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Subungual Melanoma

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41. FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA)

FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA) FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA) (FLIMMA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02425475 Recruitment Status : Completed First Posted : April 24, 2015 Last Update Posted : May 3, 2017 Sponsor: University Hospital Tuebingen Collaborators

2015 Clinical Trials

42. Melanoma Perception and Health Literacy in People of Color

and Interventions Go to Arm Intervention/treatment Experimental: ABCDEs of Melanoma Skin Cancer A modified melanoma educational intervention that uses the "ABCDEs of Melanoma" pamphlet from the Skin Cancer Foundation but also incorporates the nomenclature "melanoma skin cancer"; indicates that melanoma is relevant for everyone regardless of race and ethnicity; includes images of melanoma on ethnic skin; informs people of the likelihood of melanoma developing in acral, subungual and mucosal surfaces (...) Melanoma Perception and Health Literacy in People of Color Melanoma Perception and Health Literacy in People of Color - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Melanoma Perception and Health Literacy

2015 Clinical Trials

43. Melanoma of the lower extremities: foot site is an independent risk factor for clinical outcome. (PubMed)

patients (stage 0-II) with a cutaneous melanoma on the lower extremities (subungual melanomas were excluded). Of these, 327 were localized on the foot. Multivariate analyses were performed to evaluate disease-specific survival and disease-free interval.Distribution of known prognostic factors and patterns of progression of foot and leg melanoma differ across genders. The foot site was confirmed as a negative independent prognostic factor on disease-specific survival and disease-free interval.Foot (...) Melanoma of the lower extremities: foot site is an independent risk factor for clinical outcome. Despite the better prognosis of melanomas localized on lower extremities, some studies have suggested that melanomas on the foot are related to a poorer survival and should be considered separately.To review our case series of cutaneous melanomas on the lower extremities and to analyze the clinicopathological association, time course, types of progression, and survival differences.We included 1671

2015 International Journal of Dermatology

44. Multiple Primary Acral Melanomas in Two Young Caucasian Patients. (PubMed)

Multiple Primary Acral Melanomas in Two Young Caucasian Patients. Acral melanoma (AM) is still one of the most poorly studied melanomas. It generally presents beyond the fifth decade of life and usually is a BRAF wild-type melanoma.To report the first cases of multiple primary AM in Caucasians.Clinical, dermoscopic, pathological and molecular profiles.A healthy 34- year-old male presented an in situ subungual melanoma on his finger, and 22 months later a fast-growing nodular melanoma appeared (...) in an existing nevus on the sole. Both melanomas carried the V600E BRAF mutation. A 19-year-old female patient presented 2 in situ melanomas on different parts of her left foot within a 6-year period of time. The patients have neither familiar melanoma nor germline mutations in CDKN2A/CDK4 genes.Multiple AM in Caucasians is very rare. BRAF mutations are possible, especially in a high-risk set of patients with multiple nevi. Specific acral examination must be recommended since AM still suffers delayed

2014 Dermatology

45. Rare presentations of primary melanoma and special populations: a systematic review. (PubMed)

Rare presentations of primary melanoma and special populations: a systematic review. A subset of patients with melanoma present in rare and unique clinical circumstances requiring specific considerations with respect to diagnostic and therapeutic interventions. Herein, we present our review of patients with: (1) primary mucosal melanoma of the head and neck, gastrointestinal, and genitourinary tracts; (2) primary melanoma of the eye; (3) desmoplastic melanoma; (4) subungual melanoma; (5 (...) ) melanoma in special populations: children, nonwhites, as well as a discussion of familial melanoma.

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2014 American journal of clinical oncology

46. Skin Cancer, Melanoma

should be considered of historic interest only; they do not have independent prognostic or therapeutic significance. The cellular subtypes are the following: Superficial spreading. Nodular. Lentigo maligna. Acral lentiginous (palmar/plantar and subungual). Miscellaneous unusual types: Mucosal lentiginous (oral and genital). Desmoplastic. Verrucous. Genomic Classification Cutaneous melanoma The Cancer Genome Atlas (TCGA) Network performed an integrative multiplatform characterization of 333 cutaneous (...) Skin Cancer, Melanoma Melanoma Treatment (PDQ®)—Health Professional Version - National Cancer Institute Menu Search Search Search General Information About Melanoma Melanoma is a malignant tumor of melanocytes, which are the cells that make the pigment melanin and are derived from the neural crest. Although most melanomas arise in the skin, they may also arise from mucosal surfaces or at other sites to which neural crest cells migrate, including the uveal tract. Uveal melanomas differ

2012 PDQ - NCI's Comprehensive Cancer Database

47. Skin Malignancies, Melanoma

on the palms and soles as flat, tan, or brown stains with irregular borders; subungual lesions can be brown or black, with ulcerations in later stages Biopsy Perform excisional biopsy on suggestive lesions. The most important prognostic indicator for stage I and II tumors is thickness, so a full-thickness biopsy must be obtained for adequate pathologic interpretation. Management Surgical therapy for melanoma, as follows, is based on the predicted risk of local recurrence and metastatic disease (...) borders. Subungual lesions can be brown or black, with ulcerations in later stages. Although previously no correlation with a worse prognosis was demonstrated for these lesions when tumor thickness was considered, a study by Asgari et al of 123 acral lentiginous melanomas indicated that in patients with these neoplasms, worse melanoma-specific survival can be linked to greater tumor thickness (Breslow depth of over 2 mm), as well as to more advanced tumor stage at presentation. [ ] Desmoplastic

2014 eMedicine Surgery

48. Malignant Melanoma (Diagnosis)

. Swetter, MD. Acral lentiginous melanomas Acral lentiginous melanomas (ALMs) are the only melanomas that have an equal frequency in blacks and whites. They occur on the palms, soles, and subungual areas. Subungual melanomas often are mistaken for subungual hematomas (splinter hemorrhages). Like NM, ALM is extremely aggressive, with rapid progression from the radial to vertical growth phase. Mucosal lentiginous melanomas Mucosal lentiginous melanomas (MLMs) develop from the mucosal epithelium that lines (...) Malignant Melanoma (Diagnosis) Malignant Melanoma: Practice Essentials, Background, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjgwMjQ1LW92ZXJ2aWV3 processing > Malignant Melanoma Updated: Feb 17

2014 eMedicine.com

49. Malignant Melanoma (Overview)

. Swetter, MD. Acral lentiginous melanomas Acral lentiginous melanomas (ALMs) are the only melanomas that have an equal frequency in blacks and whites. They occur on the palms, soles, and subungual areas. Subungual melanomas often are mistaken for subungual hematomas (splinter hemorrhages). Like NM, ALM is extremely aggressive, with rapid progression from the radial to vertical growth phase. Mucosal lentiginous melanomas Mucosal lentiginous melanomas (MLMs) develop from the mucosal epithelium that lines (...) Malignant Melanoma (Overview) Malignant Melanoma: Practice Essentials, Background, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjgwMjQ1LW92ZXJ2aWV3 processing > Malignant Melanoma Updated: Feb 17, 2019

2014 eMedicine.com

50. Spatial density of primary malignant melanoma in sun-shielded body sites: A potential guide to melanoma genesis. (PubMed)

density conducted by us and others are here briefly reviewed. The access to reliable numbers along with measurable anatomical areas directed our choice of melanomas at the sun-shielded locations described here. Melanomas at the body surface. Calculations of surface areas bearing melanomas relative to the total body surface included sites on the vulva, subungual tissues, volar and palmar skin, and, for comparison melanomas of the face during the same period of time. The density of vulvar melanomas (...) was identical to that in chronically sun-exposed facial skin. Subungual melanomas were almost nine times denser than expected whereas melanomas of palms and soles showed a lower density than expected. Melanomas beneath the body surface. The densities of melanomas in the vagina, anal canal and uvea, were calculated separately and compared to the average density of cutaneous melanomas (CMMs) during the same period of time. Melanomas of the anal canal displayed a density almost twice the average for CMMs

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2011 Acta Oncologica

51. A clinicopathologic analysis of 177 acral melanomas in Koreans: relevance of spreading pattern and physical stress. (PubMed)

melanoma and evaluate how long-term physical stress or pressure strength influences acral melanoma based on the analysis of differences in incidence, prognosis of the distinct site (weight or non-weight-bearing portion of sole, volar, or subungual location), and the spreading pattern of melanoma on the soles.Cross-sectional, retrospective study of 177 Korean patients with acral melanoma from January 1, 1994, through October 31, 2012.Anatomic mapping and histopathologic examination of acral melanoma (...) , was often observed. The prognostic index and survival rate showed no significant difference between volar and subungual locations or between weight and non-weight-bearing portions of the soles.Clinicopathologic characteristics of acral melanoma diagnosed at an advanced stage and resulting in a low survival rate are not significantly different between Koreans and other Asians. Interestingly, based on our study, long-term physical stress or pressure strength can influence the incidence and spreading

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2013 JAMA dermatology (Chicago, Ill.)

52. Amelanotic acral melanomas: Clinicopathological, BRAF mutation, and KIT aberration analyses. (PubMed)

28 cases of complete-type and 7 cases of incomplete-type AAM.In all, 26 AAMs (45.7%) were located on the feet of patients, 21 of which (82.9%) showed ulceration. Sixteen cases developed in subungual areas. Nodular melanoma was the most common histopathological subtype (63.6%). The most frequent cell types affected were epithelioid and spindled. HMB-45 staining was strongly positive in 66.7% of AAMs; 4 (12.1%) were negative for HMB-45, and 3 of these were complete-type AAMs. Of 33 total patients (...) Amelanotic acral melanomas: Clinicopathological, BRAF mutation, and KIT aberration analyses. Amelanotic acral melanoma (AAM) is very rare and difficult to diagnose both clinically and pathologically. Complete-type AAM shows no black to brown pigmentation in the lesion, whereas incomplete-type AAM shows focal or subtle pigmentation. AAM has been the subject of few investigations.We analyzed the clinicopathological features, BRAF mutations, and KIT aberrations in 35 Korean AAM cases.We included

2013 Journal of American Academy of Dermatology

53. Prognosis of Acral Melanoma: A Series of 281 Patients. (PubMed)

Prognosis of Acral Melanoma: A Series of 281 Patients. Acral melanoma (AM) is an unusual malignancy with poor survival. This study defines a cohort of patients, treated at a single institution, and the factors associated with survival and comparison with nonacral cutaneous melanoma (NACM).All patients with AM presenting from 1995 to 2010 were identified from a prospectively maintained database. Analysis of clinicopathologic features of AM associated with disease-specific survival (DSS (...) ) was performed. A stratified, stage-matched survival analysis compared the outcome of 281 acral to 843 extremity NACM patients.A total of 281 AM patients (170 volar, 111 subungual) were identified. Pathologic stage (p < 0.001), ulceration (p < 0.001), Breslow thickness (p < 0.001), and a positive sentinel lymph node (p < 0.001) were found to be poor prognostic indicators associated with DSS. In stage-matched analysis, AM had a worse DSS compared with NACM (hazard ratio 1.8; 95 % CI 1.2-2.7; p < 0.01

2013 Annals of Surgical Oncology

54. Nail matrix melanoma: consecutive cases in a general practice (PubMed)

101585990 2160-9381 dermatoscopy hand foot melanoma (HFM) histologic criteria longitudinal melanonychia melanoma melanonychia striata nail matrix melanoma nevus subungual melanoma 2012 01 09 2012 02 25 2013 6 21 6 0 2012 4 1 0 0 2012 4 1 0 1 epublish 23785601 10.5826/dpc.0202a13 dp0202a13 PMC3663335 J Am Acad Dermatol. 2000 Feb;42(2 Pt 1):269-74 10642684 Br J Dermatol. 2012 Apr;166(4):727-39 22175696 Cancer Res. 1969 Mar;29(3):705-27 5773814 Histopathology. 1991 Nov;19(5):425-9 1757081 Br J Dermatol (...) Nail matrix melanoma: consecutive cases in a general practice 23785601 2013 06 21 2019 02 26 2160-9381 2 2 2012 Apr Dermatology practical & conceptual Dermatol Pract Concept Nail matrix melanoma: consecutive cases in a general practice. 202a13 10.5826/dpc.0202a13 Rosendahl Cliff C School of Medicine, The University of Queensland, Brisbane, Australia. Cameron Alan A Wilkinson David D Belt Paul P Williamson Richard R Weedon David D eng Case Reports 2012 04 30 United States Dermatol Pract Concept

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2012 Dermatology practical & conceptual

55. Melanoma Margins Excision Trial

of recurrence from previous malignancies. Exclusion Criteria: Uncertain diagnosis of melanoma i.e. so-called 'melanocytic lesion of unknown malignant potential'. Patient has already undergone wide local excision at the site of the primary index lesion. Patient unable or ineligible to undergo staging sentinel lymph node biopsy of the primary index lesion. Desmoplastic or neurotropic melanoma. Microsatellitosis as per AJCC 2009 definition Subungual melanoma Patient has already undergone a local flap (...) Melanoma Margins Excision Trial MelmarT Melanoma Margins Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. MelmarT Melanoma

2011 Clinical Trials

56. PERIUNGUAL AND SUBUNGUAL PYOGENIC GRANULOMA. (PubMed)

PERIUNGUAL AND SUBUNGUAL PYOGENIC GRANULOMA. Nail pyogenic granuloma (PG) is common, often seen as an urgent case, given the recent onset as a bleeding nodule. Nail PGs are due to different causes that act through different pathogenetic mechanisms and may be treated in several ways. Both causes and treatments of nail PG have never been classified.To classify nail PG according to the pathogenesis, describe the clinical and pathological features and provide guidelines for a correct diagnosis (...) of digits involved and clinical history help to identify the cause. When PG is single, especially if it involves the nail bed, histological examination is necessary to rule out malignant melanoma. Treatment must be chosen according to the underlying cause.© 2010 The Authors. BJD © 2010 British Association of Dermatologists.

2010 British Journal of Dermatology

57. Melanoma

, but because people with darkly pigmented skin infrequently develop other forms of melanoma, acral-lentiginous melanoma is the most common type among them. It arises on palmar, plantar, and subungual skin and has a characteristic histologic picture similar to that of lentigo maligna melanoma. This type of melanoma often has mutations in the C-kit gene. Amelanotic melanoma Amelanotic melanoma is a type of melanoma that does not produce pigment. It can be any of the 4 main types and is most often grouped (...) of cutaneous origin (not CNS and subungual melanomas) that have not metastasized, the survival rate varies depending on the thickness of the tumor at the time of diagnosis. The 5-yr survival rates range from 97% for patients with stage IA melanomas to 53% for patients with stage IIC melanomas; 10-yr survival rates range from 93% for patients with stage IA melanomas to 39% for patients with stage IIC melanomas. Mucosal melanomas (especially anorectal melanomas), which are more common among nonwhites, have

2013 Merck Manual (19th Edition)

58. Effectiveness of a knowledge-based intervention for melanoma among those with ethnic skin. (PubMed)

Effectiveness of a knowledge-based intervention for melanoma among those with ethnic skin. Among patients with melanoma, ethnic minorities are 1.96 to 3.01 times as likely to die from melanoma as Caucasians of the same age and sex.We sought to assess the effectiveness of a melanoma early detection educational intervention among those with ethnic skin.A consecutive convenience sample of patients received instruction on the ABCDEs of melanoma and skin self-examination. Self-report questionnaires (...) assessing knowledge, attitudes, and behaviors were completed before, and immediately and 3 months after, the intervention.Among the 71 participants, 21% reported a skin phenotype with at least sometimes burning. Knowledge that melanoma is a skin cancer and of the warning signs of melanoma significantly increased after the intervention and was retained at 3 months. The perception of being at risk to develop a melanoma significantly increased after the intervention and was retained at 3 months (P < .001

2010 Journal of American Academy of Dermatology

59. Nordic Adjuvant IFN Melanoma Trial

melanoma in regional lymph node(s) confirmed by lymphadenectomy. ECOG performance status of 0-1 No active medical or psychiatric disorder requiring therapy that would prevent completion of protocol Written informed consent Exclusion Criteria: Patients with unknown primary site of melanoma or primary melanoma originating apart from the skin, except subungual melanoma Patients who have clinical, radiological/laboratory or pathological evidence of incompletely resected melanoma or distant metastatic (...) Nordic Adjuvant IFN Melanoma Trial Nordic Adjuvant IFN Melanoma Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Nordic Adjuvant IFN Melanoma Trial The safety and scientific validity of this study

2010 Clinical Trials

60. Lymphangioleiomyomatosis Diagnosis and Management Part II: An Official ATS/JRS Clinical Practice Guideline

) con?rmed by tap and biochemical analysis of the ?uid 5. Lymphangioleiomyomas (lymphangiomyomas) x 6.DemonstrationofLAMcellsorLAMcellclustersoncytologicalexaminationofeffusions or lymph nodes jj 7. Histopathological con?rmation of LAM by lung biopsy or biopsy of retroperitoneal or pelvic masses De?nition of abbreviations: D2-40=podoplanin; HMB-45=human melanoma black-45; HRCT= high-resolution computed tomography; LAM=lymphangioleiomyomatosis; mTOR=mechanistic target of rapamycin; TSC=tuberous (...) the diagnosis of TSC. Features suggestive of TSC include the presence of any of the following: subungual ?bromas, facial angio?bromas, hypomelanotic macules, confetti lesions, Shagreen patches, positive family history of TSC, history of seizures or cognitive impairment, or presence of cortical dysplasias, subependymal nodules, and/or subependymal giant cell astrocytomas on brain imaging. Routine brain imaging is not indicated if clinical suspicion for TSC is low. Detailed diagnostic criteria for TSC

2017 American Thoracic Society

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