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Taste Dysfunction

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1. Nutrition and taste and smell dysfunction Full Text available with Trip Pro

Nutrition and taste and smell dysfunction Food selection plays a pivotal role in maintaining adequate nutrient intake, thus elucidating drivers of food choice is a meaningful strategy to maintain health and manage disease. Taste and smell are key determinants of food choice and warrant careful consideration. In this review, we first discuss how sensory stimulation influences food selection and metabolism. We then review the evidence regarding the relationship between taste and smell dysfunction (...) and food preferences and selection, with attention given to contexts of certain chronic diseases. We conclude with brief recommendations for the management of chemosensory disorders. While sensory abilities influence food selection, the effect of taste and smell dysfunction on long-term consumption patterns and health status must be considered in light of environment, exposure, and culture.

2018 World journal of otorhinolaryngology - head and neck surgery

2. Post-tonsillectomy taste dysfunction: Myth or reality? Full Text available with Trip Pro

Post-tonsillectomy taste dysfunction: Myth or reality? Lingual branches of the glossopharyngeal nerve (CN Ⅸ) are at risk of injury during tonsillectomy due to their proximity to the muscle layer of the palatine tonsillar bed. However, it is unclear how often this common surgery leads to taste disturbances. We conducted a literature search using PubMed, Embase, Cochrane Library, Google Scholar, PsychInfo, and Ovid Medline to evaluate the available literature on post-tonsillectomy taste disorders (...) . Studies denoting self-reported dysfunction, as well as those employing quantitative testing, i.e., chemogustometry and electrogustometry, were identified. Case reports were excluded. Of the 8 original articles that met our inclusion criteria, only 5 employed quantitative taste tests. The highest prevalence of self-reported taste disturbances occurred two weeks after surgery (32%). Two studies reported post-operative chemical gustometry scores consistent with hypogeusia. However, in the two studies

2018 World journal of otorhinolaryngology - head and neck surgery

3. Impact of salt taste dysfunction on interdialytic weight gain for hemodialysis patients; a cross-sectional study. Full Text available with Trip Pro

Impact of salt taste dysfunction on interdialytic weight gain for hemodialysis patients; a cross-sectional study. Little is known about salt taste dysfunction among hemodialysis (HD) patients. This study aimed to elucidate the prevalence of salt taste dysfunction and its relationship with interdialytic weight gain (IDWG) among HD patients.A single-center cross-sectional study involving 99 maintenance HD patients was conducted in September 2015. Salt taste threshold was measured using a salt (...) -impregnated test strip. Salt taste dysfunction was defined as a recognition threshold of ≥0.8%. IDWG was calculated as the mean value of weight gain at the beginning of each week during a 1-month period before the taste test. We performed a multivariate analysis using the standard linear regression model to investigate the association between salt taste dysfunction and IDWG.Among the 99 participants, 42% had a recognition threshold of 0.6%, whereas 38% had a recognition threshold of ≥1.6%. Overall

2019 BMC Nephrology

4. Decreased electrogustometric taste sensitivity in patients with acquired olfactory dysfunction. (Abstract)

Decreased electrogustometric taste sensitivity in patients with acquired olfactory dysfunction. Cross-modal chemosensory dysfunction between olfaction and gustation is not well known.180 participants were classified into three groups (60 with olfactory dysfunction, 60 with gustatory dysfunction and 60 healthy controls without chemosensory dysfunction). Olfactory functions were obtained with Sniffin Sticks; gustatory function was measured by suprathreshold gustatory stimuli (taste sprays (...) ) and a quasi-threshold measure of taste function (taste strips) for five taste qualities (sweet, salty, sour, bitter and umami). Electric taste threshold was measured using electrogustometry (EGM). In addition, group differences in dietary behaviors were investigated with a specifically designed questionnaire.Patients with olfactory dysfunction had increased electric taste thresholds and decreased scores for the umami taste strip test as compared to healthy controls. Overall there was no major difference

2018 Rhinology

5. Loss of smell and taste as symptoms of COVID-19: what does the evidence say?

subsequently been and revised, with 65% of 7,181 positive cases and 22% of negative cases reporting loss of smell or taste. Limitations of these data include non-random sampling, the self-reported nature of the outcome and exposure, the cross-sectional design and the effect of media coverage on responses. To their credit, the authors assessed the potential impact of this issue and found it may have influenced UK responders. Figure 2. Pooled prevalence for olfactory dysfunction in Tong et al, demonstrating (...) or taste compared with a quarter of negative cases. An extremely cautious re-analysis of the data in Tong et al shows anywhere from 30% to 80% of confirmed COVID-19 cases reporting loss of smell or taste by mid-April (Figure 3). Figure 3. Cumulative meta-analysis of the proportion of confirmed COVID-19 cases reporting olfactory dysfunction from six reports included in Tong et al. This analysis needs to be interpreted cautiously given the presence of very high heterogeneity. One of the potential

2020 Oxford COVID-19 Evidence Service

6. Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction Full Text available with Trip Pro

Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction The type 1 taste receptor member 3 (T1R3) is a G protein-coupled receptor involved in sweet-taste perception. Besides the tongue, the T1R3 receptor is highly expressed in brain areas implicated in cognition, including the hippocampus and cortex. As cognitive decline is often preceded by significant metabolic or endocrinological dysfunctions regulated (...) by the sweet-taste perception system, we hypothesized that a disruption of the sweet-taste perception in the brain could have a key role in the development of cognitive dysfunction. To assess the importance of the sweet-taste receptors in the brain, we conducted transcriptomic and proteomic analyses of cortical and hippocampal tissues isolated from T1R3 knock-out (T1R3KO) mice. The effect of an impaired sweet-taste perception system on cognition functions were examined by analyzing synaptic integrity

2017 The Journal of biological chemistry

7. Smell and Taste Dysfunction Is Associated with Higher Serum Total Cholesterol Concentrations in Chinese Adults. Full Text available with Trip Pro

Smell and Taste Dysfunction Is Associated with Higher Serum Total Cholesterol Concentrations in Chinese Adults. Background: Several lipid-related hormones and peptides, such as glucagon-like peptide-1 and leptin, are involved in the regulation of taste and smell function. However, to our knowledge, it remains unknown whether these chemosensory functions are associated with lipid profiles.Objective: We examined the cross-sectional association between taste and smell dysfunction and blood (...) cholesterol concentrations.Methods: With the use of a questionnaire, we assessed chronic smell and taste dysfunction in 12,627 Chinese participants (10,418 men and 2209 women; mean age: 54.4 y) who did not take hypolipidemic agents. Participants were categorized into 3 groups based on the number of smell and taste dysfunctions, ranging from 0 (best) to 2 (worst). A general linear model was used to test differences in serum concentrations of total cholesterol, LDL cholesterol, HDL cholesterol

2017 Journal of Nutrition

8. Assessment of taste disorders

olfactory or trigeminal nerve pathology that manifests clinically to the patient as a problem with taste. According to testing with taste strips, 5.3% of the people considered as healthy have hypogeusia although very few have complete ageusia. Welge-Lüssen A, Dörig P, Wolfensberger M, et al. A study about the frequency of taste disorders. J Neurol. 2011;258:386-392. http://www.ncbi.nlm.nih.gov/pubmed/20886348?tool=bestpractice.com The evaluation of a patient presenting with taste dysfunction comprises (...) dysfunctions within the population. Am J Med. 2006;119:91-92. http://www.ncbi.nlm.nih.gov/pubmed/16431204?tool=bestpractice.com Furthermore, taste disorders may not be noticed by the patient or the physician (e.g., in stroke) and, if testing is not performed, may be unrecognised. Heckmann JG, Stössel C, Lang CJ, et al. Taste disorders in acute stroke: a prospective observational study on taste disorders in 102 stroke patients. Stroke. 2005;36:1690-1694. http://stroke.ahajournals.org/content/36/8/1690.full

2018 BMJ Best Practice

9. Taste Dysfunction

Taste Dysfunction Taste Dysfunction Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Taste Dysfunction Taste Dysfunction Aka: Taste (...) Dysfunction , Taste Impairment , Loss of Taste , Ageusia , Dysgeusia , Hypogeusia , Phantogeusia II. Definitions Ageusia Loss of Hypogeusia Diminished Dysgeusia Altered Phantogeusia Gustatatory (without external taste stimulus) III. Pathophysiology See See Innervation via parasympathetic fibers Anterior two thirds of : Lingual nerve Posterior one third of : Loss of is usually due to differentiates only bitter, salt, sour, sweet IV. Precaution Most altered is secondary to (95% of cases) V. Causes: Altered

2018 FP Notebook

10. Gustatory Dysfunction and Decreased Number of Fungiform Taste Buds in Patients With Chronic Otitis Media With Cholesteatoma. (Abstract)

Gustatory Dysfunction and Decreased Number of Fungiform Taste Buds in Patients With Chronic Otitis Media With Cholesteatoma. To compare the number of fungiform taste buds among patients with chronic otitis media (COM), those with pars flaccida retraction type cholesteatoma, and those with pars tensa retraction type cholesteatoma in combination with gustatory function.Thirty-seven patients with COM, 22 patients with pars flaccida retraction type cholesteatoma, and 17 patients with pars tensa (...) retraction type cholesteatoma were included. An average of 10 fungiform papillae (FP) per patient in the midlateral region of the tongue were observed by confocal laser scanning microscopy in vivo, and the average number of taste buds were counted. Just before the observation of FP, electrogustometry (EGM) was performed to evaluate gustatory function.A significant decrease of the average number of fungiform taste buds and significant elevation of EGM thresholds were clarified in the pars tensa retraction

2016 Rhinology and Laryngology

11. Taste Dysfunction in Multiple Sclerosis Full Text available with Trip Pro

Taste Dysfunction in Multiple Sclerosis Empirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN (...) IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile

2016 Journal of neurology

12. Impact of antibiotics on smell dysfunction Full Text available with Trip Pro

Impact of antibiotics on smell dysfunction Viral or bacterial respiratory infections can cause long-lasting olfactory dysfunction. Antibiotic therapy is indicated in severe cases; however, it is unclear whether antibiotic use produces a positive, negative, or null effect on olfactory function. This retrospective study sought to determine whether antibiotic use has an influence on odor identification and detection threshold test scores of patients with smell dysfunction secondary to upper (...) respiratory infections (URIs), lower respiratory infections (LRIs), or rhinosinusitis.Data from a total of 288 patients presenting to the University of Pennsylvania Smell and Taste Center were evaluated.Patients with a URI etiology who had taken bactericidal antibiotics had lower detection thresholds than did patients who had not taken antibiotics (P < 0.023; analysis of covariance with age and time since infection onset as covariates). Moreover, thresholds were lower for bactericidal antibiotic users

2018 World journal of otorhinolaryngology - head and neck surgery

13. Taste and smell function in chronic disease: A review of clinical and biochemical evaluations of taste and smell dysfunction in over 5000 patients at The Taste and Smell Clinic in Washington, DC. (Abstract)

Taste and smell function in chronic disease: A review of clinical and biochemical evaluations of taste and smell dysfunction in over 5000 patients at The Taste and Smell Clinic in Washington, DC. To describe systematic methods developed over 40 years among over 5000 patients at The Taste and Smell Clinic in Washington, DC to evaluate taste and smell dysfunction.A tripartite methodology was developed. First, methods to determine clinical pathology underlying the multiple disease processes (...) responsible for taste and smell dysfunction were developed. Second, methods to determine biochemical parameters responsible for these pathologies were developed. Third, methods to implement these techniques were developed to form a unified basis upon which treatment strategies can be developed to treat these patients.Studies were performed in 5183 patients. Taste loss was present in 62% of patients, smell loss in 87%. Most patients with taste loss (52%) exhibited Type II hypogeusia; most patients

2013 American Journal of Otolaryngology

14. Earlier recovery of lingual dysfunction after middle ear surgery in pediatric versus adult patients. (Abstract)

Earlier recovery of lingual dysfunction after middle ear surgery in pediatric versus adult patients. It is generally thought that the recovery of damaged chorda tympani nerve (CTN) function after middle ear surgery is different in pediatric patients from that in adult patients. The purpose of this study was to investigate the changes and the progress of taste and somatosensory functions of the tongue after middle ear surgery in pediatric patients compared with those of adult (...) patients.Prospective study.Fifty-nine pediatric patients and 106 adult patients underwent middle ear surgery. Taste and somatosensory functions of the anterior tongue, the so-called CTN functions, were assessed using electrogustometry (EGM), a 2-point discriminator, an electrostimulator, and a questionnaire before and 2 weeks and 6 months after surgery.Two weeks after surgery, there was no significant difference in the incidence of dysgeusia and abnormal EGM thresholds between the patient groups. The incidence

2019 Laryngoscope

15. Olfactory dysfunction in the pathophysiological continuum of dementia. Full Text available with Trip Pro

Olfactory dysfunction in the pathophysiological continuum of dementia. Sensory capacities like smell, taste, hearing, vision decline with aging, but increasing evidence show that sensory dysfunctions are one of the early signs diagnosing the conversion from physiological to pathological brain state. Smell loss represents the best characterized sense in clinical practice and is considered as one of the first preclinical signs of Alzheimer's and Parkinson's disease, occurring a decade or more (...) before the onset of cognitive and motor symptoms. Despite the numerous scientific reports and the adoption in clinical practice, the etiology of sensory damage as prodromal of dementia remains largely unexplored and more studies are needed to resolve the mechanisms underlying sensory network dysfunction. Although both cognitive and sensory domains are progressively affected, loss of sensory experience in early stages plays a major role in reducing the autonomy of demented people in their daily tasks

2019 Ageing research reviews

16. Association Between Olfactory and Gustatory Dysfunction and Cognition in Older Adults. (Abstract)

Association Between Olfactory and Gustatory Dysfunction and Cognition in Older Adults. The association between olfactory dysfunction (OD) and cognitive decline is becoming apparent in the emerging literature. However, the literature demonstrating a similar effect between gustatory dysfunction (GD) and cognition is not well established.To determine whether OD and GD are independently associated with cognitive impairment.The 2013-2014 National Health and Nutrition Examination Survey was queried (...) (AFT), and Digit Symbol Substitution Test (DSST).OD was associated with both mild cognitive impairment (odds ratio [OR] 1.809, P = .004) and dementia (OR 3.173, P < .001) with CERAD testing, abnormal AFT (OR 2.424, P < .001), and abnormal DSST (OR 4.028, P < .001). GD based on 1M NaCl whole mouth taste testing was associated with dementia on CERAD testing (OR 2.217, P = .004). When smell and taste parameters were included together in the regression model, both OD and GD remained significant

2019 American journal of rhinology & allergy

17. Nervus intermedius dysfunctions after vestibular schwannoma surgery: a prospective clinical study. Full Text available with Trip Pro

of VS. The patients' taste sensation was examined using taste strips. Lacrimation was tested using the Schirmer I test. The clinical evaluation was performed before surgery and repeated at 2 weeks and at 6 months after surgery as well as during the follow-up, which extended up to 2 years. The authors tested the correlation between the NI dysfunctions and the House-Brackmann grade of facial nerve palsy.RESULTSThe taste sensation was lost on the side of surgery in 2 patients (6.6%) and decreased in 4 (...) patients (13.3%). The disturbance of taste sensation was not statistically correlated with dysfunctions of the motor portion of the facial nerve. The taste impairment resolved in 4 patients within 6 months, but 2 patients suffered from persistent loss of the taste sensation on the side of surgery during the follow-up. In 23 patients (76.6%), the baseline lacrimation was lower on the side of surgery, and it was significantly correlated with outcome for dysfunctions of the motor portion of the facial

2018 Journal of Neurosurgery

18. Sensory Dysfunction and Sexuality in the U.S. Population of Older Adults. Full Text available with Trip Pro

sexual motivation.To test the association between sexual activity and motivation in older adults and their sensory dysfunction.Sensory dysfunction was measured both by global sensory impairment (a validated measure of dysfunction shared among the 5 classic senses: olfaction, vision, taste, touch, hearing) and by total sensory burden (cumulative sensory loss). Sexual activity was quantified by frequency and type of sexual behavior. Sexual motivation was measured by the frequency of sexual ideation (...) Sensory Dysfunction and Sexuality in the U.S. Population of Older Adults. The sexual experience is shaped by sensory function; with aging, sensory dysfunction may interfere with sexuality and sexual behavior between partners. Specifically, older adults with age-related sensory dysfunction may have less sexual activity than those with better sensory function. In addition, since sexual desire and attraction rests in part upon sensory function, sensory dysfunction may also be associated with less

2018 Journal Of Sexual Medicine

19. Gustatory Dysfunction Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy

at supra-threshold among these patients using a psychophysical method through a scoring system. - Identify possible modulators for developing gustatory dysfunction among these patients using a questionnaire ( appendix) with a binary measuring unit (yes/no). Condition or disease Taste Disorders Detailed Description: PECO P Population: depressed Egyptian adults under anti-depressants therapy E1 Exposure 1: commonly prescribed tricyclic antidepressants (Imipramine, Amitriptyline, Clomipramine HCL) E2 (...) intensity at supra-threshold level on a 9 point vertical labeled scale (extremely strong, very strong, strong, slightly strong, neutral, slightly weak, weak , very weak, extremely weak) in which subjects indicate the intensity perceived when tasting a substance Gustatory dysfunction modulators [ Time Frame: during anticipated period of 6 months from January 2019 till June 2019 ] -C.M will use an assessment questionnaire (appendix) to assess possible modulators for developing gustatory dysfunction

2018 Clinical Trials

20. Etiology of subjective taste loss. (Abstract)

Etiology of subjective taste loss. Taste complaints are commonly encountered in clinical practice. Although changes in taste function may arise from varied etiologies, numerous other factors may impact patients' taste perceptions, the most common of which is olfactory dysfunction. Thus, patients with taste complaints may or may not have measurable deficits in taste function. This poses a challenge to providers faced with evaluation of patients with taste disorders, and may delay diagnosis (...) and management.We retrospectively examined records of 1108 patients evaluated at the Virginia Commonwealth University Health System Smell and Taste Clinic and compared patients' subjective taste complaints with results of objective testing of the senses of taste and smell.A total of 358 patients had a subjective taste complaint and results from both gustatory and olfactory function tests. Patients were grouped by subjective complaint as "taste only" (n = 63) or "taste and smell" (n = 295). Of patients reporting

2018 International forum of allergy & rhinology

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