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Systemic Lupus Erythematosus

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181. Development and Validation of a microRNA Panel to Differentiate between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls. (Abstract)

Development and Validation of a microRNA Panel to Differentiate between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls. MicroRNAs (miRNAs) are short non-coding RNAs that regulate genes and are both biomarkers and mediators of disease. We used small RNA (sRNA) sequencing and machine learning methodology to develop a miRNA panel to reliably differentiate between rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and control subjects.Plasma samples

2019 Journal of Rheumatology

182. Association of Childhood Abuse with Incident Systemic Lupus Erythematosus in Adulthood in a Longitudinal Cohort of Women. (Abstract)

Association of Childhood Abuse with Incident Systemic Lupus Erythematosus in Adulthood in a Longitudinal Cohort of Women. Exposure to severe stressors may alter immune function and augment inflammation and cytokine release, increasing autoimmune disease risk. We examined if childhood abuse was associated with heightened risk of incident systemic lupus erythematosus (SLE).Data were from the Nurses' Health Study II, a cohort of U.S. female nurses enrolled in 1989, followed with biennial

2019 Journal of Rheumatology

183. Blood Pressure Variability and Age-related Blood Pressure Patterns in Systemic Lupus Erythematosus. (Abstract)

Blood Pressure Variability and Age-related Blood Pressure Patterns in Systemic Lupus Erythematosus. Despite the high prevalence of cardiovascular disease among patients with systemic lupus erythematosus, the relationship between age, blood pressure, and blood pressure variability (BPV) is not well understood. We studied visit-to-visit BPV, its relationship to age, clinical, demographic characteristics and its potential role as a cardiovascular risk factor in patients with SLE.We analyzed (...) characteristics, and subsequent cardiovascular events.The mean systolic blood pressure (SBP) in SLE increased with age and was significantly higher in younger patients compared to the general population. BPV in systemic lupus was elevated across all age. BPV was significantly higher in African Americans, in patients with traditional cardiovascular risk factors, those with high disease activity, and in patients taking prednisone. Hydroxychloroquine was associated with significantly lower BPV. Within-person

2019 Journal of Rheumatology

184. Longitudinal disease- and steroid-related damage among adults with childhood-onset systemic lupus erythematosus. (Abstract)

Longitudinal disease- and steroid-related damage among adults with childhood-onset systemic lupus erythematosus. Determine whether adults with childhood-onset systemic lupus erythematosus (cSLE) are at increased risk for disease- and steroid-related damage as compared to individuals with adult-onset SLE (aSLE), and whether they continue to accumulate disease damage in adulthood.Data derive from the 2007-2015 cycles of the Lupus Outcomes Study, a longitudinal cohort of adults with confirmed SLE (...) . The Brief Index of Lupus Damage (BILD), a validated, patient-reported measure, was used to assess SLE-associated damage. Participants with baseline BILD were included (N = 1035). Diagnosis at age < 18 years was defined as cSLE (N = 113). Outcome variables included BILD score at baseline and follow-up, clinically significant change in BILD score over follow-up period, and presence of steroid-related damage (cataracts, osteoporosis-related fracture, avascular necrosis or diabetes mellitus).Mean time

2019 Seminars in arthritis and rheumatism

185. Can we validate a clinical score to predict the risk of severe infection in patients with systemic lupus erythematosus? A longitudinal retrospective study in a British Cohort. Full Text available with Trip Pro

Can we validate a clinical score to predict the risk of severe infection in patients with systemic lupus erythematosus? A longitudinal retrospective study in a British Cohort. Severe infections are a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Our primary objective was to use data from a large Spanish cohort to develop a risk score for severe infection in SLE, the SLE Severe Infection Score (SLESIS) and to validate SLESIS in a separate cohort

2019 BMJ open

186. Phase III, multicentre, randomised, double-blind, placebo-controlled, 104-week study of subcutaneous belimumab administered in combination with rituximab in adults with systemic lupus erythematosus (SLE): BLISS-BELIEVE study protocol. Full Text available with Trip Pro

Phase III, multicentre, randomised, double-blind, placebo-controlled, 104-week study of subcutaneous belimumab administered in combination with rituximab in adults with systemic lupus erythematosus (SLE): BLISS-BELIEVE study protocol. Belimumab, an anti-B-lymphocyte-stimulator antibody, is approved for the treatment of active, autoantibody-positive systemic lupus erythematosus (SLE). Rituximab, a B cell-depleting anti-CD20 antibody, remains in the SLE treatment armamentarium despite failed (...) trials in lupus nephritis and extrarenal lupus. These biologics, which operate through complementary mechanisms, might result in an enhanced depletion of circulating and tissue-resident autoreactive B lymphocytes when administered together. Thus, belimumab and rituximab combination may be a highly effective treatment of SLE. This study aims to evaluate and compare the efficacy, safety and tolerability of subcutaneous (SC) belimumab and a single cycle of rituximab in patients with SLE with belimumab

2019 BMJ open Controlled trial quality: predicted high

187. Seborrheic area involvement in patients with systemic lupus erythematosus. (Abstract)

Seborrheic area involvement in patients with systemic lupus erythematosus. The most characteristic skin manifestation of systemic lupus erythematosus (LE) is malar rash characterized by an erythematous congestive sometimes secondarily squamous eruption over the cheeks and nasal bridge, that typically spares nasolabial folds. This rash is referred to as "acute cutaneous lupus erythematosus" (ACLE) (1). Recently, 2 SLE patients with remarkable skin involvement of seborrheic area (SA) came to our

2019 Journal of the European Academy of Dermatology and Venereology

188. Urinary podocyte microparticles are associated with disease activity and renal injury in systemic lupus erythematosus. Full Text available with Trip Pro

Urinary podocyte microparticles are associated with disease activity and renal injury in systemic lupus erythematosus. New non-invasive biomarkers are demanded to identify renal damage in various autoimmune-associated kidney diseases. Glomerular podocyte damage mediated by systemic lupus erythematosus (SLE) plays an important role in the pathogenesis and progression of lupus nephritis (LN). This study evaluated whether the podocyte-derived microparticles (MPs) were novel biomarkers of clinical

2019 BMC Nephrology

189. Risk of joint replacement surgery in Taiwanese female adults with systemic lupus erythematosus: a population-based cohort study. Full Text available with Trip Pro

Risk of joint replacement surgery in Taiwanese female adults with systemic lupus erythematosus: a population-based cohort study. Female patients with systemic lupus erythematosus (SLE) are prone to have musculoskeletal system involvement, which could lead to joint damage. However, few studies have assessed the incidence of arthroplasty in female patients with SLE. The aim of this study was to investigate the risk of total hip replacement surgery and total knee replacement surgery in patients

2019 BMC Musculoskeletal Disorders

190. Aorta coarctation and systemic lupus erythematosus: A case report. Full Text available with Trip Pro

Aorta coarctation and systemic lupus erythematosus: A case report. Vasculitis is one of the common pathological hallmarks of systemic lupus erythematosus (SLE). Vascular lesions in SLE commonly involve medium- and small-sized vessels. Rarely, vasculitis in SLE may involve large vessels such as the aorta leading to life-threatening complications. Reported cases of large vessel lesions in SLE included aortic aneurysm and aortic dissection.Here, we report a 52-year-old Chinese woman with SLE, who (...) was stable on oral glucocorticoid, but showed sudden intractable hypertension and heavy proteinuria before we found aorta coarctation in her computed tomography (CT) scan of the aorta.This patient's large vascular lesions were likely secondary and not a primary manifestation of lupus activity.After endovascular stent graft repair of the abdominal aorta, her hypertension and proteinuria were controlled.In the context of reported cases of large vessel lesions in SLE, our case further supports

2019 Medicine

191. The risk of end-stage renal disease in systemic lupus erythematosus: A nationwide population-based study in Korea. Full Text available with Trip Pro

The risk of end-stage renal disease in systemic lupus erythematosus: A nationwide population-based study in Korea. Systemic lupus erythematosus (SLE) is known to be one of the leading causes of end-stage renal disease (ESRD). The aim of this study was to estimate the incidence rate of ESRD and the risk for progression to ESRD in SLE patients compared to the general population.A total of 21,253 SLE patients were extracted from the Korean National Health Insurance Service database between 2008

2019 Medicine

192. Association between lymphocyte subsets and cytomegalovirus infection status among patients with systemic lupus erythematosus: A pilot study. Full Text available with Trip Pro

Association between lymphocyte subsets and cytomegalovirus infection status among patients with systemic lupus erythematosus: A pilot study. This study aimed to determine the association between different lymphocyte subsets and cytomegalovirus (CMV) infection status in patients with systemic lupus erythematosus (SLE). We performed a retrospective study among SLE patients with CMV infection and collected patient socio-demographic and clinical characteristics, as well as their recorded

2019 Medicine

193. The diagnostic values of C-reactive protein and procalcitonin in identifying systemic lupus erythematosus infection and disease activity. Full Text available with Trip Pro

The diagnostic values of C-reactive protein and procalcitonin in identifying systemic lupus erythematosus infection and disease activity. To explore the values of C-reactive protein (CRP) and procalcitonin (PCT) in identifying infection and disease activity in systemic lupus erythematosus (SLE) patients.Patients with SLE and infection from April 2015 to January 2018 were included in this study. We compared the clinical characteristics and biomarkers between different groups and calculated

2019 Medicine

194. Multifocal head and neck amyloidosis as a diagnostic clue of systemic lupus erythematosus (SLE): A case report. Full Text available with Trip Pro

Multifocal head and neck amyloidosis as a diagnostic clue of systemic lupus erythematosus (SLE): A case report. Amyloidosis accounts for 2% of head and neck tumors. Amyloidosis that develops in the head and neck region is localized amyloidosis. Multifocal amyloidosis in the head and neck region is extremely rare.The patient presented to the clinic of otolaryngology with nasal obstruction, anosmia and left neck mass for several months.A left nasopharynx tumor was revealed under nasopharyngeal (...) scope. Eosinophilic, proteinaceous material was revealed under a pathology scope in the nasopharynx tissue and neck tumor. Congo red staining demonstrated pale congophilic amorphous material with apple-green birefringence under cross-polarized light, and multifocal amyloidosis was diagnosed. Amyloidosis secondary to systemic lupus erythematosus (SLE) was confirmed after a series of investigations.The patient underwent local excision for multifocal amyloidosis without following management. To control

2019 Medicine

195. Heart failure risk in systemic lupus erythematosus compared to diabetes mellitus and general medicaid patients. (Abstract)

Heart failure risk in systemic lupus erythematosus compared to diabetes mellitus and general medicaid patients. Patients with systemic lupus erythematosus (SLE) have a similar risk of myocardial infarction as those with diabetes mellitus (DM). Whether the risk of heart failure (HF) in SLE is similar to the elevated risk in DM is unknown. We sought to estimate the rates and risks for HF hospitalization among US Medicaid patients with SLE and to compare them to those for DM and the general

2019 Seminars in arthritis and rheumatism

196. Socioeconomic status at diagnosis influences the incremental direct medical costs of systemic lupus erythematosus: A longitudinal population-based study. Full Text available with Trip Pro

Socioeconomic status at diagnosis influences the incremental direct medical costs of systemic lupus erythematosus: A longitudinal population-based study. To assess the incremental direct medical costs of a population-based cohort of incident systemic lupus erythematosus (SLE) for the first five years after diagnosis, and impact of socioeconomic status (SES) on such incremental costs.From the administrative health databases in British Columbia, Canada, we identified all adults with newly

2019 Seminars in arthritis and rheumatism

197. Risk factors for progression of carotid intima-media thickness in patients with systemic lupus erythematosus: protocol for an observational cohort study in China. Full Text available with Trip Pro

Risk factors for progression of carotid intima-media thickness in patients with systemic lupus erythematosus: protocol for an observational cohort study in China. Accelerated atherosclerosis is a major complication of systemic lupus erythematosus (SLE), and it leads to increased cardiovascular morbidity and mortality in patients with SLE. This study aimed to investigate the natural progression of carotid intima-media thickness (CIMT), and to examine the risk factors for progression of CIMT

2019 BMJ open

198. Systemic Lupus Erythematosus and dysbiosis in the microbiome: cause or effect or both? (Abstract)

Systemic Lupus Erythematosus and dysbiosis in the microbiome: cause or effect or both? Throughout our lives we are immersed in, and colonized by, immense and complex microbial communities. These microbiota serve as activators and early sparring partners for the progressive construction of the layers within our immune defenses and are essential to immune homeostasis. Yet, at times imbalances within the microbiota may contribute to metabolic and immune regulatory abnormalities that underlie (...) the development of inflammatory and autoimmune diseases. Here, we review recent progress in investigations of the microbiome, with emphasis on the gut microbiota associated with systemic autoimmunity. In particular, these studies are beginning to illuminate aspects of the pathogenesis of Systemic Lupus Erythematosus, and may suggest that interconnections with specific disease-associated patterns of dysbiosis within gut communities are bidirectional and mutually reinforcing.Copyright © 2019 Elsevier Ltd. All

2019 Current opinion in immunology

199. Systemic lupus erythematosus and hypertension. (Abstract)

Systemic lupus erythematosus and hypertension. Systemic lupus erythematosus (SLE) is associated with a high burden of cardiovascular disease (CVD), which is in part imputed to classical vascular risk factors such as hypertension. Hypertension is frequent among patients with SLE and studies show it is more prevalent in SLE patients than in people without SLE. Despite the high frequency of hypertension in SLE patients, the pathophysiological mechanisms underlying the development of hypertension

2019 Autoimmunity reviews

200. Association of GTF2I gene polymorphisms with renal involvement of systemic lupus erythematosus in a Chinese population. Full Text available with Trip Pro

Association of GTF2I gene polymorphisms with renal involvement of systemic lupus erythematosus in a Chinese population. The purposes of the study was to validate the relationship between General transcription factor II-I (GTF2I) genetic variants and kidney involvements of systemic lupus erythematosus (SLE) patients in a Chinese Han population.Samples from 400 SLE patients and 400 age- and sex-matched healthy controls were collected and genotyped by improved multiplex ligation detection reaction (...) of rs117026326 had lower 24-hour urinary total protein (24 hours UTP, g/24 hours), 24-hour urinary protein level (g/L·24 hours), lower frequency of the proteinuria and lupus nephritis (LN). Patients carrying genotype TT at rs73366469 had higher 24-hour urinary protein level, higher frequency of the proteinuria, LN and positive anti-dsDNA than those with other genotypes.This study identified the involvement of GTF2I gene polymorphisms in development of SLE, particularly in renal involvement.

2019 Medicine

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