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Sydenham Chorea

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41. Subtle cognitive deficits in adults with a previous history of Sydenham's chorea during childhood. (Abstract)

Subtle cognitive deficits in adults with a previous history of Sydenham's chorea during childhood. To evaluate the neuropsychological profile and health-related quality of life (HRQOL) of adults who had rheumatic fever (RF) during childhood with and without Sydenham's chorea (SC).Three groups of patients were assessed: adults who had RF with SC during childhood (SC group), adults who had RF without SC during childhood (RF group), and controls (CT group). A range of neuropsychological tests

2010 Arthritis care & research

42. Off-Label Use of Intravenous Immunoglobulin for Autoimmune or Inflammatory Conditions: A Review of Clinical Effectiveness

, dermatomyositis, myasthenia gravis, polymyositis, Kawasaki disease, and Sydenham’s chorea. Each of the autoimmune conditions was investigated by one study, except for dermatomyositis and myasthenia gravis which were investigated by two and three studies, respectively. Overall, considering the limitations in the study designs, reporting of outcomes, limited sample sizes, and risk of bias, there is limited evidence to suggest that off-label IVIG is clinically effective for the treatment of autoimmune diseases

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

43. CRACKCast E175 – Neurologic Disorders

neonatal sleep myoclonus Nonepileptic apnea Opisthotonos (hyperextension, back arching, spasticity – either physiologic or pathologic in cases of meningitis, tetanus) Normal movement Non-neonates: Syncope BRUE Breath-holding spells Migraine with aura (vomiting, motor deficits, altered LOC) Sydenham’s chorea Various sleep disorders – narcolepsy, cataplexy Tics Psychogenic non-epileptic seizures Panic attacks For a more comprehensive list of mimics of epilepsy disorders, please refer to Table 174.6

2018 CandiEM

44. CRACKCast E171 – Pediatric Cardiac Disorders

carditis (murmur*, CHF, pericarditis,and various degrees of heart block), nodules, erythema marginatum, sydenham chorea. *mitral or aortic insufficiency: The murmur of mitral insufficiency is characterized as a holosystolic murmur best heard over the apex with radiation to the axilla. The murmur of aortic insufficiency is characterized as a diastolic murmur that is best heard over the base of the heart. Innocent murmurs that are normally exacerbated with fever can be mistaken for the murmurs of mitral

2018 CandiEM

45. CRACKCast E110 – Thought Disorders

erythematosus Temporal (giant cell) arteritis ORGAN FAILURE Hepatic encephalopathy Uremia NEUROLOGIC DISORDERS Alzheimer’s disease Cerebrovascular disease Encephalitis (including HIV infection) Encephalopathies Epilepsy Huntington’s disease Multiple sclerosis Neoplasms Normal-pressure hydrocephalus Parkinson’s disease Pick’s disease Wilson’s disease ENDOCRINE DISORDERS Addison’s disease Cushing’s disease Panhypopituitarism Parathyroid disease Postpartum psychosis Recurrent menstrual psychosis Sydenham’s (...) chorea Thyroid disease DEFICIENCY STATES Niacin Thiamine Vitamin B12 and folate “Psychosis” Postpartum Sarcoid thYroid Calcium and Carbon (high) HypoNa/02/Glycemia SLE Itis – encephalItis Substrate deficiency states Niacin, thiamine, Vit b12. [2] List 10 pharmacologic agents that may cause acute psychosis (Box) BOX 100.2 Pharmacologic Agents That May Cause Acute Psychosis ANTIANXIETY AGENTS Alprazolam Chlordiazepoxide Clonazepam Clorazepate Diazepam Ethchlorvynol ANTIBIOTICS Isoniazid Rifampin

2017 CandiEM

47. CRACKCast E089 – Esophagus, Stomach & Duodenum

,etc the most common causes of OPD are motility-related. 2) List 4 causes of oropharyngeal dysphagia: “immediate or transfer dysphagia” Neuromuscular – swallowing muscles don’t work Due to a cerebrovascular accident – #1 cause! Degenerative aging: Alzheimer’s, ALS, Diabetic neuropathy, muscular dystrophy, Parkinson’s, Brain tumour Immunologic – poly/dermatomyositis / MS / Myasthenia Gravis / scleroderma Infectious – botulism, diphtheria, polioMyelitis, rabies, Sydenham’s chorea, tetanus Metabolic

2017 CandiEM

48. A Strep in the right direction…

of medical student revision were stirred and I remembered St Vitus’ Dance – or, more prosaically, Sydenham’s chorea – a rare but serious consequence of an infection with Group A Streptococcus. The condition earned its name because it is characterised by rapid, uncoordinated movements mainly affecting the face, hands and feet. St Vitus is the patron saint of dancers. Sore throat is a common condition and more often than not is caused by a virus. Streptococcus pyogenes, a Group A Streptococcus (GAS

2016 Evidently Cochrane

49. Revision of the Jones Criteria for the Diagnosis of Acute Rheumatic Fever in the Era of Doppler Echocardiography Full Text available with Trip Pro

that polyarthralgia is almost always a symptom of an illness other than ARF and favored retaining polyarthralgia as a minor manifestation for low-risk populations, as per the historic Jones criteria. The inclusion of polyarthralgia as a major manifestation is applicable only for moderate- or high-incidence populations and only after careful consideration and exclusion of other causes of arthralgia such as autoimmune, viral, or reactive arthropathies ( ) (Class IIb; Level of Evidence C ). Chorea (Sydenham Chorea (...) ). Clinical Manifestations of ARF Generally, the clinical profile of ARF in low- and middle-income countries closely resembles that of high-income countries. Universally, the most common major manifestations during the first episode of ARF (the “major criteria” for diagnosis) remain carditis (50%–70%) and arthritis (35%–66%). , , , These are followed in frequency by chorea (10%–30%), which has been demonstrated to have a female predominance, and then subcutaneous nodules (0%–10%) and erythema marginatum

2015 American Heart Association

50. PANDAS and PANS: Clinical, Neuropsychological, and Biological Characterization of a Monocentric Series of Patients and Proposal for a Diagnostic Protocol. (Abstract)

, and biochemical aspects in a sample of PANS and PANDAS patients.Patients fulfilling a clinical diagnosis of PANS or PANDAS from 2014 to 2017 were enrolled. Neurological and psychiatric examination and biochemical and instrumental assessment results were collected. A neuropsychological battery was administered. For comparison purposes, a control group of patients with Sydenham's chorea (SC) was evaluated. Descriptive and comparative statistical analyses were performed.Seven subjects received a diagnosis

2019 Journal of Child and Adolescent Psychopharmacology

51. Neuropsychiatric Disorder Associated with Group G Streptococcus Infection Full Text available with Trip Pro

Neuropsychiatric Disorder Associated with Group G Streptococcus Infection Immune-mediated central nervous system manifestations of group A β-hemolytic Streptococcus (GABHS) infection include Sydenham's chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS)-which includes tic and obsessive compulsive disorders-and a variety of neurobehavioral disorders. We report a case of Streptococcus dysgalactiae subspecies equisimilis (group G Streptococcus

2018 Case reports in pediatrics

52. Trial to Evaluate the Long-term Efficacy of Oral Aripiprazole in the Treatment of Pediatric Subjects With Tourette's Disorder

, to read and understand the written word in order to complete subject-reported outcomes measures, and to be reliably rated on assessment scales. Exclusion Criteria: The subject presents with a clinical presentation and/or history that is consistent with another neurologic condition that may have accompanying abnormal movements. These include, but are not limited to, the following: Transient tic disorder; Huntington's disease; Parkinson's disease; Sydenham's chorea; Wilson's disease; Mental retardation

2018 Clinical Trials

53. Acute hyperkinetic movement disorders in Italian paediatric emergency departments. (Abstract)

movements and idiopathic AHMDs) accounted for 31.2%. Neuropsychiatric disorders prevailed among preschoolers and schoolers (51.9% and 25.2%, respectively), non-inflammatory disorders were more frequent in infants and toddlers (63.8%), whereas inflammatory conditions were more often encountered among schoolers (73.3%). In 5 out of 36 Sydenham's chorea (SC) cases, tics were the presentation symptom on admission to emergency department (ED), highlighting the difficulties in early diagnosis of SC (...) (44.5%), followed by tremors (21.1%), chorea (13.7%), dystonia (10.2%), myoclonus (6.3%) and stereotypies (4.3%). Neuropsychiatric disorders (including tic disorders, psychogenic movement disorders and idiopathic stereotypies) were the most represented cause (51.2%). Inflammatory conditions (infectious and immune-mediated neurological disorders) accounted for 17.6% of the cases whereas non-inflammatory disorders (including drug-induced AHMDs, genetic/metabolic diseases, paroxysmal non-epileptic

2018 Archives of Disease in Childhood

54. Evaluating the Efficacy and Safety of Yi-Gan San in Children and Adolescents With Tourette's Disorder

Criteria: The subject presents with a clinical presentation and/or history that is consistent with another neurologic condition that may have accompanying abnormal movements. These include, but are not limited to: Transient Tic disorder/ Huntington's disease/ Parkinson's disease/ Sydenham's chorea/ Wilson's disease/ Mental retardation/ Pervasive developmental disorder/ Traumatic brain injury/ Stroke/ Restless Legs Syndrome The subject has a history of schizophrenia, bipolar disorder, or other psychotic

2018 Clinical Trials

55. Jeffrey Aronson: When I use a word . . . Circle squarers and St Vitus

in his honour, devotees would dance so joyously that Vitus became the patron saint of dancers, actors, and people with epilepsy, whose convulsions were regarded as a form of dancing. St Vitus’ dance was then applied to the specific form of disorder otherwise known as chorea (Greek χορεία, dance) or Sydenham’s chorea, to distinguish it from other forms, since it was first described by Thomas Sydenham in Schedula Monitoria de Novis Febris Ingressu (1686): “Cuius rei experimentum a me factum in medium (...) profero, nempe in quadam Convulsionis specie quæ Chorea Sancti Viti vulgo appellatur” (“I experimentally demonstrate [the effects of venesection and purgation] in that type of seizure commonly called St Vitus dance”). St Vitus, from the Nuremberg Chronicle, 1493 (source ) The English term “St Vitus dance” is first recorded in Robert Burton’s Anatomy of Melancholy : “ Chorus sancti Viti , or Saint Vitus dance, the lascivious dance, Paracelsus calls it, because they that are taken with it, can doe

2018 The BMJ Blog

57. Obsessive Compulsive Disorder

as controversial in OCDasthatofPANDAS.Thecentralhypothesis of PANDAS derives from the observations of neurobehavioral disturbance accompanying Sydenham chorea, a sequel of rheumatic fever. An immune response to group A -hemolytic streptococcus (GABHS) infections purportedly leadstocrossreactivitywith,andin?ammation of,basalganglia,withadistinctneurobehavioral syndrome that includes OCD, tics, and perhaps hyperactivity. The diagnostic criteria were laid out by Swedo et al., 14 but detractors have argued AACAP (...) suddenly relapses. Neurologic signs, such as chorea, are evidence of rheumatic fever but may not occur for many months after infection. “Soft” neurologic signs, such as tremor and coordination dif?culties on examination, are one criterion of the PANDAS diagnosis. 14,17 Antistreptococcic antibodies such as antistreptolysin O and anti-DNase B are present in most children by early adolescence, but a 0.2 log increase (doubling) in titers is considered evidence of a recent infection. Intercurrent titers may

2012 American Academy of Child and Adolescent Psychiatry

58. The Australian guideline for prevention, diagnosis and management of acute rheumatic fever and rheumatic heart disease

? pericardial friction rub or effusion • Expanded discussion on cognitive dysfunction with chorea • Upper limits of normal (ULN) for serum streptococcal antibody titres expanded to include children and adults based on Fiji data (Table 3.6) Table 1.1 Levels of evidence for clinical interventions, and grades of recommendation Level of evidence Study design Grade of recommendation I Evidence obtained from a systematic review of all relevant RCT A Rich body of high quality RCT data II Evidence obtained from

2012 Clinical Practice Guidelines Portal

59. Rheumatic fever identification, management and secondary prevention

Islander communities living in rural or remote areas or in disadvantaged suburban areas. Sydenham (rheumatic) chorea is present in roughly 25% of Aboriginal Australians (especially female adolescents) with ARF. 11 As part of the major manifestations, Sydenham chorea is sufficient to diagnose ARF without evidence of previous S. pyogenes infection, provided other causes of chorea have been excluded. 2 The NHFA criteria consider some less specific symptoms, such as polyarthralgia and aseptic monoarthritis (...) -arthritis or polyarthralgia Sydenham chorea Erythema marginatum Subcutaneous nodules Carditis (including subclinical evidence of rheumatic valve disease on echocardiogram) Polyarthritis Sydenham chorea Erythema marginatum Subcutaneous nodules Minor manifestations Fever ESR ≥30 mm/hr or CPR ≥30 mg/L Prolonged P-R interval on ECG Fever Polyarthralgia or aseptic mono-arthritis ESR ≥30 mm/hr or CPR ≥30 mg/L Prolonged P-R interval on ECG ESR = erythrocyte sedimentation rate; CRP = c-reaction protein; ECG

2012 Clinical Practice Guidelines Portal

60. Longitudinal outcomes of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). (Abstract)

conceptualization of PANDAS as a subacute illness similar to Sydenham chorea. However, some children developed a chronic course of illness, highlighting the need for research that identifies specific symptoms or biomarkers that can be used to predict the longitudinal course of symptoms in PANDAS.

2017 European child & adolescent psychiatry Controlled trial quality: predicted high

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