How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,321 results for

Succinylcholine

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Update: Does Rocuronium Create Better Intubating Conditions Than Succinylcholine for Rapid Sequence Intubation?

Update: Does Rocuronium Create Better Intubating Conditions Than Succinylcholine for Rapid Sequence Intubation? TAKE-HOME MESSAGE Succinylcholine is superior to rocuronium in providing excellent intubating conditions for emergency rapid sequence intubation. Update:DoesRocuronium CreateBetter Intubating ConditionsThanSuccinylcholineforRapidSequence Intubation? EBEM Commentators Julie L. Welch, MD Department of Emergency Medicine Indiana University School of Medicine Indianapolis, IN Rawle (...) A. Seupaul, MD Department of Emergency Medicine University of Arkansas for Medical Sciences Little Rock, AR Results Ofthe66identi?edstudies,50met inclusion criteria for analysis, comprising 4,151 patients. Main outcomes and selected subgroup analysis are summarized in the Table. The overall evidence was deemed moderate quality because ofahighincidenceofdetectionbias (ie, 50% of the intubators were not blindedtothefasciculationscaused by succinylcholine), and there was substantial heterogeneity among

2017 Annals of Emergency Medicine Systematic Review Snapshots

2. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes

Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes CPIC GUIDELINE CLINICAL PHARMACOLOGY & THERAPEUTICS | VOLUME 0 NUMBER 0 | Month 2019 1 Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes Stephen G. Gonsalves 1 , Robert T. Dirksen 2 (...) or succinylcholine. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for the use of these agents in patients with these RYR1 or CACNA1S variants (updates at https://cpicpgx.org/guidelines and www.pharmgkb.org). The purpose of this Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline is to provide information to allow the interpretation of selected RYR1 and CACNA1S genotype re- sults so they can guide healthcare providers on the proper

2017 Clinical Pharmacogenetics Implementation Consortium

3. Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Although dantrolene effectively treats malignant hyperthermia (MH), discrepant recommendations exist concerning dantrolene availability. Whereas Malignant Hyperthermia Association of the United States guidelines state dantrolene must be available within 10 min of the decision to treat MH wherever volatile anesthetics (...) or succinylcholine are administered, a Society for Ambulatory Anesthesia protocol permits Class B ambulatory facilities to stock succinylcholine for airway rescue without dantrolene. The authors investigated (1) succinylcholine use rates, including for airway rescue, in anesthetizing/sedating locations; (2) whether succinylcholine without volatile anesthetics triggers MH warranting dantrolene; and (3) the relationship between dantrolene administration and MH morbidity/mortality.The authors performed focused

2019 EvidenceUpdates

4. Rocuronium versus succinylcholine for rapid sequence induction intubation. (PubMed)

Rocuronium versus succinylcholine for rapid sequence induction intubation. Patients often require a rapid sequence induction (RSI) endotracheal intubation technique during emergencies or electively to protect against aspiration, increased intracranial pressure, or to facilitate intubation. Traditionally succinylcholine has been the most commonly used muscle relaxant for this purpose because of its fast onset and short duration; unfortunately, it can have serious side effects. Rocuronium has (...) been suggested as an alternative to succinylcholine for intubation. This is an update of our Cochrane review published first in 2003 and then updated in 2008 and now in 2015.To determine whether rocuronium creates intubating conditions comparable to those of succinylcholine during RSI intubation.In our initial review we searched all databases until March 2000, followed by an update to June 2007. This latest update included searching the Cochrane Central Register of Controlled Trials (CENTRAL; 2015

2015 Cochrane

5. Comparing The Functional Outcome Of Different Dose Regimes Of Succinylcholine When Used For Rapid Induction And Intubation. (PubMed)

Comparing The Functional Outcome Of Different Dose Regimes Of Succinylcholine When Used For Rapid Induction And Intubation. This study was conducted to compare outcomes of different doses of succinylcholine, in terms of intubation condition, onset of action, duration of action and abdominal fasciculation.Thus, randomized control trial was conducted in the department of anaesthesia and ICU, Nishter Hospital Multan from April 2016 to November 2016. A total number of 60 patients with ASA status I (...) was 50.95±4.6, 70.7±5.66 and 94.15±8.73 seconds in three groups respectively. Similarly, the mean duration of action was 16.1±3.76, 13.55±3.01 and 8±2.05 minutes respectively.Results of our clinical trial suggest that succinylcholine in low doses shorter duration of action and low rate of abdominal fasciculation which is desirable for rapid induction but onset of action is prolonged and intubation conditions were not satisfactory predominantly. So, we concluded that low doses of succnylcholine

2019 Journal of Ayub Medical College, Abbottabad : JAMC

6. Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review. (PubMed)

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review. Although dantrolene effectively treats malignant hyperthermia (MH), discrepant recommendations exist concerning dantrolene availability. Whereas Malignant Hyperthermia Association of the United States guidelines state dantrolene must be available within 10 min of the decision to treat MH wherever volatile anesthetics or succinylcholine are administered, a Society (...) for Ambulatory Anesthesia protocol permits Class B ambulatory facilities to stock succinylcholine for airway rescue without dantrolene. The authors investigated (1) succinylcholine use rates, including for airway rescue, in anesthetizing/sedating locations; (2) whether succinylcholine without volatile anesthetics triggers MH warranting dantrolene; and (3) the relationship between dantrolene administration and MH morbidity/mortality.The authors performed focused analyses of the Multicenter Perioperative

2019 Anesthesiology

7. The Effect of Remifentanil on Succinylcholine Induced Changes in Serum Potassium and Creatine Kinase: A Prospective Randomized Double blind Study. (PubMed)

The Effect of Remifentanil on Succinylcholine Induced Changes in Serum Potassium and Creatine Kinase: A Prospective Randomized Double blind Study. Succinylcholine is still included as drugs favored by anesthetists because of its rapid onset and short duration of action. However, it can bring about complications such as hyperkalemia and increased serum creatine phosphokinase (CPK). This study aims at evaluating the effects of remifentanil on succinylcholine-induced postoperative changes in serum (...) potassium and CPK.In this study, 59 patients with short term lower abdominal surgery were randomly divided into two groups. In the first group (control group), 2 ml normal saline was used before injecting anesthetic drugs while in the second group (study group), 1 mcg/kg of remifentanil was injected. The patients were anesthetized with a combination of fentanyl (1 mg/kg) and propofol (2 mg/kg). Besides, succinylcholine (1.5 mg/kg) was used for muscle relaxation and tracheal intubation. Serum potassium

2018 Acta bio-medica : Atenei Parmensis

8. Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia

Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia (CELOTOF) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government

2018 Clinical Trials

9. Effect of Selenium on Succinylcholine-Induced POM

Effect of Selenium on Succinylcholine-Induced POM Effect of Selenium on Succinylcholine-Induced POM - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Selenium on Succinylcholine-Induced POM (...) Go to Brief Summary: For more than 60 years, succinylcholine is still being administered as the selective relaxant for rapid sequence intubation by anesthesiologists in many countries. It has been shown to possess unique features such as low cost, fast-acting, short half-life, safe metabolites, and causing excellent muscle relaxation for intubation. However, it has many side effects as well. Postoperative myalgia (POM), with an incidence rate of about 41%-92%, is one of the most common side

2018 Clinical Trials

10. Effects of Succinylcholine on Nonintubated Thoracoscopic Surgery

Effects of Succinylcholine on Nonintubated Thoracoscopic Surgery Effects of Succinylcholine on Nonintubated Thoracoscopic Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Succinylcholine (...) University Hospital Information provided by (Responsible Party): National Taiwan University Hospital Study Details Study Description Go to Brief Summary: A safe and effective surgical environment is important for nonintubated thoracoscopic surgery. The investigators hypothesize that mini-dose succinylcholine can induce ultra-short period of apnea, by which the ventilatory responses to open pneumothorax were abolished and may facilitate rapid and satisfying collapse of the operated lung during

2018 Clinical Trials

11. Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT)

Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT) Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT) (CRoSSECT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03532178

2018 Clinical Trials

12. Succinylcholine and Intracranial Pressure. (PubMed)

Succinylcholine and Intracranial Pressure. Intracranial and Hemodynamic Changes after Succinylcholine Administration in Cats. By Cottrell JE, Hartung J, Giffin JP, and Shwiry B. Anesthesia & Analgesia 1983; 62:1006-9. Reprinted with permission.Bolus injections of succinylcholine (1.5 mg/kg) significantly increased intracranial pressure (ICP) in cats under normal conditions from control levels of 8 +/- 1 mmHg to 16 +/- 3 mmHg (+/- SEM, P less than 0.01), and in the presence of artificially (...) increased ICP from control levels of 27 +/- 1 mmHg to 47 +/- 4 mmHg (P less than 0.01). These approximately 100% increases in ICP were accompanied by a transitory decrease in mean arterial pressure (approximately 10 s), followed by a 15 to 20% increase (P less than 0.05). Pulmonary arterial pressure increased 20 to 30% (P less than 0.05). These results, when considered in conjunction with results previously obtained in humans, suggest that succinylcholine may be contraindicated in neurosurgical patients.

2018 Anesthesiology

13. Emergency Department Intubation Success With Succinylcholine Versus Rocuronium: A National Emergency Airway Registry Study. (PubMed)

Emergency Department Intubation Success With Succinylcholine Versus Rocuronium: A National Emergency Airway Registry Study. Although both succinylcholine and rocuronium are used to facilitate emergency department (ED) rapid sequence intubation, the difference in intubation success rate between them is unknown. We compare first-pass intubation success between ED rapid sequence intubation facilitated by succinylcholine versus rocuronium.We analyzed prospectively collected data from the National (...) Emergency Airway Registry, a multicenter registry collecting data on all intubations performed in 22 EDs. We included intubations of patients older than 14 years who received succinylcholine or rocuronium during 2016. We compared the first-pass intubation success between patients receiving succinylcholine and those receiving rocuronium. We also compared the incidence of adverse events (cardiac arrest, dental trauma, direct airway injury, dysrhythmias, epistaxis, esophageal intubation, hypotension

2018 Annals of Emergency Medicine

14. Duloxetine for Succinylcholine-induced Postoperative Myalgia

Duloxetine for Succinylcholine-induced Postoperative Myalgia Duloxetine for Succinylcholine-induced Postoperative Myalgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Duloxetine for Succinylcholine (...) Details Study Description Go to Brief Summary: For >60 years, succinylcholine is still being administered as a selective relaxant for rapid sequence intubation by anesthesiologists in many countries. It has been shown to possess unique features such as low cost, fast-acting, short half-life, safe metabolites, and causing excellent muscle relaxation for intubation. It has many side effects as well. Postoperative myalgia (POM), with an incidence rate of ~41%-92%, is one of the most common side effects

2017 Clinical Trials

15. Rocuronium is more hepatotoxic than succinylcholine in vitro. (PubMed)

Rocuronium is more hepatotoxic than succinylcholine in vitro. The development of liver failure is a major problem in critically ill patients. The hepatotoxicity of many drugs, as one important reason for liver failure, is poorly screened for in human models. Rocuronium and succinylcholine are neuromuscular blocking agents used for tracheal intubation and for rapid-sequence induction.We used an in-vitro test with a permanent cell line and compared rocuronium and succinylcholine (...) for hepatotoxicity.In-vitro study.A basic science laboratory, University Hospital Rostock, Germany.The basic test compound is the permanent human liver cell line HepG2/C3A. In a standardised microtitre plate assay the toxicity of different concentrations of rocuronium, succinylcholine and plasma control was tested.After two incubation periods of 3 days, the viability of cells (XTT test, lactate dehydrogenase release and trypan blue staining), micro-albumin synthesis and the cytochrome 1A2 activity (metabolism

2017 European Journal of Anaesthesiology

16. Rocuronium vs. succinylcholine for rapid sequence intubation: a Cochrane systematic review. (PubMed)

Rocuronium vs. succinylcholine for rapid sequence intubation: a Cochrane systematic review. This systemic review was performed to determine whether rocuronium creates intubating conditions comparable to those of succinylcholine during rapid sequence intubation of the trachea. We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2015, Issue 2), MEDLINE (1966 to February Week 2 2015), and EMBASE (1988 to February 14 2015) for any randomised controlled trials or controlled (...) clinical trials that reported intubating conditions comparing rocuronium and succinylcholine for rapid or modified rapid sequence intubation. The dose of rocuronium was at least 0.6 mg.kg-1 and succinylcholine was at least 1 mg.kg-1 . Sixty-six studies were identified and 50 included, representing 4151 participants. Overall, succinylcholine was superior to rocuronium for achieving excellent intubating conditions (risk ratio (95%CI) 0.86 (0.81 to 0.92), n = 4151) and clinically acceptable intubation

Full Text available with Trip Pro

2017 Anaesthesia

17. Optimal dose of succinylcholine for laryngeal mask airway insertion: systematic review, meta-analysis and metaregression of randomised control trials. (PubMed)

Optimal dose of succinylcholine for laryngeal mask airway insertion: systematic review, meta-analysis and metaregression of randomised control trials. To evaluate the optimal dose of succinylcholine for laryngeal mask airway (LMA) insertion and all related morbidities.Systematic review, meta-analysis and metaregression of randomised controlled trials (RCTs).A comprehensive search of RCTs in the PubMed, Embase, the Cochrane Library and the ClinicalTrials.gov registry up to July 2016 and articles (...) that evaluated the use of succinylcholine chloride for LMA insertion were included in the analyses. The relative risk (RR) and the corresponding 95% CIs were determined.Succinylcholine as the coinduction agent and the doses were divided into mini (≤0.3 mg/kg) and low (0.3-1.0 mg/kg) doses for dose-dependent effect analyses.The primary outcome was the first-attempt LMA insertion failure rate. Secondary outcomes included all related adverse events.Data from 10 RCTs comprising 625 participants showed

Full Text available with Trip Pro

2017 BMJ open

18. Is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation?

Is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation? BestBets: Is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation? Is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation? Report By: Adam Herbstritt - Senior Emergency Registrar Search checked by Keith Amarakone - Institution: Christchurch hospital, New Zealand Date Submitted: 19th (...) August 2011 Date Completed: 17th October 2011 Last Modified: 23rd February 2012 Status: Green (complete) Three Part Question In a [patient undergoing rapid sequence induction in the emergency department] are [rocuronium and suxamethonium similar] at providing [optimal intubating conditions] Clinical Scenario You are about to perform a rapid sequence intubation on a 26 year old man. You’ve heard rocuronium may provide similar intubating conditions to succinylcholine with fewer side effects, and wonder

2012 BestBETS

19. Suxamethonium (succinylcholine) for RSI and intubation in head injury

Suxamethonium (succinylcholine) for RSI and intubation in head injury BestBets: Suxamethonium (succinylcholine) for RSI and intubation in head injury Suxamethonium (succinylcholine) for RSI and intubation in head injury Report By: Dr. Natalie May - ST5 Emergency Medicine/ST7 PEM Search checked by Kenneth Anderson - ST3 Emergency Medicine, University Hospital of South Manchester Institution: Royal Manchester Children's Hospital Date Submitted: 20th August 2011 Date Completed: 13th June 2012 Last (...) induction for CT scan; while you are pre-oxygenating another middle grade appears and helpfully reminds you that "suxamethonium will only increase this patient's intracranial pressure." You wonder whether the evidence is compelling enough to avoid suxamethonium altogether in patients with head injury. Search Strategy Ovid MEDLINE® 1948 to September 09 2011 EMBASE® 1980 to present Cochrane Database exp Succinylcholine/ OR suxamethonium.mp OR depolarising muscle relaxant*.mp OR anectine.mp AND exp

2012 BestBETS

20. Brad Arrhythmia Induced by Repeated Succinylcholine During Gynecological Laparoscopic Surgery

Brad Arrhythmia Induced by Repeated Succinylcholine During Gynecological Laparoscopic Surgery Brad Arrhythmia Induced by Repeated Succinylcholine During Gynecological Laparoscopic Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Brad Arrhythmia Induced by Repeated Succinylcholine During Gynecological Laparoscopic Surgery The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02676011 Recruitment Status : Completed First Posted : February 5, 2016 Last Update Posted : September 27, 2016 Sponsor

2016 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>