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Sublingual Immunotherapy

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141. Sublingual grass and ragweed immunotherapy: Clinical considerations-a PRACTALL consensus report. Full Text available with Trip Pro

Sublingual grass and ragweed immunotherapy: Clinical considerations-a PRACTALL consensus report. Sublingual allergen immunotherapy provides a new option for patients with allergic rhinitis in the United States. The efficacy of these sublingual immunotherapy tablets in the treatment of allergic rhinitis has been firmly established in large multicenter clinical trials. In addition, the clinical benefits of sublingual immunotherapy might persist after treatment is discontinued. Local reactions (...) , such as gastrointestinal or oropharyngeal symptoms, are common. However, severe anaphylaxis is rare, and therefore the immunotherapy tablets can be administered at home. Sublingual immunotherapy for allergic rhinitis has been used successfully for years in Europe, and these products might be appropriate for patients who do not do well with standard drug therapy or for those who prefer a disease-modifying approach. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights

2015 Journal of Allergy and Clinical Immunology

142. Utility of component analyses in subjects undergoing sublingual immunotherapy for peanut allergy. Full Text available with Trip Pro

Utility of component analyses in subjects undergoing sublingual immunotherapy for peanut allergy. Sublingual immunotherapy (SLIT) with peanut changes clinical and immune responses in most peanut-allergic individuals, but the response is highly variable.We sought to examine the component-specific effects of peanut SLIT and determine whether peanut component testing could predict the outcome of a double-blind, placebo-controlled food challenge (DBPCFC) after 12 months of peanut SLIT.We included

2015 Clinical and Experimental Allergy Controlled trial quality: uncertain

143. Smoking effects on quality of life of allergic rhinitis patients after sublingual immunotherapy. Full Text available with Trip Pro

Smoking effects on quality of life of allergic rhinitis patients after sublingual immunotherapy. Although tobacco smoking is of great concern, there is no evidence for the effects of smoking on quality of life (QoL) results after sublingual immunotherapy (SLIT).This study aims tο explore any association between smoking habits (duration and quantity) and QoL results after SLIT in allergic rhinitis (AR).One hundred and sixty three patients following SLIT for AR were participated. SLIT efficacy

2015 Rhinology

144. Sublingual Allergen Immunotherapy in HIV positive patients. (Abstract)

Sublingual Allergen Immunotherapy in HIV positive patients. HIV infection is a relative contraindication for allergic immunotherapy (AIT). In the last decade, highly active antiretroviral therapy (HAART) has improved the immune function and life expectancy in HIV-infected patients whose respiratory allergic incidence is similar to the general population. We evaluated the safety and clinical effectiveness of sublingual immunotherapy in a group of grass pollen-allergic HAART-treated HIV-positive (...) patients. Thirteen patients received sublingual immunotherapy (SLIT) tablet (Oralair, Stallergenes©) and symptomatic therapy and were compared with nine patients receiving symptomatic therapy alone. Clinical benefits were evaluated by the analysis of total combined score (TCS), sum of symptom-medication score, and a quality of life (QoL) questionnaire. HIV viral load and peripheral TCD4 lymphocytes were analyzed at the beginning and at the end of the study. Clinical efficacy data showed a significant

2015 Allergy

145. Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial. Full Text available with Trip Pro

Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial. We previously reported the initial results of the first multicenter, randomized, double-blind, placebo-controlled clinical trial of peanut sublingual immunotherapy (SLIT), observing a favorable safety profile associated with modest clinical and immunologic effects in the first year.We sought to provide long-term (3-year) clinical and immunologic outcomes for our peanut SLIT trial. Key end points

2015 The Journal of allergy and clinical immunology Controlled trial quality: predicted high

146. Immunological parameters in prophylactic sublingual immunotherapy in asymptomatic subjects sensitized to Japanese cedar pollen. Full Text available with Trip Pro

Immunological parameters in prophylactic sublingual immunotherapy in asymptomatic subjects sensitized to Japanese cedar pollen. This study aims to examine the immunological parameters, focusing IL-10 productivity, in prophylactic sublingual immunotherapy (SLIT) in asymptomatic subjects sensitized to Japanese cedar pollen (JCP).This study was conducted as part of a randomized, double-blind, placebo-controlled, multiple center trial, and was performed for two consecutive pollen seasons in 2012

2015 Allergology international : official journal of the Japanese Society of Allergology Controlled trial quality: uncertain

147. A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy Full Text available with Trip Pro

A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy 25834457 2015 04 02 2018 11 13 1178-6965 8 2015 Journal of asthma and allergy J Asthma Allergy A major step forward for sublingual immunotherapy: the quality of 5-grass pollen tablet is recognized also in Italy. 25-7 10.2147/JAA.S82077 Ciprandi Giorgio G Medicine Department, IRCCS-Azienda Ospedaliera Universitaria San Martino, Genoa, Italy. eng Journal Article 2015 03 06 New

2015 Journal of asthma and allergy

148. Effect of high-dose sublingual immunotherapy on respiratory infections in children allergic to house dust mite. Full Text available with Trip Pro

Effect of high-dose sublingual immunotherapy on respiratory infections in children allergic to house dust mite. Allergic rhinitis is characterized by eosinophil inflammation. Allergic inflammation may induce susceptibility to respiratory infections (RI). House dust mite (HDM) sensitization is very frequent in childhood. Allergen immunotherapy may cure allergy as it restores a physiologic immune and clinical tolerance to allergen and exerts anti-inflammatory activity.This study investigated (...) whether six-month high-dose, such as 300 IR (index of reactivity), HDM-sublingual immunotherapy (SLIT) could affect RI in allergic children.Globally, 40 HDM allergic children (18 males; mean age, 9.3 years) were subdivided in 2 groups: 20 treated by symptomatic drugs (group 1) and 20 by high-dose HDM-SLIT (group 2), since September 2012 to April 2013. The daily maintenance dose of HDM-SLIT was 4 pressures corresponding to 24, 4.8, and 60 µg, respectively of the major allergens Dermatophagoides

2015 Asia Pacific allergy Controlled trial quality: uncertain

149. The efficacy and safety of the Timothy grass allergy sublingual immunotherapy tablet in Canadian adults and children. Full Text available with Trip Pro

The efficacy and safety of the Timothy grass allergy sublingual immunotherapy tablet in Canadian adults and children. The effect of sublingual Timothy grass immunotherapy tablet 2800 BAU (grass SLIT-T) has been evaluated in three North American trials in adults and children who have allergic rhinitis with or without conjunctivitis (AR/C). This paper examines the effects of grass SLIT-T in Canadians.Data for grass-allergic Canadians in three randomized, placebo-controlled, double-blind trials

2015 Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology Controlled trial quality: predicted high

150. Efficacy and safety of ragweed sublingual immunotherapy in Canadian patients with allergic rhinoconjunctivitis. Full Text available with Trip Pro

Efficacy and safety of ragweed sublingual immunotherapy in Canadian patients with allergic rhinoconjunctivitis. Currently accepted therapies for ragweed allergy in North America consist of pharmacotherapy and subcutaneous allergen immunotherapy injections to treat symptoms. Allergen immunotherapy not only reduces symptoms and the need for pharmacotherapy but has also been shown to have disease-modifying potential. Recently, ragweed immunotherapy administered via sublingual allergen tablet has (...) been approved in North America for treatment of allergic rhinitis with and without conjunctivitis.This was an analysis of pooled data for a prespecified subgroup of Canadian subjects from two multicentre, randomized, double-blind placebo-controlled trials of ragweed sublingual tablet (SLIT-T; 6 and 12 Amb a 1-U of Ambrosia artemisiifolia) in patients aged ≥18y, with ragweed-induced allergic rhinoconjunctivitis (AR/C) with or without asthma. Randomized subjects used once-daily ragweed SLIT-T

2015 Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology Controlled trial quality: predicted high

151. Changes of micro-RNAs in asymptomatic subjects sensitized to Japanese cedar pollen after prophylactic sublingual immunotherapy. Full Text available with Trip Pro

Changes of micro-RNAs in asymptomatic subjects sensitized to Japanese cedar pollen after prophylactic sublingual immunotherapy. Japanese cedar pollinosis is the predominant seasonal allergic rhinitis in Japan, and it has increased in prevalence during the past 10 years. Sublingual immunotherapy (SLIT) is considered a safe and effective treatment for pollinosis. Micro-RNAs (miRNAs) are a class of short single-stranded RNA molecules that posttranscriptionally silence gene expression and may

2015 Allergy & rhinology (Providence, R.I.) Controlled trial quality: uncertain

152. Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose Full Text available with Trip Pro

Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose Sublingual immunotherapy (SLIT) is an effective and well-tolerated method of treating allergic respiratory diseases associated with seasonal and perennial allergens. In contrast to the subcutaneous route, SLIT requires a much greater amount of antigen to achieve a clinical effect. Many studies have shown that SLIT involves a dose-response relationship, and therefore it is important to use

2015 Clinical and translational allergy

153. [Study on the efficacy and safety of sublingual immunotherapy with standardized dermatophagoides farinae drops for allergic rhinitis]. (Abstract)

[Study on the efficacy and safety of sublingual immunotherapy with standardized dermatophagoides farinae drops for allergic rhinitis]. To evaluate the efficacy and safety of the sublingual immunotherapy with dermatophagoides farinae drops on patients with allergic rhinitis.One hundred and twelve cases were collected from adult patients with dust-mite allergic rhinitis of our hospital who could adhere to treatment and regular follow-up. These patients were randomly allocated to receive either (...) sublingual immunotherapy (SLIT group, n = 56) or medical treatment (Control group, n = 56). To evaluate the clinical efficacy by side effects which were registered, symptom and medication scores which were assessed and rhinoconjunctivitis quality of life questionnaire (RQLQ) which was completed in the baseline and two years after treatment.Dropouts after the 2 years' treatment were 5 of SLIT group and 4 of Control group respectively. SLIT group induced the significant reductions on both the symptom

2015 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery Controlled trial quality: uncertain

154. Clinical and cytokine responses to house dust mite sublingual immunotherapy. (Abstract)

Clinical and cytokine responses to house dust mite sublingual immunotherapy. Cytokine responses accompanying sublingual immunotherapy (SLIT) responder phenotypes have not previously been reported.To investigate clinical and cytokine responses of house dust mite (HDM) sensitive patients with allergic rhinitis receiving HDM SLIT or placebo for 2 years.Sixty adults were randomized to receive SLIT or placebo. Clinical symptoms were measured using the Total 5 Symptom Score (TSS5) and Juniper

2015 Asthma & Immunology Controlled trial quality: uncertain

155. SQ house dust mite sublingually administered immunotherapy tablet (ALK) improves allergic rhinitis in patients with house dust mite allergic asthma and rhinitis symptoms. Full Text available with Trip Pro

SQ house dust mite sublingually administered immunotherapy tablet (ALK) improves allergic rhinitis in patients with house dust mite allergic asthma and rhinitis symptoms. House dust mite (HDM) allergy is associated with persistent allergic rhinitis (AR) and allergic asthma.To investigate the efficacy and safety of a SQ HDM sublingually administered immunotherapy tablet (ALK, Hørsholm, Denmark) in adults and adolescents with HDM respiratory allergic disease and report the AR results.Six hundred

2015 Asthma & Immunology Controlled trial quality: predicted high

156. Characterization of oral immune cells in birch pollen-allergic patients: impact of the Oral Allergy Syndrome and sublingual allergen immunotherapy on antigen presenting cells. (Abstract)

Characterization of oral immune cells in birch pollen-allergic patients: impact of the Oral Allergy Syndrome and sublingual allergen immunotherapy on antigen presenting cells. A detailed characterization of human oral immune cells is needed to better understand local mechanisms associated with allergen capture following oral exposure.Oral immune cells were characterized by immunohistology and immunofluorescence in biopsies obtained from three healthy individuals and 23 birch pollen-allergic (...) patients with/without oral allergy syndrome (OAS), at baseline and after 5 months of sublingual allergen immunotherapy (AIT).Similar cell subsets (i.e., dendritic cells, mast cells, and T lymphocytes) were detected in oral tissues from healthy and birch pollen-allergic individuals. CD207+ Langerhans cells (LCs) and CD11c+ myeloid dendritic cells (DCs) were found in both the epithelium and the papillary layer of the Lamina propria (LP), whereas CD68+ macrophages, CD117+ mast cells, and CD4+ /CD8+ T

2015 Allergy

157. Onset and dose-related efficacy of house dust mite sublingual immunotherapy tablets in an environmental exposure chamber. (Abstract)

Onset and dose-related efficacy of house dust mite sublingual immunotherapy tablets in an environmental exposure chamber. The magnitude of effect of sublingual immunotherapy for house dust mite (HDM)-induced allergic rhinitis with or without conjunctivitis is uncertain, partly because there are few well-controlled trials with well-defined doses.We sought to determine the dose-related efficacy and onset of action of the HDM sublingual immunotherapy tablet MK-8237 (Merck/ALK-Abelló) using

2015 The Journal of allergy and clinical immunology Controlled trial quality: predicted high

158. Sublingual Immunotherapy for Allergic Fungal Sinusitis. Full Text available with Trip Pro

Sublingual Immunotherapy for Allergic Fungal Sinusitis. Allergic fungal sinusitis (AFS) is a condition that has an allergic basis caused by exposure to fungi in the sinonasal tract leading to chronic inflammation. Despite standard treatment modalities, which typically include surgery and medical management of allergies, patients still have a high rate of recurrence. Subcutaneous immunotherapy (SCIT) has been used as adjuvant treatment for AFS. Evidence exists to support the use of sublingual (...) immunotherapy (SLIT) as a safe and efficacious method of treating allergies, but no studies have assessed the utility of SLIT in the management of allergic fungal sinusitis. A record review of cases of AFS that are currently or previously treated with sublingual immunotherapy from 2007 to 2011 was performed. Parameters of interest included serum IgE levels, changes in symptoms, Lund-McKay scores, decreased sensitization to fungal allergens associated with AFS, and serum IgE levels. Ten patients

2015 Rhinology and Laryngology

159. Efficacy and Safety of Sublingual Immunotherapy for Two Seasons in Patients with Japanese Cedar Pollinosis. Full Text available with Trip Pro

Efficacy and Safety of Sublingual Immunotherapy for Two Seasons in Patients with Japanese Cedar Pollinosis. Japanese cedar (JC) pollinosis is the most common seasonal allergic rhinitis in Japan. Standardized JC pollen extract is available for subcutaneous immunotherapy, but this treatment is limited by potentially serious side effects. The aim of this double-blind, randomized comparative study was to evaluate the efficacy and safety of standardized JC pollen extract in a new oral formulation (...) (CEDARTOLEN®, Torii Pharmaceutical Co., Ltd., Tokyo, Japan) for sublingual immunotherapy (SLIT) for JC pollinosis.A total of 531 subjects with JC pollinosis were randomized into 2 groups at a ratio of 1:1 to receive daily sublingual administration of standardized JC pollen extract with a maintenance dose of 2,000 Japanese allergy units (JAU) or placebo for 2 consecutive pollen seasons. The efficacy was evaluated using the total nasal symptom and medication score (TNSMS) as the primary end point. Secondary

2015 International Archives of Allergy and Immunology Controlled trial quality: predicted high

160. Sublingual immunotherapy in children and its potential beneficial collateral effect on respiratory tract infections. (Abstract)

Sublingual immunotherapy in children and its potential beneficial collateral effect on respiratory tract infections. Although directed to the control of allergic symptoms, a possible effect of sublingual immunotherapy (SLIT) on susceptibility to infections has been hypothesized. Two hundred sixty-five children aged between 3 and 4 years of age affected by allergic rhinitis completed a 6 year prospective case-control study. One hundred forty-three children after 2 years of SLIT reported a lower

2015 Current medical research and opinion

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