How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

197 results for

Sydenham Chorea

Latest & greatest

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. A National Prospective Surveillance Study of Acute Rheumatic Fever in Australian Children. (Abstract)

to collect data on children with ARF across Australia. Children up to 15 years of age were included if they had an ARF episode diagnosed between October 1, 2007 and December 31, 2010 that met the case definition.ARF was identified in 151 children: 131 Indigenous Australians, 10 non-Indigenous Australians, 8 Pacific Islanders and 1 African (1 unknown). Common presenting features were joint symptoms, fever and carditis. Sydenham chorea was reported in 19% of children. Aseptic monoarthritis was a major

2012 Pediatric Infectious Dsease Journal

122. Movement disorders in autoimmune diseases. (Abstract)

Movement disorders in autoimmune diseases. Movement disorders have been known to be associated with a variety of autoimmune diseases, including Sydenham's chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcus, systemic lupus erythematosus, antiphospholipid syndrome, gluten sensitivity, paraneoplastic and autoimmune encephalopathies. Tremors, dystonia, chorea, ballism, myoclonus, parkinsonism, and ataxia may be the initial and even the only presentation

2012 Movement Disorders

123. Streptococcus and rheumatic fever. Full Text available with Trip Pro

and cardiac myosin and its peptides appear during progression of rheumatic heart disease. However, autoantibodies against collagen that are not crossreactive may form because of the release of collagen from damaged valve or to responses to collagen bound in vitro by certain serotypes of streptococci. In Sydenham chorea, human mAbs derived from disease target the group A carbohydrate epitope GlcNAc and gangliosides and dopamine receptors found on the surface of neuronal cells in the brain. Human mAbs (...) and autoantibodies in Sydenham chorea were found to signal neuronal cells and activate calcium calmodulin-dependent protein kinase II (CaMKII) in neuronal cells and recognize the intracellular protein biomarker tubulin.To summarize, pathogenic mechanisms of crossreactive autoantibodies which target the valve in rheumatic heart disease and the neuronal cell in Sydenham chorea share a common streptococcal epitope GlcNAc and target intracellular biomarkers of disease including cardiac myosin in the myocardium

2012 Current Opinion in Rheumatology

124. Anti-streptococcal antibodies reacting with brain tissue. I. Immunofluourescent studies. Full Text available with Trip Pro

Anti-streptococcal antibodies reacting with brain tissue. I. Immunofluourescent studies. Serum JD from a 14-year old girl with Sydenhams chorea contained antibodies which gave immunofluorescent staining of the limiting membrane of the brain, ependymal tissue and fibrous astrocytes. These antibodies could be completely absorbed by Str. pyogenes type 24 (NCTC 8305) but only partially if at all by type 6 matt (NCTC 8302) or type 6 glossy (NCTC 8709). In contrast, staining by the same serum (...) reactions of 3/74 could be absorbed out by Str. pyogenes type 24 but not by Str. pyogenes type 6 matt or type 6 glossy. None of these staining patterns given by serum JD or by 3/74 could be absorbed by human uterine smooth muscle. Serum 3/74 stained heart muscle but this reaction could be absorbed without affecting the brain staining reactions. Sera from 4 other patients with Sydenham's chorea were found to give staining of the ependyma and the limiting membrane, 2 only very weakly.

1976 British journal of experimental pathology

125. Anti-streptococcal antibodies reacting with brain tissue. II. Utrastructural studies. Full Text available with Trip Pro

Anti-streptococcal antibodies reacting with brain tissue. II. Utrastructural studies. The reaction of rabbit anti-Streptococcus pyogenes type 24 with mouse brain has been studied at the ultrastructural level using horseradish peroxidase labelled antiglobulin. It is shown that these antibodies, and by inference those found in Sydenham's chorea, react with the fibrous astrocyte. The cross-reacting antigen is the glial filament or a closely associated cytoplasmic constituent.

1976 British journal of experimental pathology

126. Involuntary movements in patients taking oral contraceptives Full Text available with Trip Pro

Involuntary movements in patients taking oral contraceptives Involuntary movements developed in five women taking oral contraceptives. In one, the sudden onset of a unilateral disturbance suggested a cerebral thrombosis; this case is considered to be a further example of the increased risk of cerebrovascular disease associated with oral contraception. The four other patients suffered a relapse of Sydenham's chorea between one and four months after starting an oral contraceptive regimen

1969 British medical journal


equally elevated and were significantly higher than the normal controls. When Group A antibody levels were determined on sera obtained at intervals of 5-12 months and 1-5 yr after the acute illness) it was found that the antibody levels declined within the normal range at the 5-12 month interval in patients with glomerulonephritis as well as in patients with rheumatic fever in whom no valvular involvement had complicated the disease, i.e., patients with pure Sydenham's chorea. However, in patients (...) with rheumatic valvulitis, who had been on penicillin prophylaxis after the last acute episode, the A antibody level showed little decline from the level obtained during the acute illness. The elevated antibody level in patients with rheumatic valvulitis, including patients with Sydenham's chorea with valvulitis, persisted for periods of at least 1 yr and up to 20 yr after the last acute attack. The pattern of the decline of the antibody levels to the A-variant carbohydrate as well as of the antibody titers

1968 The Journal of experimental medicine

128. Evidence-based guideline update: Plasmapheresis in neurologic disorders: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology Full Text available with Trip Pro

, based on one Class I study (Level B). Plasmapheresis is possibly effective and may be considered for acute fulminant demyelinating CNS disease (Level C). There is insufficient evidence to support or refute the use of plasmapheresis for myasthenia gravis, pediatric autoimmune neuropsychiatric disorders associated with streptococcus infection, and Sydenham chorea (Class III evidence, Level U).

2011 EvidenceUpdates

129. Rheumatic Fever

. Perivascular neutrophilic and mononuclear infiltrates of the dermis occur. CNS Sydenham chorea, the form of chorea that occurs with ARF, manifests in the CNS as hyperperfusion and increased metabolism in the basal ganglia. Increased levels of antineuronal antibodies have also been shown. Symptoms and Signs An initial episode of symptoms of rheumatic fever occurs typically about 2 to 3 wk after the streptococcal infection. Manifestations typically involve some combination of the joints, heart, skin, and CNS (...) . It sometimes lasts < 1 day. Its appearance is often delayed after the inciting streptococcal infection; it may appear with or after the other manifestations of rheumatic inflammation. CNS Sydenham chorea occurs in about 10 to 30% of children. It may develop along with other manifestations but frequently arises after the other manifestations have subsided (often months after the acute streptococcal infection) and thus may be overlooked as an indicator of acute rheumatic fever. Onset of chorea is typically

2013 Merck Manual (19th Edition)

130. Intravenous Immunoglobulin for PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections)

chronological age). Sleep disorder (insomnia, night terrors, refusal to sleep alone). Handwriting deterioration or other sign of motoric dysfunction (including new onset of motor hyperactivity, or presence of choreiform finger movements). Urinary frequency or increased urge to urinate; daytime or night-time secondary enuresis. EXCLUSION CRITERIA: History of rheumatic fever, including Sydenham chorea (the neurologic manifestation). Presence of symptoms consistent with autism, schizophrenia, or other

2011 Clinical Trials

131. Omega-3 Fatty Acids in Tourette's Disorder

and to understand the nature of the study. Subjects and their legal representatives must be considered reliable. Exclusion Criteria: Organic brain disease, for example, traumatic brain injury residua Meeting criteria for mental retardation as defined by the DSM-IV. A history of seizure disorder (other than febrile seizure). A Subjects with history of Sydenham's Chorea. Autism, schizophrenia or other psychotic disorders. A primary diagnosis of a major mood disorder that requires ongoing psychiatric treatment

2011 Clinical Trials

132. Movement disorders in paraneoplastic and autoimmune disease Full Text available with Trip Pro

ataxia and pesudoathetosis. Other disorders such as Sydenham's chorea, or chorea related to systemic lupus erythematosus and antiphospholipid syndrome occur in association with multiple antibodies, are not paraneoplastic, and are triggered by molecular mimicry or unknown mechanisms. Recent studies have revealed a new category of disorders that can be paraneoplastic or not, and associate with antibodies against cell-surface or synaptic proteins. They include anti-N-methyl-D-aspartate receptor (anti (...) Movement disorders in paraneoplastic and autoimmune disease The most relevant advances in immune-mediated movement disorders are described, with emphasis on the clinical--immunological associations, novel antigens, and treatment.Many movement disorders previously considered idiopathic or degenerative are now recognized as immune-mediated. Some disorders are paraneoplastic, such as anti-CRMP5-associated chorea, anti-Ma2 hypokinesis and rigidity, anti-Yo cerebellar ataxia and tremor, and anti-Hu

2011 Current Opinion in Neurology

133. A film of patients with movement disorders made in Queen Square, London in the Mid-1920s by Samuel Alexander Kinnier Wilson. (Abstract)

tremor, Parkinson's disease and postencephalitic parkinsonism, hemiballismus, Huntington's chorea, Sydenham's chorea, hysterical palsy and tremor, multiple sclerosis, and progressive lenticular degeneration. Most of the patients are filmed in the square outside the National Hospital. The British Film Institute dates the film to 1924 and the captions to 1925. The case records of 6 of the 14 patients, who were admitted to the National Hospital, Queen Square, under the care of Dr. SAKW have been

2011 Movement Disorders

134. Pediatric autoimmune neuropsychiatric disorders associated with streptococcus in identical siblings. (Abstract)

Pediatric autoimmune neuropsychiatric disorders associated with streptococcus in identical siblings. Termed pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), these cases of childhood-onset obsessive compulsive disorder and tic disorders resemble the presentation of Sydenham chorea, in that they have an acute onset following a group A beta-hemolytic streptococcal infection (group A Streptococcus), with accompanying neurological signs, and an episodic

2011 Journal of Child and Adolescent Psychopharmacology

135. Rheumatic fever

. An April 2013 review article in the Indian Journal of Medical Research stated that echocardiographic and Doppler (E & D) studies, despite some reservations about their utility, have identified a massive burden of rheumatic heart disease, which suggests the inadequacy of the 1992 Jones' criteria. E & D studies have identified subclinical carditis in patients with rheumatic fever, as well as in follow-ups of rheumatic heart disease patients who initially presented as having isolated cases of Sydenham's (...) chorea. Signs of a preceding streptococcal infection include: recent , raised antistreptolysin O or other streptococcal antibody titre, or positive throat culture. Major criteria [ ] : A temporary migrating inflammation of the large joints, usually starting in the legs and migrating upwards. : Inflammation of the heart muscle ( ) which can manifest as with shortness of breath, with a rub, or a new . Subcutaneous nodules: Painless, firm collections of collagen fibers over bones or . They commonly

2012 Wikipedia

136. Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic Acid) Followed by a 20 Week Elimination Phase of Folate

deafness ; Sydenham's chorea, porphyria, disturbances in the bile flow. Liver diseases: Presence or history of severe hepatic diseases including benign or malignant tumors Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its identifier (NCT number): NCT01258660 Locations Layout table

2010 Clinical Trials

137. The Immunobiology of Tourette's Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus, and Related Disorders: A Way Forward. Full Text available with Trip Pro

interest has been Group A Streptococcus (GAS), which began to receive attention as a potential cause of neuropsychiatric symptoms, following the investigation of the symptoms reported in Sydenham's chorea (SC) and rheumatic fever, such as motor tics, vocal tics, and both obsessive-compulsive and attention deficit/hyperactivity symptoms. Young children have been described as having a sudden onset of these neuropsychiatric symptoms temporally associated with GAS, but without supporting evidence (...) and MedLine databases using the following keywords: OCD, immune, PANDAS, Sydenham chorea, Tourette's disorder Group A Streptococcus. Articles were also identified through reference lists from research articles and other materials on childhood OCD, PANDAS, and TD between 1966 and December 2010. Considering the overlap of clinical and neuroanatomic findings among these disorders, this review explores evidence regarding the immunobiology as well as the relevant clinical and therapeutic aspects of TD, OCD

2010 Journal of Child and Adolescent Psychopharmacology

138. A prospective study of acute movement disorders in children. (Abstract)

. It was possible to divide the participants into three groups: (1) those with inflammatory or autoimmune disorders (n=22), (2) those with non-inflammatory disorders (n=18), and (3) those with psychogenic disorders (n=12). The inflammatory or autoimmune aetiologies included N-methyl-D-aspartate receptor encephalitis (n=5), opsoclonus-myoclonus syndrome (n=4), Sydenham chorea (n=3), systemic lupus erythematosus (n=3), acute necrotizing encephalopathy (n=3), and other types of encephalitis (n=4). Other important (...) A prospective study of acute movement disorders in children. The purpose of this study was to report a prospective cohort of children with acute-onset movement disorders.We report on 52 individuals (31 females, 21 males; mean age 6y 5mo, range 2mo-15y) with acute-onset movement disorders managed at a busy tertiary paediatric referral hospital over a 40-month period.In descending order of frequency, the movement disorders reported were chorea, dystonia, tremor, myoclonus, and parkinsonism

2010 Developmental Medicine and Child Neurology

139. St Vitus' dance

St Vitus' dance St Vitus' dance - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search St Vitus' dance Sydenham's chorea is a self-limiting disorder of movement occuring most frequently in association with rheumatic fever. It occurs mainly in females, with onset between the ages of 5 and 15 or during pregnancy. The onset is generally 2 to 6 months after streptococcal infection. ESR and antistreptolysin O titres are usually

2010 GP Notebook

140. Rheumatic fever

migratory polyarthritis (46-66% of cases), most commonly in the knee, ankle, elbow and wrists; carditis (53-68% clinical and additional ''subclinical'' diagnosed by echocardiogram), which is typically inflammation of the mitral (90%) or aortic valve (10%) in isolation, but any combination of all 4 valves have been reported; Sydenham chorea (8-15%); erythema marginatum (1-11%); and subcutaneous nodules on the flexor surfaces (1-8%). Minor criteria include fever (35-75% of cases), arthralgia (35-56

2005 Orphanet

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>