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Subcutaneous Fat Necrosis

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901. Adiponectin and Inflammatory Mediators in Mediastinal Adipose Tissues

Tissues Between Patients With Coronary Artery Diseases and With Valvular Diseases Study Start Date : January 2008 Estimated Primary Completion Date : December 2008 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort 1 CABG 2 Valve surgery Outcome Measures Go to Biospecimen Retention: Samples Without DNA Adipose tissue biopsy samples from mediastinal fat, epicardial fat, subcutaneous fat in thoracic region or abdominal region (...) and subcutaneous fat in leg were obtained soon after sternotomy or thoracotomy before the initiation of cardiopulmonary bypass. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout

2009 Clinical Trials

902. The Occlusive Dressing

amputations are very common injuries among the patients arriving at the Emergency Department. Fingertips amputations classified in 2nd and 3rd zones, in accordance with Rosenthal's classification (after the solum unguis), constitute a large proportion of them. The treatment aims at restoring a pulp with its sensitivity and a good subcutaneous fat tissue. The usual care of these amputations is a surgical treatment: it consists of pulp reconstruction by a flap (for example palmar V-Y advancement flaps (...) of Atazoy). These technique involve hospital admission, brachial plexus anaesthesia, a surgical approach with cicatrix and donor site morbidities, postoperative cares, post-surgical pain management. And of course attention must be paid to the risks of postoperative complications related either to anaesthesia and/or to surgery, like necrosis, infection, and others. We have developed a nonoperative treatment for fingertips amputations: the occlusive dressing. It's a technique that has been known for about

2009 Clinical Trials

903. Excision of Strip of Deep Fascia to Reduce Seroma Formation and Extrusion of Tissue Expanders

in mitosis returned to normal 4 weeks after expansion. The dermis and subcutaneous tissues were thinned as a result of tissue expansion leading to an overall decrease in tensile strength of the expanded skin (5-7) and this persisted 36 weeks after expansion. The subcutaneous layer of fat was intolerant to stretching causing significant thinning. With faster expansion, fat necrosis could be seen. Pressure necrosis on subcutaneous fat led to liquefaction and seroma formation. With progression of expansion (...) University Information provided by: Cairo University Study Details Study Description Go to Brief Summary: Tissue expansion has enjoyed a wide range of applications since the technique was popularized in the latter quarter of the last century. During the expansion process, subcutaneous fat liquefies, skin becomes thinner, muscles atrophy, blood inflow increases, and lymphatics get occluded. All these factors predispose to seroma formation and implant extrusion. A similar problem occurred with lymphoedema

2009 Clinical Trials

904. Impaired preadipocyte differentiation in human abdominal obesity -- role of Wnt, TNF{alpha} and inflammation. (PubMed)

the normal differentiation of the preadipocytes, and instead induced a proinflammatory and macrophage-like phenotype of the cells.The apparent number of preadipocytes in the abdominal subcutaneous tissue that can undergo differentiation is reduced in obesity with enlarged fat cells, possibly because of increased MAP4K4 levels. TNF-alpha promoted a macrophage-like phenotype of the preadipocytes, including several macrophage markers. These results document the plasticity of human preadipocytes (...) Impaired preadipocyte differentiation in human abdominal obesity -- role of Wnt, TNF{alpha} and inflammation. We examined preadipocyte differentiation in obese and nonobese individuals and the effect of cytokines and wingless-type MMTV (mouse mammary tumor virus) integration site family, member 3A (Wnt3a) protein on preadipocyte differentiation and phenotype.Abdominal subcutaneous adipose tissue biopsies were obtained from a total of 51 donors with varying BMI. After isolation of the adipose

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2009 Diabetes

905. Inflammation and Race and Gender Differences in Computerized Tomography-measured Adipose Depots. (PubMed)

and subcutaneous fat and thigh intermuscular and subcutaneous fat in older white and black adults. Data were from 2,651 black and white men and women aged 70-79 years participating in the Health, Aging, and Body Composition (Health ABC) study. Inflammatory markers, interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) were obtained from serum samples. Abdominal visceral and subcutaneous fat and thigh intermuscular and subcutaneous fat were quantified on computerized (...) fat had an inconsistent but significant association with inflammation, and there was a trend toward lower inflammatory marker concentration with increasing thigh subcutaneous fat in white and black women. Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined.

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2009 Obesity

906. Abraxane (paclitaxel)

, BIO-TF-1 showed that the albumin staining pattern matched that of SPARC, most prominently around necrosis areas. There was no correlation between albumin staining and caveolin staining. Results from study BIO-TF-2 showed that SPARC expression was absent in major organs of adult mice (liver, kidney, lung, brain, heart, stomach and spleen). Study BIO-TF-3 confirmed that SPARC expression was absent in colon, rectum, spleen, lung, prostate, heart, tonsil, lymph node, appendix, pancreas, eyeball, ovary (...) of 3 H-Abraxane (21.7 mg/kg) to tumours following single iv injection were investigated in a 24-hour study on female mice (2-4 mice/time point/group) bearing subcutaneous, implanted MX-1 human mammary tumours (Study A590.1). Results are shown in Table 5: Table 5: PK parameters in blood, plasma and tumour levels of 3 H-Abraxane in mice Treatment Iv dose mg/kg Sample AUC 0-inf (nCi·h/mL) Clearance (mL/h·kg) Vd ss (mL/kg) T ½ (h) 3 H-Abraxane 21.7 Blood 939 354 6939 17.1 Plasma 1161 287 5180 16.1

2008 European Medicines Agency - EPARs

907. Trial of Partial Breast Irradiation With Various Concurrent Chemotherapy Regimens

years post-intervention ] Subcutaneous tissue toxicity will be scored on a scale ranging from 0-4, where a higher score reflects more severe toxicity: 0= none; 1= slight induration (fibrosis) and loss of subcutaneous fat; 2= moderate fibrosis but asymptomatic; slight field contracture; <10% linear reduction; 3= severe induration and loss subcutaneous tissue; field contracture >10% linear reduction; 4= necrosis Secondary Outcome Measures : Cosmetic effect of PBIC [ Time Frame: up to 5 years post (...) skin folds, pitting edema; 4= ulceration, hemorrhage, necrosis. Late skin toxicities of PBIC [ Time Frame: up to 5 years post-intervention ] Late Skin toxicity will be scored on a scale ranging from 0-4, where a higher score reflects more severe toxicity: 0= none; 1= slight atrophy, pigmentation change, some hair loss; 2= patchy atrophy, moderate telangiectasias, total hair loss; 3= marked atrophy, gross telangiectasias; 4= ulceration Subcutaneous tissue toxicities of PBIC [ Time Frame: up to 5

2008 Clinical Trials

908. Osteogenic Profiling of Tissue From Children With Craniosynostosis

, University of Pittsburgh Study Details Study Description Go to Brief Summary: The primary objectives of this study are to procure human temporalis muscle, subcutaneous adipose (fat), and bone tissue samples from children with craniosynostosis, to grow cells from these tissues in vitro, to evaluate the osteogenic potentials of these cell types. Condition or disease Intervention/treatment Phase Craniosynostosis Other: biopsy Not Applicable Detailed Description: The screening procedures include review (...) 16, 2008 Last Update Posted: October 23, 2018 Last Verified: October 2018 Keywords provided by Joseph Losee, University of Pittsburgh: to procure human temporalis muscle, subcutaneous adipose (fat), and bone tissue samples from children with craniosynostosis, to grow cells from these tissues in vitro to evaluate the osteogenic potentials of these cell types. Additional relevant MeSH terms: Layout table for MeSH terms Craniosynostoses Synostosis Dysostoses Bone Diseases, Developmental Bone

2008 Clinical Trials

909. Clinical Evaluation of DCB-WH1 in Healing of Chronic Diabetic Foot Ulcers

to a modified Wagner system, which includes wounds involving the epidermis, the dermis, the hypodermis or the subcutaneous fat but not the tendon or joint capsule. The thickness of aforesaid layers wounds be approximately between 0.2 mm and 8 mm and is ranging in size between 3 and 15 cm2 post debridement. An ankle brachial index ≥0.80. The study ulcer should show "infection control" as judged by the investigator The subject should be free of any necrotic or infected soft and bony tissue. Signed informed (...) consent form. Exclusion Criteria: Ulcers caused by venous or arterial insufficiency, osteomyelitis. Poor nutritional status (albumin < 3g/dl), poor diabetic control (HbA1c > 10%), anemia (hemoglobin<10 g/dL), a leukocyte counts < 1,000/cumm. Requiring prostaglandin treatment. Requiring treatment with corticosteroids, immunosuppressive or chemotherapeutic agents, radiotherapy. Presence of necrosis, purulence or sinus tracts that cannot be removed by debridement. Presence of connective tissue disease

2008 Clinical Trials

910. Microcystic/Reticular Schwannoma: A Distinct Variant With Predilection for Visceral Locations. (PubMed)

ranged from 0.4 to 23 cm (median size 4.3 cm). Five tumors arose in the gastrointestinal tract, most often in the submucosa. Two cases arose in subcutaneous tissue and 1 case each in the upper respiratory tract, the adrenal gland, and deep soft tissue. None of the patients had features of neurofibromatosis type 1 or type 2 (NF1, NF2). Histologically 8 tumors were circumscribed but unencapsulated and 2 cases located in the subcutaneous fat were circumscribed and encapsulated. At visceral locations (...) Microcystic/Reticular Schwannoma: A Distinct Variant With Predilection for Visceral Locations. Schwannomas are benign, generally nonrecurring tumors most frequently arising in the subcutaneous tissue of adults with no sex predilection. Herein we report 10 cases of a distinctive morphologic variant of schwannoma with predominantly microcystic-reticular morphology and characterize the clinicopathologic spectrum. The age at presentation ranged from 11 to 93 years (median age 63 y). The tumor size

2008 American Journal of Surgical Pathology

911. Treatment of Obese Diabetic Mice with an Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels and Improves Insulin Sensitivity and Glucose Tolerance. (PubMed)

caused a sustained increase in HO-1 protein, prevented weight gain, decreased visceral and subcutaneous fat content (P < 0.03 and 0.01, respectively, compared with vehicle animals), increased serum adiponectin, and decreased plasma tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta levels (P < 0.05). HO-1 induction improved insulin sensitivity and glucose tolerance and decreased insulin levels. Upregulation of HO-1 decreased adipogenesis in bone marrow in vivo and in cultured (...) Treatment of Obese Diabetic Mice with an Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels and Improves Insulin Sensitivity and Glucose Tolerance. We hypothesized that the induction of heme oxygenase (HO)-1 and increased HO activity, which induces arterial antioxidative enzymes and vasoprotection in a mouse and a rat model of diabetes, would ameliorate insulin resistance, obesity, and diabetes in the ob mouse model of type 2 diabetes.Lean and ob

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2008 Diabetes

912. Tissue-toxic effects of phosphatidylcholine/deoxycholate after subcutaneous injection for fat dissolution in rats and a human volunteer. (PubMed)

study (30 days). A human volunteer undergoing elective liposuction was similarly treated. Cell membrane lysis, cell viability, and histologic status were determined on fresh biopsies of subcutaneous fat from the injection sites.PC/DC dose-dependently reduced membrane integrity and cell viability. Histologic alterations induced by PC/DC included fibroplasia, bandlike fibrosis in the region of the cutaneous muscle, and partial muscle loss. The highest dose caused widespread fat necrosis, fat cyst (...) formation, and necrotic changes of the walls of small blood vessels. Histologic sections of subcutaneous tissue from the human volunteer showed dose-dependent panniculitis, fat cysts, and vessel necrosis. DC (2.5%), tested for comparison in the rat, exerted membrane and histologic effects similar to those of PC/DC. Solvent controls caused negligible alterations.Injection lipolysis with PC/DC causes tissue fibrosis and necrosis of adipose and vascular tissues in rat and man, making the long-term safety

2008 Dermatologic Surgery

913. Differential gene expression indicates that 'buffalo hump' is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy. (PubMed)

in the expression of UCP2, UCP3 or of marker genes of adipogenesis in 'buffalo hump' patients relative to healthy controls. 'Buffalo hump' fat did not show the high expression of tumor necrosis factor-alpha and beta2-microglobulin identified in lipoatrophic subcutaneous fat from patients. The expression of the macrophage marker CD68 was also lower in 'buffalo hump' than in subcutaneous fat from patients. In contrast, 'buffalo hump' showed a higher expression of the cell proliferation marker PCNA.'Buffalo hump (...) and ten subcutaneous fat samples from HIV-1-infected/HAART-treated patients, and in ten healthy controls.Quantitative real-time polymerase chain reaction analysis of mitochondrial DNA and gene transcripts, and immunoblot for specific proteins.'Buffalo hump' patients had lower levels of mitochondrial DNA and mitochondrial DNA-encoded transcripts with respect to healthy controls. The uncoupling protein (UCP)-1 gene was expressed only in 'buffalo hump' fat. There were no significant changes

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2008 AIDS

914. Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects. (PubMed)

Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects. Experimental studies suggest that adipose inflammation is etiologically linked to obesity-induced systemic disease. Our goal was to characterize the state of inflammation in human fat in relation to vascular function and metabolic parameters in obese individuals.We collected subcutaneous abdominal fat in 77 obese subjects (BMI >or=30 kg/m(2)) and quantified adipose (...) to subjects with quiescent noninflamed adipose architecture (n=27). Macrophage retention in fat was linked to upregulated tissue CD68 and tumor necrosis factor (TNF)-alpha mRNA expression in addition to increased plasma hs-CRP.In a cohort of obese subjects, we demonstrate that proinflammatory changes in adipose tissue are associated with systemic arterial dysfunction and insulin resistance. These findings suggest that adipose inflammation may be linked to vascular injury and increased cardiovascular risk

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2008 Thrombosis and Vascular Biology

915. Expression of long pentraxin PTX3 in human adipose tissue and its relation with cardiovascular risk factors. (PubMed)

Expression of long pentraxin PTX3 in human adipose tissue and its relation with cardiovascular risk factors. Pentraxin 3 (PTX3) is an acute phase protein strongly expressed by advanced atherosclerotic lesions. We investigated (a) PTX3 expression and secretion in subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (VAT) obtained from 21 obese (37.4+/-8.15 yr) and 10 normal weight subjects (43.7+/-11.07 yr) and (b) the relationships of adipose PTX3 with tumour necrosis factor (...) alpha (TNFalpha) and adiponectin expression and with cardiometabolic risk factors. Real-time PCR was used to quantify specific mRNA for PTX3, CD68 (macrophage marker), TNFalpha and adiponectin. Fresh adipose tissue was cultured and PTX3 measured in the medium. Serum insulin, glucose, HDL and LDL cholesterol, triglycerides, C-reactive protein (CRP), fibrinogen, adiponectin, TNFalpha and PTX3 were measured. PTX3 expression was similar in the two fat compartments and tended to be higher in obese than

2008 Atherosclerosis

916. Primary Cutaneous PEComa: Distinctive Clear Cell Lesions of Skin. (PubMed)

on the back. The tumors involved the dermis and commonly showed infiltration into the subcutaneous fat. Architecturally, a nested, focally trabecular growth pattern with prominent vasculature composed of delicate thin-walled capillaries was observed. Six tumors were composed of epithelioid cells and 4 showed mixed epithelioid and spindle cell morphology. Tumor cells had clear, palely eosinophilic or granular cytoplasm. Multinucleate tumor giant cells were observed in 3 cases. Mitotic activity ranged from (...) 0 to 2 mitoses per 30 high power fields (mean < 1/10 HPF). Pleomorphism or necrosis was absent. All cases showed at least focal positivity for HMB-45. Melan A was positive in 5/7. In cases where HMB-45 was positive in fewer than 5% of tumor cells (5/10), microphthalmia transcription factor was positive in the majority of the tumor cell nuclei. Desmin positivity was observed in 5 and smooth muscle actin in 1 case, respectively. The other muscle markers (caldesmon, calponin) and also pan-keratin

2008 American Journal of Surgical Pathology

917. Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages. (PubMed)

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages. Adipose tissue macrophages (ATMs) have become a focus of attention recently because they have been shown to accumulate with an increase in fat mass and to be involved in the genesis of insulin resistance in obese mice. However, the phenotype and functions of human ATMs are still to be defined.The present study, performed on human subcutaneous AT, showed that ATMs from lean to overweight individuals are composed of distinct (...) macrophage subsets based on the expression of several cell surface markers: CD45, CD14, CD31, CD44, HLA-DR, CD206, and CD16, as assessed by flow cytometry. ATMs isolated by an immunoselection protocol showed a mixed expression of proinflammatory (tumor necrosis factor-alpha, interleukin-6 [IL-6], IL-23, monocyte chemoattractant protein-1, IL-8, cyclooxygenase-2) and antiinflammatory (IL-10, transforming growth factor-beta, alternative macrophage activation-associated cc chemokine-1, cyclooxygenase-1

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2008 Circulation

918. Elevated levels of tumor necrosis factor-alpha in periradicular fat tissue in patients with radiculopathy from herniated disc. (PubMed)

Elevated levels of tumor necrosis factor-alpha in periradicular fat tissue in patients with radiculopathy from herniated disc. Case-control study.To determine whether inflammatory cytokines [tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and IL-8] are elevated in tissues intimately surrounding involved nerve roots of patients suffering from radiculopathy form herniated disc (HD).Proinflammatory cytokines are postulated to play an important role in radiculopathy from HD (...) range 6.6, (1.6-16.3) pg/mL per milligram of tissue vs. 2.3 (1.3-5.0), P < 0.05] and to subcutaneous fat [0.35 (0-2.28), P < 0.001]. No significant increase of either cytokines was found in HD compared with IVD.Higher concentrations of TNF-alpha were found in EF from patients with radiculopathy from HD compared with patients suffering from other type of back pain. These results support the role of TNF-alpha in the pathogenesis of radiculopathy from HD.

2008 Spine

919. A 1-week-old newborn with hypercalcemia and palpable nodules: subcutaneous fat necrosis. (PubMed)

A 1-week-old newborn with hypercalcemia and palpable nodules: subcutaneous fat necrosis. We present a 1-week-old newborn with subcutaneous fat necrosis complicated by hypercalcemia. She received conservative treatment of adequate hydration and restricted supplementary vitamin D.

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2008 Canadian Medical Association Journal

920. Adiponectin and resistin response in the onset of obesity in male and female rats. (PubMed)

adiponectin and resistin and tissue mRNA levels were analyzed by western blot and reverse transcription-PCR, respectively. Serum levels of insulin, tumor necrosis factor-alpha (TNFalpha), and glucose were measured by enzyme-linked immunosorbent assay and by a glucose sensor. Insulin resistance was assessed by the homeostasis model assessment (HOMA).Energy intake and adipose-tissue weight were significantly increased in the CAF rats, with higher increase in visceral than in subcutaneous fat, especially (...) Adiponectin and resistin response in the onset of obesity in male and female rats. Studying the sex-dependent response of adiponectin and resistin adipose tissue expression and circulating levels in the onset of dietary obesity.Male and female 4-week-old Wistar rats were fed a control or cafeteria (CAF) diet for 15 days. Body weight and energy intake were monitored. Gonadal (visceral), retroperitoneal (visceral) and inguinal (subcutaneous) white adipose tissue (WAT) depots were collected. Serum

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2008 Obesity

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