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Subungual Melanoma

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1. Collision of subungual melanoma and subungual squamous cell carcinoma: a case series. (PubMed)

Collision of subungual melanoma and subungual squamous cell carcinoma: a case series. Subungual squamous cell carcinoma (SSCC) and subungual melanoma (SUM) are rare tumors. Several case reports of association of SSCC with SUM (SSCC-SUM) have been published.We sought to document the clinical, dermoscopic, and histologic features in a case series of SSCC-SUMs and describe their relative frequency compared with those of SSCC and SUM.All patients who underwent surgical exploration of the nail

2017 Journal of American Academy of Dermatology

2. Assessment of a Predictive Scoring Model for Dermoscopy of Subungual Melanoma In Situ. (PubMed)

Assessment of a Predictive Scoring Model for Dermoscopy of Subungual Melanoma In Situ. Subungual melanoma in situ (SMIS) is a malignant neoplasm that requires early diagnosis and complete surgical excision; however, little is known about the usefulness of the detailed dermoscopic features of longitudinal melanonychia (LM) to predict the diagnosis of SMIS.To investigate the characteristic dermoscopic findings of SMIS and to establish a predictive scoring model for the diagnosis of SMIS

2018 JAMA dermatology (Chicago, Ill.)

3. Subungual Amelanotic Melanoma Masquerading as Onychomycosis (PubMed)

Subungual Amelanotic Melanoma Masquerading as Onychomycosis Subungual amelanotic melanoma is rare. In addition, amelanotic melanoma can mimic non-melanocytic tumors. A 67-year-old woman had a four-year history of dystrophy of the left fourth fingernail. Periodic acid-Schiff staining of the nail plate demonstrated fungal hyphae, establishing a diagnosis of tinea unguium. The nail plate subsequently detached and the underlying nail bed showed a red, friable mass that was biopsied and confirmed (...) a diagnosis of melanoma. In conclusion, additional morphologic change of a persistent nail dystrophy-even with a biopsy-confirmed diagnosis of onychomycosis-may require consideration for repeat evaluation, including a biopsy, to exclude the possibility of a subungual malignant tumor.

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2018 Cureus

4. Subungual melanoma: A retrospective cohort of 157 cases from Brazilian National Cancer Institute. (PubMed)

Subungual melanoma: A retrospective cohort of 157 cases from Brazilian National Cancer Institute. Subungual melanoma (SM) is rare. The lesions are thick at the time of diagnosis. Few studies have evaluated SM in Brazil.The objective of this study was to investigate the factors associated with the survival of SM patients from the Brazilian National Cancer Institute.One-hundred and fifty-seven patients diagnosed with SM were included in this study. We evaluated the epidemiologic, clinical

2018 Journal of Surgical Oncology

5. Subungual Melanoma of the Hand. (PubMed)

Subungual Melanoma of the Hand. The diagnosis of subungual melanoma (SUM) can be challenging and SUMs generally have a worse prognosis than melanomas arising elsewhere. Due to their rarity, the evidence to guide management is limited. This study sought to identify clinicopathological features predictive of outcome and to provide guidelines for management.From a large, single-institution database, 103 patients with in situ (n = 9) or invasive (n = 94) SUMs of the hand treated between 1953 (...) (SNB), 28% of which were positive. Forty percent of SNB-positive patients had involved non-sentinel nodes (SNs) in their completion lymph node dissection. Five-year melanoma-specific survival (MSS) and disease-free survival (DFS) rates were 70% and 52%, respectively. On multivariate analysis, regional node metastasis and right-hand tumor location were significant predictors of shorter DFS and MSS, whereas mitoses negatively impacted DFS only and increasing Breslow thickness impacted MSS only.This

2018 Annals of Surgical Oncology

6. Super-thin SCIP Flap for Reconstruction of Subungual Melanoma: Aesthetic Functional Surgery. (PubMed)

Super-thin SCIP Flap for Reconstruction of Subungual Melanoma: Aesthetic Functional Surgery. This study aimed to use a superthin, free superficial circumflex iliac artery perforator (SCIP) flap in functional surgery for treating subungual melanoma and to evaluate its outcomes.Forty-one patients with primary subungual melanoma of less than or equal to 2-mm thickness who were treated with functional surgery were prospectively enrolled. After oncologic resection, a thin SCIP flap was harvested (...) Function Index following functional surgery were significantly lower than those following amputation.The superthin SCIP flap might serve as a valuable reconstruction option, providing aesthetically thin coverage and reliable outcomes, in functional surgery for treating early-stage subungual melanoma.Therapeutic, IV.

2017 Plastic and reconstructive surgery

7. Digit preserving surgery of subungual melanoma, a case series using vacuum assisted closure and full thickness skin grafting. (PubMed)

Digit preserving surgery of subungual melanoma, a case series using vacuum assisted closure and full thickness skin grafting. 28609554 2017 12 27 1468-3083 31 12 2017 Dec Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Digit preserving surgery of subungual melanoma: a case series using vacuum assisted closure and full-thickness skin grafting. e537-e538 10.1111/jdv.14400 Crisan D D Department of Dermatology & Allergology, University of Ulm

2017 Journal of the European Academy of Dermatology and Venereology

8. Frequency of Subungual Melanoma in Longitudinal Melanonychia: A Single-Center Experience. (PubMed)

Frequency of Subungual Melanoma in Longitudinal Melanonychia: A Single-Center Experience. Clinical and dermatoscopic guidelines are used to differentiate between benign longitudinal melanonychia (LM) and subungual melanoma; however, the frequency of malignancy among patients undergoing a biopsy for LM is not well defined.To describe the histologic diagnoses and malignancy among patients undergoing a biopsy for clinical LM.Retrospective cohort study of consecutive patients who underwent a nail (...) biopsy for LM at a single cancer center between 2000 and 2014. Clinical features, biopsy techniques, and histopathologic results were reviewed.Forty-two patients with 43 biopsied lesions were included. Three of the 43 biopsies revealed melanoma (mean depth 2.1 mm). The mean age among patients with malignant lesions was 60 years compared with 58.1 years for benign lesions. The mean width of all biopsied lesions was 4.2 mm, with a mean of 10.7 mm for malignant and 3.4 mm for benign. The first digit

2017 Dermatologic Surgery

9. Early Detection of Subungual Melanoma In Situ: Proposal of ABCD Strategy in Clinical Practice Based on Case Series (PubMed)

Early Detection of Subungual Melanoma In Situ: Proposal of ABCD Strategy in Clinical Practice Based on Case Series Prevalence of subungual melanoma (SUM) in Asian population is relatively high and early clinical detection improves both quality of life and survival.We sought to establish screening strategy for SUM in situ.We retrospectively reviewed medical records of 8 patients pathologically diagnosed as SUM in situ between January 2015 and September 2016.All patients in our study were adults

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2017 Annals of dermatology

10. A Case of Subungual Melanoma In Situ in an 18-Year-Old Girl Presented with Total Melanonychia (PubMed)

A Case of Subungual Melanoma In Situ in an 18-Year-Old Girl Presented with Total Melanonychia 28966533 2018 11 13 1013-9087 29 5 2017 Oct Annals of dermatology Ann Dermatol A Case of Subungual Melanoma In Situ in an 18-Year-Old Girl Presented with Total Melanonychia. 653-654 10.5021/ad.2017.29.5.653 Woo Cheong Ha CH Department of Dermatology, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea. Ham Seung Pil SP Department of Dermatology, Ilsan Paik Hospital, College

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2017 Annals of dermatology

11. A case of nodular subungual melanoma without Hutchinson's nail sign. (PubMed)

A case of nodular subungual melanoma without Hutchinson's nail sign. An early and accurate diagnosis is critical for the optimal management of subungual melanoma; the absence of Hutchinson's nail sign makes an accurate diagnosis extremely difficult. Previous publications show that most subungual melanomas have Hutchinson's nail sign. In this report, we present a rare case of a subungual melanoma without Hutchinson's nail sign and discuss the importance of cautious evaluations of Hutchinson's

2016 Australasian Journal of Dermatology

12. Subungual Melanoma

Subungual Melanoma Subungual Melanoma Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Subungual Melanoma Subungual Melanoma Aka (...) : Subungual Melanoma , Ungual Melanoma , Hutchinson Nail Sign , Hutchinson's Nail Sign , Hutchinson's Melanotic Whitlow , Acral Lentiginous Melanoma From Related Chapters II. Epidemiology Represents 2.5% of s Account for 50% of s in dark skinned patients III. Pathophysiology Type of Acral Lentiginous Melanoma IV. Characteristics Longitudinal brown-black streak May encompass entire nail Hutchinson's Nail Sign affecting proximal nail fold skin V. Evaluation: Factors suggesting Melanoma Recent change (e.g

2018 FP Notebook

13. Subungual Atypical Lentiginous Melanocytic Proliferations in Children and Adolescents: A Clinicopathologic Study. (PubMed)

, respectively. One of 4 cases tested by FISH was positive. Three lesions recurred locally without other adverse outcome.Small sample size and short clinical follow-up. Two cases were examined in partial biopsies only.Some subungual melanocytic lesions in children and adolescents are histologically indistinguishable from adult subungual melanoma in situ. While the biologic potential remains elusive, FISH might aid in risk stratification. Awareness of this rare group of lesions is crucial for facilitating (...) Subungual Atypical Lentiginous Melanocytic Proliferations in Children and Adolescents: A Clinicopathologic Study. Most subungual melanocytic lesions in children are benign, but some are difficult to classify due to prominent lentiginous growth and high-grade cytologic atypia.To characterize the clinicopathologic features of these rare lesions.Subungual atypical lentiginous melanocytic proliferations from patients <20 years of age were collected for clinical and histopathologic review

2018 Journal of American Academy of Dermatology

14. Variable Sized Cellular Remnants in the Nail Plate of Longitudinal Melanonychia: Evidence of Subungual Melanoma (PubMed)

Variable Sized Cellular Remnants in the Nail Plate of Longitudinal Melanonychia: Evidence of Subungual Melanoma 26082594 2015 06 17 2018 11 13 1013-9087 27 3 2015 Jun Annals of dermatology Ann Dermatol Variable Sized Cellular Remnants in the Nail Plate of Longitudinal Melanonychia: Evidence of Subungual Melanoma. 328-9 10.5021/ad.2015.27.3.328 Lee Dong-Youn DY Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. eng Journal Article 2015 05

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2015 Annals of dermatology

15. Subungual Exostosis in a Young Soccer Player (PubMed)

Subungual Exostosis in a Young Soccer Player Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx of the toes or fingers in young adults, considered as a rare variant of osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic subungual melanoma and glomus tumour. Misdiagnosis and total onychodystrophy frequently occur as a result of late treatment or inadequate treatment strategy (...) . Dermoscopy could be a useful technique, involved in the diagnostic process, although X-ray examination and histopathology are mandatory for the diagnosis.We report a rare case of subungual exostosis of the great toe associated with repeated trauma of the nail bed. The lack of radiographic and histopathological examination could lead to misdiagnosis and inadequate treatment. Although completely benign, subungual exostosis should be considered in differential diagnosis of nail bed tumors in young adults

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2017 Open access Macedonian journal of medical sciences

16. Subungual Nail Pigmentation and Malalignment of the Great Toe Nail in a Cancer Patient - A Diagnostic Challenge (PubMed)

Subungual Nail Pigmentation and Malalignment of the Great Toe Nail in a Cancer Patient - A Diagnostic Challenge Subungual pigmentation may have a variety of underlying pathologies, but clinicians should consider malignancies such as subungual melanoma or metastasis, even if they are not common. A delayed diagnosis can dramatically worsen the prognosis. Therefore, histologic examination is highly recommended. We present a 75-year-old female cancer patient presenting with subungual blackish (...) pigmentation of the great toe nail for several years suspicious of a subungual melanoma even by dermoscopy. Nail avulsion and histological investigations excluded melanoma. The final diagnosis was subungual hematoma with growth malalignment of the great toe nail.

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2017 Open access Macedonian journal of medical sciences

17. Subungual melanoma: a review of current treatment. (PubMed)

Subungual melanoma: a review of current treatment. Subungual melanoma typically presents as a darkened longitudinal stripe under the nail plate; however, this disease is frequently misdiagnosed, which leads to a delay in proper diagnosis. Subsequently, subungual melanoma historically has a relatively poor prognosis compared with other cutaneous melanomas, with the 5-year survival rate ranging between 16 and 80 percent. Historically, these lesions were removed using aggressive amputation (...) . To date, the National Cancer Institute does not have guidelines for the treatment of subungual melanoma.The authors conducted a complete review of all cases within the literature involving amputation and/or wide local excision for the treatment of subungual melanoma.There is currently a trend toward a more conservative approach in treating subungual melanoma; however, the literature does not offer a high level of evidence, and definitive conclusions cannot be drawn.Overall, the studies within

2014 Plastic and reconstructive surgery

18. Dermoscopy of subungual haemorrhage: Its usefulness in the differential diagnosis from nail unit melanoma. (PubMed)

Dermoscopy of subungual haemorrhage: Its usefulness in the differential diagnosis from nail unit melanoma. Subungual haemorrhages are characterized by well-circumscribed dots or blotches with a red to red-black pigmentation, but some cases can be difficult to distinguish from subungual melanoma by the naked eye alone. Dermoscopy has proven to be a useful, noninvasive tool in the diagnosis of pigmented lesions in the nail; however, few dermoscopic studies of subungual haemorrhages have been (...) reported.To investigate characteristic dermoscopic patterns of subungual haemorrhages, and to find distinctive features that can differentiate them from nail-unit melanomas.Patients with a confirmed diagnosis of either subungual haemorrhage or nail-unit melanoma at a tertiary university hospital were included in the study. Clinical features and dermoscopic patterns were evaluated.Sixty-four patients with a total of 90 lesions of subungual haemorrhage were enrolled in the study. The majority of cases (84

2013 British Journal of Dermatology

19. Subungual Melanoma of the Thumb (PubMed)

Subungual Melanoma of the Thumb 23457652 2013 03 05 2019 02 26 1937-5719 13 2013 Eplasty Eplasty Subungual melanoma of the thumb. ic26 Nocera Nadia F NF New York Medical College, Valhalla. Baruch Michael I MI Kim Minbae M eng Case Reports 2013 02 11 United States Eplasty 101316107 1937-5719 2013 3 5 6 0 2013 3 5 6 0 2013 3 5 6 1 ppublish 23457652 PMC3573745 J Am Acad Dermatol. 2000 Feb;42(2 Pt 1):269-74 10642684 J Plast Reconstr Aesthet Surg. 2007;60(6):635-8 17485051 J Hand Surg Am. 2011 Nov

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2013 Eplasty

20. Non-melanoma Hutchinson's sign: A reappraisal of this important, remarkable melanoma simulant. (PubMed)

, involvement of the PNF, nail matrix and nail bed containing atypical melanocytes in irregular array may be seen in more advanced lesions. The recent literature on non-melanoma HS simulants is summarized and clinical examples are provided.The mere presence of periungual pigmentation is neither clinically nor histologically pathognomonic of subungual melanoma and justifies the usefulness of this work stressing the non-melanoma HS.© 2017 European Academy of Dermatology and Venereology. (...) Non-melanoma Hutchinson's sign: A reappraisal of this important, remarkable melanoma simulant. More than 20 years ago, our reappraisal of the Hutchinson's sign (HS) gave birth to the concept of the pseudo-Hutchinson's sign.We have found it interesting to emphasize some important histologic points and to expand the list of the numerous HS simulants.We have examined the cutaneous samples taken from the pigmented skin of patients in association with nail matrix biopsy. We have also extended

2017 Journal of the European Academy of Dermatology and Venereology

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