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Sydenham Chorea

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1. Sydenham's Chorea. (PubMed)

Sydenham's Chorea. Sydenham's chorea is the most common acquired movement disorder of adolescence. This clinical manifestation of acute rheumatic fever has a clear and documented relationship with Group A streptococcal infections. The symptoms are involuntary choreiform movements that can affect the face and all extremities. The pathophysiology remains unclear.A 12-year-old female was brought to the emergency department with a 2-week history of involuntary muscle spasms of her right arm and leg (...) of rheumatic fever. Anti-streptolysin O titer was markedly elevated, along with DNAse-B antibodies. The patient had marked improvement of movement disorder at just over 1 week later. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Sydenham's chorea is a rare but important movement disorder often related to Group A streptococcus and rheumatic fever. The incidence of rheumatic fever has been decreasing in North America but continues to be much more prevalent in developing countries as well as immigrant

2019 Journal of Emergency Medicine

2. You can dance if you want to: A case of Sydenham's chorea. (PubMed)

You can dance if you want to: A case of Sydenham's chorea. Isolated motor disturbances in the paediatric population are uncommon presentations to the emergency department. Choreiform movements have a broad differential diagnosis and may present insidiously with progressive worsening of asymmetric clumsiness, hypotonia and dysarthria. The incidence of Sydenham's chorea (SC) caused by acute rheumatic fever (ARF) is very rare in developed countries. We report a previously healthy, vaccinated 9 (...) and inability to hold a pencil at school. He was subsequently diagnosed with chorea by the neurology team. The cause of chorea was later determined to be SC, and the patient's throat swab came back positive for group A-beta hemolytic strep (GAS) infection. We explore current literature regarding the various presentations of ARF, differential considerations in acute chorea, and diagnostic studies needed to determine the etiology of acute chorea. With the low incidence of chorea in developed nations

2019 American Journal of Emergency Medicine

3. Successful treatment of Sydenham's chorea with intravenous immunoglobulin (PubMed)

Successful treatment of Sydenham's chorea with intravenous immunoglobulin We present a case of a 10-year-old girl diagnosed with Sydenham's chorea. Despite treatment with haloperidol and valproic acid for 2 weeks and antibiotics for 5 days, her symptoms continued to worsen. She became severely impaired in daily functioning, as she could barely speak or walk, experienced major feeding difficulties and required help with all daily activities. She was treated with intravenous immunoglobulin (IVIG (...) ). Within 4 days, her symptoms started to improve and after 1-month she had fully recovered. This case reminds us that Sydenham's chorea can result in major functional impairment. There is some evidence on the beneficial effect of IVIG in the treatment of Sydenham's chorea, as is evident in our case. Therefore, IVIG should be considered as a treatment option in patients with severe chorea.2016 BMJ Publishing Group Ltd.

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2016 BMJ case reports

4. Sydenham Chorea

Sydenham Chorea Sydenham Chorea Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sydenham Chorea Sydenham Chorea Aka: Sydenham Chorea (...) , Sydenham's Chorea , Rheumatic Chorea , Saint Vitus Dance From Related Chapters II. Pathophysiology Childhood Occurs within 8 months of Streptococcal infection Specifically Group A Beta Hemolytic Late manifestation of III. Epidemiology : <5% of cases Ages: 5 to 15 years Girls affected more often than boys IV. Symptoms: Gradual onset of neurological symptoms Atypical behavior Irritability and crying Anxiety and restlessness Transient acute Poor memory retention Motor weakness Abrupt onset of choreoform

2018 FP Notebook

5. Sydenham Chorea

Sydenham Chorea Sydenham Chorea Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sydenham Chorea Sydenham Chorea Aka: Sydenham Chorea (...) , Sydenham's Chorea , Rheumatic Chorea , Saint Vitus Dance From Related Chapters II. Pathophysiology Childhood Occurs within 8 months of Streptococcal infection Specifically Group A Beta Hemolytic Late manifestation of III. Epidemiology : <5% of cases Ages: 5 to 15 years Girls affected more often than boys IV. Symptoms: Gradual onset of neurological symptoms Atypical behavior Irritability and crying Anxiety and restlessness Transient acute Poor memory retention Motor weakness Abrupt onset of choreoform

2018 FP Notebook

6. Sydenham's chorea: not gone but perhaps forgotten. (PubMed)

Sydenham's chorea: not gone but perhaps forgotten. Sydenham's chorea (SC) is characterised by chorea, emotional lability and hypotonia. In this study, we investigated the incidence and clinical presentation of childhood SC in Ireland (years 2006-2014). Nineteen cases were diagnosed. Five patients had rheumatic fever. An increasing trend with an incidence of 0.23/100 000 is reported. As most referral diagnoses included psychogenic illness, head injury and stroke, modern physicians may

2015 Archives of Disease in Childhood

7. Intravenous immunoglobulin in acute Sydenham's chorea: A systematic review. (PubMed)

Intravenous immunoglobulin in acute Sydenham's chorea: A systematic review. Sydenham's chorea (SC) is a major manifestation seen in 25% of patients with acute rheumatic fever. SC is the prototypic autoimmune neurological disorder, which has a less appreciated associated risk of psychiatric morbidity. We undertook a systematic review to examine whether the use of intravenous immunoglobulin affects clinical recovery and morbidity. © 2015 The Authors. Journal of Paediatrics and Child Health © 2015

2015 Journal of paediatrics and child health

8. Neuropsychiatric manifestations of Sydenham's chorea: a systematic review. (PubMed)

Neuropsychiatric manifestations of Sydenham's chorea: a systematic review. Sydenham's chorea is a post-streptococcal, autoimmune, neuropsychiatric movement disorder. Sydenham's chorea is a major criterion for diagnosis of acute rheumatic fever with the implication of potential long-term sequelae including cardiac complications. It is well established that there is psychiatric comorbidity in Sydenham's chorea, but there are variations in the literature regarding the nature and prevalence (...) of psychiatric diagnoses associated with Sydenham's chorea. The aim of this review was to systematically evaluate the evidence for psychiatric symptoms presenting with Sydenham's chorea. Knowledge of comorbid psychiatric symptomatology will support early diagnosis and treatment, leading to improved long-term outcomes for children with Sydenham's chorea.The study used a systematic search strategy, using MEDLINE, MEDLINE in Process, EMBASE, and The Cochrane Library. Abstracts were screened to identify relevant

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2015 Developmental Medicine and Child Neurology

9. Brain SPECT in Sydenham's chorea in remission. (PubMed)

Brain SPECT in Sydenham's chorea in remission. Sydenham's chorea, a major manifestation of rheumatic fever, is characterized by chorea, behavioral changes, and cognitive dysfunction. Perfusion changes in the basal ganglia are the most frequent imaging findings observed in patients with Sydenham's chorea.Twelve adult women with Sydenham's chorea in remission underwent brain single-photon emission computed tomography (SPECT). Their scans underwent a quantification process to evaluate (...) the perfusion of Brodmann's areas of the frontal lobes and basal ganglia. The results were compared with the findings from a control group that was matched by age.A pattern of hyperperfusion in the left putamen was observed in the patient group (P = 0.02). No significant difference was observed in relation to other brain regions.The findings of brain SPECT suggest that perfusion abnormalities of the basal ganglia may persist even after the remission of abnormal movements in patients with Sydenham's chorea

2014 Movement Disorders

10. Changes in motor cortical excitability in patients with Sydenham's chorea. (PubMed)

Changes in motor cortical excitability in patients with Sydenham's chorea. The neurophysiological characteristics of motor cortex have been well characterized in patients with Huntington's disease. We present the first data on cortical excitability in patients with Sydenham's chorea.Motor cortex excitability was examined using transcranial magnetic stimulation in 16 patients in the early clinical stages of Sydenham's chorea and in 17 age- and sex-matched control subjects. Investigations (...) included resting and active motor threshold, motor evoked potential, input-output curves, contralateral silent period, and transcallosal inhibition.Resting and active motor threshold were significantly higher and motor evoked potentials were significantly smaller in patients in comparison with controls. The input-output curves were shallower in both hemispheres of patients with chorea compared with controls. No significant differences were seen in silent period or transcallosal inhibition

2014 Movement Disorders

11. Sydenham Chorea: Rare Consequence of Rheumatic Fever (PubMed)

Sydenham Chorea: Rare Consequence of Rheumatic Fever 25493130 2015 08 18 2018 11 13 1936-9018 15 7 2014 Nov The western journal of emergency medicine West J Emerg Med Sydenham Chorea: rare consequence of rheumatic fever. 840 10.5811/westjem.2014.8.22981 Myers Paul J PJ Lehigh Valley Health Network/USF MCOM, Department of Emergency Medicine, Allentown, Pennsylvania. Kane Kathleen E KE Lehigh Valley Health Network/USF MCOM, Department of Emergency Medicine, Allentown, Pennsylvania. Porter (...) Bernadette G BG Lehigh Valley Health Network/USF MCOM, Department of Emergency Medicine, Allentown, Pennsylvania. Mazzaccaro Richard J RJ Lehigh Valley Health Network, Department of Pediatrics, Allentown, Pennsylvania. eng Case Reports Journal Article Video-Audio Media 2014 09 19 United States West J Emerg Med 101476450 1936-900X IM Child Chorea diagnosis etiology Humans Male Rheumatic Fever complications diagnosis 2014 07 09 2014 08 20 2014 12 11 6 0 2014 12 11 6 0 2015 8 19 6 0 ppublish 25493130

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2014 Western Journal of Emergency Medicine

12. Réponse spectaculaire au valproate de sodium d’une chorée de Sydenham récurrente (PubMed)

Réponse spectaculaire au valproate de sodium d’une chorée de Sydenham récurrente Sydenham's chorea is the most common acquired cause of chorea in the third world. We report a case of recurrent chorea successfully treated with sodium valproate. Miss A.C, aged 16, with a history of recurrent angina reported an episode of choreic movements 2 years before requiring treatment with haloperidol and prevention of rheumatic fever. The patient interrupted her treatment with occurrence of a relapse (...) a few months later. Brain MRI and transthoracic ultrasound were normal. Preventive treatment with extencilline and haloperidol was restarted without any improvement, hence the treatment with sodium valproate. The patient responded very well after 2 months of treatment, without recurrence at 3 years' follow-up. The treatment of Sydenham's chorea was based on neuroleptics. Recent studies advocate the use of other more effective and better tolerated molecules.

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2017 The Pan African medical journal

13. Functional Impact of Sydenham's Chorea: A Case Report (PubMed)

Functional Impact of Sydenham's Chorea: A Case Report Sydenham's chorea (SC) is the most common type of acquired chorea in childhood. In some cases, symptoms (most commonly described in terms of neurological signs) last up to 2 years, and many cases relapse. This report describes the clinical course in terms of functional abilities following diagnosis of SC.Standardized assessments across the domains of activity and participation were administered following diagnosis, prior to and following

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2013 Tremor and Other Hyperkinetic Movements

14. Treatment of sydenham chorea with intravenous immunoglobulin. (PubMed)

Treatment of sydenham chorea with intravenous immunoglobulin. Sydenham chorea is a post-streptococcal, autoimmune, neuropsychiatric, movement disorder. There is no effective treatment. In a randomized study, comparison was made of the outcomes of 10 children treated with standard management alone compared to 10 who received additional intravenous immunoglobulin. The outcomes were assessed using a clinical rating scale, brain single-photon emission computed tomography, and the duration

2012 Journal of child neurology

15. Sydenham's Chorea

Sydenham's Chorea Sydenhams Chorea Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sydenham's Chorea Sydenham's Chorea Aka: Sydenham's (...) within 3 to 6 weeks VIII. Management s have been used in the past IX. Reference Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Sydenhams Chorea." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Rheumatic Chorea (C0152113) Definition (CSP) acute, usually self-limited disorder of early life, usually between ages 5 and 15, or during pregnancy

2015 FP Notebook

16. Treatment of Sydenham’s Chorea: A Review of the Current Evidence (PubMed)

Treatment of Sydenham’s Chorea: A Review of the Current Evidence Sydenham's chorea (SC), the neurologic manifestation of rheumatic fever, remains the most prevalent form of chorea in children. Suggested treatments of chorea in SC include prophylactic penicillin, symptomatic (antipsychotic and anticonvulsant) medications, and immunomodulatory therapy (steroids, intravenous immunoglobulin (IVIG), and plasma exchange). In this manuscript, we undertook a systematic review of the published (...) literature to examine the data supporting these therapeutic recommendations.A search of PubMed, Embase, Psychinfo, and clinicaltrials.gov was conducted for publications pertaining to the treatment of SC/rheumatic chorea from 1956 to 2016.Penicillin prophylaxis appears to reduce the likelihood of further cardiac complications and the recurrence rate of chorea. Data on symptomatic therapy for chorea are limited to individual case reports or series and rare comparison studies. The efficacy of steroid use

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2017 Tremor and Other Hyperkinetic Movements

17. Language Impairment in Adolescents with Sydenham Chorea (PubMed)

Language Impairment in Adolescents with Sydenham Chorea Investigators from hospitals in Brazil tested verbal fluency in 20 adolescent patients, ages ranged from 11 to 16 years (mean 13.8 years), with Sydenham chorea compared with 20 patients with rheumatic fever without chorea and 20 healthy controls, matched for age and gender.

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2015 Pediatric neurology briefs

18. Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome. (PubMed)

Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome. To test the hypothesis that Sydenham chorea (SC) immunoglobulin G (IgG) autoantibodies bind to specific neuronal surface proteins, whereas IgG from patients with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) or Tourette syndrome (TS) do not bind to neuronal surface proteins.We used live differentiated SH-SY5Y cells, which have neuronal

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2011 Neurology

19. Tetrabenazine in Sydenham's chorea. (PubMed)

Tetrabenazine in Sydenham's chorea. 861648 1977 07 29 2018 11 13 0007-1447 1 6073 1977 May 28 British medical journal Br Med J Tetrabenazine in Sydenham's chorea. 1391-2 Hawkes C H CH Nourse C H CH eng Case Reports Journal Article England Br Med J 0372673 0007-1447 Z9O08YRN8O Tetrabenazine AIM IM Acute Disease Child Chorea drug therapy Female Humans Male Syndrome Tetrabenazine therapeutic use 1977 5 28 1977 5 28 0 1 1977 5 28 0 0 ppublish 861648 PMC1606896 Lancet. 1974 Jan 26;1(7848):104-7

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1977 British medical journal

20. The Etiology of Sydenham's Chorea: Electroencephalographic Studies (PubMed)

The Etiology of Sydenham's Chorea: Electroencephalographic Studies 20322055 2010 06 24 2018 11 13 0008-4409 44 4 1941 Apr Canadian Medical Association journal Can Med Assoc J The Etiology of Sydenham's Chorea: Electroencephalographic Studies. 365-71 Usher S J SJ Jasper H H HH eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 2010 3 24 6 0 1941 4 1 0 0 1941 4 1 0 1 ppublish 20322055 PMC1827047 Can Med Assoc J. 1933 Nov;29(5):470-5 20319287 Can Med Assoc J. 1938 Dec;39(6):565-8

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1941 Canadian Medical Association Journal

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