How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,019 results for

Subcutaneous Fat Necrosis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1001. Action of sodium deoxycholate on subcutaneous human tissue: local and systemic effects. (Abstract)

Action of sodium deoxycholate on subcutaneous human tissue: local and systemic effects. Phosphatidylcholine injections have been used as a nonsurgical alternative to the surgical removal of undesired fat. Studies in cell culture suggest that sodium deoxycholate (SD) has a detergent action in fat reduction.The objective was to study SD in subcutaneous human tissue.Thirty volunteers underwent four sessions of subcutaneous abdominal injections of diluted 2.5 or 1% SD stock solutions or placebo (...) . Clinical, hematologic, and ultrasonographic evaluations were performed for 3 months and histology at 3 and 6 months.Both concentrations of SD induced an inflammatory response at the injection site, with dose-dependent adipocyte lysis. Patients reported mild, localized heat, erythema, swelling, and intense pain. Microscopic evaluation revealed necrosis of adipose tissue with adipocyte lysis, fat dissolution, acute lymphomononuclear inflammatory reaction, and intense phagocytosis of fat cells

2007 Dermatologic Surgery Controlled trial quality: uncertain

1002. Treatment of Obese Diabetic Mice with an Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels and Improves Insulin Sensitivity and Glucose Tolerance. Full Text available with Trip Pro

caused a sustained increase in HO-1 protein, prevented weight gain, decreased visceral and subcutaneous fat content (P < 0.03 and 0.01, respectively, compared with vehicle animals), increased serum adiponectin, and decreased plasma tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta levels (P < 0.05). HO-1 induction improved insulin sensitivity and glucose tolerance and decreased insulin levels. Upregulation of HO-1 decreased adipogenesis in bone marrow in vivo and in cultured (...) Treatment of Obese Diabetic Mice with an Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels and Improves Insulin Sensitivity and Glucose Tolerance. We hypothesized that the induction of heme oxygenase (HO)-1 and increased HO activity, which induces arterial antioxidative enzymes and vasoprotection in a mouse and a rat model of diabetes, would ameliorate insulin resistance, obesity, and diabetes in the ob mouse model of type 2 diabetes.Lean and ob

2008 Diabetes

1003. Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages. Full Text available with Trip Pro

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages. Adipose tissue macrophages (ATMs) have become a focus of attention recently because they have been shown to accumulate with an increase in fat mass and to be involved in the genesis of insulin resistance in obese mice. However, the phenotype and functions of human ATMs are still to be defined.The present study, performed on human subcutaneous AT, showed that ATMs from lean to overweight individuals are composed of distinct (...) macrophage subsets based on the expression of several cell surface markers: CD45, CD14, CD31, CD44, HLA-DR, CD206, and CD16, as assessed by flow cytometry. ATMs isolated by an immunoselection protocol showed a mixed expression of proinflammatory (tumor necrosis factor-alpha, interleukin-6 [IL-6], IL-23, monocyte chemoattractant protein-1, IL-8, cyclooxygenase-2) and antiinflammatory (IL-10, transforming growth factor-beta, alternative macrophage activation-associated cc chemokine-1, cyclooxygenase-1

2008 Circulation

1004. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Full Text available with Trip Pro

Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear.We examined the relations of abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), assessed by multidetector computerized tomography, to circulating (...) , intercellular adhesion molecule-1, interleukin-6, P-selectin, and tumor necrosis factor receptor-2 (multivariable model R2 0.06 to 0.28 [SAT] and 0.07 to 0.29 [VAT]). However, compared with SAT, VAT was more highly associated with urinary isoprostanes and monocyte chemoattractant protein-1 (SAT versus VAT comparison: isoprostanes, R2 0.07 versus 0.10, P=0.002; monocyte chemoattractant protein-1, R2 0.07 versus 0.08, P=0.04). When body mass index and waist circumference were added to the models, VAT remained

2007 Circulation

1005. Comparison of autologous fat transfer in fresh, refrigerated, and frozen specimens: an animal model. (Abstract)

Comparison of autologous fat transfer in fresh, refrigerated, and frozen specimens: an animal model. The rising popularity of autologous fat transfer (AFT) has raised the questions whether cryopreserved adipocytes are a suitable substrate for soft-tissue augmentation, and which storage techniques may be most suitable for a maximally successful surgical result. An animal model of AFT was conceived using isogeneic Sprague-Dawley rats. Suction harvesting of fat and subcutaneous implantation (...) was performed with specimens stored at -16 degrees C or 1 degrees C for a period of 1 or 2 weeks, as well as a group that underwent immediate implantation. A histological comparison of the experimental and control groups clearly demonstrated a decrease in viable adipocytes and an increase in signs of inflammation and fat cell necrosis in those animals that received stored fat instead of immediate fat implantation. These changes became more severe with increased length of storage and the use of refrigeration

2000 Annals of plastic surgery

1006. Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue. Full Text available with Trip Pro

Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue. Tumor necrosis factor (TNF, cachectin) is a macrophage product that has been suggested to signal the loss of body weight, the decrease in adipose tissue and muscle mass, and anorexia during infections or chronic illness. To test this possibility, young growing rats were injected subcutaneously or intraperitoneally with human or murine recombinant TNF. After 3-4 h (...) addition in vitro did not enhance lipolysis in epididymal fat pads or proteolysis in soleus muscles. Thus, TNF treatment can induce fever without producing a catabolic state similar to that induced by endotoxin.

1988 Journal of Clinical Investigation

1007. Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients. (Abstract)

, and three had systemic symptoms. All biopsies exhibited an infiltrate of medium to large pleomorphic cells involving the subcutis with characteristic rimming of fat spaces. Five showed areas of necrosis, but only one showed marked cytophagia. In three cases the neoplastic cells did not express TCR-beta. One was strongly p53 positive, and the other two were CD56 positive. Both these patients showed epidermal involvement with lichenoid changes histologically, and both developed the haemophagocytic (...) Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic T-cell lymphoma of the skin. In the World Health Organization classification of T-cell and natural killer cell lymphoma it is listed as an example of extranodal lymphoma. In practice, however, it is most likely to present to a dermatologist.To describe the clinicopathological, immunophenotypic

2003 British Journal of Dermatology

1008. Elevated levels of tumor necrosis factor-alpha in periradicular fat tissue in patients with radiculopathy from herniated disc. (Abstract)

Elevated levels of tumor necrosis factor-alpha in periradicular fat tissue in patients with radiculopathy from herniated disc. Case-control study.To determine whether inflammatory cytokines [tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and IL-8] are elevated in tissues intimately surrounding involved nerve roots of patients suffering from radiculopathy form herniated disc (HD).Proinflammatory cytokines are postulated to play an important role in radiculopathy from HD (...) range 6.6, (1.6-16.3) pg/mL per milligram of tissue vs. 2.3 (1.3-5.0), P < 0.05] and to subcutaneous fat [0.35 (0-2.28), P < 0.001]. No significant increase of either cytokines was found in HD compared with IVD.Higher concentrations of TNF-alpha were found in EF from patients with radiculopathy from HD compared with patients suffering from other type of back pain. These results support the role of TNF-alpha in the pathogenesis of radiculopathy from HD.

2008 Spine

1009. Tissue-toxic effects of phosphatidylcholine/deoxycholate after subcutaneous injection for fat dissolution in rats and a human volunteer. (Abstract)

study (30 days). A human volunteer undergoing elective liposuction was similarly treated. Cell membrane lysis, cell viability, and histologic status were determined on fresh biopsies of subcutaneous fat from the injection sites.PC/DC dose-dependently reduced membrane integrity and cell viability. Histologic alterations induced by PC/DC included fibroplasia, bandlike fibrosis in the region of the cutaneous muscle, and partial muscle loss. The highest dose caused widespread fat necrosis, fat cyst (...) formation, and necrotic changes of the walls of small blood vessels. Histologic sections of subcutaneous tissue from the human volunteer showed dose-dependent panniculitis, fat cysts, and vessel necrosis. DC (2.5%), tested for comparison in the rat, exerted membrane and histologic effects similar to those of PC/DC. Solvent controls caused negligible alterations.Injection lipolysis with PC/DC causes tissue fibrosis and necrosis of adipose and vascular tissues in rat and man, making the long-term safety

2008 Dermatologic Surgery

1010. Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women. (Abstract)

Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women. Adipocytokines secreted by adipose tissue are suggested to play a role in the development of obesity-related complications. Regular aerobic exercise has been shown to reduce the risk of metabolic complications in obese subjects. The aim of this study was to investigate the effect of aerobic training on gene (...) ergometer. Before and after the aerobic training, (V(.-)(O(2)max)) and body composition were measured and plasma and SCAAT biopsy samples (in a subgroup of 8 subjects) were obtained for determination of plasma and messenger RNA levels of adipocytokines (leptin, adiponectin, interleukin 6, tumor necrosis factor alpha). The aerobic training resulted in an increase of subjects' V o(2)max by 12.8% (24.6 +/- 3.9 vs 27.7 +/- 4.8 mL x min(-1) x kg(-1), P < .05). Body weight and fat mass were reduced by 5.9

2006 Metabolism: clinical and experimental

1011. Pancreatic carcinoma with polyarthritis, fat necrosis, and high serum lipase and trypsin activity. Full Text available with Trip Pro

Pancreatic carcinoma with polyarthritis, fat necrosis, and high serum lipase and trypsin activity. A 46 year old white man presented with subcutaneous and intramedullary fat necrosis, destructive polyarthritis, and osteolytic bone lesions, complicating a poorly differentiated adenocarcinoma of the tail of the pancreas with metastases in the liver and omentum. There was a 100-fold increase in serum lipase and trypsin activity. His condition deteriorated rapidly, was characterised by rapid tumour (...) growth, formation of ascites, a 20 kg weight loss, extensive subcutaneous fat necrosis, and fistula formation in the left calf. Treatment with 5-fluorouracil 300 mg/m2 on days 1-5 and doxorubicin 50 mg/m2 and cisplatin 100 mg/m2 on day 1, every three weeks, was well tolerated and resulted in rapid clinical improvement. After three courses of treatment a partial remission was seen and after seven courses further improvement occurred with a return to normal of serum lipase and trypsin activity. One

1990 Gut

1012. Should we stitch the subcutaneous fat layer following saphenous vein excision for coronary revascularization? (Abstract)

. There was no difference in the rate of wound complication in the fat stitch groups (9%) compared with the no fat stitch groups (8%), however, the fat stitch groups required more surgical intervention for skin edge necrosis. It appears that closure of the subcutaneous fat following saphenectomy is unnecessary, and may be detrimental to skin healing. (...) Should we stitch the subcutaneous fat layer following saphenous vein excision for coronary revascularization? We report a prospective trial to establish whether a subcutaneous fat stitch reduces the incidence of haematoma formation, infection and wound dehiscence following saphenous vein excision for coronary revascularization. Two groups of patients undergoing coronary revascularization were studied. In the first group of 100 patients the saphenous vein was harvested from both legs. Legs were

1994 European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Controlled trial quality: uncertain

1013. Neonatal subcutaneous fat necrosis with characteristic rash and hypercalcaemia Full Text available with Trip Pro

Neonatal subcutaneous fat necrosis with characteristic rash and hypercalcaemia 17585095 2007 07 12 2018 11 13 1359-2998 92 4 2007 Jul Archives of disease in childhood. Fetal and neonatal edition Arch. Dis. Child. Fetal Neonatal Ed. Neonatal subcutaneous fat necrosis with characteristic rash and hypercalcaemia. F304 Aucharaz K S KS Department of Paediatrics, York Hospital, Wigginton Road, York, UK. ksaucharaz@hotmail.co.uk Baker E L EL Millman G C GC Ball R J RJ eng Case Reports Journal Article (...) England Arch Dis Child Fetal Neonatal Ed 9501297 1359-2998 AIM IM Exanthema etiology pathology Fat Necrosis complications pathology Female Follow-Up Studies Humans Hypercalcemia etiology therapy Infant, Newborn Subcutaneous Fat pathology 2007 6 23 9 0 2007 7 13 9 0 2007 6 23 9 0 ppublish 17585095 92/4/F304 10.1136/adc.2006.114090 PMC2675437 Neonatal Netw. 1991 Oct;10(3):7-14 1944087 Horm Res. 2006;65(6):289-94 16612105 Arch Dis Child. 1963 Oct;38:516-8 14065996

2007 Archives of Disease in Childhood. Fetal and Neonatal Edition

1014. A 1-week-old newborn with hypercalcemia and palpable nodules: subcutaneous fat necrosis. Full Text available with Trip Pro

A 1-week-old newborn with hypercalcemia and palpable nodules: subcutaneous fat necrosis. We present a 1-week-old newborn with subcutaneous fat necrosis complicated by hypercalcemia. She received conservative treatment of adequate hydration and restricted supplementary vitamin D.

2008 Canadian Medical Association Journal

1015. Expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase in subcutaneous fat necrosis. Full Text available with Trip Pro

Expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase in subcutaneous fat necrosis. The most serious complication of subcutaneous fat necrosis (SCFN), a rare condition of the newborn characterized by indurated purple nodules, is hypercalcaemia. However, the mechanism for this hypercalcaemia remains unclear.To determine whether the hypercalcaemia associated with SCFN involves expression of the vitamin D-activating enzyme 25-hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase

2008 British Journal of Dermatology

1016. Normal subcutaneous fat, necrosis of adipocytes and classification of the panniculitides. (Abstract)

Normal subcutaneous fat, necrosis of adipocytes and classification of the panniculitides. The panniculitides represent a group of heterogeneous inflammatory diseases that involve the subcutaneous fat. The specific diagnosis of these diseases requires histopathologic study because different panniculitides usually show the same clinical appearance, which consists of erythematous nodules on the lower extremities. However, the histopathologic study of panniculitis is difficult because (...) lobular panniculitides without vasculitis comprise a large series of disparate disorders, including sclerosing panniculitis, calciphylaxis, sclerema neonatorum, subcutaneous fat necrosis of the newborn, poststeroid panniculitis, lupus erythematosus profundus, pancreatic panniculitis, alpha(1)-antitrypsin deficiency panniculitis, subcutaneous Sweet syndrome, infective panniculitis, factitial panniculitis, lipodystrophy, traumatic panniculitis, subcutaneous sarcoidosis, and sclerosing postirradiation

2007 Seminars in Cutaneous Medicine and Surgery

1017. Subcutaneous fat necrosis of the newborn: a systematic evaluation of risk factors, clinical manifestations, complications and outcome of 16 children. (Abstract)

Subcutaneous fat necrosis of the newborn: a systematic evaluation of risk factors, clinical manifestations, complications and outcome of 16 children. Subcutaneous fat necrosis (SFN) of the newborn is a rare acute transient hypodermatitis that develops within the first weeks of life in term infants. It often follows a difficult delivery. Prognosis is generally good except for the development of hypercalcaemia in severe cases. Only several case reports or small patients series have been (...) , paternal or newborn risk factors for thrombosis (5/10), and dyslipidaemia (2/10). Complications were hypercalcaemia (9/16), pain (4/16), dyslipidaemia (1/16), renal insufficiency (1/16) and late subcutaneous atrophy (6/6).This study on 16 newborns with SFN provides new information. Familial or newborn risk factors for thrombosis are frequent. Macrosomia, familial dyslipidaemia and smoking should be evaluated. The main complications identified were severe pain, hypercalcaemia and subcutaneous atrophy.

2007 British Journal of Dermatology

1018. Subcutaneous fat necrosis of the newborn associated with hypercalcaemia. Full Text available with Trip Pro

Subcutaneous fat necrosis of the newborn associated with hypercalcaemia. 8071923 1994 09 27 2018 11 13 0141-0768 87 8 1994 Aug Journal of the Royal Society of Medicine J R Soc Med Subcutaneous fat necrosis of the newborn associated with hypercalcaemia. 482-3 Lewis H M HM Department of Dermatology, Children's Hospital, Birmingham, UK. Ferryman S S Gatrad A R AR Moss C C eng Case Reports Journal Article England J R Soc Med 7802879 0141-0768 IM Fat Necrosis etiology pathology therapy Humans

1994 Journal of the Royal Society of Medicine

1019. Subcutaneous fat necrosis of the newborn: hypercalcaemia with hepatic and atrial myocardial calcification. Full Text available with Trip Pro

Subcutaneous fat necrosis of the newborn: hypercalcaemia with hepatic and atrial myocardial calcification. Subcutaneous fat necrosis of the newborn (SCFN) is a very rare disorder, which can be complicated by hypercalcaemia and thrombocytopenia. The case is presented of an infant with SCFN and symptomatic hypercalcaemia, who developed calcifications in the liver, the inferior vena cava, and the atrial septum of the heart. The hypercalcaemia was treated with hyperhydration, frusemide

2003 Archives of Disease in Childhood. Fetal and Neonatal Edition

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>