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Subcutaneous Fat Necrosis

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121. Male Sexual Dysfunction

to successful intercourse with vardenafil determined in an at-home setting: a randomized, double-blind, placebo-controlled trial. J Sex Med, 2004. 1: 168. 205. Padma-Nathan, H., et al. Minimal time to successful intercourse after sildenafil citrate: results of a randomized, double-blind, placebo-controlled trial. Urology, 2003. 62: 400. 206. Rajagopalan, P., et al. Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor

2018 European Association of Urology

123. Renal Cell Carcinoma

. 185: 2035. 89. Novara, G., et al. Validation of the 2009 TNM version in a large multi-institutional cohort of patients treated for renal cell carcinoma: are further improvements needed? Eur Urol, 2010. 58: 588. 90. Waalkes, S., et al. Is there a need to further subclassify pT2 renal cell cancers as implemented by the revised 7th TNM version? Eur Urol, 2011. 59: 258. 91. Bertini, R., et al. Renal sinus fat invasion in pT3a clear cell renal cell carcinoma affects outcomes of patients without nodal (...) involvement or distant metastases. J Urol, 2009. 181: 2027. 92. Poon, S.A., et al. Invasion of renal sinus fat is not an independent predictor of survival in pT3a renal cell carcinoma. BJU Int, 2009. 103: 1622. 93. Bedke, J., et al. Perinephric and renal sinus fat infiltration in pT3a renal cell carcinoma: possible prognostic differences. BJU Int, 2009. 103: 1349. 94. Heidenreich, A., et al. Preoperative imaging in renal cell cancer. World J Urol, 2004. 22: 307. 95. Sheth, S., et al. Current concepts

2018 European Association of Urology

126. A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal

A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00851747 Recruitment Status : Terminated First Posted : February 26

2009 Clinical Trials

127. Partial breast irradiation for early breast cancer. (PubMed)

/APBI (HR 0.90, 95% CI 0.74 to 1.09, five studies, 6718 participants, high-quality evidence).Late radiation toxicity (subcutaneous fibrosis) appeared worse with PBI/APBI (OR 6.58, 95% CI 3.08 to 14.06, one study, 766 participants, moderate-quality evidence). Acute skin toxicity appeared reduced with PBI/APBI (OR 0.04, 95% CI 0.02 to 0.09, two studies, 608 participants). Telangiectasia (OR 26.56, 95% CI 3.59 to 196.51, 1 study, 766 participants) and radiological fat necrosis (OR 1.58, 95% CI 1.02

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2016 Cochrane

128. CRACKCast E120 – Dermatologic presentations

before going back to this case… So, your skin has three layers: Epidermis Keratinocytes Melanocytes Langerhans cells Dermis Connective tissue, fat, blood vessels, nerve endings, immune cells Subcutaneous layers Here’s a better approach: Make sure you ask about new foods, meds, soaps, pets, jewelry etc. (See Box 110.1 in Rosen’s for original diagram) Approach to the management of the unknown rash Time of onset Historical features Medical history Primary lesion Secondary lesion Distribution (...) : Old school definition minor (not life threatening) or major (can be life threatening) Associated with post infection or drug administration Thought to be IgM bound complex deposition in vasculature, causing badness. Now thought to be on spectrum with SJS and TEN Ie EM or SJS< 10% TBSA then grey zone of SJS / TEN 10-30% then TEN >30% Conflicting definitions exist Erythema Nodosum Source: Inflammatory conditions of the subcutaneous fat tissue Typical age group 12-20 Many causes! Eg: Strep infection

2017 CandiEM

129. CRACKCast E064 – Chemical Injuries

LIMITS the depth of acid penetration Their free hydrogen ions are easily neutralized on the skin by copious water irrigation Alkali compounds: Produce saponification and liquefactive necrosis of body fat – they produce soluble protein complexes which “permit the passage of hydroxyl ions deep into the tissue” and limiting the contact of the alkali complex on the surface of the skin. Because there is no eschar formation they usually penetrate DEEPER into the tissue 2) Describe a HAZMAT response (...) in Perspective Chemicals are everywhere, >10,000 new ones are made every year → be afraid! Most susceptible organs: skin, eyes, lungs Most commonly release substances: Volatile organic compounds (VOC’s) Herbicides Acids Ammonia Cement Drain cleaner Gasoline Pathophysiology: Most cause damage through a chemical reaction with the skin 1) Describe the difference between Alkali and Acid injuries Acidic compounds: Cause protein denaturation and coagulative necrosis with the skin The necrosis forms eschar → which

2017 CandiEM

130. CRACKCast E063 – Thermal Burns

, hemorrhagic blisters, minimal blanching, dry or moist surface Heal in 3+ weeks, or can progress to 3 rd degree burns In Kids: these can lead to severe scarring and contractures – and need excision and skin grafting if not healed by day 21. Third Degree Full-thickness – extend through entire dermis Stiff, white or tan colour, dry, leathery and insensate Require excision +/- grafting Fourth Degree Extend full-thickness and through subcutaneous fat to involve muscle or bone Stiff, charred skin ****Accuracy (...) in Perspective Tissue destruction caused by contact with heat, electrical current, radiation, or chemical agents Temperatures below 44 C are generally tolerated for long periods of time without injury Temperatures above 60 C cause protein denaturation in tissue Burn progression is a result of both necrosis and apoptosis of damaged cells The necrosis – passive process denaturing the lipid bilayer and ATP enzymes. Leading to cell swelling, loss of energy stores, and massive release of inflammatory mediators

2017 CandiEM

131. Imaging of Deep Inferior Epigastric Arteries for Surgical Planning (Breast Reconstruction Surgery)

within the flap with an extended vascular territory beyond the midline to best provide optimal perfusion, preservation of muscle innervation, and avoid fat necrosis [14-16]. Additionally, a short intramuscular course a Principal Author, Yale University School of Medicine, New Haven, Connecticut. b Research Author, Stanford University, Stanford, California. c Panel Chair, UMass Memorial Medical Center, Worcester, Massachusetts. d Panel Vice-Chair, University of Virginia Health System, Charlottesville (...) divided into intramuscular, subfascial, and subcutaneous segments [3,4]. This unpredictable anatomy may lead to lengthy perforator vessel selection and therefore longer operative times when imaging is not used as part of the preoperative planning. Additionally, preoperative imaging planning that accurately maps the perforators and its branches leads to reduced operative time, reduced abdominal morbidity, and increased flap reliability [5-13]. The information most critical to the surgical team includes

2017 American College of Radiology

132. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association

of the interleukin (IL) 1, IL-6, and tumor necrosis factor (TNF) signaling pathways. Study of the adaptive immune response demonstrated that both proinflammatory and regulatory T cells can be found in the circulation in the first week after fever onset. Expansion of the regulatory T-cell population after IVIG administration is associated with cessation of fever and clinical improvement. The self-limited nature of the disease coupled with a low rate of recurrence suggests emergence of T- and B-cell memory (...) subsides because it results from interstitial edema and inflammation and only rarely from myocardial cell necrosis. , Infrequently, acute myocardial inflammation is associated with overt ventricular ectopy, although

2017 American Heart Association

134. Hepatic Issues and Complications Associated With Inflammatory Bowel Disease: A Clinical Report From the NASPGHAN Inflammatory Bowel Disease and Hepatology Committees

: Cholelithiasis Viral Hepatitis Transplant issues IgG4 cholangiopathy Granulomatous hepatitis Primary biliary cirrhosis Hepatic amyloidosis Nonalcoholic fatty liver disease/steatohepatitis TNF ¼ tumor necrosis factor. Saubermann et al JPGN Volume 64, Number 4, April 2017 640 www.jpgn.org Copyright © ESPGHAL and NASPGHAN. All rights reserved. improve patient survival with the native liver (35). ERCP should be performed by interventional endoscopists with experience in PSC management. Perioperative antibiotics (...) , a persistent antiphospholipid antibody, oral contraceptive use, smoking, obesity, thalidomide, or having a central venous catheter (65). If thromboprophylaxis is planned, then low-molecular-weight heparin is recommended. The dosing of enoxaparin is weight based with patients>60 kg receiving either 30 mg subcutaneous twice daily, or 40 mg once daily, and patients 30 cm are associated with an odds ratio of 7 (95% confidence interval, 2.6–19.3] for the development of gallstones (70). Similarly, another study

2017 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

135. Recommendation on Design, Execution, and Reporting of Animal Atherosclerosis Studies: A Scientific Statement From the American Heart Association

ranging from 300 to 500 mg/dL. , Although the rate of atherosclerotic lesion development varies greatly between facilities, macrophage foam cells can be present in the aortic root within a month. At later stages, there are complex lesions containing spindle-shaped smooth muscle cells, increased extracellular matrix, and overlying fibrous caps. The addition of a saturated fat-enriched diet (21% wt/wt saturated fat, 0.2% wt/wt cholesterol; commonly referred to as Western diet) accelerates (...) atherosclerosis and results in elevated total plasma cholesterol concentrations of >1000 mg/dL. Western diet feeding results in a more foam cell–rich atherosclerosis, with lesions containing cholesterol crystals, necrotic cores, and calcifications. However, a fat-enriched diet can alter the outcomes of atherosclerosis because of the induction of pronounced hypercholesterolemia. For example, recombination-activating gene 1–deficient (Rag1 −/− ) mice on an apoE −/− background have attenuated atherosclerosis

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2017 American Heart Association

139. Dyslipidaemias

acid ER extended release ESC European Society of Cardiology ESRD end-stage renal disease EU European Union FACE-BD Fondamental Academic Centers of Expertise in Bipolar Disorders FATS Familial Atherosclerosis Treatment Study FCH familial combined hyperlipidaemia FDA US Food and Drug Administration FDC fixed-dose combination FH familial hypercholesterolaemia FIELD Fenofibrate Intervention and Event Lowering in Diabetes FOCUS Fixed-Dose Combination Drug for Secondary Cardiovascular Prevention GFR

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2016 European Society of Cardiology

140. Diarrhoea in Adult Cancer Patients: ESMO Clinical Practice Guidelines

Consider Clostridium dif?cile, Salmonella, Campylobacter and other causes of infectious colitis. CBC, complete blood count; i.v., intravenous; s.c., subcutaneous; tid, three times a day. Annals of Oncology Clinical Practice Guidelines Volume 29 | Supplement 4 | October 2018 doi:10.1093/annonc/mdy145 | iv135 Downloaded from https://academic.oup.com/annonc/article-abstract/29/Supplement_4/iv126/5041967 by guest on 27 March 2019sepsis, neutropaenia, bleeding or dehydration, and patients with severe (...) the diarrhoea is often bloody [V, A]. Anticholinergic, antidiarrhoeal and opioid agents should be avoided since they may aggravate ileus [V, A]. The indications for and timing of surgical intervention are controversial. The mortality rate of patients who fail to respond to medical interventions is high and many patients may not be salvageable. Nonetheless, in selected patients, surgery may be helpful to avoid progressive bowel necrosis, perforation and to help control sepsis. Commonly cited indications

2018 European Society for Medical Oncology

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