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Sucrose Hemolysis Test

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1. Sucrose Hemolysis Test

Sucrose Hemolysis Test Sucrose Hemolysis Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sucrose Hemolysis Test Sucrose Hemolysis (...) Test Aka: Sucrose Hemolysis Test From Related Chapters II. Interpretation: Normal Negative III. Interpretation: False negative EDTA use IV. Interpretation: Positive False positive Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Sucrose Hemolysis Test." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pathology and Laboratory Medicine

2018 FP Notebook

2. Sucrose Hemolysis Test

Sucrose Hemolysis Test Sucrose Hemolysis Test Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Sucrose Hemolysis Test Sucrose Hemolysis (...) Test Aka: Sucrose Hemolysis Test From Related Chapters II. Interpretation: Normal Negative III. Interpretation: False negative EDTA use IV. Interpretation: Positive False positive Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Sucrose Hemolysis Test." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pathology and Laboratory Medicine

2015 FP Notebook

3. Serum-Red Cell Interactions at Low Ionic Strength: Erythrocyte Complement Coating and Hemolysis of Paroxysmal Nocturnal Hemoglobinuria Cells (Full text)

with erythrocytes tested in the serum-sucrose system. Even though PNH hemolytic activity could be removed by prior heating of serum or barium sulfate treatment of plasma, the agglutination phenomenon still persisted. The in vitro conditions necessary for optimal sucrose hemolysis of PNH erythrocytes were described and compared with those of the classical acid hemolysis test. The requirement for less serum in the sucrose hemolysis system than needed in the standard acid hemolysis reaction makes certain (...) experiments, especially those using large amounts of autologous PNH serum, much more feasible. Additional advantages of the sucrose hemolysis test are that it can be carried out at room temperature in the presence of oxalate and citrate and that critical pH control is not essential. To date, the sucrose hemolysis test has been a sensitive and specific one for PNH. A modified test used for screening purposes, the "sugar water" test, is very easy to perform.

1967 Journal of Clinical Investigation PubMed

4. Preferential hemolysis of postnatal calf red cells induced by internal alkanlinization (Full text)

, to undergo volume shrinkage caused by the net loss of chloride ions with concomitant increase in intracellular pH. To test the potential role of intracellular pH change associated with chloride loss in promoting hemolysis, intracellular pH was altered by: (a) a direct addition of fixed acid or base to sucrose solution; (b) the removal of dissolved CO(2) from sucrose solution; and (c) the addition of cells to isotonic NaHCO(3) solution in the absence of sucrose. In all cases, only calf and not cow cells (...) Preferential hemolysis of postnatal calf red cells induced by internal alkanlinization Red blood cells from neonatal calves, but not from adult cows, rapidly hemolyze in buffered 300 mM solutions of a variety of nonelectrolytes and amino acids. Of these compounds, sucrose is chosen to elucidate the mechanism by which this preferential hemolysis takes place. As in other mammalian red cells, both calf and cow cells are found to be impermeable to sucrose and, in an isosmolar sucrose solution

1977 The Journal of general physiology PubMed

5. Heterogeneity of Antibody Response to Salmonella Lipopolysaccharide Measured by Passive Hemagglutination and Hemolysis in Mice (Full text)

, were distributed in both the light and heavy fractions isolated by sucrose density gradient fractionation and gel filtration. IgM fractions, whether tested by hemagglutination or hemolysis, were sensitive to 2-mercaptoethanol (0.15 m). On the other hand, IgG hemolytic antibodies were more sensitive to 2-mercaptoethanol than were IgG hemagglutinating antibodies. The resistance of IgG hemagglutinating activity amounted to about 72 to 95% of the total IgG recovered, whereas the resistant portion (...) Heterogeneity of Antibody Response to Salmonella Lipopolysaccharide Measured by Passive Hemagglutination and Hemolysis in Mice The complement-requiring passive hemolysis test with Salmonella typhimurium lipopolysaccharide-coated sheep erythrocytes is more sensitive for antibodies directed against the lipopolysaccharide than is the passive hemagglutination test. The hemagglutinating and hemolyzing antibodies produced in Swiss mice by hyperimmunization, either with or without Freund's adjuvant

1968 Journal of bacteriology PubMed

6. Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Adult Subjects With Chronic Kidney Disease

a positive serum or urine pregnancy test Hemoglobin ≤7.0 g/dL Received another investigational agent within 4 weeks prior to screening, or planned receipt of an unspecified investigational agent during the study period Known causes of anemia other than iron deficiency (such as hemolysis and vitamin B12 or folate deficiency) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using (...) Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Adult Subjects With Chronic Kidney Disease A Trial Comparing Ferumoxytol to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Adult Subjects With Chronic Kidney Disease - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have

2010 Clinical Trials

7. Classification of Anemias

-normal TIBC & transferrin saturation, only ~25% microcytic , Hemoglobinopathy, Lead Overload , Thalassemia normal TIBC, normal to ? serum iron & transferrin saturation major high RDW & minor normal RDW ; Sideroblastic anemia ? RDW MCV 80-100 fL Normocytic anemia Consider loss of blood, Reticulocyte count Blood loss, Hemolysis ? No blood loss ? Treat cause GI or menstrual bleed (Use of ASA/NSAIDs, warfarin etc.), high reticulocyte Anemia of chronic dx normal- ? RDW, low serum iron, low-normal TIBC (...) deficiency high RDW, low-normal reticulocyte , Hemolytic anemia Drug induced Aplastic anemia: allopurinol, antithyroid meds , chemo, chloramphenicol, chlorpromazine, clopidogrel, corticosteroids, furosemide, gold, indomethacin, interferon a2a&2b , isoniazid, methyldopa, NSAIDs, penicillamine, phenothiazines, procainamide, sulfonamides & ticlopidine. Drug induced Hemolysis in G6PD Deficiency: ascorbic acid, benzocaine, chloroquine, dapsone, hydroxychloroqine, nitrofurantoin, phenazopyridine, primaquine

2014 RxFiles

8. Trial of Atezolizumab and Vigil for Advanced Gynecological Cancers (A Companion Study to CL-PTL-119)

solution but may contain more than the stated volume to enable delivery of the entire 20 mL volume. The atezolizumab drug product is formulated as 60 mg/mL atezolizumab in 20 mM histidine acetate, 120 mM sucrose, 0.04% polysorbate 20, pH 5.8 (Phase III formulation). Other Names: TECENTRIQ™ MPDL3280A Experimental: Part 2: Vigil then Vigil + Atezo Part 2 is a randomized, open label intra-patient crossover study of Vigil, the checkpoint inhibitor Atezolizumab and the combination of the two agents. Vigil (...) ) of atezolizumab solution but may contain more than the stated volume to enable delivery of the entire 20 mL volume. The atezolizumab drug product is formulated as 60 mg/mL atezolizumab in 20 mM histidine acetate, 120 mM sucrose, 0.04% polysorbate 20, pH 5.8 (Phase III formulation). Other Names: TECENTRIQ™ MPDL3280A Active Comparator: Part 2: Atezo then Vigil + Atezo Part 2 is a randomized, open label intra-patient crossover study of Vigil, the checkpoint inhibitor Atezolizumab and the combination of the two

2017 Clinical Trials

9. Blood Flow Effects on Silicon Substrates

): Lynda Frasetto, M.D., University of California, San Francisco Study Details Study Description Go to Brief Summary: This is a non-randomized, open label, uncontrolled first in human safety study, testing the the material used in the artificial kidney device in subjects already on hemodialysis. Six subjects already on hemodialysis, who meet the study inclusion and exclusion criteria, and who dialyze at one of the UCSF associated hemodialysis units will be recruited. Each subject will be tested during (...) Detailed Description: For patient safety, the investigators will measure the following labs: Blood tests (routine safety and frequency). CBC/platelets: q 1 hr, at HD next day ABGs, including lactate: Q 1 hr x 6 Na, K, Cl, Bicarb, BUN, Creatinine, Ca, ionized Ca, Mg, Phos: Start, end, at HD next day Liver function test: Start, end, at HD next day LDH: Start, end, at HD next day Direct Coombs' Test: Start, end, at HD next day ESR and hsCRP: Start, end, at HD next day CPK: Start, end PT/PTT: Start, end

2017 Clinical Trials

10. Evaluation iNduction, Consolidation and Maintenance Treatment With Isatuximab , Carfilzomib, LEnalidomide and Dexamethasone

to adhere to the study visit schedule and other protocol requirements in the investigators opinion. WHO performance status 0-3 (WHO=3 is allowed only if caused by MM and not by co-morbid conditions) Females of childbearing potential (FCBP) (1) must agree to refrain from becoming pregnant for 28 days prior to initiation of study drug, while on study drug and for 30 days* after discontinuation from the study drug by using 2 reliable methods of contraception and must agree to regular pregnancy testing (...) and for 28 days after discontinuation from this study treatment. All subjects must agree not to share medication. All participating subjects have to follow the requirements of the Lenalidomide Pregnancy Prevention Plan Exclusion Criteria: Contraindication to any of the required concomitant drugs or supportive treatments, including hypersensitivity to antiviral drugs. Known history of allergy to Captisol® (a cyclodextrin derivative used to solubilize Carfilzomib), mannitol, sucrose, histidine (as base

2017 Clinical Trials

11. KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease

may be obtained with auto- mated CBC testing, may be high in patients who have active blood loss or hemolysis, and may be low in hypoproliferative erythropoiesis with anemia. Iron status There are two important and distinct aspects of the assessment of iron status testing: the presence or absence of storage iron and the availability of iron to support ongoing erythropoiesis. The serum ferritin is the most commonly used test for evaluation of storage iron, for which the ‘gold standard’ remains (...) Standardization (COGS) checklist for reporting clinical practice guidelines 322 FIGURES Figure 1. Receiver operating characteristic (ROC) curves, examining the utility of iron status tests to distinguish iron deficient from nondeficient study patients 293 Figure 2. Sensitivity and specificity of TSAT and serum ferritin and their combination (TSAT + ferritin) and bone marrow iron (BM iron) to identify correctly a positive erythropoietic response (Z1-g/dl [Z10-g/l] increase in Hb [DHb]) to intravenous iron

2012 National Kidney Foundation

12. Paroxysmal Nocturnal Hemoglobinuria

Nocturnal Hemoglobinuria Paroxysmal Nocturnal Hemoglobinuria Aka: Paroxysmal Nocturnal Hemoglobinuria , PNH From Related Chapters II. Pathophysiology Rare intrinsic RBC membrane defect Increased RBC sensitivity to complement damage III. Symptoms and signs Chronic Retrosternal pain Lumbar back pain Superficial migratory Nocturnal IV. Labs Test Negative Hypochromasia (Chronic urinary iron loss) Urine may be present Hemosiderin more often present or consistent with Hemosiderin s and Urine Positive (...) (Insensitive but highly specific) Increased in acid solution (Sensitive but less specific) Increased in sucrose solution V. Complications (5-10%) Thrombotic Complications Chronic VI. Management supplementation Androgen Trial for 2 months Fluoxymesterone 5-40 mg PO qd Oxymetholone 1-5 mg/kg/day PO Nandrolone decanoate 25-200 mg each week IM Dose: 0.25 - 1.0 mg/kg/day (15-40 mg PO qd) Daily steroids not recommended unless critical need Alternate day therapy may be helpful Transfusion Most patients become

2018 FP Notebook

13. Effects of the manufacturing process on the anti-A isoagglutinin titers in intravenous immunoglobulin products. (PubMed)

, which are believed to be responsible for rare hemolytic adverse events.The isoagglutinin levels of Sandoglobulin (lyophilized, sucrose-stabilized IVIG produced by Cohn-like fractionation) and Privigen (10% l-proline-stabilized IVIG produced by a chromatography-based process) were measured by the indirect agglutination test (IAT). The intrinsic isoagglutinin reduction capacity of each fractionation step was assessed in laboratory- and industry-scale experiments using the IAT and a flow cytometry (...) of the steps of the chromatography-based manufacturing process caused any decrease in anti-A isoagglutinin content. Similar results were obtained for anti-B isoagglutinin reduction.Unlike Cohn-like fractionation, chromatography-based IVIG manufacturing processes do not have an intrinsic capacity for isoagglutinin reduction. The addition of dedicated isoagglutinin reduction steps may help minimize the potential risk of hemolysis in IVIG-treated patients.© 2015 AABB.

2015 Transfusion

14. Glycogen-Storage Disease Type VII (Diagnosis)

activity. Thus, hemolysis is a result of partial erythrocyte PFK deficiency. Because the liver and kidneys express only the L isoform, these organs are spared; however, the brain and heart express predominantly the M isoform, and their lack of clinical involvement in most reported cases of classic Tarui disease is not easily explained. [ ] In late-onset Tarui disease, the myopathic syndrome results from a mutation of the M subunit distinct from those that cause classic Tarui disease. In contrast (...) who consume glucose or sucrose prior to exercise exhibit a decrease in circulating free fatty acids and ketones that are normally used as alternative energy fuels ("out of wind" phenomenon). [ , , ] The consumption of glucose signals the release of insulin from pancreatic beta-cells, leading to increased synthesis and subsequent storage of fatty acids as opposed to a release of this fuel source. In addition, the excess carbohydrates worsen the energy crisis in patients with Tarui disease because

2014 eMedicine Pediatrics

15. Fluid, Electrolyte, and Nutrition Management of the Newborn (Diagnosis)

or acidosis. As a result of an infant's compensatory mechanisms, blood pressure (BP) readings are usually within the reference range with mild or moderate hypovolemia. With severe hypovolemia, hypotension is almost invariably present. Laboratory evaluation Depending on the clinical situation and the suspected etiology of fluid and electrolyte derangements, some or all of the tests below may be warranted. Serum electrolyte, urea nitrogen, creatinine, and plasma osmolarity levels should be assessed. Keep (...) in mind that results of these tests, especially the creatinine levels, may still reflect maternal values over the first 12-24 hours. Serum creatinine normally declines postnatally, but very premature infants may have a delay in the decrease of serum creatinine levels. [ ] Accurate total urine output and total fluid intake may be assessed. In infants without urinary catheters or urine bags, diapers need to be weighed soon after voiding to reduce errors due to evaporation. [ ] Infants with reduced urine

2014 eMedicine Pediatrics

16. X-linked Immunodeficiency With Hyper IgM (Treatment)

cannot be completely ruled out. In 1993 and 1994, transmission of hepatitis C virus was reported in recipients of one of 2 IVIG products that did not undergo viral inactivation steps during manufacturing. All IVIG products currently marketed in the United States now undergo viral inactivation and removal. In order to reduce potential contamination of pathogens, all plasma for manufacture is tested at various levels and retested by viral marker and nucleic acid technology (NAT). Viral inactivation (...) be effectively removed. No case of HIV infection has resulted from treatment with IVIG because retroviruses are readily inactivated by the cold ethanol precipitation. The main concern is prions that transmit spongiform encephalopathy, referred to as variant Creutzfeldt-Jacob disease (vCJD). No blood tests or inactivation methods are currently applicable to prions. Fortunately, prions have not been directly detected in human blood, and the potential for efficient removal of prions by the current manufacturing

2014 eMedicine Pediatrics

17. Fluid, Electrolyte, and Nutrition Management of the Newborn (Treatment)

or acidosis. As a result of an infant's compensatory mechanisms, blood pressure (BP) readings are usually within the reference range with mild or moderate hypovolemia. With severe hypovolemia, hypotension is almost invariably present. Laboratory evaluation Depending on the clinical situation and the suspected etiology of fluid and electrolyte derangements, some or all of the tests below may be warranted. Serum electrolyte, urea nitrogen, creatinine, and plasma osmolarity levels should be assessed. Keep (...) in mind that results of these tests, especially the creatinine levels, may still reflect maternal values over the first 12-24 hours. Serum creatinine normally declines postnatally, but very premature infants may have a delay in the decrease of serum creatinine levels. [ ] Accurate total urine output and total fluid intake may be assessed. In infants without urinary catheters or urine bags, diapers need to be weighed soon after voiding to reduce errors due to evaporation. [ ] Infants with reduced urine

2014 eMedicine Pediatrics

18. Fluid, Electrolyte, and Nutrition Management of the Newborn (Overview)

or acidosis. As a result of an infant's compensatory mechanisms, blood pressure (BP) readings are usually within the reference range with mild or moderate hypovolemia. With severe hypovolemia, hypotension is almost invariably present. Laboratory evaluation Depending on the clinical situation and the suspected etiology of fluid and electrolyte derangements, some or all of the tests below may be warranted. Serum electrolyte, urea nitrogen, creatinine, and plasma osmolarity levels should be assessed. Keep (...) in mind that results of these tests, especially the creatinine levels, may still reflect maternal values over the first 12-24 hours. Serum creatinine normally declines postnatally, but very premature infants may have a delay in the decrease of serum creatinine levels. [ ] Accurate total urine output and total fluid intake may be assessed. In infants without urinary catheters or urine bags, diapers need to be weighed soon after voiding to reduce errors due to evaporation. [ ] Infants with reduced urine

2014 eMedicine Pediatrics

19. Glycogen-Storage Disease Type VII (Overview)

activity. Thus, hemolysis is a result of partial erythrocyte PFK deficiency. Because the liver and kidneys express only the L isoform, these organs are spared; however, the brain and heart express predominantly the M isoform, and their lack of clinical involvement in most reported cases of classic Tarui disease is not easily explained. [ ] In late-onset Tarui disease, the myopathic syndrome results from a mutation of the M subunit distinct from those that cause classic Tarui disease. In contrast (...) who consume glucose or sucrose prior to exercise exhibit a decrease in circulating free fatty acids and ketones that are normally used as alternative energy fuels ("out of wind" phenomenon). [ , , ] The consumption of glucose signals the release of insulin from pancreatic beta-cells, leading to increased synthesis and subsequent storage of fatty acids as opposed to a release of this fuel source. In addition, the excess carbohydrates worsen the energy crisis in patients with Tarui disease because

2014 eMedicine Pediatrics

20. Common Variable Immunodeficiency (Treatment)

that did not undergo viral inactivation steps during manufacturing. All IVIG products currently marketed in the United States now undergo viral inactivation and removal. In order to reduce potential contamination of pathogens, all plasma for manufacture is tested at various levels and retested by viral marker and nucleic acid technology (NAT). Viral inactivation is achieved by dry heat, pasteurization, or irradiation solvent-detergent treatment, low pH exposure, or caprolate treatment. Viral removal (...) by the cold ethanol precipitation. The main concern is prions that transmit spongiform encephalopathy or referred to as variant Creutzfeldt-Jacob disease (vCJD). Currently, no blood tests or inactivation methods are applicable to prions. Fortunately, prions have not been detected directly in human blood and the potential for efficient removal of prions by the current manufacturing processes have been documented. Acute and chronic renal failure has been reported, most often in patients with preexisting

2014 eMedicine Pediatrics

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