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Subcutaneous Fat Necrosis

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901. The Impact of Liraglutide on Glucose Tolerance and the Risk of Type 2 Diabetes in Women With Previous Pregnancy-induced Diabetes

, Intra-hepatic fat, whole body and visceral fat mass/fat-free mass, circulating lipids and cardiovascular biomarkers (highly sensitive c-reactive protein (hs-CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), tumor necrosis factor-alpha (TNF-alpha), adiponectin and plasminogen activator inhibior-1 (PAI-1)) Changes in gut microbiota [ Time Frame: baseline to 52 and 260 wks ] optional to the main protocol Changes in subjective appetite [ Time Frame: baseline to 52, 53, 260, and 261 (...) Study Completion Date : August 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Liraglutide 1.8 mg liraglutide, subcutaneous, once-daily for five years Drug: Liraglutide 1.8 mg liraglutide Other Names: Victoza NN2211 Placebo Comparator: Placebo Placebo, subcutaneous, once-daily for one year Drug: Placebo Liraglutide without the GLP-1 analogue No Intervention: Control Control without

2013 Clinical Trials

902. Hypothermia for Encephalopathy in Low Income Countries-Feasibilty

feasibility of whole body cooling within six hours of birth in infants with neonatal encephalopathy Secondary Outcome Measures : Short term morbidity [ Time Frame: 2 weeks ] Short-term neonatal morbidity - Hypotension requiring inotropes, cardiac arrhythmias (other than bradycardia), coagulopathy/thrombocytopenia requiring blood products, respiratory failure requiring ventilatory support, seizures, and subcutaneous fat necrosis. Eligibility Criteria Go to Information from the National Library of Medicine

2013 Clinical Trials

903. BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects

Natriuretic Peptide (BNP) [ Time Frame: Days -2, 7, 14 ] Blood samples will be obtained at baseline, during the infusion and after the termination of the infusion for measurement of levels of recombinant human BNP (rhBNP) and N-terminal pro-brain natriuretic peptide (NTpro-BNP). Secondary Outcome Measures : Differences in the expression of NPRC [ Time Frame: Day 7 ] Natriuretic peptides Type-A and Type-C (NPRA,NPRC) expression will be measured by RT-PCR in subcutaneous abdominal adipose tissue samples (...) obtained by percutaneous biopsy prior to infusion of rhBNP and related to the Metabolic Clearance Rate (MCR) for BNP Determine whether short term infusion of rhBNP increases metabolic rate and/or fat oxidation [ Time Frame: Day 7 ] Energy expenditure and substrate oxidation rates will be measured for 30 min at baseline, prior to the infusion of BNP, then continuously during the rhBNP infusion in a 3200 Liters Flex Room Calorimeter respiratory chambers. determine whether short term infusion of rhBNP

2013 Clinical Trials

904. Health Effects of Resistance Training on Postmenopausal Women

] Using magnetic resonance imaging (MRI) the volume of total (TAT), subcutaneous (SCAT) and visceral (VAT) white adipose tissue (Dahlqvist Leinhard 2008); the concentration of lipids diffusively stored in the liver parenchyma, and the volume of intramuscular adipose tissue (IMAT) in the quadriceps muscle will be quantified. Furthermore, the MRI images will be used to quantify the volume of and fat concentration in supraclavicular and interscapular brown adipose tissue according to our recently (...) of fat), diagnostic variables (production of myokines as irisin, immunological markers) and genetic variables (length of telomeres). The control group will be offered resistance training after the intervention period. Condition or disease Intervention/treatment Phase Hot Flashes Menopause Other: Resistance training Not Applicable Detailed Description: The first phase is planned as a pilot-study including 20 women participating for 15 weeks. Thereafter an evaluation of the sample size and the study

2013 Clinical Trials

905. Treatment of Hypertensive Leg Ulcer by Adipose Tissue Grafting

to propose subcutaneous injections of autologous fat to change the wound bed, promote healing and eliminate pain. This treatment should help to avoid long-term hospitalization (about 15 days) that can lead to physical and psychological degradation of these elderly patients. The investigators propose an open clinical study of 10 patients with a single-center recruitment (CHU Caen). The study took place over a period of 18 months with a 12-month recruitment and follow-up of 6 months for each patient (...) First Posted: August 30, 2013 Last Update Posted: April 9, 2014 Last Verified: April 2014 Keywords provided by University Hospital, Caen: necrotitis angiodermatitis autologous fat transplantation mesenchymal stem cells Additional relevant MeSH terms: Layout table for MeSH terms Ulcer Leg Ulcer Skin Ulcer Pathologic Processes Skin Diseases

2013 Clinical Trials

906. Effects of Microcurrent in a Cardiovascular Rehabilitation Home-based Program

of Cardiac Rehabilitation Home-based Program ] It was measured subcutaneous, visceral and total abdominal fat. Secondary Outcome Measures : Bioimpedance values [ Time Frame: Change from Baseline in Bioimpedance values at 8 weeks of Cardiac Rehabilitation Home-Based Program and 4 Weeks After Finishing the Protocol ] I twas used a bioimpedance scale (BIO) InnerScan Tanita, TBF-300A, which uses four electrodes (two on each foot) for the passage of an electric current. People were told to undress her clothes (...) among children and adults, as well as changing the metabolic profile: when occurs an excessive accumulation of adipose tissue (mainly central distribution) there are a set of changes / adjustments to the cardiac structure and function. The electrical stimulation of abdominal subcutaneous (electrolipolysis) is a procedure often used in physical therapy clinics to reduce waist circumference. However, the effectiveness of this intervention, the selection of parameters, and the duration of its effects

2013 Clinical Trials

907. Differential dose effect of fish oil on inflammation and adipose tissue gene expression in chronic kidney disease patients. (Abstract)

. Serum adiponectin, leptin, C-reactive protein, and tumor necrosis factor-α were not modified in either group. Interleukin-6 levels tended to decrease with 1.8 g of ω-3 PUFA. Additionally, a subset of inflammation-related genes (CD68 and MMP9) was reduced in subcutaneous adipose tissue in this group. Adiponectin, leptin, and adipoR2 gene expression were upregulated with 3.6 g of ω-3 PUFA.A moderate dose of FO alters the gene expression profile of adipose tissue to a more antiinflammatory status (...) patients with stage IV/V CKD were randomly allocated to receive 1.8 g or 3.6 g/d of ω-3 PUFA for 10 wk. Metabolic parameters, adipose tissue function, and gene expression were evaluated at baseline and 10 wk.Body weight, fat mass, energy intake, fasting glucose, and insulin were unchanged. The daily intake of 3.6 g of ω-3 PUFA resulted in decreased serum triacylglycerol and increased high-density lipoprotein cholesterol, whereas low-density lipoprotein cholesterol increased with 1.8 g of ω-3 PUFA

2013 Nutrition (Burbank, Los Angeles County, Calif.) Controlled trial quality: uncertain

908. Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans. Full Text available with Trip Pro

-C18:2 DAG species doubled after iv fat and correlated with PKCθ activation after po fat, whereas ceramides were unchanged. Only after LPS, circulating inflammatory markers (tumor necrosis factor-α, interleukin-6, and interleukin-1 receptor antagonist), their mRNA expression in subcutaneous adipose tissue, and circulating cortisol were elevated. Po fat ingestion rapidly induces insulin resistance by reducing nonoxidative glucose disposal, which associates with PKCθ activation and a rise in distinct (...) Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans. Several mechanisms, such as innate immune responses via Toll-like receptor-4, accumulation of diacylglycerols (DAG)/ceramides, and activation of protein kinase C (PKC), are considered to underlie skeletal muscle insulin resistance. In this study, we examined initial events occurring during the onset of insulin resistance upon oral high-fat loading compared with lipid and low-dose endotoxin

2013 Diabetes

909. Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin e2. Full Text available with Trip Pro

Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin e2. To examine the effect of different sources of good manufacturing practice clinical grade adipose-derived mesenchymal stem cells (AD-MSCs) on inflammatory factors in osteoarthritic (OA) chondrocytes and synoviocytes.AD-MSCs from infrapatellar Hoffa fat, subcutaneous (SC) hip fat, and SC abdominal fat were cocultured in Transwells (...) with chondrocytes or synoviocytes. Inflammatory factors (interleukin-1β [IL-1β], tumor necrosis factor α, IL-6, CXCL1/growth-related oncogene α, CXCL8/IL-8, CCL2/monocyte chemotactic protein 1, CCL3/macrophage inflammatory protein 1α, and CCL5/RANTES) were evaluated by quantitative reverse transcription-polymerase chain reaction or multiplex bead-based immunoassay. The role of different immunomodulators was analyzed.All the inflammatory factors analyzed were down-modulated at the messenger RNA or protein level

2013 Arthritis and Rheumatism

910. Role of lipomodelling in improving aesthetic outcomes in patients undergoing immediate and delayed reconstructive breast surgery. (Abstract)

October 2008 to October 2011. Fat was harvested using a low-negative pressure syringe method and centrifuged at 3000 r.p.m. for 3 min. The purified fat was injected in 1 mL increments into multilayered microtunnels, starting from deeper layers and moving to superficial layers in the subcutaneous tissue. Patient satisfaction was assessed using validated Picker questions in a face-to-face consultation during follow-up visits, and the results were documented in the case notes.Thirty-one patients (...) necrosis and 1 patient with oil cysts) developed postoperative complications. Twenty-nine patients (93%) were satisfied with the postoperative cosmetic outcome.Lipomodelling offers an additional tool to refine breast reconstructive surgery. This study demonstrates that large volumes of fat can be injected for sculpture optimisation and for reshaping reconstructed breasts with improved softness and a natural feel.Copyright © 2013 Elsevier Ltd. All rights reserved.

2013 European Journal of Surgical Oncology

911. Necrotising fasciitis of the thigh Full Text available with Trip Pro

Necrotising fasciitis of the thigh Necrotising fasciitis (NF) is an extremely virulent form of infectious fasciitis. It affects skin, subcutaneous fat and superficial and deep muscular fascia by rapidly progressive necrosis. Expeditious diagnosis and radical debridement is necessary to prevent the onset of sepsis, multisystem organ failure and possible death. Perforated rectal cancer resulting in NF can spread to the perineum and genitals known as Fournier gangrene. This case describes

2013 BMJ case reports

912. The adipose tissue production of adiponectin is increased in end-stage renal disease. Full Text available with Trip Pro

renal disease and 23 kidney donors. Blood and tissue samples were obtained at kidney transplantation and donation. The mean plasma adiponectin level was significantly increased to 15.6 mg/ml in cases compared with 8.4 mg/ml in controls. Plasma levels of the inflammatory adipokines tumor necrosis factor α, interleukin 6, and high-sensitivity C-reactive protein were significantly higher in cases compared with controls. Adiponectin mRNA and protein expression in visceral and subcutaneous fat were

2013 Kidney International

913. Inverse correlation of serum inflammatory markers with metabolic parameters in healthy, black and white pre-pubertal youth. Full Text available with Trip Pro

(magnetic resonance imaging)); total body fat (dual-energy X-ray absorptiometry), ectopic, intrahepatic lipid (IHL) and intramyocellular lipid (IMCL) fat (proton magnetic resonance spectroscopy) and serum levels of interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor alpha (TNF-α) and monocyte chemoattractant protein-1 were measured in 40 obese and non-obese children. Relationships between inflammatory cytokines and obesity were assessed by analysis of variance and Spearman's rank (...) Inverse correlation of serum inflammatory markers with metabolic parameters in healthy, black and white pre-pubertal youth. To examine for the first time the associations between pro-inflammatory cytokines and obesity-related metabolic biomarkers in, exclusively prepubertal, otherwise healthy obese and non-obese Black and White children, 7-9 years of age.Body mass index (BMI), homeostasis model assessment-estimated insulin resistance, visceral adipose tissue and subcutaneous adipose tissue (SAT

2013 International Journal of Obesity

914. The Morel-Lavallée lesion revisited: management in spinopelvic dissociation. (Abstract)

The Morel-Lavallée lesion revisited: management in spinopelvic dissociation. The Morel-Lavallée lesion occurs from a compression and shear force that usually separates the skin and subcutaneous tissue from the underlying muscular fascia. A dead space is created that becomes filled with blood, liquefied fat, and lymphatic fluid from the shearing of vasculature and lymphatics. If not treated appropriately, these lesions can become infected, cause tissue necrosis, or form chronic seromas.To review

2013 The Spine Journal

915. Burn Injury

(lower layers of reticular ) Findings Wet, weaping lesions with clear s White or pale to that when touched does not blanch Course Healing typically takes >21 days Scarring and contractures are common complications (involves stem cells, follicles, glands) Third degree (Full thickness) Pathophysiology Kills all skin layers Also involves underlying subcutaneous fat Findings Waxy, leathery, dark-brown to black, tan or white skin Bright red burns without blanching or sensation are Third Degree Burns (...) , flames, chemicals, electricity, friction or radiant and electromagnetic energy. A first degree burn is associated with redness, a second degree burn with vesication and a third degree burn with necrosis through the entire skin. Definition (MSH) Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like. Definition (CSP) damage inflicted on any part of an organism as the direct or indirect result of exposure to steam, chemicals, heat

2015 FP Notebook

916. Acute Pancreatitis

to evaluate for complications) Consider in severe , pancreatic necrosis or when other complications are suspected Acute Pancreatitis typically shows peripancreatic inflammation and fat stranding (but may be absent early in course) Identifies pancreatic edema and necrosis as well as extrapancreatitc changes including fluid accumulation for severe Pancreatitis: 78% (and LR+ 5.57) for severe Pancreatitis: 86% (and LR- 0.26) Predicts and evaluates Pancreatitis complications, length of hospital stay (...) Physical examination every 4 to 8 hours Observe for Abdominal exam for marked abdominal firmness ( , third spacing) Laboratory tests every 6 to 12 hours Comprehensive metabolic panel Imaging Consider repeat for clinical worsening or signs of complications Electrolyte disturbance Hypocalemia (related to saponification) Replace as needed Antibiotics Absolutely indicated only for concurrent infection Controversial whether to use in pancreatic necrosis Infections occur in one third of necrotizing

2015 FP Notebook

917. Wound Repair

Debridement Recut wound for clean, fresh, surgical-incision edges Undermining May be required to ensure closure and decreased skin tension Best dissection plane is between dermal layer and connective tissue, subcutaneous fat Insert closed scissors on lateral wound margin, and then spread open Repeat for opposite lateral wound margin technique Grasp with needle driver one third of way from attachment (where needle becomes straight) Evert wound edges (do not dig a ditch, build a flask) Everted edges (...) supply to tip of corner) Everts wound edges, but risk of skin necrosis and scar Everts wound edges, but risk of skin necrosis and scar Deep (interrupted dermal s) May use in clean wounds to better approximate wound edges and reduce wound edge tension Fast technique for long Lacerations, but risk of dehiscence if breaks anywhere along its length Subcuticular May use in clean wounds (surgical wounds) for close wound edge apposition (but does not allow drainage) Removal See for timing of removal XVII

2015 FP Notebook

918. Decubitus Ulcer

1: Nonblanchable erythema of intact skin (pink skin, not purple) Stage 2: Superficial or partial thickness skin loss (no slough or eschar) Stage 3: Full thickness skin loss with subcutaneous damage (crater to fascia) Stage 4: Full thickness skin loss with extensive deep damage to muscle, bone, tendon Additional findings Sinus tracts Exudate Necrotic tissue Granulation tissue Discharge and signs of infection VII. Labs culture Typically not indicated except to identify Levine Technique (...) or Cognitive or (and other causes of excessive moisture) Advanced age V. Signs: Distribution (bony prominences) Common Heel Ischial tuberosity Buttock Other Ear Occiput Greater Trochanter Lateral Malleolus VI. Examination: Ulcer Characterization Basic description Location Size (Length x Width x Depth) Stage (Types 1-4) See Staging precautions Accurate grading requires debridement of necrosis first Use other grading schemes for staging of s and s Macerated skin (moisture induced wounds) are not staged Stage

2015 FP Notebook

919. Z-Plasty

Betadine or Hibiclens preparation of site anesthesia Using #15 blade, make vertical incision along Z Excise scar Create full thickness skin flaps Undermine skin at subcutaneous fat Flaps should be freely mobile VII. Step 3: Transpose flap tips Flap tip E is transposed to point D (bottom end of Z) Simple interrupted stay s hold sides es used to hold flap tips in place Flap tip F is transposed to point C (top end of Z) Simple interrupted stay s hold sides es used to hold flap tips in place VIII. Step 4 (...) : Final appearance Line 1 is now reoriented by 90 degrees Z shape is a mirror image of incised Z IX. Complications Flap necrosis or sloughing hematoma (consider large bore needle aspiration) X. References Davidson in Cummings (1998) Otolaryngology, p. 440*1 Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Z-Plasty." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip

2015 FP Notebook

920. Venous Insufficiency

, nem meghatározott , Venás elégtelenség Norwegian Venøs insuffisiens Derived from the NIH UMLS ( ) Ontology: Lipodermatosclerosis (C0406500) Definition (SCTSPA) Disminución de la circunferencia de la pierna debida a ulceración recurrente y necrosis adiposa que produce pérdida del tejido subcutáneo en un paciente con estasis venosa Definition (SNOMEDCT_US) A decrease in lower leg circumference due to recurrent ulceration and fat necrosis causing loss of subcutaneous tissue in a patient with venous (...) stasis disease Definition (SNOMEDCT_US) A decrease in lower leg circumference due to recurrent ulceration and fat necrosis causing loss of subcutaneous tissue in a patient with venous stasis disease Concepts Disease or Syndrome ( T047 ) MSH SnomedCT 95335006 , 201301003 , 201306008 , 410016009 English Post-phlebitic liposclerosis , Acute lipodermatosclerosis , Lipodermatosclerosis , lipodermatosclerosis , lipodermatosclerosis (diagnosis) , Lipodermatosclerosis, NOS , Lipodermatosclerosis (disorder

2015 FP Notebook

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