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Sydenham Chorea

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141. Rheumatic Fever

. Perivascular neutrophilic and mononuclear infiltrates of the dermis occur. CNS Sydenham chorea, the form of chorea that occurs with ARF, manifests in the CNS as hyperperfusion and increased metabolism in the basal ganglia. Increased levels of antineuronal antibodies have also been shown. Symptoms and Signs An initial episode of symptoms of rheumatic fever occurs typically about 2 to 3 wk after the streptococcal infection. Manifestations typically involve some combination of the joints, heart, skin, and CNS (...) . It sometimes lasts < 1 day. Its appearance is often delayed after the inciting streptococcal infection; it may appear with or after the other manifestations of rheumatic inflammation. CNS Sydenham chorea occurs in about 10 to 30% of children. It may develop along with other manifestations but frequently arises after the other manifestations have subsided (often months after the acute streptococcal infection) and thus may be overlooked as an indicator of acute rheumatic fever. Onset of chorea is typically

2013 Merck Manual (19th Edition)

142. Rheumatic fever

. An April 2013 review article in the Indian Journal of Medical Research stated that echocardiographic and Doppler (E & D) studies, despite some reservations about their utility, have identified a massive burden of rheumatic heart disease, which suggests the inadequacy of the 1992 Jones' criteria. E & D studies have identified subclinical carditis in patients with rheumatic fever, as well as in follow-ups of rheumatic heart disease patients who initially presented as having isolated cases of Sydenham's (...) chorea. Signs of a preceding streptococcal infection include: recent , raised antistreptolysin O or other streptococcal antibody titre, or positive throat culture. Major criteria [ ] : A temporary migrating inflammation of the large joints, usually starting in the legs and migrating upwards. : Inflammation of the heart muscle ( ) which can manifest as with shortness of breath, with a rub, or a new . Subcutaneous nodules: Painless, firm collections of collagen fibers over bones or . They commonly

2012 Wikipedia

143. The Immunobiology of Tourette's Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus, and Related Disorders: A Way Forward. (Full text)

interest has been Group A Streptococcus (GAS), which began to receive attention as a potential cause of neuropsychiatric symptoms, following the investigation of the symptoms reported in Sydenham's chorea (SC) and rheumatic fever, such as motor tics, vocal tics, and both obsessive-compulsive and attention deficit/hyperactivity symptoms. Young children have been described as having a sudden onset of these neuropsychiatric symptoms temporally associated with GAS, but without supporting evidence (...) and MedLine databases using the following keywords: OCD, immune, PANDAS, Sydenham chorea, Tourette's disorder Group A Streptococcus. Articles were also identified through reference lists from research articles and other materials on childhood OCD, PANDAS, and TD between 1966 and December 2010. Considering the overlap of clinical and neuroanatomic findings among these disorders, this review explores evidence regarding the immunobiology as well as the relevant clinical and therapeutic aspects of TD, OCD

2010 Journal of Child and Adolescent Psychopharmacology PubMed

144. A prospective study of acute movement disorders in children. (Full text)

. It was possible to divide the participants into three groups: (1) those with inflammatory or autoimmune disorders (n=22), (2) those with non-inflammatory disorders (n=18), and (3) those with psychogenic disorders (n=12). The inflammatory or autoimmune aetiologies included N-methyl-D-aspartate receptor encephalitis (n=5), opsoclonus-myoclonus syndrome (n=4), Sydenham chorea (n=3), systemic lupus erythematosus (n=3), acute necrotizing encephalopathy (n=3), and other types of encephalitis (n=4). Other important (...) A prospective study of acute movement disorders in children. The purpose of this study was to report a prospective cohort of children with acute-onset movement disorders.We report on 52 individuals (31 females, 21 males; mean age 6y 5mo, range 2mo-15y) with acute-onset movement disorders managed at a busy tertiary paediatric referral hospital over a 40-month period.In descending order of frequency, the movement disorders reported were chorea, dystonia, tremor, myoclonus, and parkinsonism

2010 Developmental Medicine and Child Neurology PubMed

145. Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic Acid) Followed by a 20 Week Elimination Phase of Folate

deafness ; Sydenham's chorea, porphyria, disturbances in the bile flow. Liver diseases: Presence or history of severe hepatic diseases including benign or malignant tumors Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01258660 Locations Layout table

2010 Clinical Trials

146. A Bioequivalence Study of IMPLANON and Radiopaque IMPLANON (34528)(P05720)

. systolic blood pressure >140 mmHg and/or diastolic blood pressure > 90 mmHg. A history during pregnancy or during previous use of sex steroids of: jaundice and/or severe pruritus related to cholestasis; gallstone formation; porphyria; systemic lupus erythematosus; haemolytic uraemic syndrome; Sydenham's chorea; herpes gestationis; otosclerosis-related hearing loss Present use or use during 2 months prior to the start of Implanon/Radiopaque Implanon of one of the following drugs: phenytoin

2008 Clinical Trials

147. A Multicenter Trial to Evaluate the Insertion Characteristics of the Radiopaque Etonogestrel Implant Using a Next Generation Applicator (34530)(P05702)

Implant. Hypertension, i.e. systolic blood pressure >140 mmHg and/or diastolic blood pressure > 90 mmHg; A history during pregnancy or during previous use of sex steroids of: jaundice and/or severe pruritus related to cholestasis, gallstone formation, porphyria, systemic lupus erythematosus, haemolytic uraemic syndrome, Sydenham's chorea, herpes gestationis, otosclerosis-related hearing loss; Present use or use during 2 months prior to the start of Radiopaque Implant of one of the following drugs

2008 Clinical Trials

148. Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea

Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Intravenous (...) Immunoglobulins as Effective Treatment in Sydenham's Chorea The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00615797 Recruitment Status : Completed First Posted : February 14, 2008 Last Update Posted : December 4, 2014 Sponsor: University of Cape Town Collaborator: Natal Bioproducts Institute Information

2008 Clinical Trials

149. Antineuronal antibodies in Parkinson's disease. (PubMed)

Antineuronal antibodies in Parkinson's disease. Antineuronal antibodies (ANAs) have been implicated in the pathophysiology of postinfectious movement disorders, such as Sydenham's chorea. However, their relevance in other movement disorders--in the absence of infectious triggers--remains much disputed. We sought to assess the frequency of ANAs in idiopathic Parkinson's disease (IPD) and to explore whether a specific phenotype is associated with the presence of ANAs. For this purpose, we

2008 Movement Disorders

150. Cycle Control and Safety of E2-DRSP

-associated Pancreatitis, systemic lupus erythematodes, pemphigoid gestationis during a previous pregnancy, Sydenham chorea, herpes gestationis, otosclerosis-related hearing loss, history of migraine with focal neurologic symptoms, epilepsy, current or history of clinically significant depression, hereditary angioedema Additional sex steroids, other hormonal contraceptive methods (oral, transdermal) during treatment (blister in use at randomization should be finished); intra-uterine devices (IUD

2008 Clinical Trials

151. What is the True Frequency of Carditis in Acute Rheumatic Fever? A Prospective Clinical and Doppler Blind Study of 56 Children with up to 60 Months of Follow-Up Evaluation. (PubMed)

carditis. Persistence of the abnormalities was observed at a late follow-up evaluation in 72.7% of the cases. Sydenham's chorea was present in 8 patients with clinical carditis and in 10 without this disorder, 8 of whom had echocardiographic abnormalities.Patients who had acute rheumatic fever without clinical signs of carditis showed acute and late follow-up echocardiographic abnormalities suggestive of cardiac involvement. Clinicians should be attentive for the presence of cardiac involvement among (...) were evaluated at diagnosis, after 3 and 6 months, then at 2 and 5 years. All assessments were performed blindly and included physical and cardiac examination, electrocardiogram, chest X-ray, and two-dimensional color-flow Doppler echocardiography.Initial clinical carditis was observed for 27 patients (48.2%), all of whom had positive echocardiographic abnormalities. Echocardiographic abnormalities were observed in 11 patients who had arthritis or chorea presentation without initial clinical

2008 Pediatric Cardiology

152. St Vitus' dance

St Vitus' dance St Vitus' dance - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search St Vitus' dance Sydenham's chorea is a self-limiting disorder of movement occuring most frequently in association with rheumatic fever. It occurs mainly in females, with onset between the ages of 5 and 15 or during pregnancy. The onset is generally 2 to 6 months after streptococcal infection. ESR and antistreptolysin O titres are usually

2010 GP Notebook

153. Rheumatic Fever

is from aortic regurgitation as the vibration of the anterior leaflet of the mitral valve is buffeted simultaneously by the blood jets from the left atrium and the aorta. Chorea (also known as Sydenham's chorea and 'St Vitus' Dance'): Occurs in 10-30% of patients. It usually presents in children between 7-12 years, with a female preponderance. There are both psychological and physical features. It causes rapid and purposeless movements, particularly of the face and upper extremities. Paediatric (...) [ ] . Prophylactic antibiotics before dental or surgical treatment (to prevent infective endocarditis) are no longer recommended for patients with acquired valve disease. Historical perspective [ ] This often dramatic disease has been recognised for centuries. Baillou (1538-1616) realised that the arthritis was different to gout. Sydenham (1624-1668) famously described the chorea. The association of RF with sore throat was made in 1880 and the association with scarlet fever in the early 1900s. The arrival

2008 Mentor

154. PANDAS (Paediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection)

acute-onset neuropsychiatric syndrome) has been suggested, as it captures both the sudden onset and uncertainty about the aetiology. [ ] Epidemiology PANDAS is an uncommon condition and there is ongoing debate about its link with Sydenham's chorea and rheumatic fever. It is likely to have a similar autoimmune aetiology and a classification which labels it as one of the acute neuropsychiatric disorders associated with streptococcal infection has been suggested. [ ] Presentation This is usually (...) on neurological examination in absence of chorea. These children tend to have more widespread neuropsychiatric difficulties than other children with OCD, including enuresis, impulsivity and deterioration in handwriting. [ ] If overtly choreiform movements develop, the child should be considered to have developed Sydenham's chorea and these children require antibiotic prophylaxis against subsequent GABHS infection. [ ] Management This is mainly supportive. The case has been made for: Looking for active

2008 Mentor

155. Erythema Marginatum

diagnosis. [ ] Associated diseases It may be associated with carditis, arthritis, fever and . Management There is no specific management of the rash but rheumatic fever must be treated as described in the article. If the diagnosis is suspected, it is wise to start a full course of penicillin as for rheumatic fever. Complications There are no specific complications of the rash but complications such as cardiac disease and Sydenham's chorea may occur as a result of the rheumatic fever. Prognosis (...) -2005. J Paediatr Child Health. 2008 Oct44(10):564-71. doi: 10.1111/j.1440-1754.2008.01384.x. ; The resurgence of acute rheumatic fever in the United States. Pediatr Ann. 1992 Dec21(12):816-20. ; Sydenham's chorea in western Pennsylvania. Pediatrics. 2006 Apr117(4):e675-9. Epub 2006 Mar 13. ; Erythema marginatum (rheumaticum). Arch Dis Child. 1937 Aug12(70):233-8. ; Medical Pictures ; Arch Dis Child 201398:203 doi:10.1136/archdischild-2012-302732 ; Hereditary angio-oedema in Denmark: a nationwide

2008 Mentor

156. rheumatic chorea

rheumatic chorea rheumatic chorea - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search rheumatic chorea Sydenham's chorea is a self-limiting disorder of movement occuring most frequently in association with rheumatic fever. It occurs mainly in females, with onset between the ages of 5 and 15 or during pregnancy. The onset is generally 2 to 6 months after streptococcal infection. ESR and antistreptolysin O titres are usually

2010 GP Notebook

157. Sydenham's chorea

Sydenham's chorea Sydenham's chorea - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search Sydenham's chorea Sydenham's chorea is a self-limiting disorder of movement occuring most frequently in association with rheumatic fever. It occurs mainly in females, with onset between the ages of 5 and 15 or during pregnancy. The onset is generally 2 to 6 months after streptococcal infection. ESR and antistreptolysin O titres are usually

2010 GP Notebook

158. Rheumatic fever

migratory polyarthritis (46-66% of cases), most commonly in the knee, ankle, elbow and wrists; carditis (53-68% clinical and additional ''subclinical'' diagnosed by echocardiogram), which is typically inflammation of the mitral (90%) or aortic valve (10%) in isolation, but any combination of all 4 valves have been reported; Sydenham chorea (8-15%); erythema marginatum (1-11%); and subcutaneous nodules on the flexor surfaces (1-8%). Minor criteria include fever (35-75% of cases), arthralgia (35-56

2005 Orphanet

159. Sarizotan in the Treatment of Neuroleptic-induced Tardive Dyskinesia

effectively with the investigator and study staff, and to be able to complete the computerised neurocognitive test battery where necessary Exclusion Criteria: Exclusion criteria listed in the Research Criteria for Tardive Dyskinesia as defined in DSM-IV (symptoms not due to another neurological or general medical condition such as Huntington's disease, Sydenham's chorea, spontaneous dyskinesia, hyperthyroidism, Wilson's disease, ill-fitting dentures, exposure to other medications causing acute reversible

2006 Clinical Trials

160. Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder

and subjects (ages 18 and above) and assent of subjects ages 7-17 will be obtained. Exclusion Criteria: Organic brain disease, for example, traumatic brain injury residua. Mental retardation as defined by the DSM-IV-TR. A history of seizure disorder (other than febrile seizure). A history of Sydenham's Chorea. Autism, schizophrenia, other psychotic disorder, or bipolar disorder. A primary diagnosis of a major mood disorder that requires ongoing psychiatric treatment. A neurological disorder other than

2005 Clinical Trials

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