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Subcutaneous Fat Necrosis

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901. Nonalcoholic Fatty Liver Disease as the Transducer of Hepatic Oversecretion of Very-Low-Density Lipoprotein-Apolipoprotein B-100 in Obesity. (PubMed)

in 25 obese subjects. In univariate analysis, liver fat content was significantly (P<0.05 in all) associated with body mass index (r=0.65), visceral fat area (r=0.45), triglycerides (r=0.40), homeostasis model assessment score (r=0.40), VLDL-apoB-100 concentrations (r=0.44), and secretion rate (r=0.45). However, liver fat content was not associated with plasma concentrations of retinol-binding protein 4, fetuin A, adiponectin, interleukin-6, and tumor necrosis factor-alpha. Of these 25 subjects, 9 (...) diagnosed as having nonalcoholic fatty liver disease (which is highly prevalent in obese individuals and strongly associated with dyslipidemia) underwent a weight loss program. The low-fat diet achieved significant reduction in body weight, body mass index, liver fat, visceral and subcutaneous fat areas, homeostasis model assessment score, triglycerides, VLDL-apoB-100 concentrations, and VLDL-apoB-100 secretion rate. The percentage reduction of liver fat with weight loss was significantly associated

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2010 Thrombosis and Vascular Biology

902. Dose Ranging Study to Evaluate the Efficacy and Safety of SAR153191 (REGN88) in Patients With Ankylosing Spondylitis

. Drug: Placebo Pharmaceutical form: Solution for injection Route of administration: Subcutaneous Experimental: Sarilumab 100 mg q2w Sarilumab 100 mg Subcutaneous (SC) injection alternating with placebo every other week (q2w) for 12 weeks. Drug: Sarilumab Pharmaceutical form: Solution for injection Route of administration: Subcutaneous Other Names: SAR153191 REGN88 Drug: Placebo Pharmaceutical form: Solution for injection Route of administration: Subcutaneous Experimental: Sarilumab 150 mg q2w (...) Sarilumab 150 mg SC injection alternating with placebo q2w for 12 weeks. Drug: Sarilumab Pharmaceutical form: Solution for injection Route of administration: Subcutaneous Other Names: SAR153191 REGN88 Drug: Placebo Pharmaceutical form: Solution for injection Route of administration: Subcutaneous Experimental: Sarilumab 100 mg qw Sarilumab 100 mg SC injection qw for 12 weeks. Drug: Sarilumab Pharmaceutical form: Solution for injection Route of administration: Subcutaneous Other Names: SAR153191 REGN88

2010 Clinical Trials

903. HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy. (PubMed)

reduced. Gene expression of monocyte chemoattractant protein-1 was induced in visceral and subcutaneous fat, whereas tumour necrosis factor-α and interleukin-6 were induced in visceral and subcutaneous white adipose tissues, respectively. Adiponectin and leptin gene expression was repressed in all white fat depots, in concert with reduced expression of peroxisome proliferator-activated receptor γ, a master controller of adipogenesis. In brown fat, a coordinate induction in the expression (...) mice expressing a 7.7 kb HIV-1 construct (Tg26+/-) were used. Cytokine and adipokine levels were quantified using multiplex procedures. Gene expression and mitochondrial DNA abundance in visceral and subcutaneous white adipose tissues and in brown fat were determined using quantitative real-time PCR.The amount of visceral, but not subcutaneous, adipose depot was lower in Tg26+/- mice. Serum proinflammatory cytokine levels were increased in Tg26+/- mice, whereas adiponectin and leptin levels were

2010 Antiviral Therapy

904. Magnetic Anchoring and Guidance System Instrumentation for Laparo-endoscopic Single-site Surgery/Natural Orifice Transluminal Endoscopic Surgery: Lack of Histologic Damage After Prolonged Magnetic Coupling Across the Abdominal Wall. (PubMed)

. Histologic assessment was then performed.Beyond mild blanching of the peritoneal surface with a few petechiae immediately after internal component removal, no gross tissue damage was seen. These changes were undetectable by 48 hours and no intra-abdominal adhesions were identified at necropsy. NADH stain for tissue viability in the 4 nonsurvival specimens showed no tissue damage. Hematoxylin and eosin stain showed no necrosis of either superficial or deep muscle, skin, or subcutaneous fat tissue in all

2010 Urology

905. Lupus Mastitis: An Uncommon Complication of Systemic or Discoid Lupus. (PubMed)

Lupus Mastitis: An Uncommon Complication of Systemic or Discoid Lupus. Lupus mastitis is an uncommon presentation of lupus erythematosus profundus or lupus panniculitis, a rare variant of lupus erythematosus characterized by inflammation of the subcutaneous fat. Lupus mastitis can present as single or multiple subcutaneous or deep breast masses, often clinically mimicking malignancy. Although lupus mastitis is rare, with less than 25 cases reported, the histologic features are distinct (...) . Awareness of the entity and familiarity with the histologic features allow for accurate diagnosis and appropriate patient management. It most commonly affects women with a mean age at diagnosis of 40 years and an age range of 18 to 70 years. Typical histologic findings in lupus mastitis include a lymphocytic lobular panniculitis with plasma cells and hyaline fat necrosis. The lymphocytic infiltrate can be nodular, diffuse, periductal, and/or perilobular and germinal centers can frequently be identified

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2010 American Journal of Surgical Pathology

906. Combination excision and liposuction in a single-stage treatment of various skin disorders. (PubMed)

a harmonious result and simultaneously the body contour was well-balanced.Some large skin disorders at sites rich in subcutaneous fat can be treated in one stage by combining excision and liposuction with good functional and esthetic outcomes with few complications. Although the indications for this technique are limited, it is really a good option for appropriate cases. (...) by complete excision. The sliding flaps on both sides of the defect created by liposuction were pulled together to cover the defect. In our study, 40 skin disorders located on the upper arm, thigh, and trunk were treated by this technique.Forty skin disorders were excised and resulting skin defects were repaired in one stage by the surrounding sliding flaps without wound dehiscence, infection, incision edge necrosis, sensory deficit, or severe scar recurrence. The regions of liposuction presented

2010 International Journal of Dermatology

907. A Registry Study of Permanent Breast Seed Implant

3.0 scale. PBSI side effect [ Time Frame: Yearly up to 10 years ] Any toxicity related to the radiation treatment, including skin and subcutaneous, or any other organ in case of seed migration will be coded using the NCI common toxicity criteria version 3.0 scale. Fat necrosis will be diagnosed either by mammography or clinically (prolonged indurations and pain in the area of seeds implantation without evidence of infection). Cosmetic outcome [ Time Frame: Yearly up to 10 years ] Cosmetic results (...) (internal mammary chain, supra-clavicular area or axilla). Metastases [ Time Frame: Yearly up to 10 years ] Distant recurrence is defined as evidence of tumor in any area of the body. The metastasis recurrence should be proved by appropriate imaging, biopsy or fine needle aspiration PBSI side effects [ Time Frame: After procedure ] Any toxicity related to the radiation treatment, including skin and subcutaneous, or any other organ in case of seed migration will be coded using the NCI common toxicity

2010 Clinical Trials

908. Vacuum-assisted closure as a surgical assistant in life-threatening necrotizing fasciitis in children (PubMed)

Vacuum-assisted closure as a surgical assistant in life-threatening necrotizing fasciitis in children Necrotizing fasciitis is a severe soft tissue infection that can involve skin, subcutaneous fat, fascia and muscle. It can result in devastating sequelae including tissue necrosis, sepsis, toxic shock syndrome, cardiopulmonary collapse and death. To control rapidly spreading necrosis, early diagnosis and aggressive surgical treatment with extensive radical debridement of the affected areas

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2010 The Canadian Journal of Plastic Surgery

909. Cutaneous sclerosis: a previously undescribed manifestation of sclerosing mesenteritis. (PubMed)

with biopsy-proven MP presented with multiple asymptomatic, indurated subcutaneous nodules on both arms, as well as 2 indurated plaques on her abdomen. The cutaneous changes preceded the diagnosis of SM by roughly 3 years. The arm lesions were centrally depressed with a prominent groove and a peau d'orange appearance. Biopsy findings revealed a subcutaneous process with almost total replacement of adipocytes by zones of woody sclerosis and fat necrosis identical to that observed in the mesentery. To our

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2010 Archives of Dermatology

910. Sex- and Depot-Dependent Differences in Adipogenesis in Normal-Weight Humans. (PubMed)

, differentiation of femoral preadipocytes was less than that of abdominal subcutaneous preadipocytes (P = 0.04), and femoral subcutaneous preadipocytes tended to be more resistant to tumor necrosis factor-α (TNFα)-induced apoptosis (P = 0.06). Thus, turnover and utilization of the preadipocyte pool may be reduced in lower vs. the upper-body fat in women. Collectively, these data indicate that the microenvironment, rather than differences in inherent properties of preadipocytes between genders, may explain (...) ) and premenopausal women (n = 20) (age: 18-49 years, BMI: 18-26 kg/m(2)). Women had more subcutaneous and less visceral fat than men. The proportion of early differentiated adipocytes in the subcutaneous adipose tissue SVF of women was greater than in men (P = 0.01), especially in the femoral depot, although in vitro adipogenesis, as assessed by peroxisome proliferator activated receptor-γ (PPARγ) expression, was not increased in femoral preadipocytes cultured from women compared with men. In women

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2010 Obesity

911. Visceral adiposity is not associated with inflammatory markers in trauma patients. (PubMed)

of adult trauma patients requiring >48 hours of intensive care unit care over a 55-month period was analyzed. Body fat distribution was determined by radiologist review of computed tomography scans at L1. Concentric freeform regions were defined manually, and area was calculated. Visceral adiposity was defined as subcutaneous fat area: visceral area >1.35 (the median), whereas subcutaneous adiposity was defined as a ratio <1.35. Primary outcomes were proinflammatory biomarkers known to be associated (...) with chronic visceral obesity (white blood cell count, interleukin 1, 2, 4, 6, 8, 10, and tumor necrosis factor alpha). Secondary outcomes were all-cause in-hospital mortality, adult respiratory distress syndrome, and nosocomial infections.Two hundred eighty-one (19%) obese patients with available computed tomography scans from 1,510 trauma patients were included. Visceral adiposity included 140 patients, subcutaneous adiposity included 141 patients. The two groups were similar in regards to age, Trauma

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2010 Journal of Trauma

912. Pancreatic Panniculitis Associated with Acinar Cell Carcinoma of the Pancreas: A Case Report (PubMed)

was found on the laboratory examinations. The biopsy specimens from the skin lesions showed subcutaneous fat necrosis. Abdominal computed tomography (CT) revealed a large mass with central necrosis in the body and tail of the pancreas. Distal pancreatectomy, splenectomy and partial transverse colectomy were successfully performed on day 17 of the hospitalization. The histopathologic findings supported the diagnosis of acinar cell carcinoma of the pancreas (ACCP). Postoperatively, the level of serum

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2011 Annals of dermatology

913. Circulating white blood cell count and measures of adipose tissue inflammation predict higher 24 hour energy expenditure. (PubMed)

EE adjusted for age, sex, fat-free mass, and fat mass (r=0.13, P=0.04). In SAAT, tumor necrosis factor-alpha (TNF-alpha), shown as log10-transformed TNF-alpha (r=0.36, P=0.05), and plasminogen activator inhibitor-1 (PAI-1), shown as log10-transformed PAI-1 (lPAI-1; r=0.41, P=0.02), expressions were also positively correlated with adjusted 24-h EE. lPAI-1 was also correlated with adjusted sleep EE (r=0.34, P=0.07).In conclusion, circulating markers of inflammation (WBC) and markers of inflammation (...) between circulating white blood cell count (WBC) in a population of Native Americans (n=243) with measurement of EE in a respiratory chamber, and in a subset of the same population (n=34), with gene expression measures of inflammation in subcutaneous abdominal adipose tissue (SAAT). All subjects were healthy on oral glucose tolerance test. Statistically, nonnormally distributed variables were logarithmically transformed before analyses to approximate normal distributions.WBC was associated with 24-h

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2009 European Journal of Endocrinology

914. Partial breast irradiation with interstitial high-dose-rate brachytherapy in early breast cancer: results of a phase II prospective study. (PubMed)

, at a median of 8 weeks from surgery, in 65 patients. Adjuvant therapy was chemotherapy (8) and/or hormone therapy (61).Cosmetic results were good/excellent in 79 patients. Perioperative toxicity was very low. Acute skin toxicity developed in seven cases (six G1; one G2); late G3 cutaneous toxicity in one patient and late subcutaneous toxicity in five (three G1; two G2). Grade 1 teleangiectasia occurred in eight patients and grade 2 in one. Fat necrosis was symptomatic in one patient and asymptomatic

2009 European Journal of Surgical Oncology Controlled trial quality: uncertain

915. Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice. (PubMed)

, food intake, plasma biochemistry, visceral and subcutaneous fat (X-ray and CT), glucose tolerance, blood pressure and pain tolerance were measured, and histopathological examination of the liver was carried out. A significant dose-dependent decline in the gain in body weight, accumulation of visceral and subcutaneous fat and an improvement of abnormal glucose tolerance, hypertension and peripheral neuropathy were noticed in TSOD mice. In addition, hepatocellular swelling, fatty degeneration (...) of hepatocytes, inflammatory cell infiltration and single-cell necrosis were observed on histopathological examination of the liver in TSOD mice. Salacia extract markedly improved these symptoms upon treatment. Based on the above results, it is concluded that Salacia extract has remarkable potential to prevent obesity and associated metabolic disorders including the development of metabolic syndrome.

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2009 Evidence-based Complementary and Alternative Medicine (eCAM)

916. Adiponectin and Inflammatory Mediators in Mediastinal Adipose Tissues

Tissues Between Patients With Coronary Artery Diseases and With Valvular Diseases Study Start Date : January 2008 Estimated Primary Completion Date : December 2008 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Group/Cohort 1 CABG 2 Valve surgery Outcome Measures Go to Biospecimen Retention: Samples Without DNA Adipose tissue biopsy samples from mediastinal fat, epicardial fat, subcutaneous fat in thoracic region or abdominal region (...) and subcutaneous fat in leg were obtained soon after sternotomy or thoracotomy before the initiation of cardiopulmonary bypass. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout

2009 Clinical Trials

917. The Occlusive Dressing

amputations are very common injuries among the patients arriving at the Emergency Department. Fingertips amputations classified in 2nd and 3rd zones, in accordance with Rosenthal's classification (after the solum unguis), constitute a large proportion of them. The treatment aims at restoring a pulp with its sensitivity and a good subcutaneous fat tissue. The usual care of these amputations is a surgical treatment: it consists of pulp reconstruction by a flap (for example palmar V-Y advancement flaps (...) of Atazoy). These technique involve hospital admission, brachial plexus anaesthesia, a surgical approach with cicatrix and donor site morbidities, postoperative cares, post-surgical pain management. And of course attention must be paid to the risks of postoperative complications related either to anaesthesia and/or to surgery, like necrosis, infection, and others. We have developed a nonoperative treatment for fingertips amputations: the occlusive dressing. It's a technique that has been known for about

2009 Clinical Trials

918. Excision of Strip of Deep Fascia to Reduce Seroma Formation and Extrusion of Tissue Expanders

in mitosis returned to normal 4 weeks after expansion. The dermis and subcutaneous tissues were thinned as a result of tissue expansion leading to an overall decrease in tensile strength of the expanded skin (5-7) and this persisted 36 weeks after expansion. The subcutaneous layer of fat was intolerant to stretching causing significant thinning. With faster expansion, fat necrosis could be seen. Pressure necrosis on subcutaneous fat led to liquefaction and seroma formation. With progression of expansion (...) University Information provided by: Cairo University Study Details Study Description Go to Brief Summary: Tissue expansion has enjoyed a wide range of applications since the technique was popularized in the latter quarter of the last century. During the expansion process, subcutaneous fat liquefies, skin becomes thinner, muscles atrophy, blood inflow increases, and lymphatics get occluded. All these factors predispose to seroma formation and implant extrusion. A similar problem occurred with lymphoedema

2009 Clinical Trials

919. Impaired preadipocyte differentiation in human abdominal obesity -- role of Wnt, TNF{alpha} and inflammation. (PubMed)

the normal differentiation of the preadipocytes, and instead induced a proinflammatory and macrophage-like phenotype of the cells.The apparent number of preadipocytes in the abdominal subcutaneous tissue that can undergo differentiation is reduced in obesity with enlarged fat cells, possibly because of increased MAP4K4 levels. TNF-alpha promoted a macrophage-like phenotype of the preadipocytes, including several macrophage markers. These results document the plasticity of human preadipocytes (...) Impaired preadipocyte differentiation in human abdominal obesity -- role of Wnt, TNF{alpha} and inflammation. We examined preadipocyte differentiation in obese and nonobese individuals and the effect of cytokines and wingless-type MMTV (mouse mammary tumor virus) integration site family, member 3A (Wnt3a) protein on preadipocyte differentiation and phenotype.Abdominal subcutaneous adipose tissue biopsies were obtained from a total of 51 donors with varying BMI. After isolation of the adipose

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2009 Diabetes

920. Inflammation and Race and Gender Differences in Computerized Tomography-measured Adipose Depots. (PubMed)

and subcutaneous fat and thigh intermuscular and subcutaneous fat in older white and black adults. Data were from 2,651 black and white men and women aged 70-79 years participating in the Health, Aging, and Body Composition (Health ABC) study. Inflammatory markers, interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) were obtained from serum samples. Abdominal visceral and subcutaneous fat and thigh intermuscular and subcutaneous fat were quantified on computerized (...) fat had an inconsistent but significant association with inflammation, and there was a trend toward lower inflammatory marker concentration with increasing thigh subcutaneous fat in white and black women. Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined.

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2009 Obesity

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