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Subungual Melanoma

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21. Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis Full Text available with Trip Pro

pigmentation (IDP) in 28.3%. The ALMs were amelanotic in 24%, showing an atypical vascular pattern in all cases; a new dermoscopic pattern, named "vascularized parallel-ridge pattern" (VPRP), was detected in 13% of ALMs. Irregular lines were observed in 81.8% of subungual melanomas and were often associated with a multicolored background.ALM has site-specific dermoscopic patterns, with PRP being the most prevalent pattern. The newly described VPRP pattern may be an additional clue for ALM diagnosis (...) Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis The incidence of acral lentiginous melanoma (ALM) in the white population is low. Dermoscopy enhances diagnosis of ALM; however, diagnostic accuracy may sometimes be poor due to the considerable proportion of amelanotic ALM variants.To calculate the proportion of ALM among all melanoma subtypes and to determine the frequency of dermoscopic features of ALM in the Turkish population.Out of 612

2018 Dermatology practical & conceptual

22. Subungual melanoma: a review of current treatment. (Abstract)

. To date, the National Cancer Institute does not have guidelines for the treatment of subungual melanoma.The authors conducted a complete review of all cases within the literature involving amputation and/or wide local excision for the treatment of subungual melanoma.There is currently a trend toward a more conservative approach in treating subungual melanoma; however, the literature does not offer a high level of evidence, and definitive conclusions cannot be drawn.Overall, the studies within (...) Subungual melanoma: a review of current treatment. Subungual melanoma typically presents as a darkened longitudinal stripe under the nail plate; however, this disease is frequently misdiagnosed, which leads to a delay in proper diagnosis. Subsequently, subungual melanoma historically has a relatively poor prognosis compared with other cutaneous melanomas, with the 5-year survival rate ranging between 16 and 80 percent. Historically, these lesions were removed using aggressive amputation

2014 Plastic and reconstructive surgery

23. Subungual Atypical Lentiginous Melanocytic Proliferations in Children and Adolescents: A Clinicopathologic Study. (Abstract)

, respectively. One of 4 cases tested by FISH was positive. Three lesions recurred locally without other adverse outcome.Small sample size and short clinical follow-up. Two cases were examined in partial biopsies only.Some subungual melanocytic lesions in children and adolescents are histologically indistinguishable from adult subungual melanoma in situ. While the biologic potential remains elusive, FISH might aid in risk stratification. Awareness of this rare group of lesions is crucial for facilitating (...) Subungual Atypical Lentiginous Melanocytic Proliferations in Children and Adolescents: A Clinicopathologic Study. Most subungual melanocytic lesions in children are benign, but some are difficult to classify due to prominent lentiginous growth and high-grade cytologic atypia.To characterize the clinicopathologic features of these rare lesions.Subungual atypical lentiginous melanocytic proliferations from patients <20 years of age were collected for clinical and histopathologic review

2018 Journal of American Academy of Dermatology

24. Subungual Melanoma of the Thumb Full Text available with Trip Pro

Subungual Melanoma of the Thumb 23457652 2013 03 05 2019 02 26 1937-5719 13 2013 Eplasty Eplasty Subungual melanoma of the thumb. ic26 Nocera Nadia F NF New York Medical College, Valhalla. Baruch Michael I MI Kim Minbae M eng Case Reports 2013 02 11 United States Eplasty 101316107 1937-5719 2013 3 5 6 0 2013 3 5 6 0 2013 3 5 6 1 ppublish 23457652 PMC3573745 J Am Acad Dermatol. 2000 Feb;42(2 Pt 1):269-74 10642684 J Plast Reconstr Aesthet Surg. 2007;60(6):635-8 17485051 J Hand Surg Am. 2011 Nov

2013 Eplasty

25. Dermoscopy of subungual haemorrhage: Its usefulness in the differential diagnosis from nail unit melanoma. (Abstract)

Dermoscopy of subungual haemorrhage: Its usefulness in the differential diagnosis from nail unit melanoma. Subungual haemorrhages are characterized by well-circumscribed dots or blotches with a red to red-black pigmentation, but some cases can be difficult to distinguish from subungual melanoma by the naked eye alone. Dermoscopy has proven to be a useful, noninvasive tool in the diagnosis of pigmented lesions in the nail; however, few dermoscopic studies of subungual haemorrhages have been (...) reported.To investigate characteristic dermoscopic patterns of subungual haemorrhages, and to find distinctive features that can differentiate them from nail-unit melanomas.Patients with a confirmed diagnosis of either subungual haemorrhage or nail-unit melanoma at a tertiary university hospital were included in the study. Clinical features and dermoscopic patterns were evaluated.Sixty-four patients with a total of 90 lesions of subungual haemorrhage were enrolled in the study. The majority of cases (84

2013 British Journal of Dermatology

26. Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure. Full Text available with Trip Pro

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure. Acral melanoma is distinct from melanoma of other cutaneous sites, yet there is considerable variation within this category. To better define this variation, we assessed melanomas occurring on dorsal (n = 21), volar (n = 9), and subungual/interdigital (n = 13) acral skin as well as acral nevi (n = 24) for clinical, histologic, and molecular features. Melanomas on dorsal acral surfaces demonstrated clear differences (...) compared with volar and subungual/interdigital melanomas. The latter two groups exhibited significantly less frequent BRAF mutations (P = 0.01), were significantly less likely to have the superficial spreading histologic subtype (P = 0.01), occurred in older patients (P = 0.05), and had more frequent involvement in non-Caucasians (P = 0.01). These differences can be explained by differing levels of UV exposure. Subungual/interdigital melanomas had the most diverse group of oncogenic mutations including

2017 Journal of Investigative Dermatology

27. Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade. Full Text available with Trip Pro

after the first applications because the pain increased during infusion. The second course of nivolumab and ipilimumab was administered. About 2 weeks later, the patient presented with increased pain and small subungual necrosis. We treated the patient with oral analgetics and intravenous prednisolone 500 mg in tapering dosage. On digital substraction angiography occlusion of all arteries of the fingers was demonstrated. Further rheologic and anti-melanoma treatments were refused by the patient (...) Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade. Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of sympathetic nerves, hyperviscosity, hypercoagulability, vasoactive tumour-secreted substances, and immunological mechanisms have been suggested.We report a 60-year-old Caucasian

2017 BMC Cancer

28. Subungual Melanoma

Subungual Melanoma Subungual Melanoma Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Subungual Melanoma Subungual Melanoma Aka (...) : Subungual Melanoma , Ungual Melanoma , Hutchinson Nail Sign , Hutchinson's Nail Sign , Hutchinson's Melanotic Whitlow , Acral Lentiginous Melanoma From Related Chapters II. Epidemiology Represents 2.5% of s Account for 50% of s in dark skinned patients III. Pathophysiology Type of Acral Lentiginous Melanoma IV. Characteristics Longitudinal brown-black streak May encompass entire nail Hutchinson's Nail Sign affecting proximal nail fold skin V. Evaluation: Factors suggesting Melanoma Recent change (e.g

2015 FP Notebook

29. Peroperative confocal microscopy of the nail matrix in the management of in situ or minimally invasive subungual melanomas. (Abstract)

Peroperative confocal microscopy of the nail matrix in the management of in situ or minimally invasive subungual melanomas. Although dermoscopy of the nail plate is helpful to discriminate between benign and malignant causes of nail pigmentations, there remain ambiguous cases in which a matricial biopsy is required. When a subungual melanoma is diagnosed histopathologically, a complementary surgical treatment is performed secondarily, the duration of postoperative disability being accordingly (...) prolongated.The purpose of our study was to evaluate the feasibility of an intraoperative diagnosis by reflectance confocal microscopy (RCM).Our series included nine consecutive patients who underwent a matricial biopsy for an acquired melanonychia (one benign lentigo and eight melanomas). RCM examination was performed in vivo on the nail matrix after reclination of the nail plate, and/or ex vivo on the fresh tissue biopsy. RCM data were compared with histopathology.There was a good correlation between

2012 British Journal of Dermatology

30. Melanoma Treatment (PDQ®): Health Professional Version

in the skin, they may also arise from mucosal surfaces or at other sites to which neural crest cells migrate, including the uveal tract. Uveal melanomas differ significantly from cutaneous melanoma in incidence, prognostic factors, molecular characteristics, and treatment. (Refer to the PDQ summary on for more information.) Incidence and Mortality Estimated new cases and deaths from melanoma in the United States in 2020:[ ] New cases: 100,350. Deaths: 6,850. Skin cancer is the most common malignancy (...) diagnosed in the United States, with 5.4 million cancers diagnosed among 3.3 million people in 2012.[ ] Invasive melanoma represents about 1% of skin cancers but results in most deaths.[ , ] The incidence has been increasing over the past 30 years.[ ] Elderly men are at highest risk; however, melanoma is the most common cancer in young adults aged 25 to 29 years and the second most common cancer in those aged 15 to 29 years.[ ] Ocular melanoma is the most common cancer of the eye, with approximately

2016 PDQ - NCI's Comprehensive Cancer Database

31. Subungual Malignant Melanoma: Difficulty in Diagnosis Full Text available with Trip Pro

Subungual Malignant Melanoma: Difficulty in Diagnosis Subungual malignant melanoma developed on both great toes of a 61-year-old woman. The lesions had been diagnosed elsewhere as ingrowing toenails and had been treated as such for two years. The difficulty in clinical diagnosis is illustrated by the description of three other patients with subungual malignant melanoma. The tumour should be considered as a possible cause of any persistent abnormality of the nail bed or the nail itself

1974 British medical journal

32. Subungual Melanoma 25-Year Review of Cases Full Text available with Trip Pro

Subungual Melanoma 25-Year Review of Cases 14274858 1996 12 01 2018 12 01 0003-4932 161 1965 Apr Annals of surgery Ann. Surg. SUBUNGUAL MELANOMA: 25-YEAR REVIEW OF CASES. 545-52 DASGUPTA T T BRASFIELD R R eng Journal Article United States Ann Surg 0372354 0003-4932 OM Amputation Fingers Hallux Humans Lymph Node Excision Melanoma Nails Neoplasm Metastasis Prognosis Thumb Toes AMPUTATION FINGERS HALLUX LYMPH NODE EXCISION MELANOMA NAILS NEOPLASM METASTASIS PROGNOSIS THUMB TOES 1965 4 1 1965 4 1 0 (...) 1 1965 4 1 0 0 ppublish 14274858 PMC1408999 Ann Surg. 1965 Feb;161:161-9 14260012 Surgery. 1964 Sep;56:512-8 14215709 Surgery. 1963 Sep;54:426-31 14057408 J Invest Dermatol. 1957 Aug;29(2):119-29 13475952 Cancer. 1964 Oct;17:1323-39 14236766 Cancer. 1964 Jul;17:897-911 14179552

1965 Annals of Surgery

33. Subungual Exostosis in a Young Soccer Player Full Text available with Trip Pro

Subungual Exostosis in a Young Soccer Player Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx of the toes or fingers in young adults, considered as a rare variant of osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic subungual melanoma and glomus tumour. Misdiagnosis and total onychodystrophy frequently occur as a result of late treatment or inadequate treatment strategy (...) . Dermoscopy could be a useful technique, involved in the diagnostic process, although X-ray examination and histopathology are mandatory for the diagnosis.We report a rare case of subungual exostosis of the great toe associated with repeated trauma of the nail bed. The lack of radiographic and histopathological examination could lead to misdiagnosis and inadequate treatment. Although completely benign, subungual exostosis should be considered in differential diagnosis of nail bed tumors in young adults

2017 Open access Macedonian journal of medical sciences

34. Subungual Nail Pigmentation and Malalignment of the Great Toe Nail in a Cancer Patient - A Diagnostic Challenge Full Text available with Trip Pro

Subungual Nail Pigmentation and Malalignment of the Great Toe Nail in a Cancer Patient - A Diagnostic Challenge Subungual pigmentation may have a variety of underlying pathologies, but clinicians should consider malignancies such as subungual melanoma or metastasis, even if they are not common. A delayed diagnosis can dramatically worsen the prognosis. Therefore, histologic examination is highly recommended. We present a 75-year-old female cancer patient presenting with subungual blackish (...) pigmentation of the great toe nail for several years suspicious of a subungual melanoma even by dermoscopy. Nail avulsion and histological investigations excluded melanoma. The final diagnosis was subungual hematoma with growth malalignment of the great toe nail.

2017 Open access Macedonian journal of medical sciences

35. Subungual Foreign Body

Subungual Foreign Body Subungual Foreign Body Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Subungual Foreign Body Subungual Foreign (...) Body Aka: Subungual Foreign Body From Related Chapters II. Management Distal Subungual Foreign Body Trim nail Grasp foreign body with forceps and extract Observe for from Proximal Subungual Foreign Body Elevate nail with Freer elevator (avoiding nail bed injury) Attempt to grasp foreign body and extract without nail removal If unable, See Nail Removal May remove half the nail plate to access the foreign body if needed Repair if present III. References Lin, Gajendran and Orman in Herbert (2016

2018 FP Notebook

36. Subungual Hematoma

Subungual Hematoma Subungual Hematoma Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Subungual Hematoma Subungual Hematoma Aka (...) : Subungual Hematoma , Nail Trephination From Related Chapters II. Pathophysiology Bleeding develops between nail and phalanx III. Causes Crush injury to nail IV. Symptoms Severe, throbbing digital pain V. Signs Discoloration of nail Tip of digit swollen and tender VI. Associated conditions Distal VII. Imaging XRay AP, lateral and Oblique XRay of digit Indicated for Subungual Hematoma involving >50% of the nail bed Assess for distal VIII. Management: Drainage (Nail Trephination) Contraindications Phalanx

2018 FP Notebook

37. Utility of Digital Dermoscopy in the Skin Cancer Clinic

Utility of Digital Dermoscopy in the Skin Cancer Clinic Utility of Digital Dermoscopy in the Skin Cancer Clinic - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Utility of Digital Dermoscopy in the Skin (...) Summary: This feasibility study aims to evaluate the use of the BARCO NV digital dermatoscope (non-CE marked device) in the skin cancer clinic. All eligible patients attending the Dermatology outpatient skin cancer clinic will be invited to participate. Patients who consent to the study will undergo standard care which will include medical photography of skin lesion(s) and appropriate management as determined by the Consultant Dermatologist in clinic. In addition to standard care, patients

2018 Clinical Trials

38. Skin Cancer in Skin of Color

(SCC) Ethnicities with SCC as most common skin cancer Native Americans Black patients Peak at ages 40-49 Especially common in scars, chronic ulcers and lesions Ethnicities with SCC as second most common skin cancer Chinese and Japanese (peaks after age 60 years old) Hispanic patients Common presenting locations in Non-sun-exposed areas (e.g. legs, anogenital, scalp) IV. Approach: Melanoma Patients with present with at a later, more advanced stage with worse outcomes about risk and is important (...) Common presenting locations in Non-sun-exposed sites Mucous membranes Palmar, plantar and subungual ( ) more common in asian and black patients V. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Skin Cancer in Skin of Color." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Hematology and Oncology About FPnotebook.com

2018 FP Notebook

39. MelmarT Melanoma Margins Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma

the time of diagnosis, not considering the melanoma in question, as determined by the PI. Patients must have an ECOG performance score between 0 and 1. A survivor of prior cancer is eligible provided that ALL of the following criteria are met and documented: The patient has undergone potentially curative therapy for all prior malignancies, There has been no evidence of recurrence of any prior malignancies for at least FIVE years (except for successfully treated cervical or non-melanoma skin cancer (...) of satellite, in-transit, regional, or distant metastatic melanoma. Patient has undergone surgery on a separate occasion to clear the lymph nodes of the probable draining lymphatic field, including sentinel lymph node biopsy, of the index melanoma. Any additional solid tumour or hematologic malignancy during the past 5 years except T1 skin lesions of squamous cell carcinoma, basal cell carcinoma, or uterine/cervical cancer. Melanoma-related operative procedures not corresponding to criteria described

2014 Clinical Trials

40. Non-Melanoma-Associated Dyschromia of the Proximal Nail Fold Full Text available with Trip Pro

Non-Melanoma-Associated Dyschromia of the Proximal Nail Fold Subungual melanoma with pigmentation beneath the nail that extends to involve the proximal nail fold is referred to as Hutchinson's sign. Black or brown subungual discoloration involving the proximal nail fold secondary to other etiologies has been referred to as pseudo-Hutchinson's sign. Three patients with nail discoloration and concurrent dyschromia of the proximal nail fold are described: a female with a chronic subungual hematoma (...) and pseudo-Hutchinson's sign, a male with culture-confirmed Pseudomonas aeruginosa (P. aeruginosa) of the nail with green discoloration involving the proximal nail fold, and a male with an acute subungual hematoma with red-purple subungual discoloration affecting the proximal nail fold. PubMed was searched for the following: black, brown, chloronychia, discoloration, dyschromia, green, hematoma, Hutchinson's sign, nail, nail fold, proximal, pseudo-Hutchinson's sign, red, subungual melanoma, syndrome

2016 Cureus

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