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Syrup of Ipecac

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1. Syrup of Ipecac

Syrup of Ipecac Syrup of Ipecac Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Syrup of Ipecac Syrup of Ipecac Aka: Syrup of Ipecac (...) Adults: 15 to 30 ml Ipecac Child (<12 years): 15 ml Ipecac Infant (6-12 months): 5-10 ml Ipecac VIII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Syrup of Ipecac." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Ipecac (C0022046) Definition (MSH) A syrup made from the dried rhizomes of two different species, CEPHAELIS ipecacuanha

2018 FP Notebook

2. Syrup of Ipecac

Syrup of Ipecac Syrup of Ipecac Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Syrup of Ipecac Syrup of Ipecac Aka: Syrup of Ipecac (...) Adults: 15 to 30 ml Ipecac Child (<12 years): 15 ml Ipecac Infant (6-12 months): 5-10 ml Ipecac VIII. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Syrup of Ipecac." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Ipecac (C0022046) Definition (MSH) A syrup made from the dried rhizomes of two different species, CEPHAELIS ipecacuanha

2015 FP Notebook

3. A comparison of ipecac syrup and apomorphine in the immediate treatment of ingestion of poisons. (PubMed)

A comparison of ipecac syrup and apomorphine in the immediate treatment of ingestion of poisons. 4404603 1973 01 30 2018 07 03 0022-3476 82 1 1973 Jan The Journal of pediatrics J. Pediatr. A comparison of ipecac syrup and apomorphine in the immediate treatment of ingestion of poisons. 121-4 MacLean W C WC Jr eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial United States J Pediatr 0375410 0022-3476 8012-96-2 Ipecac N21FAR7B4S Apomorphine AIM IM Adolescent (...) Apomorphine adverse effects pharmacology therapeutic use Central Nervous System drug effects Child Child, Preschool Humans Infant Ipecac adverse effects pharmacology therapeutic use Poisoning drug therapy Time Factors 1973 1 1 2001 3 28 10 1 1973 1 1 0 0 ppublish 4404603 S0022-3476(73)80029-0

1973 The Journal of pediatrics

4. A clinical comparison of syrup of ipecac and apomorphine use in adults. (PubMed)

A clinical comparison of syrup of ipecac and apomorphine use in adults. A prospective, randomized study was performed to compare syrup of ipecac to apomorphine as the emetic of choice in poisoning cases. Of the 28 adults studied, 15 patients (54%) received 30 ml of ipecac orally and 13 received 0.1 mg/kg apomorphine subcutaneously. Emesis was successfully induced with initial therapy in 13 of 15 (87%) ipecac-treated patients and 10 of 13 (77%) apomorphine-treated patients. In the ipecac group (...) the mean latency period before onset of vomiting was 11.6 minutes (range 4 to 26 min) and in the apomorphine group, 5.3 minutes (range 2 to 13 min) (P less than .01). In the ipecac group, one patient suffered moderate central nervous system (CNS) depression. No hypotension or respiratory depression was observed in this group. In the apomorphine group significant CNS depression developed in eight patients (62%), hypotension developed in five (38%) and respiratory depression in one

1976 JACEP

5. "Syrup of ipecacuanha". (PubMed)

"Syrup of ipecacuanha". 1139 1976 03 15 2018 11 13 0007-1447 4 5997 1975 Dec 13 British medical journal Br Med J "Syrup of ipecacuanha". 647 eng Journal Article England Br Med J 0372673 0007-1447 8012-96-2 Ipecac AIM IM Drug Labeling Ipecac United Kingdom United States 1975 12 13 1975 12 13 0 1 1975 12 13 0 0 ppublish 1139 PMC1675664 Am J Dis Child. 1962 Feb;103:169-73 13865740

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1975 British medical journal

6. First aid interventions by laypeople for acute oral poisoning. (PubMed)

doses (MDAC), alone or in combination with other first aid interventions (a cathartic) and/or hospital treatments. Six studies investigated syrup of ipecac plus other first aid interventions (SDAC + cathartic) versus ipecac alone. The collected evidence was mostly of low to very low certainty, often downgraded for indirectness, risk of bias or imprecision due to low numbers of events.First aid interventions that limit or delay the absorption of the poison in the bodyWe are uncertain about the effect (...) , as all evidence for these outcomes was of very low certainty. No studies assessed SDAC for mortality, duration of symptoms, drug absorption or hospitalization.Only one study compared SDAC to syrup of ipecac in participants with mixed types of poisoning, providing very low-certainty evidence. Therefore we are uncertain about the effects on Glasgow Coma Scale scores (mean difference (MD) -0.15, 95% CI -0.43 to 0.13, 1 study, 34 participants) or incidence of adverse events (risk ratio (RR) 1.24, 95% CI

2018 Cochrane

7. Tide Pod Challenge: Managing caustic laundry pod ingestions

the patient’s ABCs. Emergency airway management may be required, due to altered mental status, vomiting, and oropharyngeal swelling. The first choice for management is oral intubation with direct visualization. Blind nasotracheal intubation is contraindicated ; LMAs, combination tubes with pharyngeal or tracheal balloons, retrograde intubation and bougies can increase tissue damage or cause perforation, and should be avoided. 3 Activated charcoal and ipecac syrup are contraindicated in caustic agents alone

2018 CandiEM

8. CRACKCast E147 – General Approach to the Poisoned Patient

-hypnotic, and opioid categories. Qualitative urine drug levels are inferior to quantitative serum levels in terms of guiding specific therapy. Syrup of ipecac is not indicated in the ED care of a poisoned patient. Gastric lavage is not part of routine care. When given in a timely fashion (1 hour post ingestion), activated charcoal may be indicated for potentially lethal agents in alert, cooperative patients. Whole-bowel irrigation is rarely useful for management of poisoned patients but is potentially

2018 CandiEM

11. The Trans Golgi Region is a Labile Intracellular Ca2+ Store Sensitive to Emetine (PubMed)

a detectable transient increase in cytosolic Ca2+. Our data indicates that the emetine-sensitive Ca2+ mobilizing mechanism is different from the two classical Ca2+ release mechanisms, i.e. IP3 and ryanodine receptors. This newly discovered ability of emetine to release Ca2+ from the GA may explain why chronic consumption of ipecac syrup has muscle side effects.

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2018 Scientific reports

12. Lisdexamfetamine for Adults With Bulimia Nervosa

ingredients in LDX. Subject is pregnant, plans to become pregnant, or is nursing. Subject uses syrup of ipecac to self-induce vomiting. Subject is considered a suicide risk. Subject has a known allergy to amphetamines, or other non-medical ingredients in LDX, or is sensitive to, is allergic to, or has had a reaction to other stimulant medications. Subject has been diagnosed with glaucoma (an eye disease). Subject has been diagnosed with hyperthyroidism (an overactive thyroid gland). Insufficient knowledge

2017 Clinical Trials

13. Home safety education and provision of safety equipment for injury prevention (Review).

), and for those interventions not providing safety equipment (IRR 0.78, 95% CI 0.66 to 0.92). Home safety interventions were effective in increasing the proportion of families with safe hot tap water temperatures (OR 1.41, 95% CI 1.07 to 1.86), functional smoke alarms (OR 1.81, 95% CI 1.30 to 2.52), a fire escape plan (OR 2.01, 95% CI 1.45 to 2.77), storing medicines (OR 1.53, 95% CI 1.27 to 1.84) and cleaning products (OR 1.55, 95% CI 1.22 to 1.96) out of reach, having syrup of ipecac (OR 3.34, 95% CI 1.50

2017 Evidence-based child health : a Cochrane review journal

14. Emergency Management of a Victim who has Been Poisoned

the poisonous substance. How this is done will depend on the type of the poison. Examples are listed below. ? If the poison is SWALLOWED ? Give the person who has swallowed the poison a sip of water to wash out their mouth. ? Do NOT try to make them vomit. Do NOT use Ipecac Syrup. 1;2 [Class A; LOE IV] ? If the poison is INHALED ? Immediately get the person to fresh air, without placing yourself at risk. ? Avoid breathing fumes. Special breathing apparatus may be required, for example, with cyanide

2011 Australian Resuscitation Council

15. Reducing unintentional injuries in children through parenting programmes

-to-face education, especially with the provision of safety equipment (such as smoke alarms), are effective in increasing a range of safety practices. The impact on injury rates was less clear, but there was some evidence that such interventions may reduce injury rates. It’s worth noting that although the review mentions syrup of ipecac, which in the past has been recommended to parents as a medicine to keep at home to cause vomiting following poisoning, this is no longer the case, nor is any means

2013 Evidently Cochrane

16. Reducing unintentional injuries in children through parenting programmes

-to-face education, especially with the provision of safety equipment (such as smoke alarms), are effective in increasing a range of safety practices. The impact on injury rates was less clear, but there was some evidence that such interventions may reduce injury rates. It’s worth noting that although the review mentions syrup of ipecac, which in the past has been recommended to parents as a medicine to keep at home to cause vomiting following poisoning, this is no longer the case, nor is any means

2013 Evidently Cochrane

17. Impact of a working group on gastrointestinal decontamination in Spanish emergency departments. (PubMed)

periods of time in Pediatric Emergency Departments (PEDs) included in the IWG: group A (2001-2002, 17 PED, 2157 episodes), group B (2008-2009, 22 PED, 612 episodes), and group C (2009-2011, 42 PED, 400 episodes). These periods were chosen because the main actions of the IWG were developed in the time in-between them.Of the 3169 episodes included, a gastrointestinal decontamination procedure was performed in 1031. The use of ipecac syrup decreased from 22.8% in group A to 0 in group C

2014 European Journal of Emergency Medicine

18. Toxicity, Iron (Overview)

Toxicol (Phila) . 2018 Dec 21. 55 (10):1-203. . . [Guideline] Höjer J, Troutman WG, Hoppu K, Erdman A, Benson BE, Mégarbane B, et al. Position paper update: ipecac syrup for gastrointestinal decontamination. Clin Toxicol (Phila) . 2013 Mar. 51(3):134-9. . Tenenbein M. Benefits of parenteral deferoxamine for acute iron poisoning. J Toxicol Clin Toxicol . 1996. 34(5):485-9. . Sankar J, Shukla A, Khurana R, Dubey N. Near fatal iron intoxication managed conservatively. BMJ Case Rep . 2013 Jan 31. 2013

2014 eMedicine.com

19. Toxicity, Mushroom (Follow-up)

medications. If patients exhibit excessive bronchial secretions or other symptoms of cholinergic excess (bradycardia) that are of significant concern, atropine may decrease these symptoms. If the patient presents within 1 hour of ingestion, oral administration of activated charcoal may be considered, [ ] but adsorption to activated charcoal has not been demonstrated for these constituents. [ ] No evidence suggests that routine administration of multiple doses of activated charcoal is useful. Ipecac syrup

2014 eMedicine.com

20. Toxicity, Mushroom (Treatment)

medications. If patients exhibit excessive bronchial secretions or other symptoms of cholinergic excess (bradycardia) that are of significant concern, atropine may decrease these symptoms. If the patient presents within 1 hour of ingestion, oral administration of activated charcoal may be considered, [ ] but adsorption to activated charcoal has not been demonstrated for these constituents. [ ] No evidence suggests that routine administration of multiple doses of activated charcoal is useful. Ipecac syrup

2014 eMedicine.com

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