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Sublingual Immunotherapy

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21. Long-Term Efficacy of Sublingual Mite Immunotherapy in Monosensitized and Polysensitized Children with Allergic Rhinitis: A 7-Year Prospective Study. (PubMed)

Long-Term Efficacy of Sublingual Mite Immunotherapy in Monosensitized and Polysensitized Children with Allergic Rhinitis: A 7-Year Prospective Study. Several foreign studies have shown long-term efficacy of sublingual immunotherapy (SLIT), but data on the long-term efficacy of SLIT in China are still lacking.We aimed to prospectively evaluate the long-term efficacy of a 2-year SLIT with Dermatophagoides farinae(D. farinae) drops in mono- and polysensitized children with allergic rhinitis (AR

2019 International Archives of Allergy and Immunology

22. Induction of IgG<sub>2</sub> and IgG<sub>4</sub> B-cell memory following sublingual immunotherapy for ryegrass pollen allergy. (PubMed)

Induction of IgG2 and IgG4 B-cell memory following sublingual immunotherapy for ryegrass pollen allergy. Whilst treatment for atopic rhinitis is aimed mostly to relieve symptoms, only allergen-specific immunotherapy (AIT) is targeted to modify the natural history of allergic diseases. This results in sustained clinical tolerance, even when treatment has stopped. The immunomodulatory effects of AIT are attributed mainly to increased regulatory T cell function and increased (...) allergen-specific IgG4 , yet little is known about the effect on the memory B cell compartment.We aimed to examine the effects of AIT on the IgE and IgG subclass expressing memory B cells.We recruited 29 patients with atopic seasonal rhinoconjunctivitis and performed a longitudinal analysis of the peripheral immune compartment before, during and after sublingual immunotherapy (SLIT) for allergy to temperate grass pollen, predominantly to ryegrass pollen (RGP; Lolium perenne). Using flow cytometry

2019 Allergy

23. Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization. (PubMed)

Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization. Peanut sublingual immunotherapy (SLIT) for 1 year has been shown to induce modest clinical desensitization in allergic children. Studies of oral immunotherapy, epicutaneous immunotherapy, and SLIT have suggested additional benefit with extended treatment.We sought to investigate the safety, clinical effectiveness, and immunologic changes with long-term SLIT in children

2019 Journal of Allergy and Clinical Immunology

24. Quality-of-life outcomes in patients who underwent subcutaneous immunotherapy and sublingual immunotherapy in a real-world clinical setting. (PubMed)

Quality-of-life outcomes in patients who underwent subcutaneous immunotherapy and sublingual immunotherapy in a real-world clinical setting. To compare changes in quality of life (QOL) that resulted from sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT) in a real-world clinical setting.SLIT is established as a viable alternative to SCIT for the treatment of allergic rhinitis. Although comparative trials are increasingly available, few studies have examined QOL outcomes (...) between these two treatments.One hundred and five participants who underwent immunotherapy for airborne allergies were enrolled in this prospective, single-center study. Forty participants completed the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) at initiation of therapy, after 6 months, and after 1 year of therapy. Only patients with complete time points were included in the ultimate analysis. Twenty-nine of these participants underwent SCIT and 11 underwent SLIT. The effects of age, sex

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2017 American journal of rhinology & allergy

25. [Sublingual immunotherapy for respiratory allergies]

[Sublingual immunotherapy for respiratory allergies] L'immunothérapie sublinguale comme traitement des allergies respiratoires [Sublingual immunotherapy for respiratory allergies] L'immunothérapie sublinguale comme traitement des allergies respiratoires [Sublingual immunotherapy for respiratory allergies] Martin G Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made (...) for the HTA database. Citation Martin G. L'immunothérapie sublinguale comme traitement des allergies respiratoires . [Sublingual immunotherapy for respiratory allergies] . Quebec: Institut national d'excellence en sante et en services sociaux (INESSS). 2013 Final publication URL Indexing Status Subject indexing assigned by CRD MeSH Administration, Sublingual; Desensitization, Immunologic; Humans; Respiratory Hypersensitivity Language Published French Country of organisation Canada Province or state Quebec

2014 Health Technology Assessment (HTA) Database.

26. Comparative analysis of the oral mucosae from rodents and non-rodents: Application to the nonclinical evaluation of sublingual immunotherapy products. (PubMed)

Comparative analysis of the oral mucosae from rodents and non-rodents: Application to the nonclinical evaluation of sublingual immunotherapy products. A comparative characterization of the oral mucosa in various animals is needed to identify the best animal model(s) for nonclinical evaluation of sublingual immunotherapy products. With this aim, we studied the histological characteristics and immune cell infiltrates of oral mucosae from common animal species.Three oral regions (i.e. ventral (...) of minipigs and monkeys are closest to that of humans, and the immune networks are quite similar between all rodents and non-rodents. Taking into account the ethical and logistical difficulties of performing research in the latter species, rodents and especially mice, should preferentially be used for pharmacodynamics/efficacy studies. Our data also support the use of minipigs to perform biodistribution and safety studies of sublingual immunotherapy products.

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2017 PLoS ONE

27. Long-Term Effect of Sublingual and Subcutaneous Immunotherapy in Dust Mite-Allergic Children With Asthma/Rhinitis: A 3-Year Prospective Randomized Controlled Trial. (PubMed)

Long-Term Effect of Sublingual and Subcutaneous Immunotherapy in Dust Mite-Allergic Children With Asthma/Rhinitis: A 3-Year Prospective Randomized Controlled Trial. Specific allergen immunotherapy is the only treatment modality that might change the natural course of allergic diseases in childhood. We sought to prospectively compare the long-term clinical and immunological effects of sublingual (SLIT) and subcutaneous (SCIT) immunotherapy compared with pharmacotherapy alone.In this single

2016 Journal of investigational allergology & clinical immunology

28. [Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma]

[Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma] [Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma] [Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma] S Shin, HJ Song, SY Park, YJ Jung, JY Park, J Ahn, YM Yea Record Status This is a bibliographic record of a published health (...) technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation S Shin, HJ Song, SY Park, YJ Jung, JY Park, J Ahn, YM Yea. [Assessment of the effectiveness of sublingual immunotherapy and subcutaneous immunotherapy in allergic rhinitis and asthma] Seoul: National Evidence-based Healthcare Collaborating Agency (NECA). NECA-A-11-006. 2011 Authors' conclusions Disease burdens of allergic rhinitis and asthma have recently been

2011 Health Technology Assessment (HTA) Database.

29. Systematic review: Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma

Systematic review: Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Sublingual immunotherapy improves symptoms of allergical rhinoconjunctivitis and asthma Article Text Aetiology Systematic review Sublingual immunotherapy improves symptoms of allergical

2014 Evidence-Based Medicine (Requires free registration)

30. Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review

Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review Lin SY, Erekosima N, Kim JM, Ramanathan M, Suarez-Cuervo C, Chelladurai Y, Ward D, Segal JB CRD summary This well-conducted review concluded that there was moderate evidence (...) to support the effectiveness of sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma, but high-quality trials were needed to determine the best dosing strategies. These findings are likely to be reliable. Authors' objectives To systematically review the effectiveness and safety of aqueous sublingual immunotherapy for allergic rhinoconjunctivitis and asthma. Searching The following databases were searched for articles from inception to December 2012: MEDLINE, EMBASE

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2013 DARE.

31. Sublingual dust mite immunotherapy for asthma. (PubMed)

Sublingual dust mite immunotherapy for asthma. 27174742 2018 03 21 2018 03 21 2213-2619 4 6 2016 06 The Lancet. Respiratory medicine Lancet Respir Med Sublingual dust mite immunotherapy for asthma. 436 10.1016/S2213-2600(16)30101-1 S2213-2600(16)30101-1 Harding Emilia E eng Comparative Study Multicenter Study News Randomized Controlled Trial 2016 05 09 England Lancet Respir Med 101605555 2213-2600 0 Antigens, Dermatophagoides IM Adult Animals Antigens, Dermatophagoides administration & dosage (...) Asthma diagnosis immunology therapy Double-Blind Method Female Humans Male Mites Prospective Studies Reference Values Severity of Illness Index Sublingual Immunotherapy methods Treatment Outcome United Kingdom 2016 5 14 6 0 2016 5 14 6 0 2018 3 22 6 0 ppublish 27174742 S2213-2600(16)30101-1 10.1016/S2213-2600(16)30101-1

2018 The lancet. Respiratory medicine

32. [Efficacy of sublingual immunotherapy with dermatophagoides farinae drops in children with allergic rhinitis and the change of TGF-β and IL-13 mRNA level]. (PubMed)

[Efficacy of sublingual immunotherapy with dermatophagoides farinae drops in children with allergic rhinitis and the change of TGF-β and IL-13 mRNA level]. Objective:The aim of this study is to evaluate the efficacy of sublingual immunotherapy (SLIT) with standardized dermatophagoides farinae drops and to examine the change of TGF-β and IL-13 mRNA level after 12 months SLIT in children with allergic rhinitis (AR). Method:Ninety-two children with AR were collected and randomly divided into two (...) groups: SLIT group (n=62) and control group (n=30). Before and after SLIT for 6 months and 12 months, total nasal symptoms score (TNSS) and total medication score (TMS) were evaluated. In addition, the mRNA expression of TGF-β and IL-13 in peripheral blood mononuclear cells of AR children after immunotherapy were examined by qRT-PCR. Result:There were significant differences (P<0.01) in symptom and medication scores between the two groups after 12 months treatment. The patients in SLIT group had

2018 Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

33. Basophil biomarkers as useful predictors for sublingual immunotherapy in allergic rhinitis. (PubMed)

Basophil biomarkers as useful predictors for sublingual immunotherapy in allergic rhinitis. Prevalence of allergic diseases is increasing worldwide. Allergen-specific immunotherapy (ASIT) is potentially the only curative treatment for allergy, but there is a lack of reliable methods to monitor the immune responses to ASIT and to predict clinical efficacy. Recently, the definition of allergen sensitivity threshold (CD-Sens) by Basophil Activation Tests has been suggested as potential method (...) in this context. The aim of this study was to compare trends of CD-Sens, measured by the markers CD63 and CD203c, and clinical symptoms in subjects with allergic rhinitis receiving Sublingual Immunotherapy (SLIT). 26 rhinitis patients allergic to Parietaria were selected and matched into two groups; a SLIT treated group (SG) and a reference group (RG) treated by traditional anti-allergic medications. Visual Analogue Scale (VAS) score for the four cardinal symptoms of rhinitis and peripheral blood

2018 International immunopharmacology

34. An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis. (PubMed)

An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis. Sublingual immunotherapy (SLIT) can improve the symptoms of allergic rhinitis and modify its natural history; however, its efficacy varies among patients. This study aimed to determine which factors modify the effect of SLIT through post hoc analysis of a previous phase 3 trial of standardized Japanese cedar (JC) pollen extract (CEDARTOLEN®).The study included 482

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2018 Allergology international : official journal of the Japanese Society of Allergology

35. Prolonged effect of allergen sublingual immunotherapy to grass pollen. (PubMed)

Prolonged effect of allergen sublingual immunotherapy to grass pollen. The prolonged effect of allergen immunotherapy is unknown, especially in older patients.The three-year effect of sublingual allergen-specific immunotherapy (AIT) to grass pollen on elderly patients with allergic rhinitis was analyzed.Thirty-eight elderly patients (63.18 ± 3.12 yrs.) underwent AIT to grass pollen, were monitored for three years and were compared to a placebo group. AIT was performed with the use of an oral

2018 Human vaccines & immunotherapeutics

36. Sublingual allergen immunotherapy with a liquid birch pollen product in seasonal allergic rhinoconjunctivitis with/without asthma. (PubMed)

Sublingual allergen immunotherapy with a liquid birch pollen product in seasonal allergic rhinoconjunctivitis with/without asthma. Sublingual allergen immunotherapy (SLIT) has been demonstrated to be both clinically efficacious and safe. However, in line with the current regulatory guidance from the European Medicines Agency, allergen immunotherapy (AIT) products must demonstrate their efficacy and safety in pivotal phase III trials for registration.We sought to investigate the efficacy (...) and safety of sublingual high-dose liquid birch pollen extract (40,000 allergy units native [AUN]/mL) in adults with birch pollen allergy.A randomized, double-blind, placebo-controlled, parallel-group multicenter trial was conducted in 406 adult patients with moderate-to-severe birch pollen-induced allergic rhinoconjunctivitis with or without mild-to-moderate controlled asthma. Treatment was started 3 to 6 months before the birch pollen season and continued during the season in 40 clinical study centers

2018 Journal of Allergy and Clinical Immunology

37. Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy. (PubMed)

Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy. Although Th2 cells are well known to play important roles in allergic diseases including allergic rhinitis (AR), the factors that induce and sustain the pathogenesis of AR remain unclear. The recent development of sublingual immunotherapy (SLIT) is expected to allow changes to the underlying pathogenesis of AR. However, which Th2 cell subsets are important in house dust mite

2018 Allergy

38. Single vs multiallergen sublingual immunotherapy in the polysensitized patient: a pilot study. (PubMed)

Single vs multiallergen sublingual immunotherapy in the polysensitized patient: a pilot study. Sublingual immunotherapy (SLIT) has emerged as an effective and exceptionally safe method of treatment of the atopic patient. However, the optimal number of allergens that should be included in the SLIT treatment regimen for the polysensitized patient is not known and practices vary widely. This study aims to compare the efficacy of single-allergen SLIT with pauci-allergen vs multiallergen aqueous

2018 International forum of allergy & rhinology

39. A Three-Year Course of House Dust Mite Sublingual Immunotherapy Appears Effective in Controlling the Symptoms of Allergic Rhinitis. (PubMed)

A Three-Year Course of House Dust Mite Sublingual Immunotherapy Appears Effective in Controlling the Symptoms of Allergic Rhinitis. Background Allergic rhinitis is the most common allergic disorder. Although the management of the disease is successful in many patients, based on guidelines, some of them remain with symptoms uncontrolled with pharmacotherapy. Presently, there is no substantiated information on the control of allergic rhinitis in patients who underwent sublingual immunotherapy (...) . Objective The purpose of this prospective follow-up study was to assess the control of allergic rhinitis in adults after a three-year course of house dust mite sublingual immunotherapy. Methods This prospective real-life study was designed to include adults with moderate to severe allergic rhinitis sensitized to house dust mite who underwent a three-year course of sublingual immunotherapy. Control of symptoms was assessed by Rhinitis Control Assessment Test (RCAT) after three years of house dust mite

2018 American journal of rhinology & allergy

40. Oral and Sublingual Immunotherapy for Treatment of IgE-Mediated Food Allergy. (PubMed)

Oral and Sublingual Immunotherapy for Treatment of IgE-Mediated Food Allergy. Development of active therapies for IgE-mediated food allergy is a critical action step toward alleviating the adverse medical, psychosocial, and economic burdens on affected patients and families. Significant progress has been observed specifically in the application of single-allergen oral and sublingual immunotherapy for treatment of IgE-mediated food allergy, with emphasis on milk, egg, and peanut as the primary (...) events ranging from self-limited or easily treated oropharyngeal, respiratory or gastrointestinal symptoms, to persistent abdominal complaints that lead to cessation of therapy in an estimated 10-15% of treated individuals. To date, the majority of studies have focused on single-allergen OIT approaches; however, multi-allergen OIT has shown promise in initial trials and is the subject of ongoing investigation to address the complex needs of multi-food allergic individuals. Sublingual immunotherapy

2018 Clinical Reviews in Allergy & Immunology

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