-genital), after a mean incubation period of 21 days (range: 9–90 days). The primary lesion begins as a raised papule and ulcerates before healing within 3 to 10

2016 World Health Organisation Guidelines

14. Tertiary syphilis and Kaposi's sarcoma mistaken for systemic sarcoidosis in an HIV-negative patient. (PubMed)

Tertiary syphilis and Kaposi's sarcoma mistaken for systemic sarcoidosis in an HIV-negative patient. We describe a case of an HIV-negative man who was mistakenly diagnosed as having systemic sarcoidosis, which led to a delay in diagnosing tertiary syphilis and Kaposi sarcoma (KS). The patient presented initially with scrotal swelling and leg oedema. Initial blood tests were unremarkable and HIV testing was negative. The patient then developed unilateral limb weakness. Computed tomography showed (...) research laboratory test titre and the cause of his multisystemic symptoms was revisited. He was diagnosed with tertiary syphilis and treated with antibiotics. Dermatologists reviewed the skin lesions and diagnosed KS, which was confirmed with biopsies. The patient's neurological deficit remains. Syphilis should be considered in the differential diagnosis of any patient presenting with neurological problems, skin lesions or symptoms affecting multiple systems. Co-existing KS presented an extra

2015 British Journal of Dermatology

15. Primary syphilis in HIV-negative patients is on the rise in Greece: epidemiological data for the period 2005-2012 from a tertiary referral centre in Athens, Greece. (PubMed)

Primary syphilis in HIV-negative patients is on the rise in Greece: epidemiological data for the period 2005-2012 from a tertiary referral centre in Athens, Greece. Epidemiological data on primary syphilis in Greece are limited.The purpose of the present study was to investigate the trends of the disease in Greece during the last few years and whether they are in accordance with the trends in other European countries and the United States of America.We conducted a retrospective analysis based (...) on records of patients who visited the Sexually Transmitted Infections Unit of 'A. Sygros' Hospital in Athens, Greece, during the period 2005-2012. Our hospital is a tertiary referral centre for sexually transmitted infections covering an area of more than four million people, which is almost half the population of Greece. We documented the total annual number of patients, the male to female ratio, sexual orientation, patients' ethnic origin and education level.We reviewed the records of 1185 patients

2015 Journal of the European Academy of Dermatology and Venereology

16. Evaluation of a new serological test for syphilis based on chemiluminescence assay in a tertiary care hospital (PubMed)

Evaluation of a new serological test for syphilis based on chemiluminescence assay in a tertiary care hospital Syphilis is a transfusion transmissible infections and it is mandatory to do serological test for syphilis (STS) on all donor blood samples. STS is usually based on detection of antibodies against the cardiolipin-lecithin antigen or against the Treponema-specific antigen. STS with good sensitivity and specificity helps enhance blood safety and consolidation of STS along with other (...) transfusion transmittable infections such as human immunodeficiency virus, hepatitis-C virus, and hepatitis-B virus helps in reducing the errors and enhances efficiency.This study was designed to evaluate the performance of newly introduced VITROS(®) syphilis Treponema pallidum agglutination (TPA) assay based on enhanced chemiluminescence principle for its analytical performance for use as a STS on donor blood samples at a tertiary care health center in National Capital Region, India.A total of 108 random

Full Text available with Trip Pro

2015 Asian journal of transfusion science

17. Syphilis on the rise: A prolonged syphilis outbreak among HIV-infected patients in Northern Greece (PubMed)

of syphilis in people living with HIV. The demographic, clinical, and serologic data of HIV patients diagnosed with syphilis were recorded and analyzed. Data on syphilis incidence from the general population was also compared to HIV patients' data.Fifty-eight HIV-patients of the Infectious Diseases Unit of a tertiary hospital (5.2%) were diagnosed with syphilis during a three-year period (2008-2010). Highly active antiretroviral therapy (HAART) and coexistence of other STDs were independent predictors (...) Syphilis on the rise: A prolonged syphilis outbreak among HIV-infected patients in Northern Greece Sexually transmitted diseases (STDs) are a major public health issue in Europe. Numerous outbreaks of syphilis have been described recently and an increased prevalence of high-risk sexual practices has raised concern about the transmission of HIV and other STDs. Similarly, an increase in sexually transmitted infections has been recorded in Northern Greece.This report describes a recent outbreak

Full Text available with Trip Pro

2016 Germs

18. Unusual primary syphilis: Presentation of a likely case with a review of the stages of acquired syphilis, its differential diagnoses, management, and current recommendations. (PubMed)

Unusual primary syphilis: Presentation of a likely case with a review of the stages of acquired syphilis, its differential diagnoses, management, and current recommendations. Syphilis is an ancient disease that has re-emerged in the last decade. It is prevalent among men who have sex with men and has increased in incidence with certain ethnic groups. It usually presents as primary or secondary syphilis and can progress to tertiary syphilis if not treated. Primary syphilis will classically (...) manifest as a single, painless ulcer with smooth, clean, and raised borders on the genitals or less often on the oral mucosa. Unusual primary syphilis cases have been reported and can be easily misdiagnosed with a resulting delay of treatment. Secondary syphilis is a systemic disease, wherein the treponemes have disseminated to various organ systems, typically presenting with characteristic mucocutaneous lesions. Tertiary syphilis has a higher rate of morbidity and mortality; as such, the aim

2016 International Journal of Dermatology

19. Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017. (PubMed)

Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017. To review the notification rate and characteristics of tertiary and neurosyphilis cases in Alberta, Canada in the postantibiotic era.A retrospective review of all neurosyphilis and tertiary syphilis cases reported in Alberta from 1973 to March 2017 was undertaken and cases classified into early neurosyphilis, late neurosyphilis and cardiovascular (CV) syphilis. Variables collected included demographics, sexual (...) of tertiary and neurosyphilis cases found that early and late neurosyphilis cases continue to occur in the context of cycling syphilis outbreaks. CV syphilis cases were extremely rare. Ongoing identification of new cases of syphilis and clinical evaluation of cases for complications continues to be important in the context of global resurgence of syphilis.© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

2019 BMJ open

20. Increase in Ocular Syphilis Cases at Ophthalmologic Reference Center, France, 2012-2015. (PubMed)

Increase in Ocular Syphilis Cases at Ophthalmologic Reference Center, France, 2012-2015. We describe the frequency, demographic and clinical features, and visual outcomes of ocular syphilis infections observed during 2012-2015 at a tertiary reference center in Paris, France. Twenty-one cases (29 eyes) were identified. The occurrence of ocular syphilis increased from 1 case in 2012 to 5 cases in 2013, 6 cases in 2014, and 9 cases in 2015 (2.22-25.21/1,000 individual patients/year for the period (...) ). Among case-patients, an annual 20%-33% were co-infected with HIV. Seventy-six percent of ocular syphilis infections occurred in men who have sex with men. Seventy-five percent of case-patients had a good final visual outcome (best-corrected visual acuity >0.3 logMAR score). Visual outcome was worse for HIV-positive patients than for HIV-negative patients (p = 0.0139). At follow-up, the best visual outcomes were observed in patients whose mean time from first ocular symptom to consultation was 15

Full Text available with Trip Pro

2018 Emerging Infectious Diseases

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>