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Sydenham Chorea

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141. Cycle Control and Safety of E2-DRSP

-associated Pancreatitis, systemic lupus erythematodes, pemphigoid gestationis during a previous pregnancy, Sydenham chorea, herpes gestationis, otosclerosis-related hearing loss, history of migraine with focal neurologic symptoms, epilepsy, current or history of clinically significant depression, hereditary angioedema Additional sex steroids, other hormonal contraceptive methods (oral, transdermal) during treatment (blister in use at randomization should be finished); intra-uterine devices (IUD

2008 Clinical Trials

142. A Multicenter Trial to Evaluate the Insertion Characteristics of the Radiopaque Etonogestrel Implant Using a Next Generation Applicator (34530)(P05702)

Implant. Hypertension, i.e. systolic blood pressure >140 mmHg and/or diastolic blood pressure > 90 mmHg; A history during pregnancy or during previous use of sex steroids of: jaundice and/or severe pruritus related to cholestasis, gallstone formation, porphyria, systemic lupus erythematosus, haemolytic uraemic syndrome, Sydenham's chorea, herpes gestationis, otosclerosis-related hearing loss; Present use or use during 2 months prior to the start of Radiopaque Implant of one of the following drugs

2008 Clinical Trials

143. A Bioequivalence Study of IMPLANON and Radiopaque IMPLANON (34528)(P05720)

. systolic blood pressure >140 mmHg and/or diastolic blood pressure > 90 mmHg. A history during pregnancy or during previous use of sex steroids of: jaundice and/or severe pruritus related to cholestasis; gallstone formation; porphyria; systemic lupus erythematosus; haemolytic uraemic syndrome; Sydenham's chorea; herpes gestationis; otosclerosis-related hearing loss Present use or use during 2 months prior to the start of Implanon/Radiopaque Implanon of one of the following drugs: phenytoin

2008 Clinical Trials

144. Sarizotan in the Treatment of Neuroleptic-induced Tardive Dyskinesia

effectively with the investigator and study staff, and to be able to complete the computerised neurocognitive test battery where necessary Exclusion Criteria: Exclusion criteria listed in the Research Criteria for Tardive Dyskinesia as defined in DSM-IV (symptoms not due to another neurological or general medical condition such as Huntington's disease, Sydenham's chorea, spontaneous dyskinesia, hyperthyroidism, Wilson's disease, ill-fitting dentures, exposure to other medications causing acute reversible

2006 Clinical Trials

145. Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder

and subjects (ages 18 and above) and assent of subjects ages 7-17 will be obtained. Exclusion Criteria: Organic brain disease, for example, traumatic brain injury residua. Mental retardation as defined by the DSM-IV-TR. A history of seizure disorder (other than febrile seizure). A history of Sydenham's Chorea. Autism, schizophrenia, other psychotic disorder, or bipolar disorder. A primary diagnosis of a major mood disorder that requires ongoing psychiatric treatment. A neurological disorder other than

2005 Clinical Trials

146. Levetiracetam in the Treatment of Neuroleptic-induced Tardive Dyskinesia

Subjects must have a stable neuroleptic-induced tardive dyskinesia at least 1 month prior to screening and meet tardive dyskinesia severity criteria Subjects must have used antipsychotics for at least 6 cumulative months, and, be on a stable dose for 1 month prior to screening Exclusion Criteria: Presence of any axis II condition within 6 months prior to screening Huntington´s disease, idiopathic dystonia, Wilson´s disease, Sydenham´s chorea, thyroid dysfunction, spontaneous dyskinesia Start of drugs

2005 Clinical Trials

147. Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches. Full Text available with Trip Pro

of poststreptococcal disease, such as in Sydenham's chorea. Cases of childhood TS are proposed to be caused by such a poststreptococcal mechanism, being part of a spectrum of childhood neurobehavioral disorders termed pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS). The overlap between TS and PANDAS is discussed, and a critical view of the PANDAS concept is presented. The therapeutic implications of the different pathological mechanisms are described, taking

2007 Dialogues in Clinical Neuroscience

148. Annotation: PANDAS: a model for human autoimmune disease. Full Text available with Trip Pro

by observations of similar symptoms in children with Sydenham's chorea, a search was undertaken for clinical and laboratory evidence in support of the new syndrome.Consistent and predictable clinical findings have been described in a large case series. Magnetic resonance imaging has supported the postulated pathobiology of the syndrome with evidence of inflammatory changes in basal ganglia. Antibasal ganglia antibodies have been found in some acute cases, mimicking streptococcal antigen epitopes.While PANDAS

2005 Journal of Child Psychology and Psychiatry

149. Antineuronal antibodies in Parkinson's disease. (Abstract)

Antineuronal antibodies in Parkinson's disease. Antineuronal antibodies (ANAs) have been implicated in the pathophysiology of postinfectious movement disorders, such as Sydenham's chorea. However, their relevance in other movement disorders--in the absence of infectious triggers--remains much disputed. We sought to assess the frequency of ANAs in idiopathic Parkinson's disease (IPD) and to explore whether a specific phenotype is associated with the presence of ANAs. For this purpose, we

2008 Movement Disorders

150. Incidence of anti-brain antibodies in children with obsessive-compulsive disorder. Full Text available with Trip Pro

Incidence of anti-brain antibodies in children with obsessive-compulsive disorder. Obsessions and compulsions may occur in the post-streptococcal disorders Sydenham's chorea and paediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS). The proposed mediators are anti-basal ganglia antibodies (ABGA).We tested the hypothesis that post-streptococcal autoimmunity may have a role in'idiopathic'obsessive-compulsive disorder (OCD).We examined 50 children with OCD (...) for ABGA using enzyme-linked immunosorbent assay (ELISA) and western immunoblotting. The findings were compared with paediatric autoimmune (n=50), neurological (n=100) and streptococcal (n=40) controls.The mean ABGA binding on ABGA binding on ELISA was elevated in the patient cohort compared with all control groups (P<0.005 in all comparisons). Western immunoblotting revealed positive antibody binding (as seen in Sydenham's chorea) in 42% of the patient cohort compared with 2-10% of control groups (P

2005 British Journal of Psychiatry

151. Dyskinesias and associated psychiatric disorders following streptococcal infections. Full Text available with Trip Pro

Dyskinesias and associated psychiatric disorders following streptococcal infections. The classical extrapyramidal movement disorder following beta haemolytic streptococcus (BHS) infection is Sydenham's chorea (SC). Recently, other post-streptococcal movement disorders have been described, including motor tics and dystonia. Associated emotional and behavioural alteration is characteristic.To describe experience of post-streptococcal dyskinesias and associated co-morbid psychiatric features (...) disorders were present: chorea (n = 20), motor tics (n = 16), dystonia (n = 5), tremor (n = 3), stereotypies (n = 2), opsoclonus (n = 2), and myoclonus (n = 1). Sixty five per cent of the chorea patients were female, whereas 69% of the tic patients were male. ICD-10 psychiatric diagnoses were made in 62.5%. Using the same psychiatric instrument, only 8.9% of UK children would be expected to have an ICD-10 psychiatric diagnosis. Emotional disorders occurred in 47.5%, including obsessive-compulsive

2004 Archives of Disease in Childhood

152. Echocardiographic findings in the PANDAS subgroup. Full Text available with Trip Pro

Echocardiographic findings in the PANDAS subgroup. Sydenham's chorea is the neurologic manifestation of rheumatic fever and is a diagnosis of exclusion requiring only the presence of frank chorea in the absence of another neurologic disorder. Two thirds of children with Sydenham's chorea also have rheumatic carditis (pathologic mitral valve regurgitation). Although there are similar neuropsychiatric symptoms and preceding group A beta-hemolytic streptococcal infection associated with both (...) Sydenham's chorea and the PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) subgroup, it is unknown whether patients in the PANDAS subgroup have any cardiac involvement.Sixty children meeting the criteria for PANDAS were entered into protocols at National Institute of Mental Health between 1993 and 2002. Doppler and 2-dimensional echocardiograms were performed on these subjects to assess valvular heart disease.Of these 60 children, no echocardiographic

2004 Pediatrics

153. Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity. Full Text available with Trip Pro

% respectively). Investigation found no evidence of viral encephalitis or other recognized causes of rapid-onset parkinsonism. MRI of the brain was normal in 60% but showed inflammatory changes localized to the deep grey matter in 40% of patients. We investigated the possibility that this phenotype could be a postinfectious autoimmune CNS disorder, and therefore similar to Sydenham's chorea. Anti-streptolysin-O titres were elevated in 65% of patients. Furthermore, western immunoblotting showed that 95% of EL

2004 Brain

154. Dementia-like presentation of striatal hypermetabolic state with antistriatal antibodies responsive to steroids. Full Text available with Trip Pro

Dementia-like presentation of striatal hypermetabolic state with antistriatal antibodies responsive to steroids. Hypermetabolic lesions of the striatum are rare. They usually involve autoimmunity and are associated with choreatic disorders such as Sydenham chorea, lupus, and the antiphospholipid antibody syndrome.A 48-year-old woman was initially seen with a 1-year history of progressive changes in personality and attention. There were minor associated involuntary movements. Negative routine

2004 Archives of Neurology

155. A dystonic syndrome associated with anti-basal ganglia antibodies. Full Text available with Trip Pro

in Sydenham's chorea. Three patients had a clear history of respiratory infection before the onset of their symptoms. Three patients received immunosuppressive treatment, with three showing a notable reduction in symptoms. It is hypothesised that dystonia in adults or adolescents may be part of the clinical spectrum of the post-infectious syndrome associated with ABGA. (...) A dystonic syndrome associated with anti-basal ganglia antibodies. Anti-basal ganglia antibodies (ABGA) have been associated with movement disorders (usually tics and chorea) and psychiatric disturbance in children. This report describes five adult and adolescent patients (one male, four females; mean age of onset, 16 years (range, 13-35)) who presented subacutely with a clinical syndrome dominated by dystonia and had ABGA binding to antigens of similar molecular weights to those seen

2004 Neurosurgery and Psychiatry

156. What is the True Frequency of Carditis in Acute Rheumatic Fever? A Prospective Clinical and Doppler Blind Study of 56 Children with up to 60 Months of Follow-Up Evaluation. (Abstract)

carditis. Persistence of the abnormalities was observed at a late follow-up evaluation in 72.7% of the cases. Sydenham's chorea was present in 8 patients with clinical carditis and in 10 without this disorder, 8 of whom had echocardiographic abnormalities.Patients who had acute rheumatic fever without clinical signs of carditis showed acute and late follow-up echocardiographic abnormalities suggestive of cardiac involvement. Clinicians should be attentive for the presence of cardiac involvement among (...) were evaluated at diagnosis, after 3 and 6 months, then at 2 and 5 years. All assessments were performed blindly and included physical and cardiac examination, electrocardiogram, chest X-ray, and two-dimensional color-flow Doppler echocardiography.Initial clinical carditis was observed for 27 patients (48.2%), all of whom had positive echocardiographic abnormalities. Echocardiographic abnormalities were observed in 11 patients who had arthritis or chorea presentation without initial clinical

2008 Pediatric Cardiology

157. Neuropsychiatric movement disorders following streptococcal infection. (Abstract)

Neuropsychiatric movement disorders following streptococcal infection. The aim of this study was to describe post-streptococcal movement disorders that form part of the acute rheumatic fever complex. The clinical records of patients diagnosed with Sydenham's chorea were analyzed retrospectively to investigate epidemiology, the significance of socioeconomic deprivation, clinical manifestations, treatments, outcomes, long-term morbidity, and disease evolution. Forty-two patients (21 males, 21 (...) females) were diagnosed with Sydenham's chorea. The median presentation age was 9 years 8 months (range 3y 5mo to 13y 2mo). Nineteen patients were of indigenous African ancestry; 23 were of mixed ancestry. All patients lived in poverty and had poor access to medical care. Twelve of the total group had disabling symptoms for longer than 2 years; six of these patients developed paediatric autoimmune neuropsychiatric disorder associated with Streptococcus (Paediatric autoimmune neuropsychiatric disorder

2005 Developmental Medicine and Child Neurology

158. Rheumatic Fever

is from aortic regurgitation as the vibration of the anterior leaflet of the mitral valve is buffeted simultaneously by the blood jets from the left atrium and the aorta. Chorea (also known as Sydenham's chorea and 'St Vitus' Dance'): Occurs in 10-30% of patients. It usually presents in children between 7-12 years, with a female preponderance. There are both psychological and physical features. It causes rapid and purposeless movements, particularly of the face and upper extremities. Paediatric (...) [ ] . Prophylactic antibiotics before dental or surgical treatment (to prevent infective endocarditis) are no longer recommended for patients with acquired valve disease. Historical perspective [ ] This often dramatic disease has been recognised for centuries. Baillou (1538-1616) realised that the arthritis was different to gout. Sydenham (1624-1668) famously described the chorea. The association of RF with sore throat was made in 1880 and the association with scarlet fever in the early 1900s. The arrival

2008 Mentor

159. Erythema Marginatum

diagnosis. [ ] Associated diseases It may be associated with carditis, arthritis, fever and . Management There is no specific management of the rash but rheumatic fever must be treated as described in the article. If the diagnosis is suspected, it is wise to start a full course of penicillin as for rheumatic fever. Complications There are no specific complications of the rash but complications such as cardiac disease and Sydenham's chorea may occur as a result of the rheumatic fever. Prognosis (...) -2005. J Paediatr Child Health. 2008 Oct44(10):564-71. doi: 10.1111/j.1440-1754.2008.01384.x. ; The resurgence of acute rheumatic fever in the United States. Pediatr Ann. 1992 Dec21(12):816-20. ; Sydenham's chorea in western Pennsylvania. Pediatrics. 2006 Apr117(4):e675-9. Epub 2006 Mar 13. ; Erythema marginatum (rheumaticum). Arch Dis Child. 1937 Aug12(70):233-8. ; Medical Pictures ; Arch Dis Child 201398:203 doi:10.1136/archdischild-2012-302732 ; Hereditary angio-oedema in Denmark: a nationwide

2008 Mentor

160. PANDAS (Paediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection)

acute-onset neuropsychiatric syndrome) has been suggested, as it captures both the sudden onset and uncertainty about the aetiology. [ ] Epidemiology PANDAS is an uncommon condition and there is ongoing debate about its link with Sydenham's chorea and rheumatic fever. It is likely to have a similar autoimmune aetiology and a classification which labels it as one of the acute neuropsychiatric disorders associated with streptococcal infection has been suggested. [ ] Presentation This is usually (...) on neurological examination in absence of chorea. These children tend to have more widespread neuropsychiatric difficulties than other children with OCD, including enuresis, impulsivity and deterioration in handwriting. [ ] If overtly choreiform movements develop, the child should be considered to have developed Sydenham's chorea and these children require antibiotic prophylaxis against subsequent GABHS infection. [ ] Management This is mainly supportive. The case has been made for: Looking for active

2008 Mentor

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