How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

613 results for

Sugammadex

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Sugammadex for the Reversal of Rocuronium-Induced Neuromuscular Blockade in Surgical Patients: A Review of Clinical Effectiveness

Sugammadex for the Reversal of Rocuronium-Induced Neuromuscular Blockade in Surgical Patients: A Review of Clinical Effectiveness Sugammadex for the Reversal of Rocuronium-Induced Neuromuscular Blockade in Surgical Patients: A Review of Clinical Effectiveness | CADTH.ca Find the information you need Sugammadex for the Reversal of Rocuronium-Induced Neuromuscular Blockade in Surgical Patients: A Review of Clinical Effectiveness Sugammadex for the Reversal of Rocuronium-Induced Neuromuscular (...) Blockade in Surgical Patients: A Review of Clinical Effectiveness Last updated: August 21, 2019 Project Number: RC1177-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of rocuronium with sugammadex versus rocuronium with neostigmine in patients undergoing surgery? Key Message Three systematic reviews and seven randomized controlled trials were identified regarding the comparative clinical

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

2. Sugammadex for the Recovery of Neuromuscular Blockade in Adult Patients: Clinical Effectiveness and Cost-Effectiveness - An Update

Sugammadex for the Recovery of Neuromuscular Blockade in Adult Patients: Clinical Effectiveness and Cost-Effectiveness - An Update Sugammadex for the Recovery of Neuromuscular Blockade in Adult Patients: Clinical Effectiveness and Cost-Effectiveness - An Update | CADTH.ca Find the information you need Sugammadex for the Recovery of Neuromuscular Blockade in Adult Patients: Clinical Effectiveness and Cost-Effectiveness - An Update Sugammadex for the Recovery of Neuromuscular Blockade in Adult (...) Patients: Clinical Effectiveness and Cost-Effectiveness - An Update Last updated: June 3, 2019 Project Number: RA1037-000 Product Line: Research Type: Drug Report Type: Reference List Result type: Report Question What is the clinical effectiveness regarding the use of sugammadex for the recovery of neuromuscular blockade in adult patients? What is the cost-effectiveness regarding the use of sugammadex for the recovery of neuromuscular blockade in adult patients? Key Message Five systematic reviews

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

3. Sugammadex for the Reversal of Neuromuscular Blockade in Surgical Patients: A Review of Clinical Effectiveness and Cost-Effectiveness

Sugammadex for the Reversal of Neuromuscular Blockade in Surgical Patients: A Review of Clinical Effectiveness and Cost-Effectiveness Sugammadex for the Reversal of Neuromuscular Blockade in Surgical Patients: A Review of Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Sugammadex for the Reversal of Neuromuscular Blockade in Surgical Patients: A Review of Clinical Effectiveness and Cost-Effectiveness Sugammadex for the Reversal of Neuromuscular Blockade (...) in Surgical Patients: A Review of Clinical Effectiveness and Cost-Effectiveness Last updated: August 6, 2019 Project Number: RC1161-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of rocuronium with sugammadex versus succinylcholine in patients undergoing surgery? What is the cost-effectiveness of sugammadex in patients undergoing surgery Key Message Three randomized controlled trials were

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults. (PubMed)

Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults. Acetylcholinesterase inhibitors, such as neostigmine, have traditionally been used for reversal of non-depolarizing neuromuscular blocking agents. However, these drugs have significant limitations, such as indirect mechanisms of reversal, limited and unpredictable efficacy, and undesirable autonomic responses. Sugammadex is a selective relaxant-binding agent specifically developed for rapid (...) reversal of non-depolarizing neuromuscular blockade induced by rocuronium. Its potential clinical benefits include fast and predictable reversal of any degree of block, increased patient safety, reduced incidence of residual block on recovery, and more efficient use of healthcare resources.The main objective of this review was to compare the efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade caused by non-depolarizing neuromuscular agents in adults.We searched

Full Text available with Trip Pro

2017 Cochrane

5. Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients

Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients HAYES, Inc. Record Status This is a bibliographic record of a published health technology (...) assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Comparative effectiveness of sugammadex versus neostigmine for reversal of neuromuscular blockade following surgery in adult patients . Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors' objectives Sugammadex (SUG) is indicated for the reversal of neuromuscular blockade (NMB) induced by rocuronium bromide and vecuronium bromide during surgery. SUG selectively binds

2017 Health Technology Assessment (HTA) Database.

6. Sugammadex for the Reversal of Neuromuscular Blockade in Adult Patients: A Review of Clinical Effectiveness and Cost-Effectiveness

Sugammadex for the Reversal of Neuromuscular Blockade in Adult Patients: A Review of Clinical Effectiveness and Cost-Effectiveness Sugammadex for the Reversal of Neuromuscular Blockade in Adult Patients: A Review of Clinical Effectiveness and Cost-Effectiveness | CADTH.ca Find the information you need Sugammadex for the Reversal of Neuromuscular Blockade in Adult Patients: A Review of Clinical Effectiveness and Cost-Effectiveness Sugammadex for the Reversal of Neuromuscular Blockade in Adult (...) Patients: A Review of Clinical Effectiveness and Cost-Effectiveness Published on: May 26, 2016 Project Number: RC0781-000 Product Line: Research Type: Drug Report Type: Summary with Critical Appraisal Result type: Report Question What is the clinical effectiveness of sugammadex in adult patients? What is the cost-effectiveness of sugammadex in adult patients? Key Message Four systematic reviews and ten randomized controlled trials were identified relating to the clinical effectiveness of sugammadex

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

7. Sugammadex for Adults Undergoing Surgery: Clinical and Cost-Effectiveness and Guidelines

Sugammadex for Adults Undergoing Surgery: Clinical and Cost-Effectiveness and Guidelines Sugammadex for Adults Undergoing Surgery: Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Sugammadex for Adults Undergoing Surgery: Clinical and Cost-Effectiveness and Guidelines Sugammadex for Adults Undergoing Surgery: Clinical and Cost-Effectiveness and Guidelines Published on: January 4, 2016 Project Number: RA0841-000 Product Line: Research Type: Drug Report Type (...) : Reference List Result type: Report Question 1. What is the clinical effectiveness of sugammadex in adult patients undergoing surgery? 2. What is the cost-effectiveness of sugammadex in adult patients undergoing surgery? 3. What are the guidelines associated with the use of sugammadex in adult patients undergoing surgery? Key Message One health technology assessment, two systematic reviews, one systematic review with meta-analysis, 18 randomized controlled trials, and two economic evaluations were

2016 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Diaphragmatic and intercostal electromyographic activity during neostigmine, sugammadex and neostigmine-sugammadex-enhanced recovery after neuromuscular blockade: A randomised controlled volunteer study. (PubMed)

Diaphragmatic and intercostal electromyographic activity during neostigmine, sugammadex and neostigmine-sugammadex-enhanced recovery after neuromuscular blockade: A randomised controlled volunteer study. Electromyographic activity of the diaphragm (EMGdi) during weaning from mechanical ventilation is increased after sugammadex compared with neostigmine.To determine the effect of neostigmine on EMGdi and surface EMG (sEMG) of the intercostal muscles during antagonism of rocuronium block (...) with neostigmine, sugammadex and neostigmine followed by sugammadex.Randomised, controlled, double-blind study.Intensive care research unit.Eighteen male volunteers.A transoesophageal EMGdi recorder was inserted into three groups of six anaesthetised study participants, and sEMG was recorded on their intercostal muscles. To reverse rocuronium, volunteers received 50 μg kg neostigmine, 2 mg kg sugammadex or 50 μg kg neostigmine, followed 3 min later by 2 mg kg sugammadex.We examined the EMGdi and sEMG

Full Text available with Trip Pro

2017 European Journal of Anaesthesiology

9. Half dose sugammadex combined with neostigmine is non-inferior to full dose sugammadex for reversal of rocuronium-induced deep neuromuscular blockade: a cost-saving strategy. (PubMed)

Half dose sugammadex combined with neostigmine is non-inferior to full dose sugammadex for reversal of rocuronium-induced deep neuromuscular blockade: a cost-saving strategy. Sugammadex reverses the effect of rocuronium more rapidly and effectively than neostigmine, at all levels of neuromuscular blockade (NMB). However, its cost is prohibitive. The combination of half dose sugammadex with neostigmine would be non-inferior to full dose sugammadex for the reversal of deep NMB. This approach (...) would reduce the cost of sugammadex while preserving its efficacy.Patients were randomly allocated to receive sugammadex 4 mg/kg (Group S) or sugammadex 2 mg/kg with neostigmine 50 μg/kg and glycopyrrolate 10 μg/kg (Group NS) for reversal of rocuronium deep NMB. The primary outcome was the percentage of patients who recovered to 90% Train of Four (TOF) ratio within 5 min. The non-inferiority margin was set at 10%.Twenty eight patients were enrolled in each group. The number of patients who reached

Full Text available with Trip Pro

2017 BMC Anesthesiology

10. Effects of dexamethasone on sugammadex reversal times of rocuronium: a systematic review protocol. (PubMed)

Effects of dexamethasone on sugammadex reversal times of rocuronium: a systematic review protocol. The objective of the review is to identify the effect of dexamethasone on reversal times of rocuronium when utilizing sugammadex as the reversal agent. The incidence of the prolonged time to extubation in patients who have received concurrent dexamethasone and sugammadex therapies as opposed to those who have not received dexamethasone will also be examined.The proposed PICO question is as follows (...) : In patients undergoing reversal of aminosteroidal neuromuscular blockade with rocuronium, does dexamethasone administration affect sugammadex reversal times, as compared to patients who have not received dexamethasone?

2017 JBI database of systematic reviews and implementation reports

11. Efficacy and safety of sugammadex in patients with neuromuscular disease: a systematic review

Efficacy and safety of sugammadex in patients with neuromuscular disease: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

12. Diffuse alveolar hemorrhage following sugammadex and remifentanil administration: A case report. (PubMed)

Diffuse alveolar hemorrhage following sugammadex and remifentanil administration: A case report. Diffuse alveolar hemorrhage (DAH) is a rare life-threatening condition that accompanies general anesthesia. Negative-pressure pulmonary edema (NPPE) is a rare cause of DAH.A 25-year-old male patient developed hemoptysis following remifentanil administration by bolus injection with sugammadex at the emergence from general anesthesia.Chest x-ray and computed tomography showed DAH.Conservative care (...) was provided with 4L of oxygen via nasal prong, 20 mg of Lasix and 2500 mg of tranexamic acid.The patient was discharged uneventfully.Muscle rigidity by remifentanil and the dissociated reversal of neuromuscular blockade by sugammadex was suspected as the cause of NPPE-related DAH. Therefore, the possibility NPPE-related DAH should be considered when using a bolus of remifentanil and sugammadex during emergence from general anesthesia.

2019 Medicine

13. Retrospective analysis of 30-day unplanned readmission after major abdominal surgery with reversal by sugammadex or neostigmine. (PubMed)

Retrospective analysis of 30-day unplanned readmission after major abdominal surgery with reversal by sugammadex or neostigmine. Sugammadex is associated with fewer postoperative complications, but its impact on 30-day unplanned readmission is unclear.This was a single-centre retrospective observational study of patients after major abdominal surgery between 2010 and 2017, where rocuronium was the only neuromuscular blocker used. The primary endpoint was the difference in incidence of 30-day (...) unplanned readmission between reversal with sugammadex or neostigmine. The secondary endpoints were the length of hospital stay after surgery and related hospital charges (total charges excluding those related to surgery and anaesthesia). Analysis included propensity score matching and generalised mixed-effects modelling.Mixed-effects logistic regression analysis of 1479 patients (sugammadex: 355; neostigmine: 1124) showed that the incidence of 30-day unplanned readmission was 34% lower (odds ratio

2019 British Journal of Anaesthesia

14. The effect of magnesium on the reversal of rocuronium-induced neuromuscular block with sugammadex: an ex vivo laboratory study. (PubMed)

The effect of magnesium on the reversal of rocuronium-induced neuromuscular block with sugammadex: an ex vivo laboratory study. Magnesium dose-dependently potentiates the effect of non-depolarizing neuromuscular blocking agents. We investigated whether the potentiation of rocuronium-induced blockade by magnesium reduces the effect of sugammadex in an ex-vivo environment and how this influences the safety margin of reversal.Phrenic nerve - hemidiaphragm tissue preparations were isolated from (...) ). Increasing magnesium from 1 mM to 1.5 mM during reversal of rocuronium-induced block increased the mean (95% CI) EC50 of sugammadex from 3.67 μM (3.43-3.92 μM) to 5.36 μM (5.18-5.53 μM), whereas mean (95% CI) effective concentrations for 95% effect (EC95) were not significantly different at 7.22 μM (6.09-8.54 μM) and 7.61 μM (7.05-8.20 μM), respectively (p = 0.542). When rocuronium-induced block was reversed to a train-of-four (TOF) ratio > 0.9, but with still visible fade, increasing magnesium from 1 mM

Full Text available with Trip Pro

2019 BMC Anesthesiology

15. Effect of Sugammadex on Postoperative Myasthenic Crisis in Myasthenia Gravis Patients: Propensity Score Analysis of a Japanese Nationwide Database. (PubMed)

Effect of Sugammadex on Postoperative Myasthenic Crisis in Myasthenia Gravis Patients: Propensity Score Analysis of a Japanese Nationwide Database. In myasthenia gravis (MG) patients, postoperative myasthenic crisis, and residual neuromuscular blocking agent (NMBA) can cause respiratory failure that requires mechanical ventilation. However, it remains unclear whether the use of sugammadex for NMBA reversal reduces postoperative myasthenic crisis in MG patients undergoing surgery. We analyzed (...) the association between use of sugammadex and postoperative myasthenic crisis in patients with MG using a national inpatient database.Adult patients with MG who received thymectomy under general anesthesia were identified in the Japanese Diagnosis Procedure Combination database from July 1, 2010 to March 31, 2016. Patients who received sugammadex (sugammadex group) were compared with those who did not receive sugammadex (control group). The primary outcome was postoperative myasthenic crisis

2019 Anesthesia and Analgesia

16. The effect of neuromuscular reversal agent on postoperative pain after laparoscopic gastric cancer surgery: Comparison between the neostigmine and sugammadex. (PubMed)

The effect of neuromuscular reversal agent on postoperative pain after laparoscopic gastric cancer surgery: Comparison between the neostigmine and sugammadex. Use of sugammadex for neuromuscular block reversal is associated with fewer postoperative complications than neostigmine; however, the effects on postoperative pain outcomes are largely unknown. In this retrospective study, we investigated the relationship between neuromuscular reversal agents and postoperative pain-related outcomes (...) following laparoscopic gastric cancer surgery.We reviewed the electronic health records of patients who underwent laparoscopic gastric cancer surgery between January 2010 and June 2017. Patients were divided into a sugammadex group and a neostigmine group, according to the neuromuscular block reversal agent used. We compared the pain outcomes in the first 3 days postoperatively (POD 0-3), length of hospital stay, and postoperative complications (Clavien-Dindo grade ≥II).During the study period, 3056

2019 Medicine

17. Effects of neuromuscular block reversal with sugammadex versus neostigmine on postoperative respiratory outcomes after major abdominal surgery: a randomized-controlled trial. (PubMed)

Effects of neuromuscular block reversal with sugammadex versus neostigmine on postoperative respiratory outcomes after major abdominal surgery: a randomized-controlled trial. Postoperative pulmonary complications may be better reduced by reversal of neuromuscular block with sugammadex than by reversal with neostigmine because the incidence of residual block after sugammadex application is lower and diaphragm function is less impaired than after neostigmine administration. The aim of the study (...) was to compare the effect of reversal of neuromuscular block with sugammadex or neostigmine on lung function after major abdominal surgery.One hundred and thirty adults scheduled for major abdominal surgery under combined general and epidural anesthesia were randomly allocated to receive 40 µg of neostigmine or 4 mg·kg-1 of sugammadex to reverse neuromuscular block. Two blinded researchers performed spirometry and lung ultrasound before the surgery, as well as 1 hr and 24 hr postoperatively. Differences

2019 Canadian Journal Of Anaesthesia

18. Sugammadex Administration in Pregnant Women and in Women of Reproductive Potential: A Narrative Review. (PubMed)

Sugammadex Administration in Pregnant Women and in Women of Reproductive Potential: A Narrative Review. Since its clinical introduction in 2008, sugammadex has demonstrated a high degree of safety and superior effectiveness compared to neostigmine when used to antagonize muscle relaxation produced by steroid nondepolarizing neuromuscular blockers. This includes its use in special populations, such as the elderly, children over 2 years old, and patients with renal, hepatic, or lung disease (...) . In contrast, clinical evidence guiding its use during pregnancy, in women of childbearing potential, and in lactating women, is sparse. An exception is administration at the end of surgery in parturients undergoing cesarean delivery (CD) with general anesthesia (GA), for whom effectiveness and safety evidence is rapidly accumulating. We review evidence regarding sugammadex rescue reversal shortly after high-dose rocuronium in cases of cannot intubate/cannot ventilate (CICV), the extent of placental

2019 Anesthesia and Analgesia

19. Comparison of neostigmine vs. sugammadex for recovery of muscle function after neuromuscular block by means of diaphragm ultrasonography in microlaryngeal surgery: A randomised controlled trial. (PubMed)

Comparison of neostigmine vs. sugammadex for recovery of muscle function after neuromuscular block by means of diaphragm ultrasonography in microlaryngeal surgery: A randomised controlled trial. Postoperative residual neuromuscular blockade or curarisation (PORC) is a risk directly related to the use of neuromuscular blocking agents during surgical procedures. Acceleromyography is distressing for conscious patients when assessing PORC. Diaphragm ultrasonography could be a valid alternative.The (...) primary objective was to achieve a 28% lower incidence of PORC in patients who, after rocuronium administration, received neostigmine or sugammadex at 30 min after surgery. To assess PORC, diaphragm ultrasonography was used, and thickening fractioning [the difference of thickness at the end of inspiration (TEI) and at the end of expiration (TEE), normalised for TEE (TEI - TEE/TEE)] was measured. PORC was defined as thickening fractioning of 0.36 or less. The secondary object was the comparison

2019 European Journal of Anaesthesiology

20. Retrospective Analysis of the Safety and Efficacy of Sugammadex Versus Neostigmine for the Reversal of Neuromuscular Blockade in Children. (PubMed)

Retrospective Analysis of the Safety and Efficacy of Sugammadex Versus Neostigmine for the Reversal of Neuromuscular Blockade in Children. Sugammadex, with its novel mechanism of action of encapsulation and noncompetitive binding of aminosteroid neuromuscular-blocking agents (rocuronium and vecuronium), may offer distinct advantage to pediatric patients where residual neuromuscular blockade may be poorly tolerated. Data describing its use in the pediatric population are limited, and no large (...) -scale studies are available evaluating the occurrence of adverse event across the full spectrum of ages. We sought to measure the occurrence of adverse events, assess the severity and clinical significance of the events, and quantify a surrogate measure of efficacy of sugammadex compared to neostigmine in a large population and in the full age range of children.Beginning in September 2016 through initiation of data collection, we identified from our data warehouse that all patients were treated

2019 Anesthesia and Analgesia

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>