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Sublingual Immunotherapy

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121. House Dust Mite-Specific Sublingual Immunotherapy Prevents the Development of Allergic Inflammation in a Mouse Model of Experimental Asthma. Full Text available with Trip Pro

House Dust Mite-Specific Sublingual Immunotherapy Prevents the Development of Allergic Inflammation in a Mouse Model of Experimental Asthma. Evidence regarding sublingual immunotherapy (SLIT) efficacy and its good safety profile has been demonstrated with pollen and house dust mite (HDM) allergens in the treatment of airway allergies. In addition, the use of grass pollen presents a SLIT disease-modifying treatment for respiratory allergies.The aim of this study was to demonstrate the efficacy

2016 International Archives of Allergy and Immunology

122. The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis. Full Text available with Trip Pro

The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis. An important issue in sublingual immunotherapy (SLIT) is how to improve efficacy.To compare the clinical efficacy of SLIT with vitamin D supplementation with placebo in children with allergic rhinitis. Secondary end points included lung function, exhaled nitric oxide concentration, methacholine bronchial provocation test, and serum level of calcifediol (25 (...) supplementation combined with SLIT provides an effective and well-tolerated new immunotherapy modality for treating children with allergic rhinitis. A 5-grass pollen sublingual 300 IR tablet was effective in both studied groups and also in children with comorbid mild asthma.

2016 Allergy and Asthma Proceedings Controlled trial quality: predicted high

123. The influence of house dust mite sublingual immunotherapy on the TSLP-OX40L signaling pathway in patients with allergic rhinitis. (Abstract)

The influence of house dust mite sublingual immunotherapy on the TSLP-OX40L signaling pathway in patients with allergic rhinitis. This study aimed to investigate the clinical efficacy of sublingual immunotherapy (SLIT) with house dust mite (HDM) extract and to examine T helper 2 (Th2)-type immune responses mediated by the thymic stromal lymphopoietin (TSLP-OX40L) signaling pathway in patients with moderate to severe allergic rhinitis (AR) after 12-month HDM SLIT.Forty-six cases of HDM

2016 International forum of allergy & rhinology

124. Effect of Lactobacillus rhamnosus GG and vitamin D supplementation on the immunologic effectiveness of grass-specific sublingual immunotherapy in children with allergy. (Abstract)

Effect of Lactobacillus rhamnosus GG and vitamin D supplementation on the immunologic effectiveness of grass-specific sublingual immunotherapy in children with allergy. An important issue in sublingual immunotherapy (SLIT) is how to improve efficacy.To compare the clinical and immunologic efficacy of SLIT given alone and, to enhance clinical efficacy, given with probiotic or vitamin D supplementation.One hundred children, ages 5-12 years, sensitive to grass pollen, with allergic rhinitis (...) participated in a 5-month prospective, randomized, double-blind, placebo-controlled trial. Children received 5-grass SLIT 300 IR tablets with either vitamin D 1000 IU daily supplementation, probiotic, or placebo. The control group included children with allergy who did not qualify for immunotherapy. Primary end points included a symptom-medication score, lung function, and exhaled nitric oxide concentration. The secondary end point was the immunologic efficacy measured by the following: CD4(+)CD25(+)Foxp3

2016 Allergy and Asthma Proceedings Controlled trial quality: predicted high

125. Effect of Japanese cedar-specific sublingual immunotherapy on allergen-specific T<sub>H</sub>2 cell counts in blood. (Abstract)

Effect of Japanese cedar-specific sublingual immunotherapy on allergen-specific TH2 cell counts in blood. The contribution of antigen-specific TH cells in peripheral blood to immunologic mechanisms underlying sublingual immunotherapy (SLIT) remains unclear, partly because of the lack of a standardized method for the analysis of this rare lymphocyte subset.To clarify the role of antigen-specific TH cells during SLIT using a sensitive method analyzing activation marker CD154-positive

2016 Asthma & Immunology

126. Decreased level of osteopontin in children with allergic rhinitis during sublingual immunotherapy. (Abstract)

Decreased level of osteopontin in children with allergic rhinitis during sublingual immunotherapy. Sublingual immunotherapy (SLIT) is proven to be very effective in the treatment of allergic rhinitis (AR), but its regulatory mechanism and biomarkers for predicting efficacy are still unknown. Osteopontin (OPN), as a recently described Th2 inflammation related protein, plays key role in the pathogenesis of AR. The aim of this study was to identify the expression and role of OPN during SLIT

2016 International Journal of Pediatric Otorhinolaryngology Controlled trial quality: uncertain

127. Efficacy and Safety of Grass Sublingual Immunotherapy Tablet, MK-7243: A Large Randomized Controlled Trial. Full Text available with Trip Pro

Efficacy and Safety of Grass Sublingual Immunotherapy Tablet, MK-7243: A Large Randomized Controlled Trial. 25363956 2016 01 21 2014 11 03 1098-4275 134 Suppl 3 2014 Nov Pediatrics Pediatrics Efficacy and Safety of Grass Sublingual Immunotherapy Tablet, MK-7243: A Large Randomized Controlled Trial. S161-2 10.1542/peds.2014-1817XX Winterroth Lisa C LC Seattle, WA. Willams Paul V PV Seattle, WA. eng Journal Article United States Pediatrics 0376422 0031-4005 2014 11 4 6 0 2014 11 5 6 0 2014 11 5 6

2016 Pediatrics Controlled trial quality: uncertain

128. Dose-Dependent Immunological Responses after a 6-Month Course of Sublingual House Dust Mite Immunotherapy in Patients with Allergic Rhinitis. Full Text available with Trip Pro

Dose-Dependent Immunological Responses after a 6-Month Course of Sublingual House Dust Mite Immunotherapy in Patients with Allergic Rhinitis. House dust mite (HDM) immunotherapy has proven efficacy in treating allergic rhinitis (AR) symptoms. This trial evaluated the dose-response relationship of SLIToneULTRA® HDM mix based on immunological parameters and safety in subjects with moderate-to-severe HDM AR not controlled by symptomatic medication.A randomized, parallel-group, open-label, clinical

2016 International Archives of Allergy and Immunology Controlled trial quality: uncertain

129. Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period. (Abstract)

Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period. Sublingual immunotherapy in patients with allergic rhinitis sensitised to house dust mites is safe, but its efficacy is controversial and sublingual immunotherapy with Blomia tropicalis has not yet been studied. This study sought to evaluate the efficacy of sublingual immunotherapy with house dust mite extract in children and adults with house dust mite (...) allergic rhinitis over a period of two years.A prospective observational study was conducted of children and adults diagnosed with house dust mite allergic rhinitis who were treated with sublingual immunotherapy from 2008 to 2012. Total Nasal Symptom Scores, Mini Rhinoconjunctivitis Quality of Life scores and medication usage scores were assessed prospectively.Thirty-nine patients, comprising 24 children and 15 adults, were studied. Total Nasal Symptom Scores and Mini Rhinoconjunctivitis Quality

2016 Journal of Laryngology & Otology

130. Sublingual Immunotherapy: A Useful Tool for the Allergist in Private Practice Full Text available with Trip Pro

Sublingual Immunotherapy: A Useful Tool for the Allergist in Private Practice This is a review of the author's experience with Sublingual Immunotherapy in a private office setting. Sublingual Immunotherapy should be considered by any allergy practitioner as a useful tool. Sublingual Immunotherapy is safe while at the same time it is effective. It enables the practitioner to treat asthmatics and young children without the concerns implicit with allergy injections.

2016 BioMed research international

131. Adverse reactions and tolerability of high-dose sublingual allergen immunotherapy Full Text available with Trip Pro

Adverse reactions and tolerability of high-dose sublingual allergen immunotherapy Sublingual allergen immunotherapy is an effective treatment against allergic respiratory disease. Many studies have shown the safety of this type of therapy, although the factors that might affect the tolerability of high-dose sublingual immunotherapy have not been well established. The aim of this study was to determine the factors that affect the tolerability of sublingual allergen immunotherapy.A total of 183 (...) subjects aged ≥5 years, diagnosed with allergic rhinitis with/without mild to moderate asthma due to sensitization to grass, olive pollen, or mites, were included in this open, retrospective, multicentric, noninterventional study. Sublingual immunotherapy was administered for at least 3 months.The most frequent adverse reaction was oral pruritus (13.7% of the patients). Most of the reactions were local (84.7%) and immediate (93.5%) and occurred during the initiation phase (60.6%). All reactions were

2016 Journal of asthma and allergy

132. Commentary: Sublingual Allergen Immunotherapy in HIV-Positive Patients Full Text available with Trip Pro

Commentary: Sublingual Allergen Immunotherapy in HIV-Positive Patients 27066011 2016 04 12 2018 11 13 1664-3224 7 2016 Frontiers in immunology Front Immunol Commentary: Sublingual Allergen Immunotherapy in HIV-Positive Patients. 132 10.3389/fimmu.2016.00132 Chirumbolo Salvatore S Unit of Geriatry, Department of Medicine, University of Verona , Verona , Italy. eng Journal Article 2016 03 31 Switzerland Front Immunol 101560960 1664-3224 HIV SLIT allergy and immunology anti-retroviral therapy (...) asthma basophils immunotherapy 2016 02 15 2016 03 22 2016 4 12 6 0 2016 4 12 6 0 2016 4 12 6 1 epublish 27066011 10.3389/fimmu.2016.00132 PMC4815895 J Immunol. 2013 Sep 1;191(5):2164-73 23894197 Ann Allergy Asthma Immunol. 2010 Oct;105(4):320-1 20934633 Curr Opin HIV AIDS. 2010 Mar;5(2):146-50 20543592 Allergy. 2009 Sep;64(9):1375-8 19226302 Allergy Asthma Clin Immunol. 2013 Jul 03;9(1):23 23822853 J Allergy Clin Immunol. 2012 Mar;129(3):708-714.e8 22177327 Allergy. 2016 Mar;71(3):412-5 26228482 Int

2016 Frontiers in immunology

133. Sublingual immunotherapy for pediatric allergic rhinitis: The clinical evidence Full Text available with Trip Pro

Sublingual immunotherapy for pediatric allergic rhinitis: The clinical evidence Allergic rhinitis is estimated to affect 10%-20% of pediatric population and it is caused by the IgE-sensitization to environmental allergens, most importantly grass pollens and house dust mites. Allergic rhinitis can influence patient's daily activity severely and may precede the development of asthma, especially if it is not diagnosed and treated correctly. In addition to subcutaneous immunotherapy, sublingual (...) immunotherapy (SLIT) represents the only treatment being potentially able to cure allergic respiratory diseases, by modulating the immune system activity. This review clearly summarizes and analyzes the available randomized, double-blinded, placebo-controlled trials, which aimed at evaluating the effectiveness and the safety of grass pollen and house dust mite SLIT for the specific treatment of pediatric allergic rhinitis. Our analysis demonstrates the good evidence supporting the efficacy of SLIT

2016 World journal of clinical pediatrics

134. Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut Full Text available with Trip Pro

Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut Allergen-specific immunotherapy has been proposed as an attractive strategy to actively treat food allergy using the following three different immunotherapy routes: oral (OIT), sublingual (SLIT) and epicutaneous (EPIT) immunotherapy. Regulatory T cells (Tregs) have been shown to have a pivotal role in the mechanisms (...) of immunotherapy. The aim of this study was to compare the phenotype and function of Tregs induced in peanut-sensitized BALB/c mice using these three routes of treatment. We show that although EPIT, OIT and SLIT were all able to effectively desensitize peanut-sensitized mice, they induced different subsets of Tregs. Foxp3+ Tregs were induced by the three treatment routes but with greater numbers induced by EPIT. EPIT and OIT also increased the level of LAP+ Tregs, whereas SLIT induced IL-10+ cells

2016 Cellular and Molecular Immunology

135. Critical appraisal of the clinical utility of sublingual immunotherapy in allergy Full Text available with Trip Pro

Critical appraisal of the clinical utility of sublingual immunotherapy in allergy Since it was introduced by Noon in 1911, allergen-specific immunotherapy or desensitization has been widely prescribed in the management of allergic diseases. Aimed at the etiology, it represents the only effective treatment for allergy. The basic mechanisms of immunotherapy are becoming better understood and allow us to improve this technique in the future. The sublingual immunotherapy as an alternative (...) to subcutaneous route has been widely studied. Several clinical trials confirmed that sublingual immunotherapy is efficient in reducing allergic respiratory symptoms. The sublingual immunotherapy reduces the risk of developing serious side effects due to desensitization. We performed a literature review in order to remind the mechanisms of action and to demonstrate efficacy and tolerability of the sublingual immunotherapy in the treatment of allergic rhinoconjunctivitis and asthma and its impact

2016 Contemporary clinical trials communications

136. Importance of Quality of Life for Adherence to Sublingual Immunotherapy Full Text available with Trip Pro

Importance of Quality of Life for Adherence to Sublingual Immunotherapy Background. Nonperception of efficacy ranks among the most commonly cited causes for nonadherence to sublingual immunotherapy (SLIT). Quality of life (QoL) in patients is a determining factor influencing adherence. We investigated QoL and adherence separately in SLIT patients at one pediatric practice in Germany. Methods. We conducted a noninterventional, cross-sectional, retrospective, quality-of-life survey among

2016 BioMed research international

137. Lung-derived innate cytokines: new epigenetic targets of allergen-specific sublingual immunotherapy Full Text available with Trip Pro

Lung-derived innate cytokines: new epigenetic targets of allergen-specific sublingual immunotherapy Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished.BALB/c mice were sensitized (...) intraperitoneally and challenged intranasally. Then, they received sublingual treatment with recombinant Che a 2 (rChe a 2), a major allergen of Chenopodium album. After SLIT, allergen-specific antibodies in sera, cytokine profiles of spleen cell cultures, mRNA and protein expression of lung-derived IL-33, IL-25, and TSLP (thymic stromal lymphopoietin), and histone modifications of these three genes were assessed.Following Immunotherapy, systemic immune responses shifted from Th2 to Th1 profile as demonstrated

2016 Iranian journal of basic medical sciences

138. Sublingual immunotherapy for allergic rhinitis: subjective versus objective tools to evaluate its success. Full Text available with Trip Pro

Sublingual immunotherapy for allergic rhinitis: subjective versus objective tools to evaluate its success. Biomarkers that enable objective evaluation of the clinical effects of immunotherapy for allergic rhinitis have yet to be identified.This study included 40 patients who were enrolled in a large randomized, double-blind, placebo-controlled, multicenter study examining the efficacy of sublingual immunotherapy (SLIT) using Japanese cedar (JC) pollen extract during two consecutive pollen

2016 Rhinology Controlled trial quality: uncertain

139. SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis. (Abstract)

SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis. Allergy immunotherapy is a treatment option for allergic rhinoconjunctivitis (ARC). It is unique compared with pharmacotherapy in that it modifies the immunologic pathways that elicit an allergic response. The SQ Timothy grass sublingual immunotherapy (SLIT) tablet is approved in North America and throughout Europe for the treatment of adults and children (≥5 years old

2016 Allergy and Asthma Proceedings Controlled trial quality: uncertain

140. A double blind, randomized, placebo controlled trial of the efficacy, quality of life and safety of food allergen-specific sublingual immunotherapy in client owned dogs with adverse food reactions: a small pilot study. (Abstract)

A double blind, randomized, placebo controlled trial of the efficacy, quality of life and safety of food allergen-specific sublingual immunotherapy in client owned dogs with adverse food reactions: a small pilot study. Food allergen-specific sublingual immunotherapy (FA-SLIT) has emerged as a novel and successful approach for desensitizing human patients to specific food allergens. It has not been tested in dogs.To investigate the efficacy, quality of life (QoL), tolerability and safety of FA (...) % of the owners, whereas placebo was rated as ineffective by all owners.FA-SLIT was effective, well tolerated and safe. No severe adverse events were recorded; erythema and pruritus were reported in association with only 0.7% of the dispensed doses. Larger clinical trials with more extended maintenance immunotherapy periods will be needed to provide more precise estimates of efficacy and frequency of adverse events.© 2016 ESVD and ACVD.

2016 Veterinary dermatology Controlled trial quality: predicted high

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