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Subcutaneous Fat Necrosis

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141. Management of Acute Myocardial Infarction in patients presenting with ST-segment elevation Full Text available with Trip Pro

With Acute Myocardial Infarction RIFLE- STEACS Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome RIVAL Radial Versus Femoral Access for Coronary intervention RV right ventricle/ventricular SaO 2 arterial oxygen saturation SBP systolic blood pressure s.c. subcutaneous SGLT2 sodium-glucose co-transporter-2 SPECT single-photon emission computed tomography STEMI ST-segment elevation myocardial infarction STREAM STrategic Reperfusion Early After Myocardial infarction TIMI (...) of evidence being based on expert opinion, this Task Force decided to add references to guide the reader regarding data that were taken into consideration for these decisions in some cases. 2.1 Definition of acute myocardial infarction The term acute myocardial infarction (AMI) should be used when there is evidence of myocardial injury (defined as an elevation of cardiac troponin values with at least one value above the 99th percentile upper reference limit) with necrosis in a clinical setting consistent

2017 European Society of Cardiology

143. Spherox (spheroids of human autologous matrix-associated chondrocytes) - to repair defects to the cartilage in the knee

Unexpected Serious Adverse Reaction TGF-ß Tumour growth factor TIMP Tissue Inhibitors of Matrix Metalloproteinases TNF Tumour necrosis factor USA or US United States of America VAM Swiss Drug Regulation VAS Visual Analogue Scale WBC White Blood Cell WOMAC-D-Osteoarthritis Index Western Ontario and Mc Master Universities Arthritis Index ZKBS Zentrale Kommission für Biologische Sicherheit, central commission for biological safety ?-GT Gamma glutamyltransferase CHMP assessment report EMA/349863/2017 Page 9

2017 European Medicines Agency - EPARs

144. Ribociclib (Kisqali) - breast cancer

max 2683 ng/mL, which is in a similar range as the exposure achieved at a dose of 600 mg once daily in humans. When ribociclib was combined with the ER antagonist fulvestrant, at 5 mg/week (subcutaneous injection), the anti-tumour effect was enhanced. The anti-tumour activity of ribociclib was further tested in patient-derived ER+ breast cancer xenograft models (PDX191, HBCx-34) in athymic nude mice. Ribociclib administered at 75 mg/kg/day 6 days/week for 40 days caused significant tumour growth

2017 European Medicines Agency - EPARs

145. Pentosan polysulfate sodium (Elmiron) - Interstitial Cystitis

studies (randomized, double-blind, placebo controlled) conducted in Europe which enrolled 115 patients in 7 centres in Denmark and the UK (Holm-Bentzen et al 1987). Another randomized active-controlled study comparing PPS versus Cyclosporine A was conducted in Europe and published in 2005. This study enrolled 64 patients in 7 Finnish urological units (Sairanen et al 2005). A clinical study conducted in Germany included 58 patients in order to evaluate the safety and efficacy of subcutaneous low-dose

2017 European Medicines Agency - EPARs

146. What Is the Utility of Ultrasonography for the Identification of Skin and Soft Tissue Infections in the Emergency Department? Full Text available with Trip Pro

: a report of three cases. J Emerg Med . 2014 ; 47 : 420–426 | | | | | On ultrasonography, abscesses will generally appear spherical or ovoid, although irregular borders are also commonly observed. They tend to have hypoechoic centers, and peripheral hyperemia may be noted. Cellulitis presents with hyperechoic, subcutaneous fat lobules floating in edematous fluid, referred to as “cobblestoning.” However, many abscesses are surrounded by a rim of cellulitis, so it is important to visualize the entire area (...) abscesses, pyomyositis, and necrotizing fasciitis. x 5 Talan, D.A., Mower, W.R., Krishnadasan, A. et al. Trimethoprim-sulfamethoxazole versus placebo for uncomplicated skin abscess. N Engl J Med . 2016 ; 374 : 823–832 | | | , x 6 Pulia, M.S., Calderone, M.R., Meister, J.R. et al. Update on management of skin and soft tissue infections in the emergency department. Curr Infect Dis Rep . 2014 ; 16 : 418 | | | , x 7 Kumar, M.P., Seif, D., Perera, P. et al. Point-of-care ultrasound in diagnosing pyomyositis

2017 Annals of Emergency Medicine Systematic Review Snapshots

147. Padeliporfin (Tookad) - prostate cancer / Prostatic Neoplasms

parameter CRF case report form CSR Clinical Study Report CTCAE Common Terminology Criteria for Adverse Events CTGC Central Treatment Guidance Committee DRE digital rectal examination DSMB Data Safety Monitoring Board EC European Commission ECG electrocardiogram EMA European Medicines Agency EPN Extra-prostatic necrosis EQ-5D EuroQol-5D 5-ARI 5-a-reductase inhibitor EU European Union GC Gas Chromatography GCP Good Clinical Practice GLP Good Laboratory Practice GMP Good manufacturing practice HPLC High (...) with a light dose of 200 J/cm is efficient in inducing necrosis in the dog prostate. In addition, no major secondary effects, changes in heart rate, oximetry, or body temperature have been observed thus far. No evidence of thrombosis in other organs (lung, pulmonary artery, and liver tissues) has been observed, confirming that the VTP effect is localized to the prostate. The results of studies in other tissues such as biliary, lung and renal tissue did not reveal toxicity on haemodynamic parameters (data

2017 European Medicines Agency - EPARs

148. Guidance on Primary Biliary Cholangitis

% ± 9% with placebo. (53) Predictive factors for the development of cirrhosis included serum bilirubin greater than 1 mg/dL and moderate to severe lym- phocytic piecemeal necrosis on the liver biopsy. (68) The effect of UDCA therapy on the development of esophageal varices was addressed in a prospective study of 180 patients who received UDCA versus pla- cebo and were observed for up to 4 years (69) ; a total of 139 patients had no varices, and 41 had varices at base- line. After 4 years, the risk (...) in ALP is strongly related to the severity of ductopenia and inflamma- tion; the increase in aminotransferase activity and IgG levels mainly reflects the degree of periportal and lobular necrosis and inflammation; and hyperbiliru- binemia reflects the severity of ductopenia and biliary piecemeal necrosis. A rise in serum bilirubin, -globu- lins, and hyaluronic acid together with a fall in serum albumin and platelet count are the early indicators of the development of cirrhosis and portal hyperten

2018 American Association for the Study of Liver Diseases

150. Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments: A Scientific Statement From the American Heart Association

had more visceral and deep subcutaneous fat compared with superficial subcutaneous fat. South Asians had a greater amount of abdominal adipose tissue compared with NHWs. A cross-sectional survey comparing Indians, Pakistani, Bangladeshi, and Europeans from the Newcastle Heart Project demonstrated higher rates of obesity based on BMI >30 kg/m 2 in Indian and Pakistani people compared with Bangladeshis. However, the WHR was higher in Bangladeshi and Pakistani people compared with Indians. When all (...) studies using BMI versus waist-to-hip ratio (WHR). One limitation of relying on BMI is that it does not take into account the distribution of body fat differentials, which may be better assessed with WHR. The MASALA study done in the United States showed that compared with NHWs, South Asians were less physically active and had lower adiponectin and higher resistin levels. South Asians had lower BMI, body weight, and waist circumference compared with all other racial/ethnic minority groups except

2018 American Heart Association

151. Venetoclax (Venclyxto) - Chronic, B-Cell Lymphocytic Leukemia

administered at a single dose or at repetitive doses was evaluated. Subcutaneous as well as systemic xenograft models were subjected to venetoclax single-agent therapy. The set of toxicology studies was designed to support the development of venetoclax for the target indication based on ICH S9 and for future oncology indications outside of the scope of advanced cancer and falling under the ICH M3 (R2). Conduct of an in vivo micronucleus study, fertility and early embryonic development studies

2017 European Medicines Agency - EPARs

152. Obeticholic acid (Ocaliva) - Liver Cirrhosis, Biliary

intrahepatic portosystemic shunt TNF-a tumor necrosis factor-alpha TNF-ß tumor necrosis factor-beta UDCA ursodeoxycholic acid ULN upper limit(s) of normal VAS visual analog scale VLDL very low-density lipoprotein VLDLc very low-density lipoprotein cholesterol WHO World Health Organization WHODDE World Health Organization Drug Dictionary Enhanced Assessment report EMA/725757/2016 Page 7/129 1. Background information on the procedure 1.1. Submission of the dossier The applicant Intercept Italia s.r.l (...) conducted outside the community were carried out in accordance with the ethical standards of Directive 2001/20/EC. • Tabular overview of clinical studies Study No. Objective(s) Bioavailability (BA) Study Reports 747-104 To assess the effect of fed conditions (high fat, high calorie) on the PK of OCA D8601002 To evaluate safety and PK of DSP-1747 (OCA) after single and multiple oral administration of DSP-1747 in Japanese healthy adult male volunteers 747-113 1) Determine the absolute BA of OCA in healthy

2017 European Medicines Agency - EPARs

153. Renal Cell Carcinoma

of TFEB- ampli?ed RCCs that occur in older patients. These tumours pre- sented high-grade eosinophilic cells with necrosis and papillary or pseudopapillary architecture. The expression of melanocytic markers is variable and FISH analyses revealed high levels of TFEB gene ampli?cation. The prognosis of such tumours is poor with usually advanced stage and metastatic outcome [10]. Collecting duct carcinoma (CDC) or Bellini duct carcinoma remains a highly aggressive RCC arising from the renal collecting (...) | Escudier et al.• the presence of necrosis; • the presence of microscopic vascular invasion; • the pathological tumour, node and metastasis (pTNM) staging and • description of the non-neoplastic renal tissue. Biology Beyond the classical one gene–one histology paradigm, a more complex biological classi?cation of RCC (and especially of its clear cell histotype) is emerging [14]. First, RCC proved to be an extremely heterogeneous disease [15]; beyond the seminal genetic alteration (mutation, deletion

2019 European Society for Medical Oncology

155. CRACKCast E063 – Thermal Burns

, hemorrhagic blisters, minimal blanching, dry or moist surface Heal in 3+ weeks, or can progress to 3 rd degree burns In Kids: these can lead to severe scarring and contractures – and need excision and skin grafting if not healed by day 21. Third Degree Full-thickness – extend through entire dermis Stiff, white or tan colour, dry, leathery and insensate Require excision +/- grafting Fourth Degree Extend full-thickness and through subcutaneous fat to involve muscle or bone Stiff, charred skin ****Accuracy (...) in Perspective Tissue destruction caused by contact with heat, electrical current, radiation, or chemical agents Temperatures below 44 C are generally tolerated for long periods of time without injury Temperatures above 60 C cause protein denaturation in tissue Burn progression is a result of both necrosis and apoptosis of damaged cells The necrosis – passive process denaturing the lipid bilayer and ATP enzymes. Leading to cell swelling, loss of energy stores, and massive release of inflammatory mediators

2017 CandiEM

156. CrackCAST E136 – Bone and Joint Infections

back and take a listen of episodes 116 and 117 for more review. However, Bone & Joint infections are something to know about! Approximately 1% of all hospitalised patients have a Bone & Joint Infection, something Rosen’s calls BJIs… but lets’ not use that shorthand in radio format:) What are we talking about with this chapter? Orthopedic infections classified by site of involvement: Osseous (osteomyelitis) Articular (septic/ pyogenic/suppurative arthritis) Bursal (septic bursitis) Subcutaneous (...) ossifies, a little bacteria highway now exists again Blood cultures are often negative (see wisecracks) Contiguous +/- vascular insufficiency Involves the direct spread of bacteria from surrounding infected areas Causes most osteomyelitis in the appendicular skeleton (eg. foot, hand, skull, maxilla, and mandible) Eventually infected bone becomes necrotic from lack of blood supply, causing areas termed Bone is smart. To compensate it surrounds sequestra with new bone termed involucrum. This makes

2017 CandiEM

157. CRACKCast E120 – Dermatologic presentations

before going back to this case… So, your skin has three layers: Epidermis Keratinocytes Melanocytes Langerhans cells Dermis Connective tissue, fat, blood vessels, nerve endings, immune cells Subcutaneous layers Here’s a better approach: Make sure you ask about new foods, meds, soaps, pets, jewelry etc. (See Box 110.1 in Rosen’s for original diagram) Approach to the management of the unknown rash Time of onset Historical features Medical history Primary lesion Secondary lesion Distribution (...) : Old school definition minor (not life threatening) or major (can be life threatening) Associated with post infection or drug administration Thought to be IgM bound complex deposition in vasculature, causing badness. Now thought to be on spectrum with SJS and TEN Ie EM or SJS< 10% TBSA then grey zone of SJS / TEN 10-30% then TEN >30% Conflicting definitions exist Erythema Nodosum Source: Inflammatory conditions of the subcutaneous fat tissue Typical age group 12-20 Many causes! Eg: Strep infection

2017 CandiEM

159. Diarrhoea in Adult Cancer Patients: ESMO Clinical Practice Guidelines

Consider Clostridium dif?cile, Salmonella, Campylobacter and other causes of infectious colitis. CBC, complete blood count; i.v., intravenous; s.c., subcutaneous; tid, three times a day. Annals of Oncology Clinical Practice Guidelines Volume 29 | Supplement 4 | October 2018 doi:10.1093/annonc/mdy145 | iv135 Downloaded from by guest on 27 March 2019sepsis, neutropaenia, bleeding or dehydration, and patients with severe (...) the diarrhoea is often bloody [V, A]. Anticholinergic, antidiarrhoeal and opioid agents should be avoided since they may aggravate ileus [V, A]. The indications for and timing of surgical intervention are controversial. The mortality rate of patients who fail to respond to medical interventions is high and many patients may not be salvageable. Nonetheless, in selected patients, surgery may be helpful to avoid progressive bowel necrosis, perforation and to help control sepsis. Commonly cited indications

2018 European Society for Medical Oncology

160. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association Full Text available with Trip Pro

of the interleukin (IL) 1, IL-6, and tumor necrosis factor (TNF) signaling pathways. Study of the adaptive immune response demonstrated that both proinflammatory and regulatory T cells can be found in the circulation in the first week after fever onset. Expansion of the regulatory T-cell population after IVIG administration is associated with cessation of fever and clinical improvement. The self-limited nature of the disease coupled with a low rate of recurrence suggests emergence of T- and B-cell memory (...) meningitis, irritability), heart (myocarditis, pericarditis, valvulitis), urinary tract (pyuria), pancreas (pancreatitis), and lymph nodes (lymphadenopathy). Unfortunately, lymph node pathology is nonspecific and nondiagnostic. Intracytoplasmic inclusion bodies are commonly observed in ciliated bronchial epithelial cells in autopsied cases. , , A recently proposed model of KD arteriopathy identified 3 pathological processes. The first is a necrotizing arteritis that consists of a synchronized

2017 American Heart Association

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