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Tekturna

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1. Tekturna

Tekturna Tekturna Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tekturna Tekturna Aka: Tekturna , Aliskiren , Direct renin inhibitor (...) inhibitors improve outcomes No significant benefit in , , Risk of hyptension, and increased (2016) Presc Lett 3(6):34 VIII. Indications Second line antihypertensive for those unable to use s or s IX. Dosing Start: 150 mg orally daily Maximum: 300 mg daily X. Adverse effects (up to 6%) Gastrointestinal symptoms (up to 9%) XI. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Tekturna." Click on the image (or right click

2018 FP Notebook

2. Tekturna

Tekturna Tekturna Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tekturna Tekturna Aka: Tekturna , Aliskiren , Direct renin inhibitor (...) inhibitors improve outcomes No significant benefit in , , Risk of hyptension, and increased (2016) Presc Lett 3(6):34 VIII. Indications Second line antihypertensive for those unable to use s or s IX. Dosing Start: 150 mg orally daily Maximum: 300 mg daily X. Adverse effects (up to 6%) Gastrointestinal symptoms (up to 9%) XI. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Tekturna." Click on the image (or right click

2015 FP Notebook

3. Vitamin D Augmentation of Tekturna (Aliskiren) in Hypertension

Vitamin D Augmentation of Tekturna (Aliskiren) in Hypertension Vitamin D Augmentation of Tekturna (Aliskiren) in Hypertension - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Vitamin D Augmentation (...) of Tekturna (Aliskiren) in Hypertension (VDATH) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01472796 Recruitment Status : Unknown Verified November 2011 by John M. Flack, Wayne State University. Recruitment status was: Recruiting First Posted : November 16, 2011 Last Update Posted : November 16, 2011

2011 Clinical Trials

4. Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease

Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01129557 Recruitment Status : Terminated First Posted : May

2010 Clinical Trials

5. The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis

The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01067326 Recruitment Status : Terminated (Novartis

2010 Clinical Trials

6. Single-dose Potassium Supplementation in Patients With ADHD for Whom the Anesthetic Lidocaine is Ineffective

/Olmetec) Telmisartan (Micardis) Valsartan (Diovan) Aldosterone antagonists Spironolactone (Aldactone) Eplerenone (Inspra) Renin inhibitors a. Aliskiren (Tekturna, Rasilez) Other potassium elevating agents Antibiotics, including penicillin G and trimethoprim Azole antifungals Beta-blockers Herbal supplements, including milkweed, lily of the valley, Siberian ginseng, Hawthorn berries Heparin Nonsteroidal anti-inflammatory medications (NSAIDs) Oral contraceptives containing drospirenone Contacts

2018 Clinical Trials

7. Validating a New Non-invasive Approach to Testing Lidocaine Effectiveness

) Trandolapril (Mavik/Odrik/Gopten) Zofenopril Angiotensin receptor blockers Azilsartan (Edarbi) Candesartan (Atacand) Eprosartan (Teveten) Fimasartan (Kanarb) Irbesartan (Avapro) Losartan (Cozaar) Olmesartan (Benicar/Olmetec) Telmisartan (Micardis) Valsartan (Diovan) Aldosterone antagonists Spironolactone (Aldactone) Eplerenone (Inspra) Renin inhibitors - Aliskiren (Tekturna, Rasilez) Other potassium elevating agents Antibiotics, including penicillin G and trimethoprim Azole antifungals Beta-blockers Herbal (...) ) Irbesartan (Avapro) Losartan (Cozaar) Olmesartan (Benicar/Olmetec) Telmisartan (Micardis) Valsartan (Diovan) Aldosterone antagonists Spironolactone (Aldactone) Eplerenone (Inspra) Renin inhibitors - Aliskiren (Tekturna, Rasilez) Other potassium elevating agents Antibiotics, including penicillin G and trimethoprim Azole antifungals Beta-blockers Herbal supplements, including milkweed, lily of the valley, Siberian ginseng, Hawthorn berries Heparin Nonsteroidal anti-inflammatory medications (NSAIDs) Oral

2018 Clinical Trials

8. The Effects of Renin Inhibition on Fibrinolytic Balance and Endothelial Function

Intervention/treatment Experimental: HCTZ plus Aliskiren then HCTZ and Placebo HCTZ 25 mg plus Aliskiren 150mg for 2weeks. Aliskiren is increased to 300mg for 4 week if 150mg was tolerated. Then HCTZ 25 mg po plus Placebo Drug: Aliskiren 150 mg Aliskiren 150 mg daily for 2 weeks Other Name: Tekturna Drug: Placebo Placebo tablet for Aliskerin Drug: HCTZ HCTZ 25mg every day for 18 weeks Drug: Aliskiren 300 mg Aliskiren 300 mg for 4 weeks Experimental: HCTZ and Placebo, then HCTZ and Aliskiren HCTZ 25 mg po (...) plus Placebo. Then HCTZ 25 mg plus Aliskiren 150mg for 2weeks. Aliskiren is increased to 300mg for 4 week if 150mg was tolerated. Drug: Aliskiren 150 mg Aliskiren 150 mg daily for 2 weeks Other Name: Tekturna Drug: Placebo Placebo tablet for Aliskerin Drug: HCTZ HCTZ 25mg every day for 18 weeks Drug: Aliskiren 300 mg Aliskiren 300 mg for 4 weeks Outcome Measures Go to Primary Outcome Measures : Difference in Peak Plasma PAI-1 Level [ Time Frame: baseline to 18 weeks ] Difference in Mean Plasma PAI

2017 Clinical Trials

10. Telmisartan Plus Exercise to Improve Functioning in Peripheral Artery Disease

an angiotensin receptor blocker or an ACE inhibitor or use of these medications in the past three months. Currently taking aliskiren (Tekturna). Blood pressure < 110/55 at baseline or potassium > 5.0 meq/L at baseline. Blood pressure < 100/50 after run-in or potassium >= 5.5 meq/L at the end of run-in. Severe hepatic impairment defined by two or more liver function enzyme values greater than 2.5 the upper limit of normal. Acute decline in renal function on telmisartan, defined as a 30% or greater decline

2015 Clinical Trials

15. Aliskiren Study of Safety and Efficacy in Senior Hypertensives

Aliskiren 150 mg, once a day, force titrated to Aliskiren 300 mg after 8 weeks in 50% of patients. Optional addition/titration of amlodipine 5 mg/10 mg and hydrochlorothiazide 12.5/25 mg based on systolic BP control in sequential steps Drug: Aliskiren Aliskiren 150 mg and aliskiren 300 mg tablets will be supplied centrally. These will be blinded with matching placebos for the 2 dose strengths. Other Name: Rasilez, Tekturna Drug: Amlodipine Amlodipine 5 mg/10 mg will also be blinded and supplied (...) mg and optional addition/titration of hydrochlorothiazide 12.5/25 mg based on systolic BP control in sequential steps Drug: Aliskiren Aliskiren 150 mg and aliskiren 300 mg tablets will be supplied centrally. These will be blinded with matching placebos for the 2 dose strengths. Other Name: Rasilez, Tekturna Drug: Amlodipine Amlodipine 5 mg/10 mg will also be blinded and supplied centrally. For Aliskiren dual therapy arm , Amlodipine is in the regimen; where as for monotherapy arms, Amlodipine

2013 Clinical Trials

16. 8-week Randomized, Open-label Study to Evaluate Food Effect on Efficacy and Safety of Oral Aliskiren 300 mg in Patients With Hypertension

Light Meal Versus Fasted Condition in Patients With Hypertension Study Start Date : April 2012 Actual Primary Completion Date : November 2012 Actual Study Completion Date : November 2012 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Aliskiren: Fed Aliskiren 300 mg once daily, taken 30 minutes after start of light breakfast Drug: Aliskiren Aliskiren 300 mg once daily Other Name: Tekturna (...) , rasilez Experimental: Aliskiren: Fasting Aliskiren 300 mg once daily taken after after an overnight fast Drug: Aliskiren Aliskiren 300 mg once daily Other Name: Tekturna, rasilez Outcome Measures Go to Primary Outcome Measures : Change From Baseline (Visit 3) to End of Study (Week 8) in Mean 24 Hour Ambulatory Systolic Blood Pressure (maSBP) [ Time Frame: Baseline, week 8 ] 24 hour ambulatory blood pressure measurement (ABPM) were taken twice, at baseline and at the end of 8 weeks. An Ambulatory Blood

2012 Clinical Trials

17. Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects

: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: aliskiren 300 mg once daily for 12 weeks aliskiren 300 mg daily Drug: aliskiren 300 mg once daily aliskiren 300 mg daily Other Name: Tekturna Placebo Comparator: Sugar pill/ placebo Patients were double-blind placebo-controlled randomized to either aliskiren 300 mg once daily or sugar pill/ placebo Drug: Placebo/sugar pill Sugar pill/placebo Outcome Measures Go to Primary Outcome Measures : Change in Flow-mediated

2011 Clinical Trials

18. Aliskiren Effect on Aortic Plaque Progression

Actual Study Completion Date : January 2012 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Aliskiren Aliskiren will be administered for 2 weeks at 150mg/day oral pill, followed by 34 weeks oral therapy with 300mg/day Drug: Aliskiren 150 mg/300mg Other Name: Tekturna Placebo Comparator: Placebo Placebo (sugar pill) built to mimic both the 150mg Aliskiren tablet ( administered

2011 Clinical Trials

19. Aliskiren vs Hydrochlorothiazide in Hypertensive Type II Diabetic Patients on Resistance Arteries

: Hydrochlorothiazide Hydrochlorothiazide will be used at increasing doses from 12.5 to 25 mg per day for 6-12 months. Other Name: Hydrochlorothiazide is a generic drug. Experimental: Aliskiren Treatment of patients with aliskiren and effect on small arteries Drug: Aliskiren vs. hydrochlorothiazide Aliskiren will be used at increasing doses from 150 to 300 mg per day for 6-12 months. Other Name: Aliskiren is Tekturna or Rasilez Drug: Hydrochlorothiazide Hydrochlorothiazide will be used at increasing doses from 12.5

2011 Clinical Trials

20. Effect of Short Term Aliskiren Treatment in Kidney Transplant Patients

: January 2012 Actual Study Completion Date : January 2012 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: Aliskiren Aliskiren 150 mg daily for 180 days Drug: Aliskiren Take 1 tablet (150 mg) by mouth daily for 180 days Other Name: Tekturna Placebo Comparator: Placebo Placebo identical to Aliskiren drug daily for 180 days Drug: Placebo Take 1 tablet (0 mg) daily for 180 days. Outcome

2011 Clinical Trials

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