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Tall Stature

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1. Effect of Adjusting for Tanner Stage Age on Prevalence of Short and Tall Stature of Youths in the United States. (Abstract)

Effect of Adjusting for Tanner Stage Age on Prevalence of Short and Tall Stature of Youths in the United States. To evaluate the extent to which pubertal timing alters the classification of extremes of attained stature across race-ethnicity groups of youths in the US.We performed analyses of height and Tanner staging data of 3206 cross-sectional national sample of youths ages 8-18 years (53% male, n = 1606), 72% of whom were non-Hispanic white, 9% Mexican American, and 19% non-Hispanic black (...) %) with a similar pattern in female youths. In both sexes, this pattern was eliminated with TSAHAZ, with Mexican American youth becoming statistically not different from their non-Hispanic white and non-Hispanic black peers.Differences in timing of puberty between race-ethnicity groups affects estimated prevalence of shortness and tallness of attained height that remains uncaptured with CAHAZ. Adjustment for pubertal development might help isolate crucial determinants of attained stature and other aspects

2018 Journal of Pediatrics

2. "A child may be tall but also stunted." Conceptualization of and meanings attached to childhood height and short stature in rural Tanzania. Full Text available with Trip Pro

"A child may be tall but also stunted." Conceptualization of and meanings attached to childhood height and short stature in rural Tanzania. Stunting affects large numbers of under-fives in Tanzania. But do caretakers of under-fives recognize height as a marker of child growth? What meanings do they attach to linear growth? An ethnographic study using cultural schemas theory was conducted in a rural community in Southeastern Tanzania to investigate caregivers' conceptualizations of child height (...) , and frequent illness. Culturally, a child could be tall but also stunted. Traditional rather than biomedical care was used to remedy growth problems in children. Public health programmers should seek to understand the local knowledge and schemas of child stature employed by people in their own context before designing and implementing interventions.© 2018 The Authors. Maternal and Child Nutrition Published by John Wiley & Sons, Ltd.

2018 Maternal & child nutrition

3. Balanced Reciprocal Translocation t(X;1) in a Girl with Tall Stature and Primary Amenorrhea Full Text available with Trip Pro

Balanced Reciprocal Translocation t(X;1) in a Girl with Tall Stature and Primary Amenorrhea Chromosomal translocations constitute one of the most important, yet uncommon, causes of primary amenorrhea and gonadal dysgenesis. Although X-autosome translocations are frequently associated with streak gonads and clinical features of the Turner syndrome, the majority of X-autosome carriers may present with a variable phenotype, developmental delay, and recognizable X-linked syndrome due to nonrandom X (...) -inactivation. In this article, we describe a healthy 15.5-year-old girl with primary amenorrhea, gonadal dysgenesis, and tall stature without other manifestations of the Turner syndrome. Relevant clinical, biochemical, endocrinological, and cytogenetical evaluations were performed. Initial investigations revealed hypergonadotropic hypogonadism (FSH=134 mIU/mL [normal=10-15 mIU/mL], LH=47.5 [normal=10-15 mIU/mL], and estradiol=24.3 pmol/L). On ultrasound examination of the pelvis, streak ovaries

2017 Iranian journal of medical sciences

4. Tall stature: a difficult diagnosis? Full Text available with Trip Pro

Tall stature: a difficult diagnosis? Referral for an assessment of tall stature is less common than for short stature. Tall stature is defined as a height more than two standard deviations above the mean for age. The majority of subjects with tall stature show a familial tall stature or a constitutional advance of growth (CAG), which is a diagnosis of exclusion. After a careful physical evaluation, tall subjects may be divided into two groups: tall subjects with normal appearance and tall (...) subjects with abnormal appearance. In the case of normal appearance, the paediatric endocrinologist will have to evaluate the growth rate. If it is normal for age and sex, the subject may be classified as having familial tall stature, CAG or obese subject, while if the growth rate is increased it is essential to evaluate pubertal status and thyroid status. Tall subjects with abnormal appearance and dysmorphisms can be classified into those with proportionate and disproportionate syndromes.A careful

2017 Italian journal of pediatrics

5. Tall Stature Women Fetal Weight Estimation

Tall Stature Women Fetal Weight Estimation Tall Stature Women Fetal Weight Estimation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Tall Stature Women Fetal Weight Estimation (TSFW) The safety (...) Daykan, Meir Medical Center Study Details Study Description Go to Brief Summary: To investigate the difference of clinical VS sonographic fetal weight estimation of tall women stature (above 10t percentile) Condition or disease Intervention/treatment Ultrasonography, Prenatal Diagnostic Test: Fetal wight estimation Detailed Description: Women undergoing delivery after week 39 will be estimated of their fetal wight with clinical estimation and then sonographic estimation. each women will be case

2017 Clinical Trials

6. MANAGEMENT OF ENDOCRINE DISEASE: Diagnostic and therapeutic approach of tall stature. Full Text available with Trip Pro

MANAGEMENT OF ENDOCRINE DISEASE: Diagnostic and therapeutic approach of tall stature. Tall stature is defined as a height of more than 2 standard deviations (s.d.) above average for same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal disorders leading to abnormal growth are excluded. However, the majority of these patients have familial tall stature or constitutional advance of growth (generally associated with obesity), both of which are diagnoses (...) of exclusion. It is necessary to have familiarity with a large number of rarer overgrowth syndromes, especially because some of them may have severe complications such as aortic aneurysm, thromboembolism and tumor predisposition and demand-specific follow-up approaches. Additionally, endocrine disorders associated with tall stature have specific treatments and for this reason their recognition is mandatory. With this review, we intend to provide an up-to-date summary of the genetic conditions associated

2017 European Journal of Endocrinology

7. Tall Stature

Tall Stature Tall Stature Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tall Stature Tall Stature Aka: Tall Stature From Related (...) Chapters II. Differential Diagnosis Normal variants Constitutional Tall Stature Familial Tall Stature Endocrine disorders excess (GH secreting tumors, pituitary , or or ) (Untreated, pubertal) ( ) tic disorders - disproportionate overgrowth Beckwith-Wiedemann Syndrome tic disorders - proportionate overgrowth (Sotos Syndrome) Weaver Syndrome III. Evaluation Assess parental heights See See IV. Labs: Specific (IGF-1) - consult local endocrinology ( ) Amino acid screen ( ) Karyotype ( , XXY in males

2018 FP Notebook

8. Evaluation and phenotypic characteristics of 293 Danish girls with tall stature: effects of oral administration of natural 17β-estradiol. Full Text available with Trip Pro

Evaluation and phenotypic characteristics of 293 Danish girls with tall stature: effects of oral administration of natural 17β-estradiol. Reduction of adult height by sex steroid treatment was introduced decades ago in tall statured children, but controlled trials are lacking and treatment is controversial. In this study, we wanted to evaluate the phenotypic characteristics in girls referred due to tall stature and the effect of oral administration of 17β-estradiol on predicted adult height (...) in girls.A single-centre retrospective observational study of 304 girls evaluated consecutively due to tall stature between 1993 and 2013. 207 patients diagnosed with constitutionally tall stature (CTS), 60 (29%) girls ended up being treated with 17β-estradiol with a duration of 1.7 y (1.2; 2.5) (median (25; 75 percentile)), and final height was available in 26 girls.At baseline, 20% of girls with CTS had supranormal IGF-I, whereas reproductive hormones were within the normal range. Final adult height

2016 Pediatric Research

9. Melanocortin-4 Receptor Deficiency Phenotype with an Interstitial 18q Deletion: A Case Report of Severe Childhood Obesity and Tall Stature Full Text available with Trip Pro

Melanocortin-4 Receptor Deficiency Phenotype with an Interstitial 18q Deletion: A Case Report of Severe Childhood Obesity and Tall Stature Childhood obesity is a growing health concern, associated with significant physical and psychological morbidity. Childhood obesity is known to have a strong genetic component, with mutations in the melanocortin-4 receptor (MC4R) gene being the most common monogenetic cause of obesity. Over 166 different MC4R mutations have been identified in persons (...) with hyperphagia, severe childhood obesity, and increased linear growth. However, it is unclear whether the MC4-R deficiency phenotype is due to haploinsufficiency or dominant-negative effects by the mutant receptor. We report the case of a four-and-a-half-year-old boy with an interstitial deletion involving the long arm of chromosome 18 (46,XY,del(18)(q21.32q22.1)) encompassing the MC4R gene. This patient presented with tall stature and hyperphagia within his first 18 months of life leading to significant

2016 Case reports in pediatrics

10. Potential Misclassification of Blood Pressure Status in Children and Adolescents With Short or Tall Stature. Full Text available with Trip Pro

Potential Misclassification of Blood Pressure Status in Children and Adolescents With Short or Tall Stature. Blood pressure (BP) is measured in percentiles that are adjusted for sex, age, and height percentile in children and adolescents. Standard tables for the conversion of BP percentiles do not present exact BP percentile cutoffs for extremes in stature, either short (<5th percentile) or tall (>95th percentile). An algorithm can be used to calculate exact BP percentiles across a range (...) of height z scores. We compared values from standard BP tables with exact calculations of BP percentiles to see which were better at identifying hypertension in more than 5,000 children with either short or tall stature. Study subjects were 3-17-year-old patients within HealthPartners Medical Group, an integrated health care delivery system in Minnesota, at any time between 2007 and 2012. Approximately half of the subjects who met the criteria for hypertension using exact calculation would

2015 American Journal of Epidemiology

11. Diagnostic Work-up and Follow-up in Children with Tall Stature: A Simplified Algorithm for Clinical Practice Full Text available with Trip Pro

Diagnostic Work-up and Follow-up in Children with Tall Stature: A Simplified Algorithm for Clinical Practice No evidence-based guideline has been published about optimal referral criteria and diagnostic work-up for tall stature in children. The aim of our study was to describe auxological and clinical characteristics of a cohort of children referred for tall stature, to identify potential candidates for adult height reduction, and to use these observations for developing a simple algorithm (...) for diagnostic work-up and follow-up in clinical practice.Data regarding family and medical history, auxological measurements, bone age development, physical examination, additional diagnostic work-up, and final diagnosis were collected from all children referred for tall stature, irrespective of their actual height standard deviation score (HSDS). Predicted adult height (PAH) was calculated in children above 10 years. Characteristics of patients with an indication for adult height reduction were

2015 Journal of clinical research in pediatric endocrinology

12. Short and tall stature: a new paradigm emerges. Full Text available with Trip Pro

Short and tall stature: a new paradigm emerges. In the past, the growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis was often considered to be the main system that regulated childhood growth and, therefore, determined short stature and tall stature. However, findings have now revealed that the GH-IGF-1 axis is just one of many regulatory systems that control chondrogenesis in the growth plate, which is the biological process that drives height gain. Consequently, normal growth (...) in children depends not only on GH and IGF-1 but also on multiple hormones, paracrine factors, extracellular matrix molecules and intracellular proteins that regulate the activity of growth plate chondrocytes. Mutations in the genes that encode many of these local proteins cause short stature or tall stature. Similarly, genome-wide association studies have revealed that the normal variation in height seems to be largely due to genes outside the GH-IGF-1 axis that affect growth at the growth plate through

2015 Nature reviews. Endocrinology

13. Evaluation and Treatment of Tall Statured Girls

Evaluation and Treatment of Tall Statured Girls Evaluation and Treatment of Tall Statured Girls - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation and Treatment of Tall Statured Girls (TallgirlsDK (...) provided by (Responsible Party): Anders Juul, Rigshospitalet, Denmark Study Details Study Description Go to Brief Summary: Objective To evaluate the phenotypic characteristics and diagnoses in a large cohort of 304 consecutive girls referred due to tall stature. Furthermore, to evaluate the effect of oral administration of 17β-estradiol on predicted adult height in constitutionally tall statured girls. Design A single-centre retrospective observational study of 304 girls evaluated due to tall stature

2015 Clinical Trials

14. Characterization of an Activating R1353H Insulin-like Growth Factor 1 Receptor Variant in a Male with Extreme Tall Height. Full Text available with Trip Pro

Characterization of an Activating R1353H Insulin-like Growth Factor 1 Receptor Variant in a Male with Extreme Tall Height. The insulin-like growth factor1 receptor (IGF1R) is important in growth and development, and inactivating IGF1R mutations cause short stature and relatively high levels of serum IGF-I. We identified an unclassified IGF1RR1353H variant in a male with extreme tall height, very low levels of serum IGF-I and delayed and prolonged growth spurt. The index case's mother and three (...) sons all carried the variant, but so far only the eldest son (age 18 years) presented with tall height. We hypothesized that the variant could constitute an activating mutation.The IGF1RR1353H variant was investigated in Igf1r-/- mouse embryonic fibroblasts (R-cells) by cell cycle, colony formation and transcriptome analyses.The IGF1RR1353H (R-1353) exhibited significantly increased cell proliferation, G1-S progression and colony formation in soft agar. RNA sequencing identified 195 differentially

2018 European Journal of Endocrinology

15. Investigation and management of tall stature. Full Text available with Trip Pro

Investigation and management of tall stature. Referral for an assessment of tall stature is much less common than for short stature. Although the commonest cause is an underlying familial tendency to tallness, there are important disorders that should be considered at the initial assessment. Distinguishing these conditions from normal variations of growth is the key objective when managing the child and family. In some children, further targeted investigations will be needed and in rare (...) instances intervention to limit final height may be appropriate. This article discusses a structured approach to the assessment and management of a child with tall stature. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

2014 Archives of Disease in Childhood

16. A High-Throughput, Field-Based Phenotyping Technology for Tall Biomass Crops Full Text available with Trip Pro

A High-Throughput, Field-Based Phenotyping Technology for Tall Biomass Crops Recent advances in omics technologies have not been accompanied by equally efficient, cost-effective, and accurate phenotyping methods required to dissect the genetic architecture of complex traits. Even though high-throughput phenotyping platforms have been developed for controlled environments, field-based aerial and ground technologies have only been designed and deployed for short-stature crops. Therefore, we (...) developed and tested Phenobot 1.0, an auto-steered and self-propelled field-based high-throughput phenotyping platform for tall dense canopy crops, such as sorghum (Sorghum bicolor). Phenobot 1.0 was equipped with laterally positioned and vertically stacked stereo RGB cameras. Images collected from 307 diverse sorghum lines were reconstructed in 3D for feature extraction. User interfaces were developed, and multiple algorithms were evaluated for their accuracy in estimating plant height and stem

2017 Plant physiology

17. Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect? Full Text available with Trip Pro

, slow postnatal growth, short stature, hypotonia, developmental delay, and neuroblastoma diagnosed at the age of 8 mo. Her father had tall stature, dysmorphic facial features, and intellectual disability consistent with Weaver syndrome, whereas her mother had short stature, cognitive delays, and chronic nonprogressive leukocytosis. It has been previously shown that EZH2 directly controls DNA methylation through physical association with DNMTs, including DNMT3A, with concomitant H3K27 methylation (...) Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect? Overgrowth syndromes are a clinically heterogeneous group of disorders characterized by localized or generalized tissue overgrowth and varying degrees of developmental and intellectual disability. An expanding list of genes associated with overgrowth syndromes

2018 Cold Spring Harbor Molecular Case Studies

18. An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities. Full Text available with Trip Pro

An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities. C-type natriuretic peptide (CNP)/natriuretic peptide receptor 2 (NPR2) signaling is essential for long bone growth. Enhanced CNP production caused by chromosomal translocations results in tall stature, a Marfanoid phenotype, and skeletal abnormalities. A similar phenotype was described in a family with an activating NPR2 mutation within (...) and mutant NPR2 can form stable heterodimers, suggesting a dominant-positive effect. In accordance with augmented endogenous receptor activity, plasma N-terminal pro-CNP (a marker of CNP production in tissues) was reduced in the proband.We report the first activating mutation within the kinase homology domain of NPR2, resulting in extremely tall stature. Our observations emphasize the important role of this domain in the regulation of guanylyl cyclase activity and bone growth in response to CNP.

2013 Journal of Clinical Endocrinology and Metabolism

19. Tall Stature

Tall Stature Tall Stature Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Tall Stature Tall Stature Aka: Tall Stature From Related (...) Chapters II. Differential Diagnosis Normal variants Constitutional Tall Stature Familial Tall Stature Endocrine disorders excess (GH secreting tumors, pituitary , or or ) (Untreated, pubertal) ( ) tic disorders - disproportionate overgrowth Beckwith-Wiedemann Syndrome tic disorders - proportionate overgrowth (Sotos Syndrome) Weaver Syndrome III. Evaluation Assess parental heights See See IV. Labs: Specific (IGF-1) - consult local endocrinology ( ) Amino acid screen ( ) Karyotype ( , XXY in males

2015 FP Notebook

20. A FAMILY TENDENCY TO TALLNESS OF STATURE, OBESITY, AND DIABETES Full Text available with Trip Pro

A FAMILY TENDENCY TO TALLNESS OF STATURE, OBESITY, AND DIABETES 20775858 2011 03 31 2011 03 31 0007-1447 2 3647 1930 Nov 29 British medical journal Br Med J A FAMILY TENDENCY TO TALLNESS OF STATURE, OBESITY, AND DIABETES. 904-5 Allison R S RS eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1930 11 29 0 0 1930 11 29 0 1 ppublish 20775858 PMC2451821

1930 British medical journal

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