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Sun Damaged Skin

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1. Assessment of Predictors of Sun Sensitivity as Defined by Fitzpatrick Skin Phototype in an Ecuadorian Population and Its Correlation with Skin Damage. (PubMed)

Assessment of Predictors of Sun Sensitivity as Defined by Fitzpatrick Skin Phototype in an Ecuadorian Population and Its Correlation with Skin Damage. The Fitzpatrick skin phototype scale (FSPTS) is a widely used instrument to assess skin type.A cross-sectional survey collected responses from 254 subjects from Quito regarding self-reported FSPTS, gender, age, education, and tobacco and alcohol consumption. Univariate and multivariate logistic regression analyses were performed to determine (...) if ethnicity, hair color, and eye color significantly predict FSPTS. In addition, we studied the correlation between FSPTS and the SCINEXA scale with Pearson's correlation coefficient.Ethnicity, eye color, and hair color are significant independent predictors of FSPTS (p < 0.0001).Patient self-reported race and pigmentary phenotypes are inaccurate predictors of sun sensitivity as defined by Fitzpatrick skin phototype. Our study does not fully represent the population of the country. There are limitations

2019 Dermatology

2. Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged Skin

Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged Skin "Oral Nicotinamide Reduces Actinic Keratoses in Adults with Sun-Damaged" by Stacy E. Legg < > > > > > Title Author Date of Graduation Summer 8-13-2016 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies First Advisor Annjanette Sommers, PA-C, MS Second Advisor Jennifer Van Atta, PA-C, MS Rights . Abstract Background: Actinic keratoses (AKs) are skin lesions primarily caused (...) cohorts, with different doses of nicotinamide used. Cohort 1 found that the number of AKs were 35% less in the nicotinamide group at 2 months (95% confidence interval (CI): 23-45%; p Conclusion: The two studies reviewed demonstrated a reduction in AKs in patients taking oral nicotinamide. Providers should consider oral nicotinamide supplementation in patients with sun-damaged skin. Further research is needed to explore the action of nicotinamide on the prevention of AKs and NMSC. Keywords

2016 Pacific University EBM Capstone Project

3. Melanoma on Chronically Sun Damaged Skin: Lentigo Maligna and Desmoplastic Melanoma. (PubMed)

Melanoma on Chronically Sun Damaged Skin: Lentigo Maligna and Desmoplastic Melanoma. There are multiple, genetically distinct pathways that give rise to melanoma. Melanomas on sun damaged skin (MSDS) - including lentigo maligna (LM) and desmoplastic melanoma (DM) - have distinct genetic profiles and are uniquely linked to chronic ultraviolet (UV) exposure. In this article we discuss the etiologies of LM and DM, emerging diagnostic adjuncts that may be helpful in accurately identifying (...) these lesions, and the clinical relevance of their frequent co-occurrence. We present unique and overlapping features of these entities and discuss challenges in MSDS management, including margin assessment, excision, and the potential role of non-surgical therapy. Finally, we address the role of immunotherapy in invasive disease. Understanding MSDS as distinct from melanoma arising on intermittently sun-exposed or sun-protected skin will ultimately help optimize patient outcomes.Copyright © 2019. Published

2019 Journal of American Academy of Dermatology

4. Emergence and Evolution of Mutational Hotspots in Sun-Damaged Skin. (PubMed)

Emergence and Evolution of Mutational Hotspots in Sun-Damaged Skin. In this issue, Albibas et al. investigate the mutational nature of p53-immunopositive patches, commonly observed in sun-damaged skin. p53-immunopositive patches have long been suspected to be lineal precursors to actinic keratoses and cutaneous squamous cell carcinomas. However, the mutations actually giving rise to p53-immunopositive patches, and their relationship to skin cancer, have never been defined. The considerable (...) clinical and economic costs of monitoring and treating sun-damaged skin demand we better understand the evolution of these common premalignancies.Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

2018 Journal of Investigative Dermatology

5. Evaluation of MITF, SOX10, MART-1, and R21 Immunostaining for the Diagnosis of Residual Melanoma In Situ on Chronically Sun-Damaged Skin. (PubMed)

Evaluation of MITF, SOX10, MART-1, and R21 Immunostaining for the Diagnosis of Residual Melanoma In Situ on Chronically Sun-Damaged Skin. Melanocytic immunostains can assist in margin evaluation of melanoma in situ (MIS) excisions; however, their accuracy and reliability relative to hematoxylin & eosin (H&E) is yet to be determined.The objective of this study was to evaluate the sensitivity, specificity, and concordance of 4 melanocyte-specific immunostains for diagnosing MIS occurring (...) 28 melanocytes per 0.5 mm for chronically sun-damaged skin versus residual MIS on H&E, respectively. Statistically significantly higher melanocyte densities were observed using MITF, MART-1, and SOX10 on negative margins. The sensitivity and interobserver concordance was highest using MITF and SOX10. The intraobserver agreement on 4 duplicate images was 85%.In conclusion, the nuclear immunostains (MITF and SOX10) show the most promise for improving the diagnosis of MIS in chronically sun-damaged

2018 Dermatologic Surgery

6. Clinical, dermoscopic and reflectance confocal microscopy characterization of facial basal cell carcinomas presenting as small white lesions on sun-damaged skin. (PubMed)

Clinical, dermoscopic and reflectance confocal microscopy characterization of facial basal cell carcinomas presenting as small white lesions on sun-damaged skin. 30239981 2019 01 03 1365-2133 180 1 2019 Jan The British journal of dermatology Br. J. Dermatol. Clinical, dermoscopic and reflectance confocal microscopy characterization of facial basal cell carcinomas presenting as small white lesions on sun-damaged skin. 229-230 10.1111/bjd.17241 Liopyris K K http://orcid.org/0000-0001-9566-8238 (...) Dermatology Service, Memorial Sloan Kettering Cancer Center, 800 Veterans Memorial Highway, 2nd floor, Hauppauge, New York, NY, 11788, U.S.A. Dermatology Department, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain. Marchetti M A MA Dermatology Service, Memorial Sloan Kettering Cancer Center, 800 Veterans Memorial Highway, 2nd floor, Hauppauge, New York, NY, 11788, U.S.A. Rabinovitz H H Skin Cancer Associates, Plantation, FL, U.S.A. Marghoob A A AA Dermatology Service, Memorial Sloan Kettering

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2018 British Journal of Dermatology

7. Sun Damaged Skin

Sun Damaged Skin Sun Damaged Skin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sun Damaged Skin Sun Damaged Skin Aka: Sun Damaged (...) are a random sampling from a Bing search on the term "Sun Damaged Skin." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Skin Aging (C0037271) Definition (MEDLINEPLUS) Your skin changes as you age. You might notice wrinkles, age spots and dryness. Your skin also becomes thinner and loses fat, making it less plump and smooth. It might take longer to heal, too. is a major cause of skin aging. You can protect yourself

2018 FP Notebook

8. Fractional sunburn threshold UVR doses generate equivalent vitamin D and DNA damage in skin types I-VI, but with epidermal DNA damage gradient correlated to skin darkness. (PubMed)

Fractional sunburn threshold UVR doses generate equivalent vitamin D and DNA damage in skin types I-VI, but with epidermal DNA damage gradient correlated to skin darkness. Public health guidance recommends limiting sun exposure to sub-sunburn levels, but it is unknown whether these can gain vitamin D (for musculoskeletal health) while avoiding epidermal DNA damage (initiates skin cancer). Well-characterized healthy humans of all skin types (I-VI, lightest to darkest skin) were exposed to a low (...) formation strongly correlated with skin darkness (r = 0.74, P < 0.0001), which reflected melanin content and showed increasing protection across the skin types, ranging from darkest skin, where high CPD levels occurred superficially, with none in the germinative basal layer, to lightest skin, where CPD levels were induced evenly across the epidermal depth. People with darker skin can be encouraged to use sub-sunburn UVR-exposure to enhance their vitamin D. In people with lighter skin, basal cell damage

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2018 Journal of Investigative Dermatology

9. Iris Freckles a Potential Biomarker for Chronic Sun Damage. (PubMed)

Iris Freckles a Potential Biomarker for Chronic Sun Damage. To investigate the role of sunlight exposure in iris freckles formation.We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure.Six hundred thirty-two participants (n = 360; 57% female) were examined. Mean (...) lentigines (72% vs. 45%), and a high total nevus body count (>10; 78% vs. 67%).The association of iris freckles, behavioral factors, and dermatologic findings, as well as the topographical distribution, indicate that sunlight exposure may trigger the formation of iris freckles. The evaluation of iris freckles offers an easily accessible potential biomarker, which might be helpful in indicating sun damage on the skin associated with cutaneous malignancies. Furthermore, the evaluation of iris freckles

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2017 Investigative Ophthalmology & Visual Science

10. Determination of the Sun Protection Factor (SPF) of a Cosmetic Daily De-fence Skin Cream

Determination of the Sun Protection Factor (SPF) of a Cosmetic Daily De-fence Skin Cream Determination of the Sun Protection Factor (SPF) of a Cosmetic Daily De-fence Skin Cream - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Determination of the Sun Protection Factor (SPF) of a Cosmetic Daily De-fence Skin Cream The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03136107 Recruitment Status : Completed First Posted : May 2, 2017 Last Update Posted : March 12, 2018 Sponsor: GlaxoSmithKline Information

2017 Clinical Trials

11. Assessment of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure

Assessment of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure Assessment of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information (...) . Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Assessment of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does

2017 Clinical Trials

12. Evaluation of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure

Evaluation of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure Evaluation of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information (...) . Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does

2017 Clinical Trials

13. Clinical and dermoscopic characteristics of melanomas on nonfacial chronically sun-damaged skin. (PubMed)

Clinical and dermoscopic characteristics of melanomas on nonfacial chronically sun-damaged skin. Melanomas on chronically sun-damaged skin (CSDS) can be difficult to identify and often manifest morphologic features that overlap with benign lesions.We describe and analyze the clinical and dermoscopic characteristics of melanomas on nonfacial CSDS.Melanoma cases on nonfacial CSDS were retrospectively identified from the biopsy specimen logs of 6 melanoma clinics. Clinical and dermoscopic images

2015 Journal of American Academy of Dermatology

14. Phase IIB Randomized Study of Topical Difluoromethylornithine and Topical Diclofenac on Sun-Damaged Skin of the Forearm. (PubMed)

Phase IIB Randomized Study of Topical Difluoromethylornithine and Topical Diclofenac on Sun-Damaged Skin of the Forearm. Prevention of nonmelanoma skin cancers remains a health priority due to high costs associated with this disease. Diclofenac and difluoromethylornithine (DFMO) have demonstrated chemopreventive efficacy for cutaneous squamous cell carcinomas. We designed a randomized study of the combination of DFMO and diclofenac in the treatment of sun-damaged skin. Individuals with visible (...) cutaneous sun damage were eligible. Subjects were randomized to one of the three groups: topical DFMO applied twice daily, topical diclofenac applied daily, or DFMO plus diclofenac. The treatment was limited to an area on the left forearm, and the duration of use was 90 days. We hypothesized that combination therapy would have increased efficacy compared with single-agent therapy. The primary outcome was change in karyometric average nuclear abnormality (ANA) in the treated skin. Individuals assessing

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2015 Cancer prevention research (Philadelphia, Pa.) Controlled trial quality: uncertain

15. Prevalence of sun-protective behavior and intentional sun tanning in German adolescents and adults: results of a nationwide telephone survey. (PubMed)

Prevalence of sun-protective behavior and intentional sun tanning in German adolescents and adults: results of a nationwide telephone survey. The incidence rate of melanoma in the Caucasian population is rising worldwide. One of the major environmental risk factors for melanoma is the exposure to ultraviolet (UV) radiation. To prevent skin damage caused by UV exposure, several organizations recommend wearing protective clothing, staying in the shade, avoiding the outdoors during midday (...) and using sunscreen.To provide representative data on factors associated with sun-protective behaviours and intentional sun exposure during summertime in the German population.A population-based sample of 3000 German residents aged 14-45 years (response: 32.1%) was interviewed via telephone from October to December 2015. Survey participants provided data on the use of recommended sun-protective measures on a sunny summer day and their intentional sun exposure during summertime. Data were weighted by age

2017 Journal of the European Academy of Dermatology and Venereology

16. Sun Safety Ink! A Sun Safety Program for the Tattoo Community

not only to protect themselves from harmful UVR rays but also to reduce damage to their tattoos. Klein Buendel, Inc. (KB) proposes to develop and test Sun Safety INK (SSI), a skin cancer prevention program targeted to clients of licensed tattoo studios. The studios have been selected as the venue for this study because tattoo salons, at times, promote sun protection for new tattoos to keep them from fading, and offer a unique opportunity to reach younger adults who have high sunburn rates and are often (...) . Collaborators: National Cancer Institute (NCI) University of Colorado, Denver Information provided by (Responsible Party): Klein Buendel, Inc. Study Details Study Description Go to Brief Summary: Over 3.5 million cases of non-melanoma skin cancers occur annually and melanoma rates have doubled in the last 30 years, burdening the nation's health system. Klein Buendel, Inc. (KB) proposes to develop Sun Safety INK! (SSI!), a skin cancer prevention program targeted to clients of licensed tattoo studios because

2017 Clinical Trials

17. Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis (PubMed)

formation. However, UVB radiation by the sun, which causes DNA damage, is the most relevant cause for NMSC. A potential role of Rac1 in UV-light-induced skin carcinogenesis has not been investigated so far. To investigate this, we irradiated mice with epidermal Rac1 deficiency (Rac1-EKO) and their controls using a well-established protocol for long-term UV-irradiation. Most of the Rac1-EKO mice developed severe skin erosions upon long-term UV-irradiation, unlike their controls. These skin erosions (...) Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis Non-melanoma skin cancer (NMSC) is the most common type of cancer. Increased expression and activity of Rac1, a small Rho GTPase, has been shown previously in NMSC and other human cancers; suggesting that Rac1 may function as an oncogene in skin. DMBA/TPA skin carcinogenesis studies in mice have shown that Rac1 is required for chemically induced skin papilloma

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2017 Cell death & disease

18. Phototherapeutic modalities pose no significantly increased risk of oxidative damage to DNA in dark skinned individuals. (PubMed)

Phototherapeutic modalities pose no significantly increased risk of oxidative damage to DNA in dark skinned individuals. 8-oxoguanine, a major product of DNA oxidation, is considered a key parameter in measuring the carcinogenic effects of ultraviolet radiation.To assess and compare the carcinogenic potential of different photo (chemo) therapeutic modalities in photoresponsive skin diseases by measuring the levels of 8-oxoguanine in dark-skinned individuals before and after photo (chemo (...) also taken from the sun-protected skin in 21 controls subjects who had no dermatological disease.Regardless of the disease, a significantly higher level of 8-oxoguanine was found after treatment when compared to the pre-treatment baseline levels; however, these levels were comparable to those in control subjects. A weakly significant positive correlation was found between cumulative dose and 8-oxoguanine levels following psoralen plus ultraviolet-A therapy. In controls, comparing the 8-oxoguanine

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2017 Indian journal of dermatology, venereology and leprology Controlled trial quality: uncertain

19. Sun exposure makes people both more and less likely to die of melanoma. How can that be?

dermatologists, for treatment of all the sun damage on their skin. While at those appointments, the dermatologists find melanomas that otherwise might have gone undetected. More importantly, some of those melanomas might be relatively mild, and if undetected might have never become life-threatening. My wife, for example, is a redhead, whose family is chock full of people who have been diagnosed with melanoma. So she has been diligent about seeing dermatologists regularly. One of those doctors removed a bad (...) ? The answer is pale-faced Paula. Surprised? Let me unpack this mystery and explain why sun exposure simultaneously kills people, while making the cancers they are diagnosed with appear to be less life-threatening. I will start with what you probably know already. Melanoma is a potentially life-threatening skin cancer. It occurs usually as a , including fair complexion and sun exposure. (I lost my beloved redheaded aunt to melanoma when she was tragically young.) All else equal, people who , or in tanning

2019 KevinMD blog

20. The CD133<sup>+</sup> cell content correlates with tumor growth in melanomas from skin with chronic sun-induced damage. (PubMed)

The CD133+ cell content correlates with tumor growth in melanomas from skin with chronic sun-induced damage. Melanoma is responsible for almost 80% of the deaths attributed to skin cancer. Stem cells, defined by CD133 expression, have been implicated in melanoma tumour growth, but their specific role is still uncertain.We hypothesized that the phenotypic heterogeneity of human cutaneous melanomas is related to their content of CD133+ cells.We compared the percentages of CD133+ cells (...) in 29 tumours from four classic types of melanoma: lentigo maligna melanoma (LMM), superficial spreading melanoma, nodular melanoma and acral lentiginous melanoma (ALM). Also, we compared the percentages of CD133+ cells in melanomas with different degrees of exposure to ultraviolet radiation: 16 melanomas from skin with chronic sun-induced damage and 13 melanomas from skin without such damage.We found a statistically significant increase of CD133+ cells in three different contexts: in melanomas

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2013 British Journal of Dermatology

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