How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,016 results for

Subcutaneous Fat Necrosis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

921. Consensus recommendations for the diagnosis, treatment and control of Mycobacterium ulcerans infection (Bairnsdale or Buruli ulcer) in Victoria, Australia

. Epidemiology Mycobacterium ulcerans was discovered in 1948 by Australian scientists who were investigating a cluster of patients with unusual skin ulcers in the Bairnsdale region of eastern Victoria. M. ulcerans is related to the causative agents of tuberculosis and leprosy, but is transmitted from the environment rather than from person to person. The major virulence factor is a lipid toxin, mycolactone, which causes necrosis of fat and subcutaneous tissue. M. ulcerans infection is not fatal, but can (...) that undergoes necrosis and evolves to a deeply undermined ulcer. Lesions are usually painless or minimally painful. Less commonly, the initial lesion may resemble a plaque or necrotic patch of skin. Systemic symptoms (fever, malaise) are rare. Fully developed ulcers are characteristically deeply undermined, meaning a probe can be passed easily under the edge into the space left by necrotic liquefied fat tissue. Lesions can occur anywhere and may be multiple, but a single lesion on the leg or arm is most

2007 MJA Clinical Guidelines

922. Improving outcomes in breast cancer

on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108, 411 without breast cancer. Lancet 1997;350:1047- 59.14 The risk of breast cancer is affected by lifestyle. Obesity is associated with a two-fold increase in risk among post-menopausal women; this has been linked with high intake of meat and dairy fat, but the precise nature of these relationships are still unclear

2002 National Institute for Health and Clinical Excellence - Clinical Guidelines

924. Clinical practice guidelines for the management of early breast cancer

of invasive cancer after surgical excision of DCIS. In a report of mammographically-detected DCIS, invasive cancer occurred in 13 per cent of women within eight years of complete surgical excision of intermediate to high-grade DCIS. 38 This represents a ten-fold risk compared with recent incidence figures. Although there are no reliable predictors for probability of progression to invasive carcinoma, the risk may be greater when DCIS displays features such as comedo necrosis or high nuclear grade. 39

2001 Cancer Australia

926. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. (Full text)

subjects matched for age, height, weight, and physical activity to assess the sensitivity of liver and muscle to insulin. Proton ((1)H) magnetic resonance spectroscopy studies were performed to measure intramyocellular lipid and intrahepatic triglyceride content. Rates of whole-body and subcutaneous fat lipolysis were assessed by measuring the rates of [(2)H(5)]glycerol turnover in combination with microdialysis measurements of glycerol release from subcutaneous fat. We performed (31)P magnetic (...) dysfunction, as reflected by a reduction of approximately 30 percent in mitochondrial phosphorylation (P=0.01 for the comparison with controls), since there were no significant differences in systemic or localized rates of lipolysis or plasma concentrations of tumor necrosis factor alpha, interleukin-6, resistin, or adiponectin.These data support the hypothesis that insulin resistance in the skeletal muscle of insulin-resistant offspring of patients with type 2 diabetes is associated with dysregulation

2004 NEJM PubMed abstract

927. Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. (Abstract)

infusions) as well as levels of inflammatory mediators and other risk factors for coronary heart disease in 15 obese women before and 10 to 12 weeks after abdominal liposuction. Eight of the women had normal glucose tolerance (mean [+/-SD] body-mass index, 35.1+/-2.4), and seven had type 2 diabetes (body-mass index, 39.9+/-5.6).Liposuction decreased the volume of subcutaneous abdominal adipose tissue by 44 percent in the subjects with normal glucose tolerance and 28 percent in those with diabetes; those (...) with normal oral glucose tolerance lost 9.1+/-3.7 kg of fat (18+/-3 percent decrease in total fat, P=0.002), and those with type 2 diabetes lost 10.5+/-3.3 kg of fat (19+/-2 percent decrease in total fat, P<0.001). Liposuction did not significantly alter the insulin sensitivity of muscle, liver, or adipose tissue (assessed by the stimulation of glucose disposal, the suppression of glucose production, and the suppression of lipolysis, respectively); did not significantly alter plasma concentrations of C

2004 NEJM

928. What is the effect of liposuction on CHD risk factors in overweight and/or obese patients?

obese women before and 10 to 12 weeks after abdominal liposuction. Eight of the women had normal glucose tolerance (mean [+/-SD] body-mass index, 35.1+/-2.4), and seven had type 2 diabetes (body-mass index, 39.9+/-5.6). RESULTS: Liposuction decreased the volume of subcutaneous abdominal adipose tissue by 44 percent in the subjects with normal glucose tolerance and 28 percent in those with diabetes; those with normal oral glucose tolerance lost 9.1+/-3.7 kg of fat (18+/-3 percent decrease in total (...) fat, P=0.002), and those with type 2 diabetes lost 10.5+/-3.3 kg of fat (19+/-2 percent decrease in total fat, P Liposuction did not significantly alter the insulin sensitivity of muscle, liver, or adipose tissue (assessed by the stimulation of glucose disposal, the suppression of glucose production, and the suppression of lipolysis, respectively); did not significantly alter plasma concentrations of C-reactive protein, interleukin-6, tumor necrosis factor alpha, and adiponectin; and did

2006 TRIP Answers

929. Osteogenic Profiling of Tissue From Children With Craniosynostosis

, University of Pittsburgh Study Details Study Description Go to Brief Summary: The primary objectives of this study are to procure human temporalis muscle, subcutaneous adipose (fat), and bone tissue samples from children with craniosynostosis, to grow cells from these tissues in vitro, to evaluate the osteogenic potentials of these cell types. Condition or disease Intervention/treatment Phase Craniosynostosis Other: biopsy Not Applicable Detailed Description: The screening procedures include review (...) 16, 2008 Last Update Posted: October 23, 2018 Last Verified: October 2018 Keywords provided by Joseph Losee, University of Pittsburgh: to procure human temporalis muscle, subcutaneous adipose (fat), and bone tissue samples from children with craniosynostosis, to grow cells from these tissues in vitro to evaluate the osteogenic potentials of these cell types. Additional relevant MeSH terms: Layout table for MeSH terms Craniosynostoses Synostosis Dysostoses Bone Diseases, Developmental Bone

2008 Clinical Trials

930. Trial of Partial Breast Irradiation With Various Concurrent Chemotherapy Regimens

years post-intervention ] Subcutaneous tissue toxicity will be scored on a scale ranging from 0-4, where a higher score reflects more severe toxicity: 0= none; 1= slight induration (fibrosis) and loss of subcutaneous fat; 2= moderate fibrosis but asymptomatic; slight field contracture; <10% linear reduction; 3= severe induration and loss subcutaneous tissue; field contracture >10% linear reduction; 4= necrosis Secondary Outcome Measures : Cosmetic effect of PBIC [ Time Frame: up to 5 years post (...) skin folds, pitting edema; 4= ulceration, hemorrhage, necrosis. Late skin toxicities of PBIC [ Time Frame: up to 5 years post-intervention ] Late Skin toxicity will be scored on a scale ranging from 0-4, where a higher score reflects more severe toxicity: 0= none; 1= slight atrophy, pigmentation change, some hair loss; 2= patchy atrophy, moderate telangiectasias, total hair loss; 3= marked atrophy, gross telangiectasias; 4= ulceration Subcutaneous tissue toxicities of PBIC [ Time Frame: up to 5

2008 Clinical Trials

931. Clinical Evaluation of DCB-WH1 in Healing of Chronic Diabetic Foot Ulcers

to a modified Wagner system, which includes wounds involving the epidermis, the dermis, the hypodermis or the subcutaneous fat but not the tendon or joint capsule. The thickness of aforesaid layers wounds be approximately between 0.2 mm and 8 mm and is ranging in size between 3 and 15 cm2 post debridement. An ankle brachial index ≥0.80. The study ulcer should show "infection control" as judged by the investigator The subject should be free of any necrotic or infected soft and bony tissue. Signed informed (...) consent form. Exclusion Criteria: Ulcers caused by venous or arterial insufficiency, osteomyelitis. Poor nutritional status (albumin < 3g/dl), poor diabetic control (HbA1c > 10%), anemia (hemoglobin<10 g/dL), a leukocyte counts < 1,000/cumm. Requiring prostaglandin treatment. Requiring treatment with corticosteroids, immunosuppressive or chemotherapeutic agents, radiotherapy. Presence of necrosis, purulence or sinus tracts that cannot be removed by debridement. Presence of connective tissue disease

2008 Clinical Trials

932. Partial Breast Irradiation (PBI) for Selected Patients With Early Breast Cancer

Radiotherapy as Measured by Percentage of Participants Achieving a Dosimetrically Satisfactory Treatment Plan [ Time Frame: Within 1 year of protocol registration ] -The study will be deemed infeasible if more than 4 patients cannot be given treatment because her tumor is such that a dosimetrically satisfactory treatment plan cannot be devised for her. Feasibility of PBI Directed External Radiotherapy as Measured by Development of Histological Fat Necrosis or Other Grade 4 Skin or Grade 4 Subcutaneous (...) Toxicity, or Requires Surgery for the Skin/Subcutaneous Toxicity [ Time Frame: Within 1 year of protocol registration ] -The study will be deemed infeasible if more than 4 patients develop histological fat necrosis or other grade 4 skin or grade 4 subcutaneous toxicity, or requires surgery for her skin or subcutaneous toxicity Secondary Outcome Measures : Incidence and Severity of Cutaneous Toxicity [ Time Frame: Up to 5 years ] Uses RTOG/EORTC Late Radiation Morbidity Scoring Scheme Grade 0 = none

2006 Clinical Trials

933. Visceral adipose tissue zinc finger protein 36 mRNA levels are correlated with insulin, insulin resistance index, and adiponectinemia in women. (Full text)

protein 36 (ZFP36), which is known to down-regulate tumor necrosis factor-alpha TNF-alpha) expression.The objective of this study was to further examine the relationship between ZFP36 gene expression levels, obesity-related phenotypes, and adipokines.Abdominal subcutaneous and omental adipose tissue samples were obtained from 46 women undergoing elective gynecological surgery. Adipose tissue ZFP36 mRNA abundance was assessed by quantitative real-time PCR. Body fat accumulation and distribution were (...) measured by dual X-ray absorptiometry and computed tomography. Fasting blood levels of glucose, insulin, and lipids, and circulating TNF-alpha, interleukin-6 (IL-6), resistin, and adiponectin were also measured.No correlation was observed between s.c. ZFP36 mRNA levels and any of the phenotypes tested. However, although omental ZFP36 mRNA levels were not correlated with measures of body fatness and lipid profile, they were negatively correlated with fasting insulin levels (R = -0.31; P = 0.05

2007 European Journal of Endocrinology PubMed abstract

934. Effects of different hypocaloric diets on protein secretion from adipose tissue of obese women. (Abstract)

-linked immunosorbent assays) from subcutaneous adipose tissue in 40 obese but otherwise healthy women. Similar results were obtained by the two diets. Body weight decreased by approximately 7.5%. The secretion rate of leptin decreased by approximately 40%, as did that of tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-6 and -8 decreased by 25-30%, whereas the secretion of plasminogen activator inhibitor 1 (PAI-1) and adiponectin did not show any changes. Regarding mRNA expression (...) Effects of different hypocaloric diets on protein secretion from adipose tissue of obese women. Little is known about common factors (e.g., macronutrients and energy supply) regulating the protein secretory function of adipose tissue. We therefore compared the effects of randomly assigned 10-week hypoenergetic (-600 kcal/day) diets with moderate-fat/moderate-carbohydrate or low-fat/high-carbohydrate content on circulating levels and production of proteins (using radioimmunoassays and enzyme

2004 Diabetes Controlled trial quality: uncertain

935. Influence of parturition and diets enriched in n-3 or n-6 polyunsaturated fatty acids on immune response of dairy cows during the transition period. (Full text)

Influence of parturition and diets enriched in n-3 or n-6 polyunsaturated fatty acids on immune response of dairy cows during the transition period. The objectives of this study were to evaluate the functional properties of immunocompetent cells in dairy cows fed diets enriched in n-3 or n-6 polyunsaturated fatty acids during the transition period. Six weeks before calving, 21 primiparous and 27 multiparous pregnant Holstein dairy cows were randomly allotted to 1 of 3 dietary fat treatments (...) : calcium salts of palm oil (Megalac), micronized soybeans, or whole flaxseed, which are, respectively, rich in saturated, n-6, or n-3 fatty acids. On wk 6 and 3 before parturition, cows received a subcutaneous injection of ovalbumin to measure the antibody response in colostrum and serum. Colostrum samples were collected at the first milking after calving, and blood samples were taken 6, 3, and 1 wk before the expected calving date and 1, 3, and 6 wk after calving. Blood mononuclear cells were cultured

2004 Journal of dairy science Controlled trial quality: uncertain PubMed abstract

936. Changes in serum levels of E-selectin correlate to improved glycaemic control and reduced obesity in subjects with the metabolic syndrome. (Abstract)

the effect of physical exercise and pravastatin (40 mg daily) on serum levels of CAMs and a possible role of adipose tissue in regulating serum levels of CAMs were investigated.The study was designed as an unmasked randomized 2x2 factorial trial of 12 weeks duration in 32 subjects with the metabolic syndrome. Changes from baseline were studied, and correlations between changes in CAMs, anthropometric measures, regional fat distribution, glycaemic control and the adipocytokine tumour necrosis factor (...) -a (TNF-a) and adiponectin were investigated.No significant changes in CAMs were observed in any of the intervention groups. However, when examining the whole study population regardless of intervention, changes in serum E-selectin were significantly correlated to changes in body mass index (r=0.48, p=0.006), waist circumference (r=0.48, p=0.006), fasting glucose (r=0.43, p=0.02) and HbA1c (r=0.45, p=0.01), but not to changes in visceral fat, subcutaneous fat, TNF-a or adiponectin.Changes in glycaemic

2005 Scandinavian journal of clinical and laboratory investigation Controlled trial quality: uncertain

937. Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism. (Full text)

= 0.012), RLP-cholesterol (beta coefficient = -0.377; P = 0.016), and triglycerides (beta coefficient = -0.374; P = 0.013). By contrast, leptin was not an independent predictor of these TRL markers. Plasma apoB-48, apoC-III, RLP-cholesterol, and triglycerides were all significantly and positively associated with plasma insulin, HOMA, and visceral, subcutaneous, and total ATMs (P <0.05).These data suggest that the plasma adiponectin concentration may not only link abdominal fat, insulin resistance (...) Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism. Adipocytokines are bioactive peptides that may play an important role in the regulation of glucose and lipid metabolism. In this study, we investigated the association of plasma adipocytokine concentrations with markers of triglyceride-rich lipoprotein (TRL) metabolism in men.Fasting adiponectin, leptin, resistin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha

2005 Clinical Chemistry PubMed abstract

938. Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects. (Full text)

Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects. Experimental studies suggest that adipose inflammation is etiologically linked to obesity-induced systemic disease. Our goal was to characterize the state of inflammation in human fat in relation to vascular function and metabolic parameters in obese individuals.We collected subcutaneous abdominal fat in 77 obese subjects (BMI >or=30 kg/m(2)) and quantified adipose (...) to subjects with quiescent noninflamed adipose architecture (n=27). Macrophage retention in fat was linked to upregulated tissue CD68 and tumor necrosis factor (TNF)-alpha mRNA expression in addition to increased plasma hs-CRP.In a cohort of obese subjects, we demonstrate that proinflammatory changes in adipose tissue are associated with systemic arterial dysfunction and insulin resistance. These findings suggest that adipose inflammation may be linked to vascular injury and increased cardiovascular risk

2008 Thrombosis and Vascular Biology PubMed abstract

939. Expression of long pentraxin PTX3 in human adipose tissue and its relation with cardiovascular risk factors. (Abstract)

Expression of long pentraxin PTX3 in human adipose tissue and its relation with cardiovascular risk factors. Pentraxin 3 (PTX3) is an acute phase protein strongly expressed by advanced atherosclerotic lesions. We investigated (a) PTX3 expression and secretion in subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (VAT) obtained from 21 obese (37.4+/-8.15 yr) and 10 normal weight subjects (43.7+/-11.07 yr) and (b) the relationships of adipose PTX3 with tumour necrosis factor (...) alpha (TNFalpha) and adiponectin expression and with cardiometabolic risk factors. Real-time PCR was used to quantify specific mRNA for PTX3, CD68 (macrophage marker), TNFalpha and adiponectin. Fresh adipose tissue was cultured and PTX3 measured in the medium. Serum insulin, glucose, HDL and LDL cholesterol, triglycerides, C-reactive protein (CRP), fibrinogen, adiponectin, TNFalpha and PTX3 were measured. PTX3 expression was similar in the two fat compartments and tended to be higher in obese than

2008 Atherosclerosis

940. Microcystic/Reticular Schwannoma: A Distinct Variant With Predilection for Visceral Locations. (Abstract)

ranged from 0.4 to 23 cm (median size 4.3 cm). Five tumors arose in the gastrointestinal tract, most often in the submucosa. Two cases arose in subcutaneous tissue and 1 case each in the upper respiratory tract, the adrenal gland, and deep soft tissue. None of the patients had features of neurofibromatosis type 1 or type 2 (NF1, NF2). Histologically 8 tumors were circumscribed but unencapsulated and 2 cases located in the subcutaneous fat were circumscribed and encapsulated. At visceral locations (...) Microcystic/Reticular Schwannoma: A Distinct Variant With Predilection for Visceral Locations. Schwannomas are benign, generally nonrecurring tumors most frequently arising in the subcutaneous tissue of adults with no sex predilection. Herein we report 10 cases of a distinctive morphologic variant of schwannoma with predominantly microcystic-reticular morphology and characterize the clinicopathologic spectrum. The age at presentation ranged from 11 to 93 years (median age 63 y). The tumor size

2008 American Journal of Surgical Pathology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>