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Subungual Melanoma

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21. Population-based incidence and melanoma-specific survival of cutaneous malignant melanoma in a Colombian population 2000-2009. (PubMed)

of melanomas presented on the plants or palms (16%) and under the nails (7.1%); at least 24.3% of melanomas were ulcerated, and 21.1% had a Breslow thickness more than 2 mm. Melanoma-specific 5-year survival was 79.3%, with worst survival for melanomas localized on the plants (64.6%) and subungual areas (55.6%). Affiliation to the subsidized type of affiliation to the social security system was statistically significantly (P = 0.003) associated with poorer survival (68.8%) compared to the special regimes (...) Population-based incidence and melanoma-specific survival of cutaneous malignant melanoma in a Colombian population 2000-2009. Demographic, clinical, and morphological characteristics of cutaneous melanoma are unknown for the Colombian population. We aim to provide these characteristics as well as population-based incidence and survival data.All patients with an invasive cutaneous melanoma diagnosed in the period 2000-2009 registered in the population-based cancer registry of the metropolitan

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2017 International Journal of Dermatology

22. Peroperative confocal microscopy of the nail matrix in the management of in situ or minimally invasive subungual melanomas. (PubMed)

Peroperative confocal microscopy of the nail matrix in the management of in situ or minimally invasive subungual melanomas. Although dermoscopy of the nail plate is helpful to discriminate between benign and malignant causes of nail pigmentations, there remain ambiguous cases in which a matricial biopsy is required. When a subungual melanoma is diagnosed histopathologically, a complementary surgical treatment is performed secondarily, the duration of postoperative disability being accordingly (...) prolongated.The purpose of our study was to evaluate the feasibility of an intraoperative diagnosis by reflectance confocal microscopy (RCM).Our series included nine consecutive patients who underwent a matricial biopsy for an acquired melanonychia (one benign lentigo and eight melanomas). RCM examination was performed in vivo on the nail matrix after reclination of the nail plate, and/or ex vivo on the fresh tissue biopsy. RCM data were compared with histopathology.There was a good correlation between

2012 British Journal of Dermatology

23. Subungual Melanoma

Subungual Melanoma Subungual Melanoma Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Subungual Melanoma Subungual Melanoma Aka (...) : Subungual Melanoma , Ungual Melanoma , Hutchinson Nail Sign , Hutchinson's Nail Sign , Hutchinson's Melanotic Whitlow , Acral Lentiginous Melanoma From Related Chapters II. Epidemiology Represents 2.5% of s Account for 50% of s in dark skinned patients III. Pathophysiology Type of Acral Lentiginous Melanoma IV. Characteristics Longitudinal brown-black streak May encompass entire nail Hutchinson's Nail Sign affecting proximal nail fold skin V. Evaluation: Factors suggesting Melanoma Recent change (e.g

2015 FP Notebook

24. Melanoma Treatment (PDQ®): Health Professional Version

, Sober AJ: Ultra-late recurrence (15 years or longer) of cutaneous melanoma. Cancer 79 (12): 2361-70, 1997. [ ] Cellular and Molecular Classification of Melanoma The descriptive terms for clinicopathologic cellular subtypes of malignant melanoma should be considered of historic interest only; they do not have independent prognostic or therapeutic significance. The cellular subtypes are the following: Superficial spreading. Nodular. Lentigo maligna. Acral lentiginous (palmar/plantar and subungual (...) Melanoma Treatment (PDQ®): Health Professional Version Melanoma Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): ; 2002-. Search

2018 PDQ - NCI's Comprehensive Cancer Database

25. The causes of nail apparatus pigmentation presenting to a melanoma screening clinic a prospective study. (PubMed)

The causes of nail apparatus pigmentation presenting to a melanoma screening clinic a prospective study. Advanced stage primary cutaneous malignant melanoma (PCMM) has a high mortality. PCMM may affect any area of the skin, including the nail apparatus (malignant melanoma or subungual melanoma). Although nail apparatus malignant melanoma (NAMM) is rare, delayed diagnosis carries a poor prognosis.The primary aim was to study the range of nail presentations and identify key patterns to aid (...) in differential diagnosis. A secondary aim was to quantify the number of patients requiring surgery, indications for biopsy, and the incidence and characteristics of NAMM.This was a prospective study of all referrals with nail apparatus pigmentation to a weekly dedicated melanoma screening clinic over a 6-month period.In total, 2246 patients were included. Of the 38 patients referred with nail pigmentation, 1 (2.6%) was diagnosed with NAMM and involved a fungating amelanotic lesion of the right hallux

2019 Clinical & Experimental Dermatology

26. Incidence of melanoma and outcomes of longitudinal melanonychia in a cohort of cases referred to a London dermatology department. (PubMed)

Incidence of melanoma and outcomes of longitudinal melanonychia in a cohort of cases referred to a London dermatology department. Longitudinal melanonychia is a pigmented longitudinal band on the nail plate and may occur due to melanocyte activation, nail matrix nevus, lentigo or subungual melanoma.1 In a racially diverse community, melanonychia is a relatively common presenting complaint. However, despite this, little is known about the incidence of melanoma in longitudinal melanonychia

2019 British Journal of Dermatology

27. Is the Distance Enough to Eradicate in situ or Early Invasive Subungual Melanoma by Wide Local Excision From the Point of View of Matrix-to-Bone Distance for Safe Inferior Surgical Margin in Koreans. (PubMed)

Is the Distance Enough to Eradicate in situ or Early Invasive Subungual Melanoma by Wide Local Excision From the Point of View of Matrix-to-Bone Distance for Safe Inferior Surgical Margin in Koreans. 21846959 2012 04 18 2018 12 01 1421-9832 223 2 2011 Dermatology (Basel, Switzerland) Dermatology (Basel) Is the distance enough to eradicate in situ or early invasive subungual melanoma by wide local excision? from the point of view of matrix-to-bone distance for safe inferior surgical margin (...) in Koreans. 122-3 10.1159/000329432 Kim Jun Young JY Jung Han Jin HJ Lee Weon Ju WJ Kim Do Won DW Yoon Ghil Suk GS Kim Dong-Sun DS Park Mae Ja MJ Lee Seok-Jong SJ eng Letter Research Support, Non-U.S. Gov't Comment 2011 08 16 Switzerland Dermatology 9203244 1018-8665 IM Dermatology. 2010;220(2):173-5 20016126 Female Humans Melanoma surgery Nail Diseases surgery Skin Neoplasms surgery Skin Transplantation methods 2011 8 18 6 0 2011 8 19 6 0 2012 4 19 6 0 ppublish 21846959 000329432 10.1159/000329432

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2011 Dermatology

28. Conservative surgical management of subungual (matrix derived) melanoma: report of seven cases and literature review. (PubMed)

Conservative surgical management of subungual (matrix derived) melanoma: report of seven cases and literature review. Subungual melanoma (SUM) is a rare entity, comprising approximately 0·7-3·5% of all melanoma subtypes. SUM histopathologically belongs to the acral lentiginous pathological subtype of malignant melanoma. Its diagnosis is helped by dermoscopy but pathological examination of doubtful cases is required. Classical management of SUM is based on radical surgery, namely distal phalanx (...) amputation. Conservative treatment with nonamputative wide excision of the nail unit followed by a skin graft has been insufficiently reported in the medical literature even though it is performed in many centres.To report a series of patients with in situ or minimally invasive SUM treated by conservative surgery, to investigate the postoperative evolution and to evaluate the outcome with a review of the literature.We performed a retrospective extraction study from our melanoma register of all patients

2011 British Journal of Dermatology

29. Subungual Malignant Melanoma: Difficulty in Diagnosis (PubMed)

Subungual Malignant Melanoma: Difficulty in Diagnosis Subungual malignant melanoma developed on both great toes of a 61-year-old woman. The lesions had been diagnosed elsewhere as ingrowing toenails and had been treated as such for two years. The difficulty in clinical diagnosis is illustrated by the description of three other patients with subungual malignant melanoma. The tumour should be considered as a possible cause of any persistent abnormality of the nail bed or the nail itself

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1974 British medical journal

30. Subungual Melanoma 25-Year Review of Cases (PubMed)

Subungual Melanoma 25-Year Review of Cases 14274858 1996 12 01 2018 12 01 0003-4932 161 1965 Apr Annals of surgery Ann. Surg. SUBUNGUAL MELANOMA: 25-YEAR REVIEW OF CASES. 545-52 DASGUPTA T T BRASFIELD R R eng Journal Article United States Ann Surg 0372354 0003-4932 OM Amputation Fingers Hallux Humans Lymph Node Excision Melanoma Nails Neoplasm Metastasis Prognosis Thumb Toes AMPUTATION FINGERS HALLUX LYMPH NODE EXCISION MELANOMA NAILS NEOPLASM METASTASIS PROGNOSIS THUMB TOES 1965 4 1 1965 4 1 0

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1965 Annals of Surgery

31. Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis (PubMed)

pigmentation (IDP) in 28.3%. The ALMs were amelanotic in 24%, showing an atypical vascular pattern in all cases; a new dermoscopic pattern, named "vascularized parallel-ridge pattern" (VPRP), was detected in 13% of ALMs. Irregular lines were observed in 81.8% of subungual melanomas and were often associated with a multicolored background.ALM has site-specific dermoscopic patterns, with PRP being the most prevalent pattern. The newly described VPRP pattern may be an additional clue for ALM diagnosis (...) Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis The incidence of acral lentiginous melanoma (ALM) in the white population is low. Dermoscopy enhances diagnosis of ALM; however, diagnostic accuracy may sometimes be poor due to the considerable proportion of amelanotic ALM variants.To calculate the proportion of ALM among all melanoma subtypes and to determine the frequency of dermoscopic features of ALM in the Turkish population.Out of 612

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2018 Dermatology practical & conceptual

32. Comparing SLNE With or Without Preoperative Hybrid SPECT/CT in Melanoma

information, Layout table for eligibility information Ages Eligible for Study: 18 Years to 75 Years (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients with malignant melanoma in AJCC stages Ib / II Tumor depth of ≥1.0 mm Age ≥18 years to ≤75 years Have a primary melanoma that is cutaneous (including head, neck, trunk, extremity, scalp, palm, sole, subungual skin tissues Eastern Cooperative Oncology Group (ECOG) performance status 0-1 (...) Comparing SLNE With or Without Preoperative Hybrid SPECT/CT in Melanoma Comparing SLNE With or Without Preoperative Hybrid SPECT/CT in Melanoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparing SLNE

2018 Clinical Trials

33. Melanoma Treatment (PDQ®): Health Professional Version

, Sober AJ: Ultra-late recurrence (15 years or longer) of cutaneous melanoma. Cancer 79 (12): 2361-70, 1997. [ ] Cellular and Molecular Classification of Melanoma The descriptive terms for clinicopathologic cellular subtypes of malignant melanoma should be considered of historic interest only; they do not have independent prognostic or therapeutic significance. The cellular subtypes are the following: Superficial spreading. Nodular. Lentigo maligna. Acral lentiginous (palmar/plantar and subungual (...) Melanoma Treatment (PDQ®): Health Professional Version Melanoma Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Warning: The NCBI web site requires JavaScript to function. Search database Search term Search NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): ; 2002-. Search

2016 PDQ - NCI's Comprehensive Cancer Database

34. Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure. (PubMed)

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure. Acral melanoma is distinct from melanoma of other cutaneous sites, yet there is considerable variation within this category. To better define this variation, we assessed melanomas occurring on dorsal (n = 21), volar (n = 9), and subungual/interdigital (n = 13) acral skin as well as acral nevi (n = 24) for clinical, histologic, and molecular features. Melanomas on dorsal acral surfaces demonstrated clear differences (...) compared with volar and subungual/interdigital melanomas. The latter two groups exhibited significantly less frequent BRAF mutations (P = 0.01), were significantly less likely to have the superficial spreading histologic subtype (P = 0.01), occurred in older patients (P = 0.05), and had more frequent involvement in non-Caucasians (P = 0.01). These differences can be explained by differing levels of UV exposure. Subungual/interdigital melanomas had the most diverse group of oncogenic mutations including

2017 Journal of Investigative Dermatology

35. Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade. (PubMed)

after the first applications because the pain increased during infusion. The second course of nivolumab and ipilimumab was administered. About 2 weeks later, the patient presented with increased pain and small subungual necrosis. We treated the patient with oral analgetics and intravenous prednisolone 500 mg in tapering dosage. On digital substraction angiography occlusion of all arteries of the fingers was demonstrated. Further rheologic and anti-melanoma treatments were refused by the patient (...) Paraneoplastic acral vascular syndrome in a patient with metastatic melanoma under immune checkpoint blockade. Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of sympathetic nerves, hyperviscosity, hypercoagulability, vasoactive tumour-secreted substances, and immunological mechanisms have been suggested.We report a 60-year-old Caucasian

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2017 BMC Cancer

36. Malignant Melanoma: Beyond the Basics. (PubMed)

Malignant Melanoma: Beyond the Basics. After reading this article, the participant should be able to: 1. Discuss the initial management of cutaneous malignant melanoma with regard to diagnostic biopsy and currently accepted resection margins. 2. Be familiar with the management options for melanoma in specific situations such as subungual melanoma, auricular melanoma, and melanoma in the pregnant patient. 3. Discuss the differentiating characteristics of desmoplastic melanoma and its treatment (...) lymphoscintigraphy and wide local excision under local anesthesia, with sentinel lymph node biopsy under general anesthesia delayed until after delivery. Management of desmoplastic melanoma is currently controversial with regard to the indications for sentinel lymph node biopsy and the efficacy of postoperative radiation therapy. Subungual and auricular melanoma have evolved from being treated by amputation of the involved appendage to less radical procedures-ear reconstruction is now attempted in the absence

2016 Plastic and reconstructive surgery

37. Non-Melanoma-Associated Dyschromia of the Proximal Nail Fold (PubMed)

Non-Melanoma-Associated Dyschromia of the Proximal Nail Fold Subungual melanoma with pigmentation beneath the nail that extends to involve the proximal nail fold is referred to as Hutchinson's sign. Black or brown subungual discoloration involving the proximal nail fold secondary to other etiologies has been referred to as pseudo-Hutchinson's sign. Three patients with nail discoloration and concurrent dyschromia of the proximal nail fold are described: a female with a chronic subungual hematoma (...) and pseudo-Hutchinson's sign, a male with culture-confirmed Pseudomonas aeruginosa (P. aeruginosa) of the nail with green discoloration involving the proximal nail fold, and a male with an acute subungual hematoma with red-purple subungual discoloration affecting the proximal nail fold. PubMed was searched for the following: black, brown, chloronychia, discoloration, dyschromia, green, hematoma, Hutchinson's sign, nail, nail fold, proximal, pseudo-Hutchinson's sign, red, subungual melanoma, syndrome

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2016 Cureus

38. MelmarT Melanoma Margins Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma

. Microsatellitosis as per AJCC 2009 definition Subungual melanoma Patient has already undergone a local flap reconstruction of the defect after excision of the primary and determination of an accurate excision margin is impossible. History of previous or concurrent (i.e., second primary) invasive melanoma. Melanoma located distal to the metacarpophalangeal joint, on the tip of the nose, the eyelids or on the ear, mucous membranes or internal viscera. Physical, clinical, radiographic or pathologic evidence (...) MelmarT Melanoma Margins Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma MelmarT Melanoma Margins Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2014 Clinical Trials

39. Subungual tumors (PubMed)

Subungual tumors 23997727 2013 09 02 2019 01 08 1558-9455 7 3 2012 Sep Hand (New York, N.Y.) Hand (N Y) Subungual tumors. 252-8 10.1007/s11552-012-9418-0 Dooley Timothy P TP Allegheny General Hospital Orthopaedics Department, Pittsburgh, PA USA. Kindt Katie E KE Baratz Mark E ME eng Journal Article United States Hand (N Y) 101264149 1558-9447 2013 9 3 6 0 2013 9 3 6 0 2013 9 3 6 1 ppublish 23997727 10.1007/s11552-012-9418-0 9418 PMC3418367 J Bone Joint Surg Am. 1956 Jun;38-A(3):517-39 (...) ; discussion, 539-40; passim 13319408 Eur J Dermatol. 2000 Dec;10(8):604-6 11125321 J Am Acad Dermatol. 1998 Oct;39(4 Pt 1):560-4 9777762 J Surg Oncol. 1987 Jun;35(2):107-12 3586679 Melanoma Res. 1998 Apr;8(2):181-6 9610874 Scand J Plast Reconstr Surg Hand Surg. 2003;37(2):121-4 12755514 Ann Surg. 2001 Feb;233(2):250-8 11176132 Cutis. 2001 Jan;67(1):59-64 11204607 N Engl J Med. 2004 Feb 19;350(8):757-66 14973217 J Hand Surg Am. 1996 May;21(3):506-11 8724488 J Hand Surg Br. 2002 Jun;27(3):229-31 12074607 J

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2012 Hand (New York, N.Y.)

40. Revised U.K. guidelines for the management of cutaneous melanoma

, and to dress the wound while awaiting de?nitive pathology. Biopsies of possible subungual melanomas should be carried out by surgeons regularly doing so. The nail should be removed suf?ciently for the nail matrix to be adequately sam- pled: clinically obvious tumour should be biopsied if present. Prophylactic excision of naevi, or of small ( 4 mm, no ulceration IIC > 4 mm, with ulceration IIIA Any Breslow thickness, no ulceration Micrometastases 1–3 nodes IIIB Any Breslow thickness, with ulceration Any (...) Revised U.K. guidelines for the management of cutaneous melanoma BAD GUIDELINES BJD British Journal of Dermatology Revised U.K. guidelines for the management of cutaneous melanoma 2010 J.R. Marsden, J.A. Newton-Bishop,* L. Burrows, M. Cook, P.G. Corrie,§ N.H. Cox,– M.E. Gore,** P. Lorigan, R. MacKie, P. Nathan,§§ H. Peach,–– B. Powell*** and C. Walker University Hospital Birmingham, Birmingham B29 6JD, U.K. *University of Leeds, Leeds LS9 7TF, U.K. Salisbury District Hospital, Salisbury SP2 8BJ

2010 British Association of Dermatologists

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