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1. Sunburn

Sunburn Sunburn - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sunburn Last reviewed: February 2019 Last updated: March 2018 Summary Sunburn is an acute inflammatory skin condition characterised by erythema, oedema, vesiculation, and desquamation, with associated symptoms of pain and/or pruritus. Sunburn is a major preventable risk factor for accelerated photo-ageing and most common forms of skin cancer. The disease (...) typically runs a self-limited course and is treated symptomatically. Education about future sunburn prevention via sun avoidance during peak daylight hours and the use of protective clothing/sunscreen are key interventions. Definition Sunburn is an acute inflammatory reaction of the skin induced by over-exposure to UV radiation. Skin findings include erythema and oedema, with or without vesiculation, followed by desquamation. Symptoms include pain and/or pruritus. Acute sunburn is a self-limited

2018 BMJ Best Practice

2. Prevalence of Sun Protection Use and Sunburn and Association of Demographic and Behaviorial Characteristics With Sunburn Among US Adults. Full Text available with Trip Pro

Prevalence of Sun Protection Use and Sunburn and Association of Demographic and Behaviorial Characteristics With Sunburn Among US Adults. Monitoring sun protection and sunburn over time at the population level can provide valuable information about progress toward skin cancer prevention goals and inform future intervention efforts.To examine the prevalence of sun protection use (shade, sunscreen, and clothing) and sunburn and the association between sunburn and individual characteristics (...) and health behaviors in the US population.In this cross-sectional study using a nationally representative sample of 31 162 US adults from the 2015 National Health Interview Survey-Cancer Control Supplement, household interviews of civilian, noninstitutionalized US adults were conducted throughout 2015 in person and completed on the telephone when necessary. Data analysis was performed from August 16, 2016, to September 6, 2017.The prevalence of sunburn and use of sun protection and their association

2018 JAMA dermatology (Chicago, Ill.)

3. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn. Full Text available with Trip Pro

Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn. Sunlight contains ultraviolet (UV)A and UVB radiation. UVB is essential for vitamin D synthesis but is the main cause of sunburn and skin cancer. Sunscreen use is advocated to reduce the sun's adverse effects but may compromise vitamin D status.To assess the ability of two intervention sunscreens to inhibit vitamin D synthesis during a week-long sun holiday.The impact (...) in the intervention groups was measured. Behaviour, UV radiation exposure, clothing cover and sunburn were monitored. Serum 25-hydroxyvitamin D3 [25(OH)D3 ] was assessed by high-performance liquid chromatography-tandem mass spectrometry.Use of intervention sunscreens was the same (P = 0·60), and both equally inhibited sunburn, which was present in the discretionary use group. There was an increase (P < 0·001) in mean ± SD 25(OH)D3 (28·0 ± 16·5 nmol L-1 ) in the discretionary use group. The high and low UVA-PF

2019 British Journal of Dermatology

4. Greater efficacy of SPF 100+ sunscreen compared to SPF 50+ in sunburn prevention during five consecutive days of sunlight exposure: A Randomized, Double-Blind Clinical Trial. (Abstract)

Greater efficacy of SPF 100+ sunscreen compared to SPF 50+ in sunburn prevention during five consecutive days of sunlight exposure: A Randomized, Double-Blind Clinical Trial. Beach vacations are high-risk settings for overexposure to ultraviolet (UV) radiation.To compare the sunburn protective efficacy of SPF 50+ and SPF 100+ sunscreens under actual use at the beach METHODS: A prospective, randomized, double-blind, single-center, split body/face study of 55 healthy subjects. Each subject (...) applied both sunscreens to randomized side of the face/body for up to 5 consecutive days. Blinded clinical evaluation of erythema by a single grader and objective instrumental assessments, colorimetry and diffuse reflectance spectroscopy, were performed the morning following each sun-exposure.After five days, 31 (56%) subjects had more sunburn on the SPF 50+ side and 4 (7%) on the SPF 100+ side. Overall, mean erythema intensity demonstrated statistically significantly less erythema on the SPF 100

2019 Journal of American Academy of Dermatology

5. Sunburn and sun protection in black skin. (Abstract)

Sunburn and sun protection in black skin. People with black skin are much less susceptible to sunburn than white-skinned individuals, yet there are scarce data on self-reported incidence of sunburn and sun protection measures in people with deeply-pigmented skin.An on-line survey tool was used to collect self-assessed data about demographic variables, sunburn incidence, and use of sun protection modalities.Two-thirds of respondents with black skin living in the UK claimed never to have been (...) sunburnt; a much higher proportion than those living in South Africa and Nigeria where 34 and 46%, respectively, reported never experiencing sunburn. Similar results were seen in the reported use of sun protection measures between the countries with two-thirds of black people living in the UK claiming they never used any form of sun protection compared with about one-third of Black Africans. Black people living in the UK were more likely to use sunscreen as a form of sun protection, whereas sunscreen

2019 International Journal of Dermatology

6. No effect of Turkish bath (Hammam) on sunburn after exposure to natural ultraviolet radiation: A randomized controlled blinded trial. (Abstract)

No effect of Turkish bath (Hammam) on sunburn after exposure to natural ultraviolet radiation: A randomized controlled blinded trial. Scrubbing of the skin during Hammam, a Turkish spa treatment, removes cells from the ultraviolet radiation absorbing stratum corneum.The aim of this study was to assess if skin is more susceptible to sunburn after a Hammam treatment.In this randomized controlled trial with a paired design, healthy adult participants with skin types 1-3 were randomized to receive (...) between the Hammam- and the control side. Secondary outcomes were differences in pain and visually assessed erythema.Twelve participants were included with complete follow-up. Eight participants had type-3 skin and four had type-2 skin. There was no difference between the Hammam and the control side for any of the outcomes. Even though erythema assessed by chromatography was slightly higher for the Hammam side, the difference was insignificant.Hammam treatment did not increase sunburn, measured by UV

2018 Journal of cosmetic dermatology Controlled trial quality: predicted high

7. Pilot Study of Intervention to Reduce Sunburns in Melanoma Survivors

Pilot Study of Intervention to Reduce Sunburns in Melanoma Survivors Pilot Study of Intervention to Reduce Sunburns in Melanoma Survivors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pilot Study (...) of Intervention to Reduce Sunburns in Melanoma Survivors The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03518229 Recruitment Status : Not yet recruiting First Posted : May 8, 2018 Last Update Posted : June 7, 2018 See Sponsor

2018 Clinical Trials

8. Sunburn as a Cause of Unexpected Neutrophilia in a Healthy Pregnant Woman Full Text available with Trip Pro

Sunburn as a Cause of Unexpected Neutrophilia in a Healthy Pregnant Woman Neutrophilia has a broad differential diagnosis and represents a systemic response to an infection or other inflammatory pathologies.A 31-year-old woman, Gravida 3, Para 2 at 28 weeks of gestation, presented to the day assessment unit following routine blood tests that showed an unexpected marked neutrophilia. The underlying cause of the neutrophilia was sunburn. The sunburn recovered and her neutrophil count (...) spontaneously normalised.Clinicians can add sunburn to the broad differential diagnosis of neutrophilia.

2018 Case reports in obstetrics and gynecology

9. Decision Tree Model vs Traditional Measures to Identify Patterns of Sun-Protective Behaviors and Sun Sensitivity Associated With Sunburn. Full Text available with Trip Pro

Decision Tree Model vs Traditional Measures to Identify Patterns of Sun-Protective Behaviors and Sun Sensitivity Associated With Sunburn. Understanding patterns of sun-protective behaviors and their association with sunburn can provide important insight into measurement approaches and intervention targets.To assess whether decision-based modeling can be used to identify patterns of sun-protective behaviors associated with the likelihood of sunburn and to compare the predictive value (...) , using sunscreen, seeking shade, wearing a hat, and wearing protective clothing), and sunburn were examined using a χ2 automatic interaction detection method for decision tree analysis. Results were compared with a composite score approach.In our study population of 28 558 respondents with complete data (54.1% women; mean [SD] age, 49.0 [18.0] years), 20 patterns of sun protection were identified. Among 15 992 sun-sensitive individuals, those who used only sunscreen had the highest likelihood

2018 JAMA dermatology (Chicago, Ill.)

10. Fractional sunburn threshold UVR doses generate equivalent vitamin D and DNA damage in skin types I-VI, but with epidermal DNA damage gradient correlated to skin darkness. Full Text available with Trip Pro

Fractional sunburn threshold UVR doses generate equivalent vitamin D and DNA damage in skin types I-VI, but with epidermal DNA damage gradient correlated to skin darkness. Public health guidance recommends limiting sun exposure to sub-sunburn levels, but it is unknown whether these can gain vitamin D (for musculoskeletal health) while avoiding epidermal DNA damage (initiates skin cancer). Well-characterized healthy humans of all skin types (I-VI, lightest to darkest skin) were exposed to a low (...) -dose series of solar simulated UVR of 20%-80% their individual sunburn threshold dose (minimal erythema dose). Significant UVR dose responses were seen for serum 25-hydroxyvitamin D and whole epidermal cyclobutane pyrimidine dimers (CPDs), with as little as 0.2 minimal erythema dose concurrently producing 25-hydroxyvitamin D and CPD. Fractional MEDs generated equivalent levels of whole epidermal CPD and 25-hydroxyvitamin D across all skin types. Crucially, we showed an epidermal gradient of CPD

2018 Journal of Investigative Dermatology

11. Association between sunburn and demographic factors and health behaviour among Danish students. Full Text available with Trip Pro

Association between sunburn and demographic factors and health behaviour among Danish students. Sunburn is associated with an increased risk for skin cancer. Denmark has one of the highest incidences of melanoma in the world, although it is a relatively northern country. The objective of this study was to determine whether sunburn is associated with demographic factors and health behaviour among young Danes. Cross-sectional data of >55,000 15- to 25-year-old students participating in the Danish (...) National Youth Study were collected in 2014. Multilevel logistic regression analysis was used to determine associations. Overall, 45% of the students had experienced at least one sunburn in Denmark, and 60% had experienced one sunburn abroad in the past year. Females had higher odds for sunburns than males. Education and geographical region were associated with sunburn but with opposite trends related for sunburn experienced in Denmark and abroad. Students who had poor dietary habits (only abroad

2018 Preventive Medicine

12. Development in sunburn 2007-2015 and skin cancer projections 2007-2040 of campaign results in the Danish population. Full Text available with Trip Pro

Development in sunburn 2007-2015 and skin cancer projections 2007-2040 of campaign results in the Danish population. Exposure to ultraviolet radiation is the main risk factor for skin cancer. Denmark has one of the highest incidences of skin cancer in the world. In 2007, a long-term sun safety campaign was launched in Denmark. We have evaluated the effects on prevalence of sunburn and modeled the effects on future melanoma incidence.Sunburn was evaluated by annual cross-sectional surveys (...) representative for the Danish population on age, gender, and region. During 2007-2015, survey data were collected for 33.315 Danes. Cutaneous Melanoma incidences were modeled in the Prevent program, using population projections, historic incidence, sunburn exposure, and relative risk of sunburn on melanoma.The prevalence of sunburn in Denmark was reduced with 1% annually during 2007 to 2015. The campaign is estimated to have reduced the number of skin cancer cases with 664 annually in 2040 and 14.326 totally

2018 Medicine

13. Knowledge deficit, attitude and behavior scales association to objective measures of sun exposure and sunburn in a Danish population based sample. Full Text available with Trip Pro

Knowledge deficit, attitude and behavior scales association to objective measures of sun exposure and sunburn in a Danish population based sample. The objective of this study was to develop new scales measuring knowledge and attitude about UVR and sun related behavior, and to examine their association to sun related behavior objectively measured by personal dosimetry. During May-August 2013, 664 Danes wore a personal electronic UV-dosimeter for one week that measured their UVR exposure (...) of melanoma and Perceived barrier towards sun avoidance between 12 and 15' were both associated with increased risk of sunburn. Attitude towards tan was associated to both outdoor time and exposure as well as use of protection, but not to sunburn. The results regarding Knowledge deficit of UV and risk of melanoma associated to UVR exposure and Perceived barrier towards sun avoidance between 12 and 15 emphasize the importance of awareness of melanoma risk and the priority of the skin cancer prevention

2017 PLoS ONE

14. Clinical Trial of the Safety and Efficacy of SP160412 in the Temporary Relief of Mild to Moderate Sunburn

Clinical Trial of the Safety and Efficacy of SP160412 in the Temporary Relief of Mild to Moderate Sunburn Clinical Trial of the Safety and Efficacy of SP160412 in the Temporary Relief of Mild to Moderate Sunburn - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Clinical Trial of the Safety and Efficacy of SP160412 in the Temporary Relief of Mild to Moderate Sunburn The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03332524

2017 Clinical Trials

15. Vitamin D Prevents Sunburn: Tips for the Summer? Full Text available with Trip Pro

Vitamin D Prevents Sunburn: Tips for the Summer? In the article by Scott et al, a high dose of vitamin D attenuated the inflammatory response to UV radiation in a small group of normal volunteers. The best results were in those subjects who had the greatest increase in circulating 25hydroxyvitamin D. Using microarray analyses these subjects showed a reduction in the expression of inflammatory markers with an increase in markers of skin barrier repair.Copyright © 2017 The Author. Published

2017 Journal of Investigative Dermatology

16. Sunburn and ambient temperature. (Abstract)

Sunburn and ambient temperature. 28865077 2018 12 20 1365-2133 178 2 2018 02 The British journal of dermatology Br. J. Dermatol. Sunburn and ambient temperature. e124 10.1111/bjd.15926 Diffey B B 0000-0002-8955-125X Newcastle University, Dermatological Sciences, Newcastle, NE2 4HH, U.K. eng Letter 2017 12 21 England Br J Dermatol 0004041 0007-0963 2017 9 3 6 0 2017 9 3 6 0 2017 9 3 6 0 ppublish 28865077 10.1111/bjd.15926

2017 British Journal of Dermatology

17. SPF 100+ sunscreen is more protective against sunburn than SPF 50+ in actual-use: Results of a randomized, double-blind, split-face, natural sunlight exposure, clinical trial. (Abstract)

SPF 100+ sunscreen is more protective against sunburn than SPF 50+ in actual-use: Results of a randomized, double-blind, split-face, natural sunlight exposure, clinical trial. The value of additional photoprotection provided by use of high-sun protection factor (SPF) sunscreens is controversial, and limited clinical evidence exists.To compare the sunburn protection provided by SPF 100+ and SPF 50+ sunscreen in conditions of actual use.A total of 199 healthy men and women (≥18 years (...) ) participated in a natural sunlight, single-exposure, split-face, randomized, double-blind study in Vail, Colorado. Each participant wore both sunscreens simultaneously during activities, with no use restrictions other than designation of the treatment area. Erythema was clinically assessed on the day following exposure. Comparative efficacy was evaluated through bilateral comparison of sunburn between treatment areas and erythema score, as evaluated separately for each treatment area.Following an average

2017 Journal of American Academy of Dermatology Controlled trial quality: uncertain

18. Data on solar sunburning ultraviolet (UVB) radiation at an urban Mediterranean climate Full Text available with Trip Pro

Data on solar sunburning ultraviolet (UVB) radiation at an urban Mediterranean climate This article describes data on the intensity of ultraviolet B (UVB) radiation collected during field questionnaire-based surveys in Athens, Greece. The surveys were conducted over 11 days of July and October 2010 at three different urban, outdoor sites. A total of 1104 interviews were conducted. The participants were asked to report whether they felt they got a sunburn at the moment of the interview

2017 Data in brief

19. Vitamin D as a Therapeutic Option for Sunburn: Clinical and Biologic Implications Full Text available with Trip Pro

Vitamin D as a Therapeutic Option for Sunburn: Clinical and Biologic Implications 29064295 2018 04 26 2018 11 13 1557-7430 36 11 2017 Nov DNA and cell biology DNA Cell Biol. Vitamin D as a Therapeutic Option for Sunburn: Clinical and Biologic Implications. 879-882 10.1089/dna.2017.3978 Scott Jeffrey F JF 1 Department of Dermatology, University Hospitals Cleveland Medical Center , Cleveland, Ohio. 2 Department of Dermatology, Case Western Reserve University School of Medicine , Cleveland, Ohio (...) . Lu Kurt Q KQ 1 Department of Dermatology, University Hospitals Cleveland Medical Center , Cleveland, Ohio. 2 Department of Dermatology, Case Western Reserve University School of Medicine , Cleveland, Ohio. eng Journal Article 2017 10 24 United States DNA Cell Biol 9004522 1044-5498 0 Anti-Inflammatory Agents 1406-16-2 Vitamin D IM Anti-Inflammatory Agents pharmacology therapeutic use Humans Skin drug effects radiation effects Sunburn drug therapy Vitamin D pharmacology therapeutic use 2017 10 25

2017 DNA and cell biology

20. CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation Full Text available with Trip Pro

CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation Casein kinase 1α (CK1α), a component of the β-catenin destruction complex, is a critical regulator of Wnt signaling; its ablation induces both Wnt and p53 activation. To characterize the role of CK1α (encoded by Csnk1a1) in skin physiology, we crossed mice harboring floxed Csnk1a1 with mice expressing K14-Cre-ERT2 to generate mice in which tamoxifen induces the deletion of Csnk1a1 exclusively (...) -stimulating hormone (α-MSH), was not activated in the CK1α ablation-induced hyperpigmentation, which is in contrast to the mechanism of p53-dependent UV tanning. Nevertheless, acute sunburn effects were successfully prevented in the hyperpigmented skin of SKO mice. CK1α inhibition induces skin-protective eumelanin but no carcinogenic pheomelanin and may therefore constitute an effective strategy for safely increasing eumelanin via UV-independent pathways, protecting against acute sunburn.

2017 Proceedings of the National Academy of Sciences of the United States of America

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