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Sublingual Immunotherapy

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61. Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre-school children. Full Text available with Trip Pro

Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre-school children. The preventive effect of allergen immunotherapy (AIT) on allergy and asthma development is currently assessed using primary and secondary AIT approaches. Knowledge of the immunological effects of these interventions is limited and the impact on epitope diversity remains to be defined.We used high-density peptide arrays that included all known Dermatophagoides pteronyssinus (Der p (...) diversity was seen. At 24 months of treatment, IgG4 diversity for HDM allergens was significantly higher in the pAIT-treated patients compared to placebo group (P < 0.05). Potentially beneficial changes in epitope recognition throughout the treatment are also seen in peptides derived from Der f proteome.These data suggest a beneficial immunomodulation of preventive sublingual immunotherapy at a molecular level by favoring a broader blocking repertoire and inhibiting epitope spreading.© 2018 EAACI

2018 Allergy Controlled trial quality: uncertain

62. Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy. (Abstract)

Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy. Although Th2 cells are well known to play important roles in allergic diseases including allergic rhinitis (AR), the factors that induce and sustain the pathogenesis of AR remain unclear. The recent development of sublingual immunotherapy (SLIT) is expected to allow changes to the underlying pathogenesis of AR. However, which Th2 cell subsets are important in house dust mite

2018 Allergy Controlled trial quality: uncertain

63. An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis. Full Text available with Trip Pro

An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis. Sublingual immunotherapy (SLIT) can improve the symptoms of allergic rhinitis and modify its natural history; however, its efficacy varies among patients. This study aimed to determine which factors modify the effect of SLIT through post hoc analysis of a previous phase 3 trial of standardized Japanese cedar (JC) pollen extract (CEDARTOLEN®).The study included 482

2018 Allergology international : official journal of the Japanese Society of Allergology Controlled trial quality: uncertain

64. Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites Full Text available with Trip Pro

Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites This study aims to determine the efficacy and safety of house dust mite (HDM)-sublingual immunotherapy (SLIT) in elderly patients with AR.A total of 45 patients aged ≥ 60 years with HDM-induced AR who had ≥ 3 A/H ratio on skin prick test and/or ≥ 0.35 IU/L to both Dermatophagoides farinae and Dermatophagoides pteronyssinus by ImmunoCAP were enrolled in 4 university hospitals. To evaluate

2018 Allergy, asthma & immunology research Controlled trial quality: uncertain

65. Systematic review: Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma

Systematic review: Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma Article Text Aetiology Systematic review Sublingual immunotherapy improves symptoms of allergical

2014 Evidence-Based Medicine

66. Oral and Sublingual Immunotherapy: Potential Causes for Eosinophilic Gastrointestinal Disorders? (Abstract)

Oral and Sublingual Immunotherapy: Potential Causes for Eosinophilic Gastrointestinal Disorders? Food allergy is a common health problem worldwide, with increasing prevalence during recent decades. The only approved treatments for food allergy are food avoidance and administration of emergency medications in case of accidental exposure, which negatively affects patients' quality of life, so new treatments are highly desirable. Different food immunotherapy modalities have recently been used (...) , with variable success rates in the induction of desensitization and tolerance, and different numbers and types of adverse reactions. Adverse reactions, especially intolerable gastrointestinal symptoms, are the most important causes of immunotherapy withdrawal. Eosinophilic esophagitis has been reported as a complication of milk, egg, and peanut oral immunotherapies and sublingual immunotherapy for respiratory allergies, but not for food allergies. Eosinophilic gastritis and eosinophilic colitis also rarely

2017 International Archives of Allergy and Immunology

67. Long-Term Effect of Sublingual and Subcutaneous Immunotherapy in Dust Mite-Allergic Children With Asthma/Rhinitis: A 3-Year Prospective Randomized Controlled Trial. (Abstract)

Long-Term Effect of Sublingual and Subcutaneous Immunotherapy in Dust Mite-Allergic Children With Asthma/Rhinitis: A 3-Year Prospective Randomized Controlled Trial. Specific allergen immunotherapy is the only treatment modality that might change the natural course of allergic diseases in childhood. We sought to prospectively compare the long-term clinical and immunological effects of sublingual (SLIT) and subcutaneous (SCIT) immunotherapy compared with pharmacotherapy alone.In this single

2016 Journal of investigational allergology & clinical immunology Controlled trial quality: uncertain

68. Satisfaction and quality of life of allergic patients following sublingual five-grass pollen tablet immunotherapy in Spain Full Text available with Trip Pro

Satisfaction and quality of life of allergic patients following sublingual five-grass pollen tablet immunotherapy in Spain Five-grass pollen tablet is an effective and well-tolerated therapy for patients with allergic rhinoconjunctivitis (ARC). This trial sought to determine the satisfaction and health-related quality of life (HRQoL) of patients undergoing this treatment.This was a cross-sectional, multicentre, observational, naturalistic study, following a discontinuous pre- and co-seasonal (...) five-grass pollen regimen over two seasons in Spain (2012, 2013). The HRQoL of the patients was measured with the specific Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) for adults, adolescent (AdolRQLQ), or paediatric (PRQLQ) patients. Treatment satisfaction was assessed by the Satisfaction Scale for Patients Receiving Allergen Immunotherapy (ESPIA) questionnaire. Patients/investigators were surveyed on beliefs and attitudes towards the five-grass pollen tablet. ARC evolution according

2017 Drugs in context

69. The effects of house dust mite sublingual immunotherapy (SLIT)-tablet effects on immunological biomarkers and nasal allergen challenge symptoms. Full Text available with Trip Pro

The effects of house dust mite sublingual immunotherapy (SLIT)-tablet effects on immunological biomarkers and nasal allergen challenge symptoms. 28911971 2018 05 04 1097-6825 141 2 2018 Feb The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. The effects of house dust mite sublingual immunotherapy tablet on immunologic biomarkers and nasal allergen challenge symptoms. 785-788.e9 S0091-6749(17)31429-X 10.1016/j.jaci.2017.08.016 Gunawardana Natasha C NC Imperial Clinical

2017 Journal of Allergy and Clinical Immunology Controlled trial quality: uncertain

70. Could Sublingual Immunotherapy Affect Oral Health in Children with Asthma and/or Allergic Rhinitis Sensitized to House Dust Mite. (Abstract)

Could Sublingual Immunotherapy Affect Oral Health in Children with Asthma and/or Allergic Rhinitis Sensitized to House Dust Mite. Sublingual immunotherapy (SLIT) has been successfully employed in IgE-mediated respiratory allergies. However, it is not known whether the modulation of immune responses in the sublingual area during SLIT has any deleterious effect on oral health. We sought to determine the oral health prospectively in children receiving SLIT for house dust mite allergy.Eighteen

2017 International Archives of Allergy and Immunology

71. Differences and similarities between sublingual immunotherapy of allergy and oral tolerance. (Abstract)

Differences and similarities between sublingual immunotherapy of allergy and oral tolerance. Allergen immunotherapy is the only treatment altering the natural course of IgE-mediated allergies. Whereas the subcutaneous route for immunotherapy (SCIT) has been historically considered as a reference, we discuss herein the relative advantages of the sublingual and oral routes as alternatives to SCIT in order to elicit allergen-specific tolerance. The buccal and gut immune systems are similarly (...) organized to favor immune tolerance to antigens/allergens, due to the presence of tolerogenic dendritic cells and macrophages promoting the differentiation of CD4+ regulatory T cells. Sublingual immunotherapy (SLIT) is now established as a valid treatment option, with clinical efficacy demonstrated in allergic rhinoconjunctivitis (to either grass, tree, weed pollens or mite allergens) and encouraging results obtained in the management of mild/moderate allergic asthma. While still exploratory, oral

2017 Seminars in immunology

72. A randomized, double-blind, placebo controlled trial of sublingual immunotherapy with house-dust mite extract for allergic rhinitis. (Abstract)

A randomized, double-blind, placebo controlled trial of sublingual immunotherapy with house-dust mite extract for allergic rhinitis. This study was designed to evaluate the efficacy and safety of sublingual immunotherapy (SLIT) with house-dust mite (HDM) extract in Chinese patients with HDM-induced allergic rhinitis (AR).A randomized, double-blind, placebo controlled trial was conducted with the outpatients of the Eye, Ear, Nose, and Throat Hospital, Fudan University. Forty-eight patients were

2017 American journal of rhinology & allergy Controlled trial quality: predicted high

73. Effect of Sublingual Immunotherapy in Patients With Atopic Dermatitis

Effect of Sublingual Immunotherapy in Patients With Atopic Dermatitis Effect of Sublingual Immunotherapy in Patients With Atopic Dermatitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect (...) of Sublingual Immunotherapy in Patients With Atopic Dermatitis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03388866 Recruitment Status : Active, not recruiting First Posted : January 3, 2018 Last Update Posted : January 17, 2019 Sponsor: Casa Espirita Terra de Ismael Collaborator: Fundação de Amparo à

2017 Clinical Trials

74. Effectiveness of Specific Sublingual Immunotherapy in Korean Patients with Atopic Dermatitis Full Text available with Trip Pro

Effectiveness of Specific Sublingual Immunotherapy in Korean Patients with Atopic Dermatitis Sublingual immunotherapy (SLIT) with house dust mites (HDM) preparation has recently been proven to be beneficial for treating allergic rhinitis and asthma. However, there has been no report regarding the efficacy and safety of SLIT in Korean patients with atopic dermatitis (AD).We intended to investigate the efficacy and safety of SLIT in Korean patients with AD.A total of 34 patients with AD

2017 Annals of dermatology

75. Effect of adjuvanted and standard sublingual immunotherapy on respiratory function in pure rhinitis due to house dust mite over a 5-year period Full Text available with Trip Pro

Effect of adjuvanted and standard sublingual immunotherapy on respiratory function in pure rhinitis due to house dust mite over a 5-year period Allergen-specific immunotherapy (AIT) still remains the only causal treatment for IgE mediated respiratory diseases (rhinitis/asthma) In addition to the observed clinical decrease in symptoms, AIT can provide a long-lasting and preventive effect. In particular it can modify the progression from rhinitis to asthma.The study was observational, open, non

2017 The World Allergy Organization journal

76. Evaluation of a sublingual immunotherapy solution in olive-induced respiratory allergy in Jordan: a retrospective observational study Full Text available with Trip Pro

Evaluation of a sublingual immunotherapy solution in olive-induced respiratory allergy in Jordan: a retrospective observational study Olive pollen is an important cause of respiratory allergy in the Middle East. In this study, the clinical characteristics of adults and children with confirmed allergic rhinitis (AR; with or without asthma) in Jordan were described, and the use of sublingual immunotherapy (SLIT) in a real-life clinical setting was assessed.This retrospective observational study

2017 Journal of asthma and allergy

77. Pharmacoeconomics of sublingual immunotherapy with the 5-grass pollen tablets for seasonal allergic rhinitis Full Text available with Trip Pro

Pharmacoeconomics of sublingual immunotherapy with the 5-grass pollen tablets for seasonal allergic rhinitis Allergic rhinitis has a very high burden regarding both direct and indirect costs. This makes essential in the management of AR to reduce the clinical severity of the disease and thus to lessen its costs. This particularly concerns allergen immunotherapy (AIT), that, based on its immunological action on the causes of allergy, extends its benefit also after discontinuation (...) of the treatment. From the pharmacoeconomic point of view, any treatment must be evaluated according to its cost-effectiveness, that is, the ratio between the cost of the intervention and its effect. A favorable cost-benefit ratio for AIT was defined, starting from the first studies in the 1990s on subcutaneous immunotherapy (SCIT) in AR patients, that highlighted a clear advantage on costs over the treatment with symptomatic drugs. Such outcome was confirmed also for sublingual immunotherapy (SLIT), that has

2017 Clinical and molecular allergy : CMA

78. Corrigendum: Subcutaneous and Sublingual Immunotherapy in Allergic Asthma in Children Full Text available with Trip Pro

Corrigendum: Subcutaneous and Sublingual Immunotherapy in Allergic Asthma in Children [This corrects the article on p. 82 in vol. 5, PMID: 28484690.].

2017 Frontiers in pediatrics

79. Debut of Gastroesophageal Reflux Concomitant with Administration of Sublingual Immunotherapy Full Text available with Trip Pro

Debut of Gastroesophageal Reflux Concomitant with Administration of Sublingual Immunotherapy Gastroesophageal reflux disease (GORD) is an often debilitating condition characterised by retrograde flow of content from stomach into the oesophagus, where the low pH of the stomach acid irritates the mucosa of the oesophagus. The most dominant symptoms in GORD are pyrosis, regurgitation, and dysphagia. Sublingual immunotherapy (SLIT) was first described in 1986. Following this description, the use (...) to administration of sublingual immunotherapy for house dust mite in allergic rhinitis. The patient had to stop the SLIT after two weeks of administration due to GORD. The cessation resulted in rapid resolution of symptoms.

2017 Case reports in gastrointestinal medicine

80. Quality of life improvement after a three-year course of sublingual immunotherapy in patients with house dust mite and grass pollen induced allergic rhinitis: results from real-life Full Text available with Trip Pro

Quality of life improvement after a three-year course of sublingual immunotherapy in patients with house dust mite and grass pollen induced allergic rhinitis: results from real-life Along with its high prevalence, the burden of allergic rhinitis rests upon the serious impact on quality of life of patients. Allergic rhinitis is associated with impairments in daily activities, work and school performance, and practical problems. Patients suffer from sleep disorders and emotional problems. Тhe (...) advantages of sublingual immunotherapy on quality of life have only recently begun to emerge. The objective of this prospective real-life study was to evaluate the effect of a three-year course of sublingual immunotherapy with house dust mite (HDM) and grass pollen extracts on quality of life in adults with allergic rhinitis.A total number of 191 adult patients [105 (54,979%) men; mean age 27.3 years (SD-6.14)] with moderate to severe allergic rhinitis and clinically relevant sensitization to house dust

2017 Health and quality of life outcomes

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