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Sublingual Immunotherapy

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161. Efficacy of Sublingual Immunotherapy with Dermatophagoides farinae Extract in Monosensitized and Polysensitized Patients with Allergic Rhinitis: Clinical Observation and Analysis Full Text available with Trip Pro

Efficacy of Sublingual Immunotherapy with Dermatophagoides farinae Extract in Monosensitized and Polysensitized Patients with Allergic Rhinitis: Clinical Observation and Analysis To investigate differences in the efficacy of sublingual immunotherapy with Dermatophagoides farinae drops in monosensitized and polysensitized allergic rhinitis patients.The patients enrolled in the study were treated for more than one year by sublingual immunotherapy (SLIT) using Dermatophagoides farinae drops (...) and polysensitized patients could be cured by SLIT using Dermatophagoides farinae drops. This study provides a reference for the selection of allergens to be used in immunotherapy for polysensitized AR patients.

2015 BioMed research international

162. High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: A double-blind, placebo-controlled study (Abstract)

High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe: A double-blind, placebo-controlled study Sublingual allergen-specific immunotherapy is a viable alternative to subcutaneous immunotherapy particularly attractive for use in children.This study investigated efficacy and safety of high-dose sublingual immunotherapy (SLIT) in children allergic to grass pollen in a randomized, double-blind, placebo-controlled trial.After a baseline

2012 EvidenceUpdates Controlled trial quality: predicted high

163. [Long-term clinical effect and safety observation of sublingual dermatophagoides farinae drop in preschool and school-age children with allergic rhinitis]. (Abstract)

[Long-term clinical effect and safety observation of sublingual dermatophagoides farinae drop in preschool and school-age children with allergic rhinitis]. Objective:To evaluate the efficacy of specific sublingual immunotherapy (SLIT) with Dermatophagoides farinae drops on preschool and school age children with allergic rhinitis.Method:Fifty preschool children (≤6 year), and 52 school age children (> 6 year), who suffered from dust mite induced allergic rhinitis, were randomly divided (...) into subingual immunotherapy (SLIT) + drug group and drug group. SLIT + drug group was treated with a standardized subingual immunotherapy drops of Dermatophagoides farinae and combined with symptomatic therapy, drug group was treated with mometasone furoate nasal spray and dseloratdine tablets as symptomatic treatment. These children were followed up for 2 years with one visit in every 3 months. Symptom scores and medication scores were record at each visit. Comprehensive evaluation of symptom, medication

2018 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery Controlled trial quality: uncertain

164. [Effect of sublingual dust mite drops on single or multiple allergens allergic rhinitis in children]. (Abstract)

[Effect of sublingual dust mite drops on single or multiple allergens allergic rhinitis in children]. Objective:Evaluation of the efficacy of standardized dust mite drops in sublingual immunotherapy(SLIT) for allergic rhinitis in children.Method:A retrospective analysis of 174 children who received SLIT with standardized dermatophagoides farinae drops for 2 years.These patients had been divided into two groups:monoasensitized group(n=61) and polysensitized group(n=113).The total medication (...) immunotherapy,the expression of IL4 and IL-17α is downregulated, IL-2 and TGF-β1 is up-regulated.Conclusion:①Dust mites under the SLIT,can significantly improve the monosensitized and polyasensitized allergic children nasal symptoms,reduce the drug use, and two groups have the equivalent effect.②Dust mite drops SLIT,can be used to the monosensitized and polyasensitized allergic children.③The rise of dust mites specific IgG4 can be used as immunotherapy effective predictors.④After immunotherapy, Thl/Th2

2018 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery Controlled trial quality: uncertain

165. A Study to Assess Primarily the Tolerability and Safety of SAR439794 After Repeated Sublingual Daily Administration in Peanut Allergic Adult and Adolescent Patients

by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03463135 Recruitment Status : Active, not recruiting First Posted : March 13, 2018 Last Update Posted : March 25, 2019 Sponsor: Sanofi Information provided by (Responsible Party): Sanofi Study Details Study Description Go to Brief Summary: Primary Objective: To assess tolerability and safety of SAR439794 [peanut extract (PE) sublingual immunotherapy (SLIT) adjuvanted with Glucopyranosyl Lipid A (GLA)] after repeated (...) antibodies (anti-HBc Ab), anti-hepatitis C virus antibodies (anti-HCV Ab), anti-human immunodeficiency Virus 1 and 2 antibodies (anti-HIV1 and anti- HIV2 Ab). Presence of sublingual epithelium and oral mucosa wound or infection (abcess, ulcer, candidiasis, gingivitis, etc.) or painful tooth decay. Participation in any food immunotherapy interventional study within the past 6 months. Patients who had received any monophosphoryl lipid (MPL)- or glucopyranosyl lipid A (GLA)-containing products within

2018 Clinical Trials

166. Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy. Full Text available with Trip Pro

Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy. Sublingual (SLIT) and oral immunotherapy (OIT) are promising treatments for food allergy, but underlying mechanisms are poorly understood. Dendritic cells (DCs) induce and maintain Th2-type allergen-specific T cells, and also regulate innate immunity through their expression of Toll-like receptors (TLRs). We examined how SLIT and OIT influenced DC innate and adaptive immune responses

2014 Clinical immunology (Orlando, Fla.) Controlled trial quality: uncertain

167. Efficacy and safety of sublingual immunotherapy in children aged 3-13 years with allergic rhinitis. Full Text available with Trip Pro

Efficacy and safety of sublingual immunotherapy in children aged 3-13 years with allergic rhinitis. Sublingual immunotherapy (SLIT) is recommended for allergic diseases. However, clinical studies containing evidence-based data of this treatment in young children, which is rarely reported in the literature, are needed. This study was designed to assess the efficacy and safety of SLIT in children, including very young children.Two hundred sixty-four children aged 3-13 years old (133 children, 3-5

2014 American journal of rhinology & allergy Controlled trial quality: uncertain

168. [Long-term clinical efficacy of sublingual immunotherapy in children with allergic rhinitis]. (Abstract)

[Long-term clinical efficacy of sublingual immunotherapy in children with allergic rhinitis]. To evaluate the sustained efficacy of 2-year sublingual immunotherapy (SLIT) and 1 year after 2-year SLIT in children with allergic rhinitis (AR).This study is a randomized, open and prospective trial. One hundred twenty children (between 4 and 11 years old) suffering from AR duo to mite were chosen from November, 2008 to June, 2009 in department of otolaryngology in our hospital divided into two

2014 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery Controlled trial quality: uncertain

169. Effects of sublingual immunotherapy for Dermatophagoides farinae on Th17 cells and CD4(+) CD25(+) regulatory T cells in peripheral blood of children with allergic asthma. (Abstract)

Effects of sublingual immunotherapy for Dermatophagoides farinae on Th17 cells and CD4(+) CD25(+) regulatory T cells in peripheral blood of children with allergic asthma. Sublingual immunotherapy is becoming a more common treatment for allergic diseases, particularly in pediatric clinics. This type of treatment is highly effective for Dermatophagoides farinae allergy, but the mechanisms resulting in immune tolerance have not been investigated. We explored the effects of sublingual immunotherapy (...) with D. farinae drops on populations of subsets of T immune cells, specifically Th17 cells and CD4(+) CD25(+) regulatory T cells (Treg cells), in peripheral blood of children with allergic asthma.We assessed immune cell populations in 60 patients allergic to D. farinae who were randomly divided into 2 groups: a treatment group (n = 30) and a control group (n = 30), treated with sublingual administration of D. farinae drops or placebo, respectively, for 48 weeks. Clinical symptoms of asthma were

2014 International forum of allergy & rhinology

170. Sublingual immunotherapy: current concepts for the U.S. practitioner. (Abstract)

Sublingual immunotherapy: current concepts for the U.S. practitioner. Estimates of the prevalence of allergic rhinitis in the United States range from 20% to 40%. Allergen-specific immunotherapy (SIT) is typically recommended for patients with allergic rhinitis who fail medical treatment, desire an alternative to pharmacotherapy, or would like to pursue therapy that can potentially change the natural history of the disease. Sublingual immunotherapy (SLIT) involves dosing the allergen under (...) of SLIT for inhalant allergic rhinitis.SLIT is a safe and effective immune modulating treatment that decreases symptoms and medication use for allergic rhinitis. Further study is needed to determine the relative effectiveness of SLIT compared to subcutaneous immunotherapy, the role of multiple-allergen vs single-allergen SLIT, the use of SLIT in special populations (pregnancy, patients taking beta-blockers), and optimal dosing of U.S. products.SLIT is safe and effective, and offers a convenient

2014 International forum of allergy & rhinology

171. High-dose sublingual immunotherapy in patients with uncontrolled allergic rhinitis sensitized to pollen: a real-life clinical study. (Abstract)

High-dose sublingual immunotherapy in patients with uncontrolled allergic rhinitis sensitized to pollen: a real-life clinical study. High-dose pollen sublingual immunotherapy (SLIT) is indicated in patients with moderate to severe allergic rhinitis (AR), especially those who are unable to control their disease with pharmacotherapy. We explore the use of high-dose SLIT in patients with severe AR and sensitized to pollen, in real-life clinical practice. We also analyzed the effect on asthma.This

2014 International forum of allergy & rhinology

172. Comment on "Anaphylaxis caused by in-season switchover of sublingual immunotherapy formulation" (Abstract)

Comment on "Anaphylaxis caused by in-season switchover of sublingual immunotherapy formulation" 25557000 2015 10 23 2018 12 02 1399-3038 26 1 2015 Feb Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Comment on 'Anaphylaxis caused by in-season switchover of sublingual immunotherapy formulation'. 92 10.1111/pai.12329 Hsiao Kuang-Chih KC Epworth Allergy Specialists, Epworth HealthCare Richmond, Richmond

2014 Pediatric Allergy and Immunology

173. Study Immunology and Safety of 60-day Treatment of SQ Grass SLIT (Sublingual Immunotherapy)-Tablet in Adult Subjects With Grass Pollen-induced Allergic Rhinoconjunctivitis

Study Immunology and Safety of 60-day Treatment of SQ Grass SLIT (Sublingual Immunotherapy)-Tablet in Adult Subjects With Grass Pollen-induced Allergic Rhinoconjunctivitis Study Immunology and Safety of 60-day Treatment of SQ Grass SLIT (Sublingual Immunotherapy)-Tablet in Adult Subjects With Grass Pollen-induced Allergic Rhinoconjunctivitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search (...) for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study Immunology and Safety of 60-day Treatment of SQ Grass SLIT (Sublingual Immunotherapy)-Tablet in Adult Subjects With Grass Pollen-induced Allergic Rhinoconjunctivitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has

2014 Clinical Trials

174. Comments on: "Anaphylaxis caused by in-season switchover of sublingual immunotherapy formulation" (Abstract)

Comments on: "Anaphylaxis caused by in-season switchover of sublingual immunotherapy formulation" 25298112 2015 10 22 2018 12 02 1399-3038 25 7 2014 Nov Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Comments on: 'Anaphylaxis caused by in-season switchover of sublingual immunotherapy formulation'. 715-6 10.1111/pai.12290 Yalaoui Tarik T Stallergenes, Antony, France. de Beaumont Olivier O eng Letter

2014 Pediatric Allergy and Immunology

175. A web-based tool for improving adherence to sublingual immunotherapy. (Abstract)

A web-based tool for improving adherence to sublingual immunotherapy. 24965104 2015 07 30 2015 11 19 1399-3038 25 6 2014 Oct Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol A web-based tool for improving adherence to sublingual immunotherapy. 611-2 10.1111/pai.12260 Tripodi Salvatore S Pediatric Department and Pediatric Allergy Unit, "Sandro Pertini" Hospital, Rome, Italy. salvatore.tripodi@gmail.com (...) . Comberiati Pasquale P Di Rienzo Businco Andrea A eng Letter 2014 08 29 England Pediatr Allergy Immunol 9106718 0905-6157 IM Adolescent Adult Asthma immunology therapy Child Female Humans Internet Italy Male Monitoring, Physiologic Patient Compliance Physician-Patient Relations Precision Medicine Quality Improvement Rhinitis, Allergic immunology therapy Software Sublingual Immunotherapy methods Young Adult 2014 6 27 6 0 2014 6 27 6 0 2015 8 1 6 0 ppublish 24965104 10.1111/pai.12260

2014 Pediatric Allergy and Immunology

176. The Efficacy of Sublingual Immunotherapy with Dermatophagoides farinae Vaccine in a Murine Atopic Dermatitis Model. (Abstract)

The Efficacy of Sublingual Immunotherapy with Dermatophagoides farinae Vaccine in a Murine Atopic Dermatitis Model. Sublingual immunotherapy (SLIT) is a potential treatment for house dust mite-induced atopic dermatitis (AD). However, the mechanisms of action are not clear.To establish a mouse model of AD in order to study the effect and mechanisms of SLIT.Mice were sensitized and subsequently challenged by repeated cutaneous application of Der f allergen extract. Sensitized mice were SLIT

2014 Clinical and Experimental Allergy

177. Anaphylaxis caused by in-season switchover of sublingual immunotherapy formulation. (Abstract)

Anaphylaxis caused by in-season switchover of sublingual immunotherapy formulation. 25200920 2015 10 21 2015 01 20 1399-3038 25 7 2014 Nov Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Pediatr Allergy Immunol Anaphylaxis caused by in-season switchover of sublingual immunotherapy formulation. 714-5 10.1111/pai.12268 Hsiao Kuang-Chih KC Epworth HealthCare Richmond, Richmond, Vic., Australia; Murdoch Childrens Research Institute (...) , Melbourne, Vic., Australia; Royal Children's Hospital, Melbourne, Vic., Australia. kuangchih.hsiao@mcri.edu.au. Smart Joanne J eng Case Reports Letter 2014 09 29 England Pediatr Allergy Immunol 9106718 0905-6157 0 Allergens 0 Antigens, Plant 0 Plant Extracts 0 Sweet Vernal, orchard, Perennial Rye, Timothy and Kentucky Blue Grass Mixed Pollens Allergen Extract YKH834O4BH Epinephrine IM Pediatr Allergy Immunol. 2014 Nov;25(7):715-6 25298112 Administration, Sublingual Allergens administration & dosage

2014 Pediatric Allergy and Immunology

178. Sublingual immunotherapy alters expression of IL-4 and its soluble and membrane-bound receptors. (Abstract)

Sublingual immunotherapy alters expression of IL-4 and its soluble and membrane-bound receptors. Seasonal allergic rhinitis (SAR) is a disease of increasing prevalence, which results from an inappropriate T helper cell, type 2 (Th2) response to pollen. Specific immunotherapy (SIT) involves repeated treatment with small doses of pollen and can result in complete and lasting reversal of SAR. Here, we assayed the key Th2 cytokine, IL-4, and its soluble and membrane-bound receptor in patients (...) effects of immunotherapy with potential basic and clinical research implications. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2014 Allergy

179. Grass pollen sublingual immunotherapy: A double-blind, placebo-controlled study in elderly patients with seasonal allergic rhinitis. (Abstract)

Grass pollen sublingual immunotherapy: A double-blind, placebo-controlled study in elderly patients with seasonal allergic rhinitis. This study evaluates the safety and efficacy of specific sublingual immunotherapy (SLIT) against grass pollen allergens in patients >60 years of age with seasonal allergic rhinitis (SAR) and/or asthma. This study sought to assess nasal symptoms during the grass pollen season, reduce medication use, and monitor adverse reactions during immunotherapy.Seventy-eight

2014 American journal of rhinology & allergy Controlled trial quality: uncertain

180. Efficacy and safety of grass sublingual immunotherapy tablet, MK-7243: a large randomized controlled trial. (Abstract)

Efficacy and safety of grass sublingual immunotherapy tablet, MK-7243: a large randomized controlled trial. In North America, few studies have evaluated sublingual immunotherapy for allergic rhinitis with or without conjunctivitis (AR/C); pediatric data are sparse. The authors report findings from the largest published immunotherapy trial yet conducted in adults and children.To evaluate grass sublingual immunotherapy tablet (MK-7243) treatment in subjects with AR/C.North American subjects (5-65

2014 Asthma & Immunology Controlled trial quality: predicted high

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