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Syphilis Antibody

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1. Syphilis infection

Syphilis infection Syphilis infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Syphilis infection Last reviewed: February 2019 Last updated: May 2018 Summary A common sexually transmitted infection. Approximately 10 million to 12 million new infections worldwide each year. Caused by the spirochaetal bacterium Treponema pallidum , subspecies pallidum . Clinical presentation is often asymptomatic, but can (...) manifest in a number of ways. Diagnosis is usually straightforward after clinical examination and serological tests. Treatment is with penicillin. Untreated syphilis facilitates HIV transmission and causes considerable morbidity, such as cardiovascular and neurological disease, as well as a congenital syndrome in the newborn. Syphilis in pregnancy is a major cause of miscarriage, stillbirth, and perinatal morbidity and mortality in some parts of the world. Definition Syphilis is a sexually transmitted

2018 BMJ Best Practice

2. Diagnosis and management of gonorrhoea and syphilis

– Evolution of reported cases / 100 000 inhabitants for gonorrhoea, by gender, Belgium, 2002-2016 15 Figure 2 – Evolution of reported cases / 100 000 inhabitants for syphilis, by gender, Belgium, 2002-2016 18 Figure 3 – Evolution of reported cases / 100 000 inhabitants for chlamydia, by gender, Belgium, 2002-2016 20 Figure 4 – Evolution of antimicrobial resistance for gonorrhoea in Belgium – 2013 - 2017 86 Figure 5 – Treponemal infection antibody patterns over time 115 Figure 6 – Traditional algorithm (...) European Centre for Disease Prevention and Control EIA Enzyme immunoassays EMA European Medicines Agency EUCAST European Committee on Antibiotic Susceptibility Testing FDA US Food and Drug Administration FP False positive FN False negative FTA-ABS Fluorescent treponemal antibody absorption test GDG Guideline development group 12 Diagnosis and management of gonorrhoea and syphilis KCE Report 310 GRADE Grading of recommendations assessment, development and evaluation HIV Human Immunodeficiency Virus IM

2019 Belgian Health Care Knowledge Centre

3. Early syphilis: screen and treat to prevent transmission

syphilis (no clinical signs). If untreated, severe late complications occur in 10% to 30% of patients. The disease does not provide lasting immunity, and so reinfection is possible. Confirmation of the syphilis diagnosis is generally based on serology, combining a test for treponemal antibodies, such as the ELISA test, if positive, with an additional non-treponemal serological test, such as the VDRL test. In the absence of known resistance of treponema pallidum (syphilis) to penicillins, the first-line (...) Early syphilis: screen and treat to prevent transmission Prescrire IN ENGLISH - Spotlight ''Early syphilis: screen and treat to prevent transmission'', 1 March 2018 {1} {1} {1} | | > > > Early syphilis: screen and treat to prevent transmission Spotlight Every month, the subjects in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight Early syphilis: screen and treat to prevent transmission

2018 Prescrire

4. Syphilis in pregnancy

Syphilis in pregnancy Maternity and Neonatal C linical G uideline Queensland Health Syphilis in pregnancy Queensland Clinical Guideline: Syphilis in pregnancy Refer to online version, destroy printed copies after use Page 2 of 31 Document title: Syphilis in pregnancy Publication date: December 2018 Document number: MN18.44-V1-R23 Document supplement: The document supplement is integral to and should be read in conjunction with this guideline. Amendments: Full version history is supplied (...) Officer, Queensland Health, GPO Box 48, Brisbane Qld 4001, email ip_officer@health.qld.gov.au, phone (07) 3234 1479. Queensland Clinical Guideline: Syphilis in pregnancy Refer to online version, destroy printed copies after use Page 3 of 31 Flow Chart: Antenatal care IM: intramuscular injection, MSM: Men who have sex with men, PCR: Polymerase Chain Reaction QSSS: Queensland Syphilis Surveillance Service, STI: sexually transmitted infection, 4 weeks before birth · Indicated following risk assessment

2019 Queensland Health

5. Rate of decline in nontreponemal antibody titers and seroreversion after treatment of early syphilis (PubMed)

Rate of decline in nontreponemal antibody titers and seroreversion after treatment of early syphilis Syphilis management is complex and demonstration of treatment response requires monitoring of nontreponemal antibody titers for a ≥ 4-fold decline and/or seroreversion to nonreactive titers.We evaluated data from a multicenter clinical trial of syphilis treatment conducted from 2000 to 2009 involving human immunodeficiency virus (HIV)-negative patients 18 years or older with early syphilis (...) of seroreversion compared with females and titers > 1:32, respectively.Despite a ≥ 4-fold RPR titer decline after treatment, the majority of HIV-negative patients with early syphilis failed to have seroreversion at 12 months. Nontreponemal antibody titers often persist despite an appropriate treatment response.

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2017 Sexually transmitted diseases

6. Public health guidance on antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility in the EU/EEA ? addressing the vulnerable populations

the uptake of antenatal screening in order to: ? decrease the rate of MTCT or reduce the number of MTCT for HIV, HBV and syphilis; and ? increase the number of pregnant women tested for rubella antibodies during pregnancy? Assessing the criteria for initiating or discontinuing antenatal screening programmes was not included in the objectives of this guidance. SCIENTIFIC ADVICE Antenatal screening for HIV, hep B, syphilis and rubella susceptibility in the EU/EEA 3 2 Background Mother-to-child transmission (...) Public health guidance on antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility in the EU/EEA ? addressing the vulnerable populations SCIENTIFIC ADVICE Antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility in the EU/EEA – addressing the vulnerable populations www.ecdc.europa.euECDC SCIENTIFIC ADVICE Antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility in the EU/EEA – addressing the vulnerable populations ii This report

2017 European Centre for Disease Prevention and Control - Public Health Guidance

7. Syphilis Infection in Pregnant Women: Screening

infection is caused by the Treponema pallidum bacteria. Current screening tests for syphilis rely on detection of antibodies to the infection rather than direct detection of the bacteria. Screening for syphilis infection is a 2-step process. Traditionally, screening involved an initial “nontreponemal” antibody test (ie, Venereal Disease Research Laboratory test or rapid plasma reagin [RPR] test) to detect biomarkers released from damage caused by syphilis infection, followed by a confirmatory (...) a different treponemal antibody) is performed. The USPSTF found no studies comparing the false-positive rate of the traditional screening algorithm with that of the reverse sequence screening algorithm among pregnant women. The CDC has provided more detailed guidance on testing for and treatment of sexually transmitted diseases, including syphilis. Treatment In 2015, the CDC recommended parenteral benzathine penicillin G for the treatment of syphilis in pregnant women. Evidence on the efficacy or safety

2018 U.S. Preventive Services Task Force

8. WHO guideline on syphilis screening and treatment for pregnant women

with syphilis do not have any symptoms or have only minor symptoms and do not realize that anything is wrong. Identifying asymptomatic infection, especially among pregnant women, through screening using laboratory tests and treatment of positive cases will prevent further transmission and adverse pregnancy outcomes and congenital syphilis. The available laboratory tests for syphilis include direct detection methods (i.e. dark-field microscopy, direct fluorescent antibody test and nucleic acid amplification (...) testing, although plasma can be used in some non-treponemal serological tests. Cerebrospinal fluid is used to diagnose congenital and tertiary syphilis and when neurological symptoms are present.11 RAPID SYPHILIS TESTS (RSTS) In the past decade, a number of point-of-care rapid syphilis tests (RSTs) for treponemal antibodies in syphilis infection have been developed. RSTs provide treponemal antibody results in 10–15 minutes and can be performed on-site in any setting since they do not require

2017 World Health Organisation Guidelines

9. Antenatal screening approaches effective in preventing MTCT of HIV, HBV, syphilis and rubella in vulnerable populations

not specifically concentrate on this group. The prevalence of HIV, hepatitis B, syphilis and seronegativity for rubella antibodies is often higher in migrant populations than in general populations and migrant women face considerable challenges in accessing healthcare services. 3.2.1 HIV No controlled studies on antenatal screening for HIV among migrant women or ethnic groups were found, however, 21 descriptive studies were included and some excerpts from these appear below. A European review described (...) Antenatal screening approaches effective in preventing MTCT of HIV, HBV, syphilis and rubella in vulnerable populations TECHNICAL REPORT Antenatal screening approaches effective in preventing mother- child-transmission of HIV, hepatitis B, syphilis and rubella in vulnerable populations Literature review www.ecdc.europa.euECDC TECHNICAL REPORT Antenatal screening approaches effective in preventing mother-to-child transmission of HIV, hepatitis B, syphilis and rubella in vulnerable populations

2017 European Centre for Disease Prevention and Control - Literature Reviews

10. Effectiveness and cost-effectiveness of antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility

Effectiveness and cost-effectiveness of antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility TECHNICAL REPORT Effectiveness and cost- effectiveness of antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility Literature review www.ecdc.europa.euECDC TECHNICAL REPORT Effectiveness and cost-effectiveness of antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility Literature review ii This report was commissioned by the European (...) Gomes and Ana-Belen Escriva are acknowledged for internal ECDC support. Suggested citation: European Centre for Disease Prevention and Control. Effectiveness and cost-effectiveness of antenatal screening for HIV, hepatitis B, syphilis and rubella susceptibility. Stockholm: ECDC; 2017. Stockholm, March 2017 ISBN 978-92-9498-035-9 doi: 10.2900/51864 Catalogue number TQ-04-17-185-EN-N © European Centre for Disease Prevention and Control, 2017 Reproduction is authorised, provided the source

2017 European Centre for Disease Prevention and Control - Literature Reviews

11. Syphilis Antibody

Syphilis Antibody Syphilis Antibody Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Syphilis Antibody Syphilis Antibody Aka: Syphilis (...) Antibody , Syphilis Serology , Syphilis Screening , Syphilis False Positive , Syphilis Testing , Syphilis Diagnosis , Treponema test II. Indication ( ) detection Syphilis Screening annually for all Skin lesions or other clinical findings suggestive of Confirmation of positive III. Background Antigen Extracts from beef heart (cardiolipin) Non-specific antibodies bind cardiolipin IV. Labs: Tests for detection of Treponemal Pallidum Antibody Non- l Derived Substance precipitates (false negatives in first

2018 FP Notebook

12. Surveillance of Maternal Syphilis in China: Pregnancy Outcomes and Determinants of Congenital Syphilis (PubMed)

syphilis (1.3% to 0.4%), neonatal deaths (1.3% to 0%), and neonatal asphyxia (0.9% to 0%). Both prevention and treatment interventions increased, including antenatal testing (93.5% to 93.9%), any treatment (76.6% to 85.2%), adequate treatment (51.1% to 65.1%), and treatment initiated in the first trimester (30.7% to 42.8%). In the logistic regression analysis, higher maternal rapid plasma reagin antibody titers (aOR=1.1 95%CI=1.0-1.1) and third-trimester syphilis diagnosis (aOR=1.7 95%CI=1.1-2.6) were (...) Surveillance of Maternal Syphilis in China: Pregnancy Outcomes and Determinants of Congenital Syphilis BACKGROUND We sought to describe the epidemiological characteristics of pregnant women with syphilis in Beijing, China, and to investigate the determinants of adverse pregnancy outcomes, including congenital syphilis. MATERIAL AND METHODS We used data from laboratory-confirmed syphilis-infected women who delivered between 2013 and 2015 and were registered in China's Information Management

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2018 Medical science monitor : international medical journal of experimental and clinical research

13. WHO guidelines for the treatment of Treponema pallidum (syphilis)

) Methodologist: Nancy Santesso. ACKNOWLEDGEMENTSWHO GUIDELINES FOR THE TREATMENT OF TREPONEMA PALLIDUM (SYPHILIS) iv ABBREVIATIONS AND ACRONYMS AIDS acquired immune deficiency syndrome AMR antimicrobial resistance CI confidence interval DFA direct fluorescent antibody DNA deoxyribonucleic acid DOI declaration of interests FTA-ABS fluorescent treponemal antibody absorbed GDG Guideline Development Group GRADE Grading of Recommendations Assessment, Development and Evaluation GUD genital ulcer disease HIV human (...) that measure antibodies to infection (including Treponema pallidum haemagglutination assay [TPHA], Treponema pallidum particle agglutination assay [TPPA], fluorescent treponemal antibody absorbed [FTA-ABS]) and non-treponemal tests that are indirect markers measuring host immune response to infections (including rapid plasma reagin [RPR], Venereal Diseases Research Laboratory [VDRL], Toluidine Red Unheated Serum Test [TRUST]). Rapid treponemal tests for syphilis and dual HIV and syphilis tests are now

2016 World Health Organisation Guidelines

14. Screening for Syphilis Infection in Pregnant Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. (PubMed)

antibody titer) with rapid plasma reagin screening using undiluted samples (2.9%). No studies were identified for harms of penicillin in pregnancy.Screening for syphilis infection in pregnant women is associated with reduced incidence of congenital syphilis, and available evidence supports the need for reflexive testing for positive test results. (...) Screening for Syphilis Infection in Pregnant Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. The incidence of syphilis and congenital syphilis in the United States has increased after reaching historic lows in the early 2000s.To systematically review literature on the effectiveness and harms of screening for syphilis in pregnancy and the harms of penicillin treatment in pregnancy to inform the US Preventive Services Task Force.MEDLINE, PubMed

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2018 JAMA

15. Syphilis: an atypical case of sepsis and multiple anogenital lesions in secondary syphilis (PubMed)

non-tender irregular, healing lesion on the shaft of the penis. Laboratory analysis was significant for leukocytosis and elevated creatinine. Serum screening rapid plasma reagin was positive, and further testing revealed a titer of 1:32, with confirmation via fluorescent treponemal antibody absorption test. The patient was diagnosed with secondary syphilis, which was determined to be the underlying etiology of the sepsis as all other serological evaluations were negative. He was treated (...) Syphilis: an atypical case of sepsis and multiple anogenital lesions in secondary syphilis The incidence of syphilis has historically been cyclical in nature, often in relation to the rise and fall of public health initiatives directed toward eradication along with social attitudes toward sexual practices. The incidence of syphilis has increased by 15% in the last 6 years in the United States, with similar increases worldwide. Herein, we present an atypical case of syphilis presenting

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2016 Journal of community hospital internal medicine perspectives

16. Laboratory evaluation of four HIV/syphilis rapid diagnostic tests. (PubMed)

and so improve the accessibility of syphilis testing and treatment.As part of the World Health Organization pre-qualification of in vitro diagnostics assessment, the laboratory performance of four dual HIV-Syphilis rapid diagnostic tests (SD Bioline HIV/Syphilis Duo, DPP HIV-Syphilis Assay, Multiplo Rapid TP/HIV Antibody Test and Insti Multiplex HIV-1/HIV-2/Syphilis Antibody Test) was assessed using a well characterized multiregional panel of stored sera specimens.In total 400 specimens were tested (...) Laboratory evaluation of four HIV/syphilis rapid diagnostic tests. Sexually transmitted infections, such as HIV and syphilis, are one of the major health care problems worldwide, especially in low- and middle income countries. HIV screening programmes have been widely used for many years. The introduction of rapid point-of-care tests (RDTs) that can detect both HIV and syphilis, using one single blood specimen, would be a promising tool to integrate the detection of syphilis into HIV programmes

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2019 BMC Infectious Diseases

17. Field evaluation of SD BIOLINE HIV/Syphilis Duo assay among pregnant women attending routine antenatal care in Juba, South Sudan. (PubMed)

Field evaluation of SD BIOLINE HIV/Syphilis Duo assay among pregnant women attending routine antenatal care in Juba, South Sudan. The SD BIOLINE HIV/Syphilis Duo assay is the first World Health Organization prequalified dual rapid diagnostic test for simultaneous detection of HIV and Treponema pallidum antibodies in human blood. Prior to introducing the test into antenatal clinics across South Sudan, a field evaluation of its clinical performance in diagnosing both HIV and syphilis in pregnant (...) women was conducted. SD Bioline test performance on venous blood samples was compared with (i) Vironostika HIV1/2 Uniform II Ag/Ab reference standard and Alere Determine HIV 1/2 non-reference standard for HIV diagnosis, and (ii) Treponema pallidum hemagglutination reference standard and Rapid plasma reagin non-reference standard for syphilis. Sensitivity, specificity, positive predictive value (PPN), negative predictive value (NPV) and kappa (κ) value were calculated for each component against

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2018 PLoS ONE

18. Decline in the seroprevalence of syphilis markers among first-time blood donors in Libreville (Gabon) between 2004 and 2016. (PubMed)

by testing a large sample of first-time blood donors in the capital Libreville.The detection of Treponema pallidum was done using a Rapid Plasma Reagin test (RPR) and confirmed by an ELISA test using the Biorad Syphilis Total Antibody EIA II kit or BioMerieux Trepanostika TP recombinant. Assays were performed by dedicated technicians according to manufacturers' recommendations and following the laboratory standard operating procedures. Test results were manually transferred into the laboratory Excel (...) Decline in the seroprevalence of syphilis markers among first-time blood donors in Libreville (Gabon) between 2004 and 2016. Very few studies have been conducted on the seroprevalence of syphilis in Gabon. According to the World Health Organization, the average seroprevalence of syphilis has declined from 5.5 to 1.1% in Central Africa. The aim of this study was to test the hypothesis that syphilis decreased in Gabon between 2004 and 2016 and to identify factors involved in this pattern

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2019 BMC Public Health

19. High prevalence of hepatitis B and syphilis in illegal gold miners in French Guiana. (PubMed)

High prevalence of hepatitis B and syphilis in illegal gold miners in French Guiana. This study aimed to estimate the prevalence of Hepatitis B, D, and C viruses and syphilis in the population of illegal gold miners in French Guiana. The prevalence of HBsAg carriage was high (4.6%, 95%CI= 2.6-6.6) among this hard to reach population as well as the seropositivity for treponemal antibodies (11.5%, 95%CI=8.5-14.6), with higher prevalence in women (p=0,009). This population may represent key

2019 Clinical Microbiology and Infection

20. Systematic review: Penicillin is the drug of choice to treat all stages of syphilis despite a paucity of clinical trials data for the treatment of some stages, pregnant women and HIV-infected people

syphilis infection. 1 In the pre-antibiotic era, people with early syphilis, whose non-treponemal antibody tests failed to revert to negative (ie, remained ‘serofast’), had a worse long-term prognosis. This systematic review examines the evidence supporting penicillin and non-penicillin-based regimens for the treatment of: (1) the different stages of syphilis; (2) pregnant women and (3) HIV-infected people. The … Request Permissions If you wish to reuse any or all of this article please use the link (...) Systematic review: Penicillin is the drug of choice to treat all stages of syphilis despite a paucity of clinical trials data for the treatment of some stages, pregnant women and HIV-infected people Penicillin is the drug of choice to treat all stages of syphilis despite a paucity of clinical trials data for the treatment of some stages, pregnant women and HIV-infected people | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you

2015 Evidence-Based Medicine (Requires free registration)

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