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Subcutaneous Fat Necrosis

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981. HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy. Full Text available with Trip Pro

reduced. Gene expression of monocyte chemoattractant protein-1 was induced in visceral and subcutaneous fat, whereas tumour necrosis factor-α and interleukin-6 were induced in visceral and subcutaneous white adipose tissues, respectively. Adiponectin and leptin gene expression was repressed in all white fat depots, in concert with reduced expression of peroxisome proliferator-activated receptor γ, a master controller of adipogenesis. In brown fat, a coordinate induction in the expression (...) mice expressing a 7.7 kb HIV-1 construct (Tg26+/-) were used. Cytokine and adipokine levels were quantified using multiplex procedures. Gene expression and mitochondrial DNA abundance in visceral and subcutaneous white adipose tissues and in brown fat were determined using quantitative real-time PCR.The amount of visceral, but not subcutaneous, adipose depot was lower in Tg26+/- mice. Serum proinflammatory cytokine levels were increased in Tg26+/- mice, whereas adiponectin and leptin levels were

2010 Antiviral Therapy

982. Magnetic Anchoring and Guidance System Instrumentation for Laparo-endoscopic Single-site Surgery/Natural Orifice Transluminal Endoscopic Surgery: Lack of Histologic Damage After Prolonged Magnetic Coupling Across the Abdominal Wall. (Abstract)

. Histologic assessment was then performed.Beyond mild blanching of the peritoneal surface with a few petechiae immediately after internal component removal, no gross tissue damage was seen. These changes were undetectable by 48 hours and no intra-abdominal adhesions were identified at necropsy. NADH stain for tissue viability in the 4 nonsurvival specimens showed no tissue damage. Hematoxylin and eosin stain showed no necrosis of either superficial or deep muscle, skin, or subcutaneous fat tissue in all

2010 Urology

983. Adiponectin and Inflammatory Mediators in Mediastinal Adipose Tissues

Tissues Between Patients With Coronary Artery Diseases and With Valvular Diseases Study Start Date : January 2008 Estimated Primary Completion Date : December 2008 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort 1 CABG 2 Valve surgery Outcome Measures Go to Biospecimen Retention: Samples Without DNA Adipose tissue biopsy samples from mediastinal fat, epicardial fat, subcutaneous fat in thoracic region or abdominal region (...) and subcutaneous fat in leg were obtained soon after sternotomy or thoracotomy before the initiation of cardiopulmonary bypass. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout

2009 Clinical Trials

984. Excision of Strip of Deep Fascia to Reduce Seroma Formation and Extrusion of Tissue Expanders

in mitosis returned to normal 4 weeks after expansion. The dermis and subcutaneous tissues were thinned as a result of tissue expansion leading to an overall decrease in tensile strength of the expanded skin (5-7) and this persisted 36 weeks after expansion. The subcutaneous layer of fat was intolerant to stretching causing significant thinning. With faster expansion, fat necrosis could be seen. Pressure necrosis on subcutaneous fat led to liquefaction and seroma formation. With progression of expansion (...) University Information provided by: Cairo University Study Details Study Description Go to Brief Summary: Tissue expansion has enjoyed a wide range of applications since the technique was popularized in the latter quarter of the last century. During the expansion process, subcutaneous fat liquefies, skin becomes thinner, muscles atrophy, blood inflow increases, and lymphatics get occluded. All these factors predispose to seroma formation and implant extrusion. A similar problem occurred with lymphoedema

2009 Clinical Trials

985. The Occlusive Dressing

amputations are very common injuries among the patients arriving at the Emergency Department. Fingertips amputations classified in 2nd and 3rd zones, in accordance with Rosenthal's classification (after the solum unguis), constitute a large proportion of them. The treatment aims at restoring a pulp with its sensitivity and a good subcutaneous fat tissue. The usual care of these amputations is a surgical treatment: it consists of pulp reconstruction by a flap (for example palmar V-Y advancement flaps (...) of Atazoy). These technique involve hospital admission, brachial plexus anaesthesia, a surgical approach with cicatrix and donor site morbidities, postoperative cares, post-surgical pain management. And of course attention must be paid to the risks of postoperative complications related either to anaesthesia and/or to surgery, like necrosis, infection, and others. We have developed a nonoperative treatment for fingertips amputations: the occlusive dressing. It's a technique that has been known for about

2009 Clinical Trials

986. A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal

A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00851747 Recruitment Status : Terminated First Posted : February 26

2009 Clinical Trials

987. Necrotizing Fasciitis versus Pyomyositis: Discrimination with Using MR Imaging Full Text available with Trip Pro

T2-weighted images (27% of the patients with NF vs. 100% in the patients with PM), diffuse CE of muscles (18% vs. 100%, respectively), thick irregular enhancement of the deep fascia (0% vs. 75%, respectively) and intramuscular abscess (0% vs. 88%, respectively). For all patients with NF and PM, the superficial fascia and muscle showed hyperintense signals on T2-weighted images and CE was seen on fat-suppressed CE T1-weighted images. The subcutaneous tissue and deep fascia showed hyperintense (...) Necrotizing Fasciitis versus Pyomyositis: Discrimination with Using MR Imaging We wanted to evaluate the MR findings for differentiating between necrotizing fasciitis (NF) and pyomyositis (PM).The MR images of 19 patients with surgically confirmed NF (n = 11) and pathologically confirmed PM (n = 8) were retrospectively reviewed with regard to the presence or absence of any MRI finding criteria that could differentiate between them.The patients with NF had a significantly greater prevalence

2009 Korean Journal of Radiology

988. Partial breast irradiation with interstitial high-dose-rate brachytherapy in early breast cancer: results of a phase II prospective study. (Abstract)

, at a median of 8 weeks from surgery, in 65 patients. Adjuvant therapy was chemotherapy (8) and/or hormone therapy (61).Cosmetic results were good/excellent in 79 patients. Perioperative toxicity was very low. Acute skin toxicity developed in seven cases (six G1; one G2); late G3 cutaneous toxicity in one patient and late subcutaneous toxicity in five (three G1; two G2). Grade 1 teleangiectasia occurred in eight patients and grade 2 in one. Fat necrosis was symptomatic in one patient and asymptomatic

2009 European Journal of Surgical Oncology Controlled trial quality: uncertain

989. Circulating white blood cell count and measures of adipose tissue inflammation predict higher 24 hour energy expenditure. Full Text available with Trip Pro

EE adjusted for age, sex, fat-free mass, and fat mass (r=0.13, P=0.04). In SAAT, tumor necrosis factor-alpha (TNF-alpha), shown as log10-transformed TNF-alpha (r=0.36, P=0.05), and plasminogen activator inhibitor-1 (PAI-1), shown as log10-transformed PAI-1 (lPAI-1; r=0.41, P=0.02), expressions were also positively correlated with adjusted 24-h EE. lPAI-1 was also correlated with adjusted sleep EE (r=0.34, P=0.07).In conclusion, circulating markers of inflammation (WBC) and markers of inflammation (...) between circulating white blood cell count (WBC) in a population of Native Americans (n=243) with measurement of EE in a respiratory chamber, and in a subset of the same population (n=34), with gene expression measures of inflammation in subcutaneous abdominal adipose tissue (SAAT). All subjects were healthy on oral glucose tolerance test. Statistically, nonnormally distributed variables were logarithmically transformed before analyses to approximate normal distributions.WBC was associated with 24-h

2009 European Journal of Endocrinology

990. Subcutaneous and Visceral Adipose Tissue Gene Expression of Serum Adipokines That Predict Type 2 Diabetes. Full Text available with Trip Pro

Subcutaneous and Visceral Adipose Tissue Gene Expression of Serum Adipokines That Predict Type 2 Diabetes. Type 2 diabetes mellitus (T2D) is predicted by central obesity and circulating adipokines regulating inflammation. We hypothesized that visceral adipose tissue (VAT) in T2D expresses greater levels of proinflammatory molecules. Paired samples of subcutaneous (SAT) and VAT were excised at elective surgery (n = 16, 6 with T2D, n = 8 age- and gender- matched controls). Metabolic parameters (...) were measured in the fasted state: body composition by dual-energy X-ray absorptiometry and insulin action by hyperinsulinemic-euglycemic clamp. Adipose tissue mRNA gene expression was measured by quantitative reverse transcriptase-PCR. Subjects with T2D had higher VAT expression of molecules regulating inflammation (tumor necrosis factor-alpha (TNFalpha), macrophage inflammatory protein (MIP), interleukin-8 (IL-8)). Fasting glucose related to VAT expression of TNFalpha, MIP, serum amyloid A (SAA

2009 Obesity

991. Subcutaneous and Visceral Adipose Tissue FTO Gene Expression and Adiposity, Insulin Action, Glucose Metabolism, and Inflammatory Adipokines in Type 2 Diabetes Mellitus and in Health. (Abstract)

, and measures of adiposity with FTO gene expression in adipose tissue.Paired subcutaneous and visceral fat were excised at elective surgery in n = 16 subjects (six with T2D, age-matched). Metabolic parameters were measured in fasted state; body composition by dual-energy X-ray absorptiometry; and insulin action by hyperinsulinemic euglycemic clamp. Adipose tissue mRNA gene expression was determined by quantitative RT-PCR.Subjects with T2D had SAT and VAT FTO mRNA expression similar to controls (...) Subcutaneous and Visceral Adipose Tissue FTO Gene Expression and Adiposity, Insulin Action, Glucose Metabolism, and Inflammatory Adipokines in Type 2 Diabetes Mellitus and in Health. FTO gene variants are linked to obesity. We tested for site-specific differences in FTO gene expression in subcutaneous and visceral adipose tissue (SAT and VAT, respectively) from individuals with and without type 2 diabetes mellitus (T2D) and the relationships between fasting glucose, in vivo insulin action

2009 Obesity Surgery

992. mRNA concentrations of MIF in subcutaneous abdominal adipose cells are associated with adipocyte size and insulin action. Full Text available with Trip Pro

(by quantitative real-time PCR) in freshly isolated adipocytes (monocyte chemoattractant protein (MCP) 1 and MCP2, macrophage inflammatory protein (MIP) 1alpha, MIP1beta and MIP2, macrophage migration inhibitory factor (MIF), tumor necrosis factor alpha, interleukin (IL) 6 and IL8; n=22) and cultured preadipocytes (MCP1, MIP1alpha, MIF, IL6 and matrix metalloproteinase 2; n=33) from subcutaneous abdominal adipose tissue (by aspiration biopsy, n=34), body fat by dual-energy X-ray absorptiometry, glucose (...) mRNA concentrations of MIF in subcutaneous abdominal adipose cells are associated with adipocyte size and insulin action. To determine whether the mRNA concentrations of inflammation response genes in isolated adipocytes and in cultured preadipocytes are related to adipocyte size and in vivo insulin action in obese individuals.Cross-sectional inpatient study.Obese Pima Indians with normal glucose tolerance.Adipocyte diameter (by microscope technique; n=29), expression of candidate genes

2009 International Journal of Obesity

993. A chronic pressure ulcer model in the nude mouse. (Abstract)

. Pressure was then periodically applied (2 hours compression, 1 hour recovery) using a Neodymium magnet in conjunction with the disk in the unanesthetized mouse. Cycles were repeated for 1, 4, 6, 8, or 10 times. Controls underwent the same procedure without placement of the magnet. The pressure ulcer grade was found to be cycle dependent,with the highest degree after 10 cycles. Histological evaluations revealed signs of necrosis in the skin and subcutaneous fat after four, and in the muscle after eight (...) A chronic pressure ulcer model in the nude mouse. The pathophysiology of pressure ulcers is not yet fully understood. Widely used experimental models lead to pressure ulcers in the skin and the subcutaneous tissue only. The aim of the present study was to develop a clinically relevant deep pressure ulcer model in nude mice involving all relevant tissue layers. Balb/c nude mice were anesthetized and a steel disk was implanted under the great gluteus muscle. Full recovery was allowed for 10 days

2009 Wound Repair and Regeneration

994. Impaired preadipocyte differentiation in human abdominal obesity -- role of Wnt, TNF{alpha} and inflammation. Full Text available with Trip Pro

the normal differentiation of the preadipocytes, and instead induced a proinflammatory and macrophage-like phenotype of the cells.The apparent number of preadipocytes in the abdominal subcutaneous tissue that can undergo differentiation is reduced in obesity with enlarged fat cells, possibly because of increased MAP4K4 levels. TNF-alpha promoted a macrophage-like phenotype of the preadipocytes, including several macrophage markers. These results document the plasticity of human preadipocytes (...) Impaired preadipocyte differentiation in human abdominal obesity -- role of Wnt, TNF{alpha} and inflammation. We examined preadipocyte differentiation in obese and nonobese individuals and the effect of cytokines and wingless-type MMTV (mouse mammary tumor virus) integration site family, member 3A (Wnt3a) protein on preadipocyte differentiation and phenotype.Abdominal subcutaneous adipose tissue biopsies were obtained from a total of 51 donors with varying BMI. After isolation of the adipose

2009 Diabetes

995. Inflammation and Race and Gender Differences in Computerized Tomography-measured Adipose Depots. Full Text available with Trip Pro

and subcutaneous fat and thigh intermuscular and subcutaneous fat in older white and black adults. Data were from 2,651 black and white men and women aged 70-79 years participating in the Health, Aging, and Body Composition (Health ABC) study. Inflammatory markers, interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) were obtained from serum samples. Abdominal visceral and subcutaneous fat and thigh intermuscular and subcutaneous fat were quantified on computerized (...) fat had an inconsistent but significant association with inflammation, and there was a trend toward lower inflammatory marker concentration with increasing thigh subcutaneous fat in white and black women. Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined.

2009 Obesity

996. Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients. Full Text available with Trip Pro

Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients. Inflammation in adipose tissue has been implicated in vascular dysfunction, but the local mechanisms by which this occurs are unknown.Small arteries with and without perivascular adipose tissue were taken from subcutaneous gluteal fat biopsy samples and studied with wire myography and immunohistochemistry. We established that healthy adipose tissue around human small arteries (...) necrosis factor receptor 1 12.4+/-1.1% versus 6.7+/-1%, P<0.001). Application of the cytokines tumor necrosis factor receptor-alpha and interleukin-6 to perivascular fat around healthy blood vessels reduced dilator activity, resulting in the obese phenotype. These effects could be reversed with free radical scavengers or cytokine antagonists. Similarly, induction of hypoxia stimulated inflammation and resulted in loss of anticontractile capacity, which could be rescued by catalase and superoxide

2009 Circulation

997. Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice. Full Text available with Trip Pro

, food intake, plasma biochemistry, visceral and subcutaneous fat (X-ray and CT), glucose tolerance, blood pressure and pain tolerance were measured, and histopathological examination of the liver was carried out. A significant dose-dependent decline in the gain in body weight, accumulation of visceral and subcutaneous fat and an improvement of abnormal glucose tolerance, hypertension and peripheral neuropathy were noticed in TSOD mice. In addition, hepatocellular swelling, fatty degeneration (...) of hepatocytes, inflammatory cell infiltration and single-cell necrosis were observed on histopathological examination of the liver in TSOD mice. Salacia extract markedly improved these symptoms upon treatment. Based on the above results, it is concluded that Salacia extract has remarkable potential to prevent obesity and associated metabolic disorders including the development of metabolic syndrome.

2009 Evidence-based Complementary and Alternative Medicine (eCAM)

998. Cervarix - human papillomavirus vaccine [types 16, 18] (recombinant, adjuvanted, adsorbed)

thereafter following intramuscular administration, and at 168 hours post-dose was 11.4 ng equivalents of MPL/g. The elimination half-life following intravenous administration was 76.5 hours. Relatively low quantifiable levels of radioactivity were detected in all tissues investigated at 56 days post-dose in both studies, with the highest concentrations observed in the fat and spleen. The routes and rates of elimination were similar following both intramuscular and intravenous administration. The major (...) % of the dose appeared to be absorbed. However, the total absorption is likely to be much higher than this value since only 0.2% of the dose was recovered from the injection site. In conclusion the pharmacokinetic studies conducted in rats have shown that MPL-related material is widely distributed throughout the body, notably to the fat and spleen, and is then likely eliminated mainly via the expired air, with only low levels of radioactivity remaining in the carcass. Toxicology • Single dose toxicity

2007 European Medicines Agency - EPARs

999. Abraxane (paclitaxel)

, BIO-TF-1 showed that the albumin staining pattern matched that of SPARC, most prominently around necrosis areas. There was no correlation between albumin staining and caveolin staining. Results from study BIO-TF-2 showed that SPARC expression was absent in major organs of adult mice (liver, kidney, lung, brain, heart, stomach and spleen). Study BIO-TF-3 confirmed that SPARC expression was absent in colon, rectum, spleen, lung, prostate, heart, tonsil, lymph node, appendix, pancreas, eyeball, ovary (...) of 3 H-Abraxane (21.7 mg/kg) to tumours following single iv injection were investigated in a 24-hour study on female mice (2-4 mice/time point/group) bearing subcutaneous, implanted MX-1 human mammary tumours (Study A590.1). Results are shown in Table 5: Table 5: PK parameters in blood, plasma and tumour levels of 3 H-Abraxane in mice Treatment Iv dose mg/kg Sample AUC 0-inf (nCi·h/mL) Clearance (mL/h·kg) Vd ss (mL/kg) T ½ (h) 3 H-Abraxane 21.7 Blood 939 354 6939 17.1 Plasma 1161 287 5180 16.1

2008 European Medicines Agency - EPARs

1000. Beromun (tasonermin)

Beromun (tasonermin) CPMP/2/99 1/23 EMEA 2000 SCIENTIFIC DISCUSSION Name of the medicinal product: Beromun Marketing Authorisation Holder: Boehringer Ingelheim International GmbH Binger Strasse 173 D-55216 Ingelheim am Rhein Germany Active substance: Tumor necrosis factor alfa-1a International Nonproprietary Name: Tasonermin Pharmaco-therapeutic group (ATC Code): LO3AA Therapeutic indication: As an adjunct to surgery for subsequent removal of the tumour so as to prevent or delay amputation (...) , or in the palliative situation, for irresectable soft tissue sarcoma of the limbs, used in combination with melphalan via mild hyperthermic isolated limb perfusion (ILP).CPMP/2/99 2/23 EMEA 2000 1. Introduction Beromun contains the active ingredient tasonermin also known as tumour necrosis factor alfa-1a or TNFa-1a. Tasonermin is a non-glycosylated cytokine produced from E.coli using rDNA technology. The protein consists of three identical polypeptide chains of 157 amino acids combined to form a compact, bell

2005 European Medicines Agency - EPARs

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