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Sydenham Chorea

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161. Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children

, childhood-onset schizophrenia, dyslexia, obsessive compulsive disorder, Sydenham's chorea, and Tourette's syndrome. Results of the MRIs showing the anatomy of the brain and brain function will be compared across age, sex (gender), and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations. Condition or disease XXY (Klinefelter) Sex Chromosome Variation Sex Chromosome Aneuploidy XXXY XXXXXY XYY (Jacob) XXYY X (XO, Turner) XXX (Trisomy X

1999 Clinical Trials

162. Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)

infections. In this subgroup, periodic exacerbations appear to be triggered by GABHS infections in a manner similar to that of Sydenham's chorea, the neurological variant of rheumatic fever. Rheumatic fever is a disorder with a presumed post-streptococcal autoimmune etiology. The streptococcal pathogenesis of rheumatic fever is supported by studies that have demonstrated the effectiveness of penicillin prophylaxis in preventing recurrences of this illness. A trial of penicillin prophylaxis in the PANDAS (...) History of rheumatic fever, including Sydenham's chorea Diagnosis of autism, schizophrenia or other psychotic disorder Chronic illnesses, particularly neurologic and immunologic disorders Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00001359

1999 Clinical Trials

163. Is obsessive–compulsive disorder an autoimmune disease? Full Text available with Trip Pro

streptococcal infections and the development of OCD and tic disorders in children. It has been suggested that OCD in some susceptible individuals may be caused by an autoimmune response to streptococcal infections, that is, a similar biological mechanism to that associated with Sydenham's chorea. The term "pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections" (PANDAS) has been used to describe a subset of children with abrupt onset or exacerbations of OCD or tics, or both

2001 CMAJ: Canadian Medical Association Journal

164. A pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infections. (Abstract)

A pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infections. Some children with obsessive-compulsive disorder (OCD) and tic disorders appear to have symptom exacerbations triggered by group A beta-hemolytic streptococcal infections in a manner that is similar to rheumatic fever and its neurologic variant, Sydenham's chorea. Because penicillin prophylaxis has proven to be effective in preventing recurrences of rheumatic fever

1999 Biological psychiatry Controlled trial quality: uncertain

165. Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesis. Full Text available with Trip Pro

Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesis. The classical neurological disorder after group A beta haemolytic streptococcal infection is Sydenham's chorea. Recently a tic disorder occurring after group A streptococcal infection has been described and termed PANDAS (paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection). It is proposed that antibodies induced after group A streptococcal infection react with basal ganglia (...) neurones in Sydenham's chorea and PANDAS. Anti-basal ganglia antibodies (ABGA) are present in most cases of acute Sydenham's chorea, but rarely in controls.To investigate the hypothesis that Tourette's syndrome may be associated with group A streptococcal infection and ABGA.100 patients with Tourette's syndrome (DSM-IV-TR) were enrolled in a cross sectional study. Children with neurological disease (n = 50) and recent uncomplicated streptococcal infection (n = 40), adults with neurological disease (n

2003 Neurosurgery and Psychiatry

166. Parkinsonian features after streptococcal pharyngitis. (Abstract)

Parkinsonian features after streptococcal pharyngitis. Bradykinesia and rigidity developed in a 10-year-old girl during an episode of Sydenham chorea. These parkinsonian features improved over 6 months. Serum analysis demonstrated elevated anti-streptolysin-O and anti-basal ganglia antibodies. We suggest that autoimmune antibodies may cause remitting parkinsonian signs subsequent to streptococcal tonsillitis as part of the spectrum of poststreptococcal CNS disease.

2003 Journal of Pediatrics

167. rheumatic chorea

rheumatic chorea rheumatic chorea - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search rheumatic chorea Sydenham's chorea is a self-limiting disorder of movement occuring most frequently in association with rheumatic fever. It occurs mainly in females, with onset between the ages of 5 and 15 or during pregnancy. The onset is generally 2 to 6 months after streptococcal infection. ESR and antistreptolysin O titres are usually

2010 GP Notebook

168. Sydenham's chorea

Sydenham's chorea Sydenham's chorea - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search Sydenham's chorea Sydenham's chorea is a self-limiting disorder of movement occuring most frequently in association with rheumatic fever. It occurs mainly in females, with onset between the ages of 5 and 15 or during pregnancy. The onset is generally 2 to 6 months after streptococcal infection. ESR and antistreptolysin O titres are usually

2010 GP Notebook

169. Rheumatic chorea: relationship to systemic manifestations and response to corticosteroids. (Abstract)

Rheumatic chorea: relationship to systemic manifestations and response to corticosteroids. To describe Sydenham chorea among children in a cohort of patients with rheumatic fever (RF).An existing database was used to identify demographic characteristics, clinical manifestations, and therapy in persons with RF identified in Salt Lake City, Utah, from 1985 through January 2002.Of 584 cases in the database, 537 (91%) were new-onset RF (median age of 10 years) and 177 (33%) had chorea. Patients (...) with chorea were more often female (OR = 0.37, 95% CI = 0.25-0.55, P < .0001) and were less likely to have carditis or arthritis. Prednisone treatment may lead to a shortened course of chorea (4.0 weeks in prednisone-treated [n = 32] vs 9.0 weeks in untreated [n = 14]; P < .0001). Among 33 patients seen at a median of 10.3 years (range 6.3-14.9 years) after their initial bout of chorea, 20% reported residual tremor or mood swings. Ten of the 33 (30%) had one or more recurrences of chorea.Chorea affected

2007 Journal of Pediatrics

170. Oral contraceptive induced chorea: another condition associated with anti-basal ganglia antibodies. Full Text available with Trip Pro

Oral contraceptive induced chorea: another condition associated with anti-basal ganglia antibodies. Use of oral contraceptives is a recognised but infrequent cause of chorea. This type of chorea has usually been considered a reactivation of Sydenham's chorea by an unknown mechanism. A patient developed a chorea triggered by the use of oral contraceptives with no definite evidence of previous Sydenham's chorea or recent streptoccocal infections. However, the patient had positive anti-basal (...) ganglia antibodies, which supports an immunological basis for the pathophysiology of this chorea.

2004 Neurosurgery and Psychiatry

171. Rheumatic chorea in northern Australia: a clinical and epidemiological study Full Text available with Trip Pro

Rheumatic chorea in northern Australia: a clinical and epidemiological study To describe the epidemiology and clinical features of Sydenham's chorea in the Aboriginal population of northern Australia a review was conducted of 158 episodes in 108 people: 106 were Aborigines, 79 were female, and the mean age was 10.9 years at first episode. Chorea occurred in 28% of cases of acute rheumatic fever, carditis occurred in 25% of episodes of chorea, and arthritis in 8%. Patients with carditis (...) or arthritis tended to have raised acute phase reactants and streptococcal serology. Two episodes lasted at least 30 months. Mean time to first recurrence of chorea was 2.1 years compared with 1.2 years to second recurrence. Established rheumatic heart disease developed in 58% of cases and was more likely in those presenting with acute carditis, although most people who developed rheumatic heart disease did not have evidence of acute carditis with chorea. Differences in the patterns of chorea and other

1999 Archives of Disease in Childhood

172. Is there any advice in someone wishing to become pregnant with a prior history of Sydenham's chorea?

Is there any advice in someone wishing to become pregnant with a prior history of Sydenham's chorea? Is there any advice in someone wishing to become pregnant with a prior history of Sydenham's chorea? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe (...) across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Is there any advice in someone wishing to become pregnant with a prior history of Sydenham's chorea? Unfortunately, we have been unable to locate any evidence to support your management. eMedicine has

2007 TRIP Answers

173. Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea

Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Intravenous (...) Immunoglobulins as Effective Treatment in Sydenham's Chorea The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00615797 Recruitment Status : Completed First Posted : February 14, 2008 Last Update Posted : December 4, 2014 Sponsor: University of Cape Town Collaborator: Natal Bioproducts Institute Information

2008 Clinical Trials

174. Randomized double-blind study with prednisone in Sydenham's chorea. (Abstract)

Randomized double-blind study with prednisone in Sydenham's chorea. In this randomized, double-blind, parallel study of a group of 22 children and teenagers, prednisone efficacy in acute Sydenham's chorea was assessed. Use of prednisone (2 mg/kg/day during 4 weeks, followed by a gradual discontinuation) in the 22 patients and in a placebo group (n = 15) was evaluated by a chorea intensity score based on presence, distribution, and interference of choreic movement on daily activities. Each (...) patient was evaluated by the same pediatric neurologist weekly during the first month, followed by evaluation on weeks 8 and 12, with further evaluations as necessary if choreic movements persisted. Although initial chorea intensity was similar in both groups, a significant difference was observed after 1 week of medication (P < 0.001) with a larger reduction in the prednisone group, that continued until the end of the study. Percentage decrease in chorea intensity scale score also was persistently

2006 Pediatric neurology Controlled trial quality: uncertain

175. Treatment of Sydenham's chorea with intravenous immunoglobulin, plasma exchange, or prednisone. (Abstract)

Treatment of Sydenham's chorea with intravenous immunoglobulin, plasma exchange, or prednisone. Sydenham's chorea has been established as a postinfectious autoimmune neuropsychiatric disorder. Corticosteroids have been used to treat patients with severe disease but are not always effective, and relapses are frequent after cessation. Eighteen subjects were entered into this randomized-entry controlled trial designed to determine if intravenous immunoglobulin or plasma exchange would be superior (...) to prednisone in decreasing the severity of chorea. Mean chorea severity for the entire group was significantly lower at the 1-month follow-up evaluation (overall 48% improvement). Although the between-group differences were not statistically significant, clinical improvements appeared to be more rapid and robust in the intravenous immunoglobulin and plasma exchange groups than in the prednisone group (mean chorea severity scores decreased by 72% in the intravenous immunoglobulin group, 50% in the plasma

2005 Journal of child neurology Controlled trial quality: uncertain

176. Obsessive-compulsive spectrum disorders in rheumatic fever with and without Sydenham's chorea. (Abstract)

Obsessive-compulsive spectrum disorders in rheumatic fever with and without Sydenham's chorea. Recent findings suggest that acute-phase rheumatic fever (RF) patients present with higher frequencies of obsessive-compulsive disorder (OCD) and tic disorders. Until now, there have been no such studies in RF in non-acute phases.To verify whether patients with a history of RF with or without Sydenham's chorea (SC) present with higher rates of OCD, tic disorders, and other obsessive-compulsive (OC

2004 Journal of Clinical Psychiatry

177. Obsessive-compulsive symptoms in adults with history of rheumatic fever, Sydenham's chorea and type I diabetes mellitus: preliminary results. (Abstract)

Obsessive-compulsive symptoms in adults with history of rheumatic fever, Sydenham's chorea and type I diabetes mellitus: preliminary results. Rheumatic fever (RF) associated with Sydenham's chorea (a neurological variant of RF), but not RF without chorea, has been acutely related to obsessive-compulsive symptomatology/disorder (OCS/OCD). This study investigated the presence of OCS in adults who had RF with or without chorea in childhood.The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS (...) ) was used to evaluate OCS in 38 adults with history of RF (13 with chorea; 25 without chorea) or diabetes (controls; n = 19).The OCS was similar in both groups, although the intensity of symptoms was not clinically relevant. Moreover, subjects with RF with or without chorea did not score differently in the Y-BOCS.The similar occurrence of OCS in patients with history of RF and diabetes suggests that the development of this symptomatology, triggered by group A beta-haemolytic streptococcus infections

2005 Acta Psychiatrica Scandinavica

178. Tracing Sydenham's chorea: historical documents from a British paediatric hospital. Full Text available with Trip Pro

Tracing Sydenham's chorea: historical documents from a British paediatric hospital. Sydenham's chorea (SC) became a well defined nosological entity only during the second half of the nineteenth century. Such progress was promoted by the availability of large clinical series provided by newly founded paediatric hospitals. This paper analyses the demographic and clinical features of patients with chorea admitted to the first British paediatric hospital (the Hospital for Sick Children, Great

2005 Archives of Disease in Childhood

179. Sydenham's chorea in western Pennsylvania. Full Text available with Trip Pro

Sydenham's chorea in western Pennsylvania. Chorea is characterized by involuntary, fleeting, irregular, nonrhythmic movements that flow from 1 body region to another. There are many causes of childhood chorea, including cerebrovascular accidents, collagen vascular diseases, drug intoxication, hyperthyroidism, Wilson's disease, Huntington's disease, and infectious agents. Although Sydenham's chorea (SC), a nonsuppurative sequela of group A streptococcal infection, is known to be a common cause (...) of chorea, multiple laboratory and radiographic studies are often obtained to determine the cause of pediatric chorea. We conducted a retrospective chart review to determine the causes of childhood chorea seen in a large children's hospital in an area endemic for acute rheumatic fever (ARF). The utility of neuroimaging in establishing a final diagnosis of SC is discussed.Patients who received a diagnosis of chorea between 1980 and 2004 at the Children's Hospital of Pittsburgh were identified from

2006 Pediatrics

180. Nerve conduction study in Sydenham's chorea. (Abstract)

Nerve conduction study in Sydenham's chorea. Sydenham's chorea (SC) is a late complication of group A beta-hemolytic streptococci infection presumably caused by an abnormal autoimmune reaction. Despite rare case reports of peripheral neuropathy associated with streptococcal infection, there is no investigation of peripheral nerve in SC. We performed nerve conduction studies in a cohort of patients with SC. The neurophysiology investigation comprised measurement of amplitude and sensory

2005 Movement Disorders

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