How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,106 results for

Subcutaneous Fat Necrosis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1001. Beromun (tasonermin)

Beromun (tasonermin) CPMP/2/99 1/23 EMEA 2000 SCIENTIFIC DISCUSSION Name of the medicinal product: Beromun Marketing Authorisation Holder: Boehringer Ingelheim International GmbH Binger Strasse 173 D-55216 Ingelheim am Rhein Germany Active substance: Tumor necrosis factor alfa-1a International Nonproprietary Name: Tasonermin Pharmaco-therapeutic group (ATC Code): LO3AA Therapeutic indication: As an adjunct to surgery for subsequent removal of the tumour so as to prevent or delay amputation (...) , or in the palliative situation, for irresectable soft tissue sarcoma of the limbs, used in combination with melphalan via mild hyperthermic isolated limb perfusion (ILP).CPMP/2/99 2/23 EMEA 2000 1. Introduction Beromun contains the active ingredient tasonermin also known as tumour necrosis factor alfa-1a or TNFa-1a. Tasonermin is a non-glycosylated cytokine produced from E.coli using rDNA technology. The protein consists of three identical polypeptide chains of 157 amino acids combined to form a compact, bell

2005 European Medicines Agency - EPARs

1002. Aloxi (palonosetron hydrochloride)

apparent in lungs, liver, adrenals and testes and lowest in fat, bone (without marrow) and the medulla (brain). Concentrations generally peaked within two hours, later peaks were observed in skin, testes, liver, stomach, bone and fat. Concentration ratios in the brain peaked at 30 min; chromatographic analysis indicated only palonosetron, no metabolites. The kinetic pattern in the brain mirrored that in plasma, indicating rapid elimination. By 96 hours, concentrations in all tissues, except the eye (...) weights were reduced in males at 120 mg/kg/day. In a one-month rat study changes at 180 mg/kg/day included reduced body weight gain, occasional signs and numerous clinical pathology variations, most of which were within the normal range. Low testis and secondary sex organ weights were associated with degeneration and necrosis of the seminiferous epithelium. Low thymus weights in females associated with lymphoid depletion and high liver weights in both sexes with foamy cytoplasmic swelling

2006 European Medicines Agency - EPARs

1003. Crixivan - indinavir

not associated with drug-induced renal injury. In rats administered very high doses of indinavir, renal tubular necrosis and vacuolation were observed. Serum biochemical, haematological and urinanalytical changes were noted in rats and mice exposed to indinavir concentrations in the clinical range. These changes seem to be of minor toxicological significance. Repeated dose toxicity studies in rats and dogs given indinavir sulphate at doses up to 160 mg/kg/day together with two degradates did not show any (...) studies. Data from 374 subjects was presented, of whom 179 were HIV patients. The vast majority of the subjects included were male (84 %). One study was performed in subjects with mild to moderate hepatic impairment. Indinavir is rapidly absorbed in the fasted state (T max of 0.8 hours) with an absolute bioavailability of approximately 60 % within the dose range of 400 mg to 800 mg. The bioavailability of a single 800 mg dose was approximately 65 %. Administration of a 400 mg dose with a high-fat

2005 European Medicines Agency - EPARs

1004. Consensus recommendations for the diagnosis, treatment and control of Mycobacterium ulcerans infection (Bairnsdale or Buruli ulcer) in Victoria, Australia Full Text available with Trip Pro

. Epidemiology Mycobacterium ulcerans was discovered in 1948 by Australian scientists who were investigating a cluster of patients with unusual skin ulcers in the Bairnsdale region of eastern Victoria. M. ulcerans is related to the causative agents of tuberculosis and leprosy, but is transmitted from the environment rather than from person to person. The major virulence factor is a lipid toxin, mycolactone, which causes necrosis of fat and subcutaneous tissue. M. ulcerans infection is not fatal, but can (...) that undergoes necrosis and evolves to a deeply undermined ulcer. Lesions are usually painless or minimally painful. Less commonly, the initial lesion may resemble a plaque or necrotic patch of skin. Systemic symptoms (fever, malaise) are rare. Fully developed ulcers are characteristically deeply undermined, meaning a probe can be passed easily under the edge into the space left by necrotic liquefied fat tissue. Lesions can occur anywhere and may be multiple, but a single lesion on the leg or arm is most

2007 MJA Clinical Guidelines

1005. Improving outcomes in breast cancer

on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108, 411 without breast cancer. Lancet 1997;350:1047- 59.14 The risk of breast cancer is affected by lifestyle. Obesity is associated with a two-fold increase in risk among post-menopausal women; this has been linked with high intake of meat and dairy fat, but the precise nature of these relationships are still unclear

2002 National Institute for Health and Clinical Excellence - Clinical Guidelines

1007. Cost-effectiveness of becaplermin for nonhealing neuropathic diabetic foot ulcers

The study population comprised adult patients with diabetes mellitus, Type 1 or Type 2, and a foot ulcer. The foot ulcer had to have been present for at least 8 weeks, be full-thickness (to subcutaneous fat), and be free of local wound infection, cellulites or osteomyelitis. It also had to have been debrided to remove callus, necrotic debris and slough. Setting The setting was the community. The economic study was carried out in Ontario, Canada. Dates to which data relate The dates to which

2003 NHS Economic Evaluation Database.

1008. Clinical practice guidelines for the management of early breast cancer

of invasive cancer after surgical excision of DCIS. In a report of mammographically-detected DCIS, invasive cancer occurred in 13 per cent of women within eight years of complete surgical excision of intermediate to high-grade DCIS. 38 This represents a ten-fold risk compared with recent incidence figures. Although there are no reliable predictors for probability of progression to invasive carcinoma, the risk may be greater when DCIS displays features such as comedo necrosis or high nuclear grade. 39

2001 Cancer Australia

1010. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. (Abstract)

infusions) as well as levels of inflammatory mediators and other risk factors for coronary heart disease in 15 obese women before and 10 to 12 weeks after abdominal liposuction. Eight of the women had normal glucose tolerance (mean [+/-SD] body-mass index, 35.1+/-2.4), and seven had type 2 diabetes (body-mass index, 39.9+/-5.6).Liposuction decreased the volume of subcutaneous abdominal adipose tissue by 44 percent in the subjects with normal glucose tolerance and 28 percent in those with diabetes; those (...) with normal oral glucose tolerance lost 9.1+/-3.7 kg of fat (18+/-3 percent decrease in total fat, P=0.002), and those with type 2 diabetes lost 10.5+/-3.3 kg of fat (19+/-2 percent decrease in total fat, P<0.001). Liposuction did not significantly alter the insulin sensitivity of muscle, liver, or adipose tissue (assessed by the stimulation of glucose disposal, the suppression of glucose production, and the suppression of lipolysis, respectively); did not significantly alter plasma concentrations of C

2004 NEJM

1011. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. Full Text available with Trip Pro

subjects matched for age, height, weight, and physical activity to assess the sensitivity of liver and muscle to insulin. Proton ((1)H) magnetic resonance spectroscopy studies were performed to measure intramyocellular lipid and intrahepatic triglyceride content. Rates of whole-body and subcutaneous fat lipolysis were assessed by measuring the rates of [(2)H(5)]glycerol turnover in combination with microdialysis measurements of glycerol release from subcutaneous fat. We performed (31)P magnetic (...) dysfunction, as reflected by a reduction of approximately 30 percent in mitochondrial phosphorylation (P=0.01 for the comparison with controls), since there were no significant differences in systemic or localized rates of lipolysis or plasma concentrations of tumor necrosis factor alpha, interleukin-6, resistin, or adiponectin.These data support the hypothesis that insulin resistance in the skeletal muscle of insulin-resistant offspring of patients with type 2 diabetes is associated with dysregulation

2004 NEJM

1012. What is the effect of liposuction on CHD risk factors in overweight and/or obese patients?

obese women before and 10 to 12 weeks after abdominal liposuction. Eight of the women had normal glucose tolerance (mean [+/-SD] body-mass index, 35.1+/-2.4), and seven had type 2 diabetes (body-mass index, 39.9+/-5.6). RESULTS: Liposuction decreased the volume of subcutaneous abdominal adipose tissue by 44 percent in the subjects with normal glucose tolerance and 28 percent in those with diabetes; those with normal oral glucose tolerance lost 9.1+/-3.7 kg of fat (18+/-3 percent decrease in total (...) fat, P=0.002), and those with type 2 diabetes lost 10.5+/-3.3 kg of fat (19+/-2 percent decrease in total fat, P Liposuction did not significantly alter the insulin sensitivity of muscle, liver, or adipose tissue (assessed by the stimulation of glucose disposal, the suppression of glucose production, and the suppression of lipolysis, respectively); did not significantly alter plasma concentrations of C-reactive protein, interleukin-6, tumor necrosis factor alpha, and adiponectin; and did

2006 TRIP Answers

1013. Clinical and histopathologic features of 8 patients with microscopic polyangiitis including two with a slowly progressive clinical course. (Abstract)

on their extremities. Livedo reticularis (5/8, 68%) was also observed. Six of the 8 patients with MPA were given the diagnosis within 3 months of their initial manifestation. In skin biopsy specimens, necrotizing vasculitis was noted in the reticular dermis to the subcutaneous fat. In contrast, the other two patients with MPA were given the diagnosis about 10 years after their initial manifestation. Histopathologic findings demonstrated necrotizing vasculitis with moderate neutrophilic infiltrations (...) Clinical and histopathologic features of 8 patients with microscopic polyangiitis including two with a slowly progressive clinical course. Microscopic polyangiitis (MPA) is a systemic antineutrophil cytoplasmic autoantibody-associated vasculitis associated with necrotizing and crescentic glomerulonephritis and pulmonary capillaritis. MPA generally has a rapidly progressive clinical course, but there have been recent reports of slowly progressive cases.To evaluate the typical cutaneous findings

2007 Journal of American Academy of Dermatology

1014. Adipocyte death, adipose tissue remodeling, and obesity complications. Full Text available with Trip Pro

Adipocyte death, adipose tissue remodeling, and obesity complications. We sought to determine the role of adipocyte death in obesity-induced adipose tissue (AT) inflammation and obesity complications.Male C57BL/6 mice were fed a high-fat diet for 20 weeks to induce obesity. Every 4 weeks, insulin resistance was assessed by intraperitoneal insulin tolerance tests, and epididymal (eAT) and inguinal subcutaneous AT (iAT) and livers were harvested for histological, immunohistochemical, and gene (...) expression analyses.Frequency of adipocyte death in eAT increased from <0.1% at baseline to 16% at week 12, coincident with increases in 1) depot weight; 2) AT macrophages (ATM Phi s) expressing F4/80 and CD11c; 3) mRNA for tumor necrosis factor (TNF)-alpha, monocyte chemotactic protein (MCP)-1, and interleukin (IL)-10; and 4) insulin resistance. ATM Phi s in crown-like structures surrounding dead adipocytes expressed TNF-alpha and IL-6 proteins. Adipocyte number began to decline at week 12. At week 16

2007 Diabetes

1015. Fulminant pulmonary calciphylaxis and metastatic calcification causing acute respiratory failure in a uremic patient. (Abstract)

Fulminant pulmonary calciphylaxis and metastatic calcification causing acute respiratory failure in a uremic patient. Calciphylaxis is a rare and life-threatening disorder characterized by small-vessel mural calcification with intimal proliferation, fibrosis, and thrombosis, resulting in tissue ischemic necrosis. Although it has been viewed as a systemic disease involving mainly the dermis, subcutaneous fat, or muscle, calciphylaxis of other organs rarely is reported. We describe the case

2006 American Journal of Kidney Diseases

1016. Diabetic (lymphocytic) mastopathy with exuberant lymphohistiocytic and granulomatous response: a case report with review of the literature. (Abstract)

a fibrotic breast parenchyma with foci of dense fibrosis and scattered inconspicuous breast epithelium surrounded by lymphocytes that formed aggregates and follicles with germinal centers. The inflammation was in a periductal, perilobular, and perivascular distribution. In addition, an exuberant inflammatory response with histiocytes and fibroblasts was present. This inflammatory response focally surrounded areas of fat necrosis and formed noncaseating granulomas with rare multinucleated giant cells (...) . This process had infiltrative, ill-defined edges and involved the subcutaneous tissues. The overlying epidermis was normal. The final diagnosis was diabetic mastopathy with an exuberant lymphohistiocytic response. The differential diagnosis included Rosai-Dorfman disease, inflammatory myofibroblastic tumor, granulomatous mastitis, sclerosing lipogranulomatous response/sclerosing lipogranuloma, lupus panniculitis, and rheumatoid nodules. Immunohistochemical studies and flow cytometry confirmed

2006 American Journal of Surgical Pathology

1017. Cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases. (Abstract)

with intermittent genital bleeding and a painful mass. Most lesions were located primarily in subcutaneous tissue. Most cases were grossly well marginated. Two cases showed foci of hemorrhage and 1 case showed foci of necrosis. Microscopically, 41 tumors were well circumscribed, and 2 tumors infiltrated into the surrounding tissue. All tumors consisted of bland, spindle-shaped cells, short bundles of wispy collagen and numerous small- to medium-sized thick-walled vessels. Intralesional fat was present in 12

2004 American Journal of Surgical Pathology

1018. Partial breast irradiation with interstitial 60CO brachytherapy results in frequent grade 3 or 4 toxicity. Evidence based on a 12-year follow-up of 70 patients. (Abstract)

, 85% of the patients experienced Grade > or =2 telangiectasis and 41% had Grade 3 telangiectasis. Eighty-eight percent had fibrosis of some form, and 35% had grade > or =3 fibrosis. Forty-one percent of the cohort displayed fat necrosis, which was always accompanied by Grade > or =3 fibrosis or telangiectasis. The cosmetic results were poor in 50% (17/34) of the patients. The radiosensitivity of the fibroblasts was increased in only 2/24 patients (8% of the investigated cases, in agreement (...) postoperative lumpectomy cavity (i.e., plane). For radiobiologic considerations, the clinical target volume (CTV) was calculated retrospectively with a 10-mm safety margin, resulting in a 72-cm(3) median CTV (range, 36-108 cm(3)) irradiated with a reference dose of 28 Gy. In the assessment of the skin and subcutaneous toxicity, the RTOG late radiation morbidity scoring system was applied. The radiosensitivity of the cultured fibroblasts was determined by clonogenic assay to check whether individual

2004 Biology and Physics

1019. Accelerated partial breast irradiation: an analysis of variables associated with late toxicity and long-term cosmetic outcome after high-dose-rate interstitial brachytherapy. (Abstract)

. 0.71; p=0.009). Late subcutaneous toxicity was rated as Grade 0, 1, 2, 3, or 4 in 55%, 15%, 12%, 5%, and 13% of patients, respectively. The risk of Grade 0/1 vs. Grade 2-4 subcutaneous toxicity was significantly associated only with a lower value of DHI (0.77 vs. 0.73; p=0.02). To further explore factors that might contribute to the risk of fat necrosis (symptomatic or asymptomatic), a separate analysis showed that only dose hotspots as reflected in V150 and V200 were significantly associated (...) with elevated risk. The use of adriamycin-based chemotherapy after APBI was found to be associated with a significant increase in the incidence of higher-grade skin toxicity and a higher risk of fat necrosis and suboptimal cosmetic outcome. Patient age, volume of resection, extent of axillary surgery, a history of diabetes or hypertension, and the use of tamoxifen were not found to be significantly associated with cosmetic outcome or late normal tissue complications.Long-term cosmetic results and the risk

2006 Biology and Physics

1020. Sandal burns and their treatment in children. (Abstract)

Sandal burns and their treatment in children. Sandal is an ancient, primitive heating device that is still in use by both poor and rich people in mountain areas of Middle Asia. Sandal burn injuries are a serious health problem. Characteristics of sandal burns include not only skin injuries of various depths but also injuries to underlying tissues: subcutaneous fat, fasciae, muscles, and even bones. Sandal burns are characterized by such severe deep injuries because of a close contact (...) of the body with live coals or woods. The main goal of this work was to present the most complete information about sandal burns and discuss the most effective methods of treatment for sandal burns. This treatment is used to accelerate the rejection of necrotic tissue, to prepare the wound for early autodermoplastic surgery, to decrease the postburn contractures/deformities, and also to shorten hospital stay for the patients.

2004 Journal of Burn Care & Rehabilitation

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>