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Subungual Melanoma

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41. Malignant Melanoma: Beyond the Basics. (Abstract)

of gross invasion into the perichondrium, and subungual melanomas may be treated with wide local excision down to and including the periosteum, with immediate full-thickness skin grafting over bone. Although surgical treatment remains the current gold standard, recent advances in immunotherapy and targeted molecular therapy for metastatic melanoma show great promise for the development of medical therapies for melanoma. (...) Malignant Melanoma: Beyond the Basics. After reading this article, the participant should be able to: 1. Discuss the initial management of cutaneous malignant melanoma with regard to diagnostic biopsy and currently accepted resection margins. 2. Be familiar with the management options for melanoma in specific situations such as subungual melanoma, auricular melanoma, and melanoma in the pregnant patient. 3. Discuss the differentiating characteristics of desmoplastic melanoma and its treatment

2016 Plastic and reconstructive surgery

42. FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA)

patients with pigmented lesions, which are excised in order to exclude or diagnose cutaneous melanoma. Criteria Inclusion Criteria: Patients ≥ 18 years of age Male or female Patients having pigmented lesions with suspicion of dysplastic nevus or melanoma, in whom an excision is performed in order to exclude or diagnose malignant melanoma Patients who gave their written informed consent. Exclusion Criteria: Patients with skin type V and VI according to Fitzpatrick's scale; Where there is a risk (...) FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA) FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2015 Clinical Trials

43. Melanoma Perception and Health Literacy in People of Color

and Interventions Go to Arm Intervention/treatment Experimental: ABCDEs of Melanoma Skin Cancer A modified melanoma educational intervention that uses the "ABCDEs of Melanoma" pamphlet from the Skin Cancer Foundation but also incorporates the nomenclature "melanoma skin cancer"; indicates that melanoma is relevant for everyone regardless of race and ethnicity; includes images of melanoma on ethnic skin; informs people of the likelihood of melanoma developing in acral, subungual and mucosal surfaces (...) detection especially in individuals with low health literacy. Condition or disease Intervention/treatment Phase Melanoma Behavioral: ABCDEs of Melanoma Skin Cancer Behavioral: ABCDEs of Melanoma Not Applicable Detailed Description: This targeted educational intervention will compare a standard melanoma education pamphlet with one that has been modified to target people of color. Both pamphlets will include the ABCDEs of melanoma, risk factors, prevention and treatment. In addition, the targeted pamphlet

2015 Clinical Trials

44. Melanoma of the lower extremities: foot site is an independent risk factor for clinical outcome. Full Text available with Trip Pro

patients (stage 0-II) with a cutaneous melanoma on the lower extremities (subungual melanomas were excluded). Of these, 327 were localized on the foot. Multivariate analyses were performed to evaluate disease-specific survival and disease-free interval.Distribution of known prognostic factors and patterns of progression of foot and leg melanoma differ across genders. The foot site was confirmed as a negative independent prognostic factor on disease-specific survival and disease-free interval.Foot (...) Melanoma of the lower extremities: foot site is an independent risk factor for clinical outcome. Despite the better prognosis of melanomas localized on lower extremities, some studies have suggested that melanomas on the foot are related to a poorer survival and should be considered separately.To review our case series of cutaneous melanomas on the lower extremities and to analyze the clinicopathological association, time course, types of progression, and survival differences.We included 1671

2015 International Journal of Dermatology

45. Revised U.K. guidelines for the management of cutaneous melanoma

as necessary to re?ect changes in practice in light of new evi- dence. Integration with national cancer guidance Multidisciplinary care of the patient is held to be the most desirable model, as recommended in the Calman/Hine report. 4 This has been de?ned by the National Institute for Health and Clinical Excellence (NICE) Improving Outcomes for People with Skin Tumours including Melanoma. 5 Core services will be provided within each Cancer Network by Local Skin Cancer Multidisciplinary Teams (LSMDTs (...) ). Specialist services will be provided by Specialist Skin Cancer Multidisciplinary Teams (SSMDTs). For melanoma there is a clear demarcation of care such that more advanced primary melanoma, rare subtypes of melanoma, melanoma in children, and patients eligible for trial entry or sentinel lymph node biopsy (SLNB) should be promptly referred for investigation and treatment from an LSMDT to an SSMDT (Table 1). Prevention of melanoma Individuals, and particularly children, should not get sunburnt (Level I). 6

2010 British Association of Dermatologists

46. Multiple Primary Acral Melanomas in Two Young Caucasian Patients. (Abstract)

Multiple Primary Acral Melanomas in Two Young Caucasian Patients. Acral melanoma (AM) is still one of the most poorly studied melanomas. It generally presents beyond the fifth decade of life and usually is a BRAF wild-type melanoma.To report the first cases of multiple primary AM in Caucasians.Clinical, dermoscopic, pathological and molecular profiles.A healthy 34- year-old male presented an in situ subungual melanoma on his finger, and 22 months later a fast-growing nodular melanoma appeared (...) in an existing nevus on the sole. Both melanomas carried the V600E BRAF mutation. A 19-year-old female patient presented 2 in situ melanomas on different parts of her left foot within a 6-year period of time. The patients have neither familiar melanoma nor germline mutations in CDKN2A/CDK4 genes.Multiple AM in Caucasians is very rare. BRAF mutations are possible, especially in a high-risk set of patients with multiple nevi. Specific acral examination must be recommended since AM still suffers delayed

2014 Dermatology

47. Malignant Melanoma (Diagnosis)

generally reserved for adjuvant treatment of advanced melanoma. Malignant melanoma. Image courtesy of Hon Pak, MD. See , a Critical Images slideshow, to help identify various skin lesions. Also, see slideshow to help identify and treat malignant intraocular melanomas. Signs and symptoms The history should address the following: Family history of melanoma or skin cancer Family history of irregular, prominent moles Family history of pancreatic cancer or astrocytoma Previous melanoma (sometimes multiple (...) . Interestingly, melanoma does not have a direct relationship with the amount of sun exposure because it is more common in white-collar workers than in those who work outdoors. Sunburn Acute, intense, and intermittent blistering sunburns, especially on areas of the body that only occasionally receive sun exposure, are the greatest risk factor for the development of sun exposure–induced melanoma. This sun-associated risk factor is different than that for squamous and basal cell skin cancers, which

2014 eMedicine.com

48. Malignant Melanoma (Overview)

reserved for adjuvant treatment of advanced melanoma. Malignant melanoma. Image courtesy of Hon Pak, MD. See , a Critical Images slideshow, to help identify various skin lesions. Also, see slideshow to help identify and treat malignant intraocular melanomas. Signs and symptoms The history should address the following: Family history of melanoma or skin cancer Family history of irregular, prominent moles Family history of pancreatic cancer or astrocytoma Previous melanoma (sometimes multiple; patients (...) . Interestingly, melanoma does not have a direct relationship with the amount of sun exposure because it is more common in white-collar workers than in those who work outdoors. Sunburn Acute, intense, and intermittent blistering sunburns, especially on areas of the body that only occasionally receive sun exposure, are the greatest risk factor for the development of sun exposure–induced melanoma. This sun-associated risk factor is different than that for squamous and basal cell skin cancers, which

2014 eMedicine.com

49. Skin Malignancies, Melanoma

and genetic markers are also essential. Creation of a successful public awareness campaign, such as those in Australia and New Zealand, is crucial. Previous Next: Questions & Answers Overview Previous References Heaton KM, Sussman JJ, Gershenwald JE, et al. Surgical margins and prognostic factors in patients with thick (>4mm) primary melanoma. Ann Surg Oncol . 1998 Jun. 5(4):322-8. . American Cancer Society. What Are the Key Statistic About Melanoma? Detailed Guide: Skin Cancer - Melanoma. . Sacchetto L (...) syndrome types A and B. N Engl J Med . 1986 Dec 18. 315(25):1615-6. . Koh HK, Michalik E, Sober AJ, et al. Lentigo maligna melanoma has no better prognosis than other types of melanoma. J Clin Oncol . 1984 Sep. 2(9):994-1001. . Asgari MM, Shen L, Sokil MM, Yeh I, Jorgenson E. Prognostics factors and survival in acral lentiginous melanoma. Br J Dermatol . 2017 Apr 22. . American Joint Committee on Cancer. Malignant melanoma of the skin. American Joint Committee on Cancer: AJCC Cancer Staging Manual

2014 eMedicine Surgery

50. Amelanotic acral melanomas: Clinicopathological, BRAF mutation, and KIT aberration analyses. (Abstract)

28 cases of complete-type and 7 cases of incomplete-type AAM.In all, 26 AAMs (45.7%) were located on the feet of patients, 21 of which (82.9%) showed ulceration. Sixteen cases developed in subungual areas. Nodular melanoma was the most common histopathological subtype (63.6%). The most frequent cell types affected were epithelioid and spindled. HMB-45 staining was strongly positive in 66.7% of AAMs; 4 (12.1%) were negative for HMB-45, and 3 of these were complete-type AAMs. Of 33 total patients (...) Amelanotic acral melanomas: Clinicopathological, BRAF mutation, and KIT aberration analyses. Amelanotic acral melanoma (AAM) is very rare and difficult to diagnose both clinically and pathologically. Complete-type AAM shows no black to brown pigmentation in the lesion, whereas incomplete-type AAM shows focal or subtle pigmentation. AAM has been the subject of few investigations.We analyzed the clinicopathological features, BRAF mutations, and KIT aberrations in 35 Korean AAM cases.We included

2013 Journal of American Academy of Dermatology

51. Prognosis of Acral Melanoma: A Series of 281 Patients. (Abstract)

Prognosis of Acral Melanoma: A Series of 281 Patients. Acral melanoma (AM) is an unusual malignancy with poor survival. This study defines a cohort of patients, treated at a single institution, and the factors associated with survival and comparison with nonacral cutaneous melanoma (NACM).All patients with AM presenting from 1995 to 2010 were identified from a prospectively maintained database. Analysis of clinicopathologic features of AM associated with disease-specific survival (DSS (...) ) was performed. A stratified, stage-matched survival analysis compared the outcome of 281 acral to 843 extremity NACM patients.A total of 281 AM patients (170 volar, 111 subungual) were identified. Pathologic stage (p < 0.001), ulceration (p < 0.001), Breslow thickness (p < 0.001), and a positive sentinel lymph node (p < 0.001) were found to be poor prognostic indicators associated with DSS. In stage-matched analysis, AM had a worse DSS compared with NACM (hazard ratio 1.8; 95 % CI 1.2-2.7; p < 0.01

2013 Annals of Surgical Oncology

52. A clinicopathologic analysis of 177 acral melanomas in Koreans: relevance of spreading pattern and physical stress. Full Text available with Trip Pro

melanoma and evaluate how long-term physical stress or pressure strength influences acral melanoma based on the analysis of differences in incidence, prognosis of the distinct site (weight or non-weight-bearing portion of sole, volar, or subungual location), and the spreading pattern of melanoma on the soles.Cross-sectional, retrospective study of 177 Korean patients with acral melanoma from January 1, 1994, through October 31, 2012.Anatomic mapping and histopathologic examination of acral melanoma (...) , was often observed. The prognostic index and survival rate showed no significant difference between volar and subungual locations or between weight and non-weight-bearing portions of the soles.Clinicopathologic characteristics of acral melanoma diagnosed at an advanced stage and resulting in a low survival rate are not significantly different between Koreans and other Asians. Interestingly, based on our study, long-term physical stress or pressure strength can influence the incidence and spreading

2013 JAMA dermatology (Chicago, Ill.)

53. Nail matrix melanoma: consecutive cases in a general practice Full Text available with Trip Pro

101585990 2160-9381 dermatoscopy hand foot melanoma (HFM) histologic criteria longitudinal melanonychia melanoma melanonychia striata nail matrix melanoma nevus subungual melanoma 2012 01 09 2012 02 25 2013 6 21 6 0 2012 4 1 0 0 2012 4 1 0 1 epublish 23785601 10.5826/dpc.0202a13 dp0202a13 PMC3663335 J Am Acad Dermatol. 2000 Feb;42(2 Pt 1):269-74 10642684 Br J Dermatol. 2012 Apr;166(4):727-39 22175696 Cancer Res. 1969 Mar;29(3):705-27 5773814 Histopathology. 1991 Nov;19(5):425-9 1757081 Br J Dermatol (...) Nail matrix melanoma: consecutive cases in a general practice 23785601 2013 06 21 2019 02 26 2160-9381 2 2 2012 Apr Dermatology practical & conceptual Dermatol Pract Concept Nail matrix melanoma: consecutive cases in a general practice. 202a13 10.5826/dpc.0202a13 Rosendahl Cliff C School of Medicine, The University of Queensland, Brisbane, Australia. Cameron Alan A Wilkinson David D Belt Paul P Williamson Richard R Weedon David D eng Case Reports 2012 04 30 United States Dermatol Pract Concept

2012 Dermatology practical & conceptual

54. Conservative surgical management of subungual (matrix derived) melanoma: report of seven cases and literature review. (Abstract)

Conservative surgical management of subungual (matrix derived) melanoma: report of seven cases and literature review. Subungual melanoma (SUM) is a rare entity, comprising approximately 0·7-3·5% of all melanoma subtypes. SUM histopathologically belongs to the acral lentiginous pathological subtype of malignant melanoma. Its diagnosis is helped by dermoscopy but pathological examination of doubtful cases is required. Classical management of SUM is based on radical surgery, namely distal phalanx (...) amputation. Conservative treatment with nonamputative wide excision of the nail unit followed by a skin graft has been insufficiently reported in the medical literature even though it is performed in many centres.To report a series of patients with in situ or minimally invasive SUM treated by conservative surgery, to investigate the postoperative evolution and to evaluate the outcome with a review of the literature.We performed a retrospective extraction study from our melanoma register of all patients

2011 British Journal of Dermatology

55. Is the Distance Enough to Eradicate in situ or Early Invasive Subungual Melanoma by Wide Local Excision From the Point of View of Matrix-to-Bone Distance for Safe Inferior Surgical Margin in Koreans. Full Text available with Trip Pro

Is the Distance Enough to Eradicate in situ or Early Invasive Subungual Melanoma by Wide Local Excision From the Point of View of Matrix-to-Bone Distance for Safe Inferior Surgical Margin in Koreans. 21846959 2012 04 18 2018 12 01 1421-9832 223 2 2011 Dermatology (Basel, Switzerland) Dermatology (Basel) Is the distance enough to eradicate in situ or early invasive subungual melanoma by wide local excision? from the point of view of matrix-to-bone distance for safe inferior surgical margin (...) in Koreans. 122-3 10.1159/000329432 Kim Jun Young JY Jung Han Jin HJ Lee Weon Ju WJ Kim Do Won DW Yoon Ghil Suk GS Kim Dong-Sun DS Park Mae Ja MJ Lee Seok-Jong SJ eng Letter Research Support, Non-U.S. Gov't Comment 2011 08 16 Switzerland Dermatology 9203244 1018-8665 IM Dermatology. 2010;220(2):173-5 20016126 Female Humans Melanoma surgery Nail Diseases surgery Skin Neoplasms surgery Skin Transplantation methods 2011 8 18 6 0 2011 8 19 6 0 2012 4 19 6 0 ppublish 21846959 000329432 10.1159/000329432

2011 Dermatology

56. Subungual Foreign Body

Subungual Foreign Body Subungual Foreign Body Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Subungual Foreign Body Subungual Foreign (...) Body Aka: Subungual Foreign Body From Related Chapters II. Management Distal Subungual Foreign Body Trim nail Grasp foreign body with forceps and extract Observe for from Proximal Subungual Foreign Body Elevate nail with Freer elevator (avoiding nail bed injury) Attempt to grasp foreign body and extract without nail removal If unable, See Nail Removal May remove half the nail plate to access the foreign body if needed Repair if present III. References Lin, Gajendran and Orman in Herbert (2016

2016 FP Notebook

57. Subungual Hematoma

Subungual Hematoma Subungual Hematoma Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Subungual Hematoma Subungual Hematoma Aka (...) : Subungual Hematoma , Nail Trephination From Related Chapters II. Pathophysiology Bleeding develops between nail and phalanx III. Causes Crush injury to nail IV. Symptoms Severe, throbbing digital pain V. Signs Discoloration of nail Tip of digit swollen and tender VI. Associated conditions Distal VII. Imaging XRay AP, lateral and Oblique XRay of digit Indicated for Subungual Hematoma involving >50% of the nail bed Assess for distal VIII. Management: Drainage (Nail Trephination) Contraindications Phalanx

2015 FP Notebook

58. Skin Cancer in Skin of Color

(SCC) Ethnicities with SCC as most common skin cancer Native Americans Black patients Peak at ages 40-49 Especially common in scars, chronic ulcers and lesions Ethnicities with SCC as second most common skin cancer Chinese and Japanese (peaks after age 60 years old) Hispanic patients Common presenting locations in Non-sun-exposed areas (e.g. legs, anogenital, scalp) IV. Approach: Melanoma Patients with present with at a later, more advanced stage with worse outcomes about risk and is important (...) Common presenting locations in Non-sun-exposed sites Mucous membranes Palmar, plantar and subungual ( ) more common in asian and black patients V. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Skin Cancer in Skin of Color." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Hematology and Oncology About FPnotebook.com

2015 FP Notebook

59. Subungual tumors Full Text available with Trip Pro

Subungual tumors 23997727 2013 09 02 2019 01 08 1558-9455 7 3 2012 Sep Hand (New York, N.Y.) Hand (N Y) Subungual tumors. 252-8 10.1007/s11552-012-9418-0 Dooley Timothy P TP Allegheny General Hospital Orthopaedics Department, Pittsburgh, PA USA. Kindt Katie E KE Baratz Mark E ME eng Journal Article United States Hand (N Y) 101264149 1558-9447 2013 9 3 6 0 2013 9 3 6 0 2013 9 3 6 1 ppublish 23997727 10.1007/s11552-012-9418-0 9418 PMC3418367 J Bone Joint Surg Am. 1956 Jun;38-A(3):517-39 (...) ; discussion, 539-40; passim 13319408 Eur J Dermatol. 2000 Dec;10(8):604-6 11125321 J Am Acad Dermatol. 1998 Oct;39(4 Pt 1):560-4 9777762 J Surg Oncol. 1987 Jun;35(2):107-12 3586679 Melanoma Res. 1998 Apr;8(2):181-6 9610874 Scand J Plast Reconstr Surg Hand Surg. 2003;37(2):121-4 12755514 Ann Surg. 2001 Feb;233(2):250-8 11176132 Cutis. 2001 Jan;67(1):59-64 11204607 N Engl J Med. 2004 Feb 19;350(8):757-66 14973217 J Hand Surg Am. 1996 May;21(3):506-11 8724488 J Hand Surg Br. 2002 Jun;27(3):229-31 12074607 J

2012 Hand (New York, N.Y.)

60. Spatial density of primary malignant melanoma in sun-shielded body sites: A potential guide to melanoma genesis. Full Text available with Trip Pro

density conducted by us and others are here briefly reviewed. The access to reliable numbers along with measurable anatomical areas directed our choice of melanomas at the sun-shielded locations described here. Melanomas at the body surface. Calculations of surface areas bearing melanomas relative to the total body surface included sites on the vulva, subungual tissues, volar and palmar skin, and, for comparison melanomas of the face during the same period of time. The density of vulvar melanomas (...) was identical to that in chronically sun-exposed facial skin. Subungual melanomas were almost nine times denser than expected whereas melanomas of palms and soles showed a lower density than expected. Melanomas beneath the body surface. The densities of melanomas in the vagina, anal canal and uvea, were calculated separately and compared to the average density of cutaneous melanomas (CMMs) during the same period of time. Melanomas of the anal canal displayed a density almost twice the average for CMMs

2011 Acta Oncologica

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