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Succinylcholine

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1. Update: Does Rocuronium Create Better Intubating Conditions Than Succinylcholine for Rapid Sequence Intubation?

Update: Does Rocuronium Create Better Intubating Conditions Than Succinylcholine for Rapid Sequence Intubation? TAKE-HOME MESSAGE Succinylcholine is superior to rocuronium in providing excellent intubating conditions for emergency rapid sequence intubation. Update:DoesRocuronium CreateBetter Intubating ConditionsThanSuccinylcholineforRapidSequence Intubation? EBEM Commentators Julie L. Welch, MD Department of Emergency Medicine Indiana University School of Medicine Indianapolis, IN Rawle (...) A. Seupaul, MD Department of Emergency Medicine University of Arkansas for Medical Sciences Little Rock, AR Results Ofthe66identi?edstudies,50met inclusion criteria for analysis, comprising 4,151 patients. Main outcomes and selected subgroup analysis are summarized in the Table. The overall evidence was deemed moderate quality because ofahighincidenceofdetectionbias (ie, 50% of the intubators were not blindedtothefasciculationscaused by succinylcholine), and there was substantial heterogeneity among

2017 Annals of Emergency Medicine Systematic Review Snapshots

2. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes

Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes CPIC GUIDELINE CLINICAL PHARMACOLOGY & THERAPEUTICS | VOLUME 0 NUMBER 0 | Month 2019 1 Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes Stephen G. Gonsalves 1 , Robert T. Dirksen 2 (...) or succinylcholine. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of these agents in patients with these RYR1 or CACNA1S variants (updates at https://cpicpgx.org/guidelines and www.pharmgkb.org). The purpose of this Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline is to provide information to allow the interpretation of selected RYR1 and CACNA1S genotype re- sults so they can guide healthcare providers on the proper

2017 Clinical Pharmacogenetics Implementation Consortium

3. Comparison of rocuronium at two different doses and succinylcholine for endotracheal intubation in adult patients for elective surgeries. Full Text available with Trip Pro

Comparison of rocuronium at two different doses and succinylcholine for endotracheal intubation in adult patients for elective surgeries. The effects of rocuronium at two different doses, that is, 0.6 mg/kg (2 × ED95) and 0.9 mg/kg (3 × ED95), were compared with succinylcholine (2 mg/kg) when used for endotracheal intubation in adult patients for elective surgeries under general anesthesia.Ninety patients were divided into three groups of 30 each. Groups A, B received injection rocuronium (...) at 0.6 mg/kg, 0.9 mg/kg respectively and Group C received succinylcholine at 2 mg/kg. Onset of action of relaxant, intubation conditions, time taken to intubate and duration of action were compared.To compare the statistical difference in the age, weight, height of the study subjects, onset of action of relaxant, intubation conditions, time taken to intubate, and duration of action analysis of variance and unpaired t-test were used.The onset time was considerably shorter with rocuronium 0.9 mg/kg

2019 Saudi journal of anaesthesia Controlled trial quality: uncertain

4. To Evaluate the Efficacy of Intravenous Infusion of Dexmedetomidine as Premedication in Attenuating the Rise of Intraocular Pressure Caused by Succinylcholine in Patients Undergoing Rapid Sequence Induction for General Anesthesia: A Randomized Study. Full Text available with Trip Pro

To Evaluate the Efficacy of Intravenous Infusion of Dexmedetomidine as Premedication in Attenuating the Rise of Intraocular Pressure Caused by Succinylcholine in Patients Undergoing Rapid Sequence Induction for General Anesthesia: A Randomized Study. Laryngoscopy and intubation performed during RSI lead to choroidal blood volume increase and an eventual rise in intraocular pressure (IOP). Use of succinylcholine (SCh) causes an undesirable rise in IOP which is further aggravated by laryngoscopy

2019 Anesthesia, essays and researches Controlled trial quality: uncertain

5. Comparison of atracurium and methocarbamol for preventing succinylcholine-induced muscle fasciculation: A randomized controlled trial. (Abstract)

Comparison of atracurium and methocarbamol for preventing succinylcholine-induced muscle fasciculation: A randomized controlled trial. Fasciculation is a minor adverse effect of succinylcholine and may be an unpleasant experience for patient. The aim of this study was to compare the use of atracurium and methocarbamol to decrease the occurrence and severity of succinylcholine-induced muscle fasciculation. Fifty-nine adults with American Society of Anesthesiologists I or II hospitalized (...) for elective surgery were randomly assigned to two groups: Group A (n = 29) who received succinylcholine 1 mg/kg body weight (BW) intravenously followed by 0.2-0.5 mg/kg BW atracurium and patients in Group B (n= 29) who received succinylcholine 1 mg/kg BW intravenously followed by methocarbamol 0.2-0.5 mg/kg BW. Anesthesia was induced in all patients with thiopental sodium 3-5 mg/kg. Fasciculation was scored on a four-point (0-4) Likert scale. There were no statistically significant differences

2019 Journal of advanced pharmaceutical technology & research Controlled trial quality: uncertain

6. The Influence of Two Different Doses of Magnesium Sulfate on Intraocular Pressure Variations after Injection of Succinylcholine and Endotracheal Intubation: A Prospective, Randomized, Parallel Three-Arm, Double-blind, Placebo-controlled Clinical Trial. Full Text available with Trip Pro

The Influence of Two Different Doses of Magnesium Sulfate on Intraocular Pressure Variations after Injection of Succinylcholine and Endotracheal Intubation: A Prospective, Randomized, Parallel Three-Arm, Double-blind, Placebo-controlled Clinical Trial. The use of succinylcholine for rapid sequence induction in patients with open globe injuries may be detrimental to the eye.The aim of this study is to determine if the premedication with magnesium sulfate (MgSO4) could attenuate the increase (...) in intraocular pressure (IOP) associated with succinylcholine injection and intubation.Operation theaters in a tertiary care University Hospital between December 2014 and July 215.This was a prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial.One hundred and thirteen patients' physical status ASA Classes I and II underwent elective cataract surgery under general anesthesia.These patients allocated into three groups: Group C (control group) received 100 ml normal

2019 Anesthesia, essays and researches Controlled trial quality: predicted high

7. Low-dose Succinylcholine to Facilitate Laryngeal Mask Airway Insertion: A Comparison of Two Doses. Full Text available with Trip Pro

Low-dose Succinylcholine to Facilitate Laryngeal Mask Airway Insertion: A Comparison of Two Doses. Around the world, the use of the laryngeal mask airway (LMA) is becoming more common for different surgeries accounting for it being the dominant choice of airway in numerous surgeries. Although propofol is known to blunt the laryngeal reflexes often patient movement, coughing, and gagging occur on insertion. This study aims to identify the optimum dose of succinylcholine required to facilitate (...) LMA insertion comparing placebo, 0.1 mg/kg and 0.25 mg/kg of succinylcholine. Further objectives were to compare (a) the overall insertion conditions of the LMA, (b) the number of insertion attempts, (c) the amount of propofol consumption, and (d) the hemodynamics in the three groups.This is a prospective, double-blinded, randomized control trial of 283 patients randomized into three groups-placebo, 0.1 mg/kg and 0.25 mg/kg of succinylcholine. It was done in the day case theatres of a tertiary

2019 Anesthesia, essays and researches Controlled trial quality: uncertain

8. A Randomized Controlled Trial to Compare Preemptive Analgesic Efficacy and Safety of Pregabalin and Gabapentin for Succinylcholine-Induced Myalgia. Full Text available with Trip Pro

A Randomized Controlled Trial to Compare Preemptive Analgesic Efficacy and Safety of Pregabalin and Gabapentin for Succinylcholine-Induced Myalgia. Succinylcholine is a drug of choice for rapid induction of anesthesia but produces postoperative myalgia. Preemptive analgesia is intended to decrease perception of pain before exposure to painful stimuli. Pregabalin and gabapentin, analogs of the inhibitory neurotransmitter gamma aminobutyric acid, are effective in several models of neuropathic (...) pain, incisional, inflammatory, and formalin-induced injury. However, the data available on their preemptive analgesic efficacy in succinylcholine myalgia are sparse. This study was designed to compare the preemptive analgesic efficacy and safety of pregabalin and gabapentin.This randomized clinical trial included 120 surgical patients of either sex, between 18 and 70 years, and of American Society of Anesthesiologists-I/II grade. Patients were randomly allocated to control and test groups

2019 Nigerian medical journal : journal of the Nigeria Medical Association Controlled trial quality: uncertain

9. Comparing The Functional Outcome Of Different Dose Regimes Of Succinylcholine When Used For Rapid Induction And Intubation. (Abstract)

Comparing The Functional Outcome Of Different Dose Regimes Of Succinylcholine When Used For Rapid Induction And Intubation. This study was conducted to compare outcomes of different doses of succinylcholine, in terms of intubation condition, onset of action, duration of action and abdominal fasciculation.Thus, randomized control trial was conducted in the department of anaesthesia and ICU, Nishter Hospital Multan from April 2016 to November 2016. A total number of 60 patients with ASA status I (...) was 50.95±4.6, 70.7±5.66 and 94.15±8.73 seconds in three groups respectively. Similarly, the mean duration of action was 16.1±3.76, 13.55±3.01 and 8±2.05 minutes respectively.Results of our clinical trial suggest that succinylcholine in low doses shorter duration of action and low rate of abdominal fasciculation which is desirable for rapid induction but onset of action is prolonged and intubation conditions were not satisfactory predominantly. So, we concluded that low doses of succnylcholine

2019 Journal of Ayub Medical College, Abbottabad : JAMC Controlled trial quality: uncertain

10. Succinylcholine and Intracranial Pressure. (Abstract)

Succinylcholine and Intracranial Pressure. Intracranial and Hemodynamic Changes after Succinylcholine Administration in Cats. By Cottrell JE, Hartung J, Giffin JP, and Shwiry B. Anesthesia & Analgesia 1983; 62:1006-9. Reprinted with permission.Bolus injections of succinylcholine (1.5 mg/kg) significantly increased intracranial pressure (ICP) in cats under normal conditions from control levels of 8 +/- 1 mmHg to 16 +/- 3 mmHg (+/- SEM, P less than 0.01), and in the presence of artificially (...) increased ICP from control levels of 27 +/- 1 mmHg to 47 +/- 4 mmHg (P less than 0.01). These approximately 100% increases in ICP were accompanied by a transitory decrease in mean arterial pressure (approximately 10 s), followed by a 15 to 20% increase (P less than 0.05). Pulmonary arterial pressure increased 20 to 30% (P less than 0.05). These results, when considered in conjunction with results previously obtained in humans, suggest that succinylcholine may be contraindicated in neurosurgical patients.

2018 Anesthesiology

11. Effects of Succinylcholine on Nonintubated Thoracoscopic Surgery

Effects of Succinylcholine on Nonintubated Thoracoscopic Surgery Effects of Succinylcholine on Nonintubated Thoracoscopic Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Succinylcholine (...) University Hospital Information provided by (Responsible Party): National Taiwan University Hospital Study Details Study Description Go to Brief Summary: A safe and effective surgical environment is important for nonintubated thoracoscopic surgery. The investigators hypothesize that mini-dose succinylcholine can induce ultra-short period of apnea, by which the ventilatory responses to open pneumothorax were abolished and may facilitate rapid and satisfying collapse of the operated lung during

2018 Clinical Trials

12. Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT)

Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT) Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT) (CRoSSECT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03532178

2018 Clinical Trials

13. Emergency Department Intubation Success With Succinylcholine Versus Rocuronium: A National Emergency Airway Registry Study. Full Text available with Trip Pro

Emergency Department Intubation Success With Succinylcholine Versus Rocuronium: A National Emergency Airway Registry Study. Although both succinylcholine and rocuronium are used to facilitate emergency department (ED) rapid sequence intubation, the difference in intubation success rate between them is unknown. We compare first-pass intubation success between ED rapid sequence intubation facilitated by succinylcholine versus rocuronium.We analyzed prospectively collected data from the National (...) Emergency Airway Registry, a multicenter registry collecting data on all intubations performed in 22 EDs. We included intubations of patients older than 14 years who received succinylcholine or rocuronium during 2016. We compared the first-pass intubation success between patients receiving succinylcholine and those receiving rocuronium. We also compared the incidence of adverse events (cardiac arrest, dental trauma, direct airway injury, dysrhythmias, epistaxis, esophageal intubation, hypotension

2018 Annals of Emergency Medicine

14. Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia

Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia (CELOTOF) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government

2018 Clinical Trials

15. Effect of Selenium on Succinylcholine-Induced POM

Effect of Selenium on Succinylcholine-Induced POM Effect of Selenium on Succinylcholine-Induced POM - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Selenium on Succinylcholine-Induced POM (...) Go to Brief Summary: For more than 60 years, succinylcholine is still being administered as the selective relaxant for rapid sequence intubation by anesthesiologists in many countries. It has been shown to possess unique features such as low cost, fast-acting, short half-life, safe metabolites, and causing excellent muscle relaxation for intubation. However, it has many side effects as well. Postoperative myalgia (POM), with an incidence rate of about 41%-92%, is one of the most common side

2018 Clinical Trials

16. The Effect of Remifentanil on Succinylcholine Induced Changes in Serum Potassium and Creatine Kinase: A Prospective Randomized Double blind Study. (Abstract)

The Effect of Remifentanil on Succinylcholine Induced Changes in Serum Potassium and Creatine Kinase: A Prospective Randomized Double blind Study. Succinylcholine is still included as drugs favored by anesthetists because of its rapid onset and short duration of action. However, it can bring about complications such as hyperkalemia and increased serum creatine phosphokinase (CPK). This study aims at evaluating the effects of remifentanil on succinylcholine-induced postoperative changes in serum (...) potassium and CPK.In this study, 59 patients with short term lower abdominal surgery were randomly divided into two groups. In the first group (control group), 2 ml normal saline was used before injecting anesthetic drugs while in the second group (study group), 1 mcg/kg of remifentanil was injected. The patients were anesthetized with a combination of fentanyl (1 mg/kg) and propofol (2 mg/kg). Besides, succinylcholine (1.5 mg/kg) was used for muscle relaxation and tracheal intubation. Serum potassium

2018 Acta bio-medica : Atenei Parmensis Controlled trial quality: uncertain

17. Suxamethonium (succinylcholine) for RSI and intubation in head injury Full Text available with Trip Pro

Suxamethonium (succinylcholine) for RSI and intubation in head injury BestBets: Suxamethonium (succinylcholine) for RSI and intubation in head injury Suxamethonium (succinylcholine) for RSI and intubation in head injury Report By: Dr. Natalie May - ST5 Emergency Medicine/ST7 PEM Search checked by Kenneth Anderson - ST3 Emergency Medicine, University Hospital of South Manchester Institution: Royal Manchester Children's Hospital Date Submitted: 20th August 2011 Date Completed: 13th June 2012 Last (...) induction for CT scan; while you are pre-oxygenating another middle grade appears and helpfully reminds you that "suxamethonium will only increase this patient's intracranial pressure." You wonder whether the evidence is compelling enough to avoid suxamethonium altogether in patients with head injury. Search Strategy Ovid MEDLINE® 1948 to September 09 2011 EMBASE® 1980 to present Cochrane Database exp Succinylcholine/ OR suxamethonium.mp OR depolarising muscle relaxant*.mp OR anectine.mp AND exp

2012 BestBETS

18. Is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation?

Is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation? BestBets: Is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation? Is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation? Report By: Adam Herbstritt - Senior Emergency Registrar Search checked by Keith Amarakone - Institution: Christchurch hospital, New Zealand Date Submitted: 19th (...) August 2011 Date Completed: 17th October 2011 Last Modified: 23rd February 2012 Status: Green (complete) Three Part Question In a [patient undergoing rapid sequence induction in the emergency department] are [rocuronium and suxamethonium similar] at providing [optimal intubating conditions] Clinical Scenario You are about to perform a rapid sequence intubation on a 26 year old man. You’ve heard rocuronium may provide similar intubating conditions to succinylcholine with fewer side effects, and wonder

2012 BestBETS

19. Rocuronium is more hepatotoxic than succinylcholine in vitro. (Abstract)

Rocuronium is more hepatotoxic than succinylcholine in vitro. The development of liver failure is a major problem in critically ill patients. The hepatotoxicity of many drugs, as one important reason for liver failure, is poorly screened for in human models. Rocuronium and succinylcholine are neuromuscular blocking agents used for tracheal intubation and for rapid-sequence induction.We used an in-vitro test with a permanent cell line and compared rocuronium and succinylcholine (...) for hepatotoxicity.In-vitro study.A basic science laboratory, University Hospital Rostock, Germany.The basic test compound is the permanent human liver cell line HepG2/C3A. In a standardised microtitre plate assay the toxicity of different concentrations of rocuronium, succinylcholine and plasma control was tested.After two incubation periods of 3 days, the viability of cells (XTT test, lactate dehydrogenase release and trypan blue staining), micro-albumin synthesis and the cytochrome 1A2 activity (metabolism

2017 European Journal of Anaesthesiology

20. Duloxetine for Succinylcholine-induced Postoperative Myalgia

Duloxetine for Succinylcholine-induced Postoperative Myalgia Duloxetine for Succinylcholine-induced Postoperative Myalgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Duloxetine for Succinylcholine (...) Details Study Description Go to Brief Summary: For >60 years, succinylcholine is still being administered as a selective relaxant for rapid sequence intubation by anesthesiologists in many countries. It has been shown to possess unique features such as low cost, fast-acting, short half-life, safe metabolites, and causing excellent muscle relaxation for intubation. It has many side effects as well. Postoperative myalgia (POM), with an incidence rate of ~41%-92%, is one of the most common side effects

2017 Clinical Trials

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