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Subcutaneous Fat Necrosis

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61. Systemic lupus erythematosus with widespread subcutaneous fat calcification. (PubMed)

Systemic lupus erythematosus with widespread subcutaneous fat calcification. 4820822 1974 06 05 2018 11 13 0035-9157 67 3 1974 Mar Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Systemic lupus erythematosus with widespread subcutaneous fat calcification. 215-7 Powell R J RJ eng Journal Article England Proc R Soc Med 7505890 0035-9157 886U3H6UFF Chloroquine VB0R961HZT Prednisone IM Adipose Tissue pathology Adult Calcinosis complications Chloroquine therapeutic use Female Fever (...) Humans Lupus Erythematosus, Systemic complications Necrosis Prednisone therapeutic use Splenomegaly 1974 3 1 1974 3 1 0 1 1974 3 1 0 0 ppublish 4820822 PMC1645348 Arch Dermatol. 1969 Jul;100(1):17-22 5822350 Proc R Soc Med. 1972 Jul;65(7):591 5085931

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1974 Proceedings of the Royal Society of Medicine

62. Effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in drug-naive subjects with type 2 diabetes. (PubMed)

index 24.5 ± 0.5 kg/m(2)) were randomized into exenatide, insulin, or pioglitazone for 6 months. Intrahepatic fat (IHF), visceral fat (VF), and subcutaneous fat (SF) were measured using proton nuclear magnetic resonance spectroscopy. Plasma tumor necrosis factor α (TNFα) and adiponectin were assayed by ELISA. HbA1c declined significantly in all three groups. Body weight, waist, and serum triglycerides decreased with exenatide. After interventions, IHF significantly reduced with three treatments (...) Effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in drug-naive subjects with type 2 diabetes. Ectopic accumulation of lipids in nonadipose tissues plays a primary role in the pathogenesis of type 2 diabetes mellitus (T2DM). This study was to examine the effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in T2DM. Thirty-three drug-naive T2DM patients (age 52.7 ± 1.7 years, HbA1c 8.7 ± 0.2 %, body mass

2014 Acta diabetologica

63. In vivo bioimaging analysis of stromal vascular fraction-assisted fat grafting: the interaction and mutualism of cells and grafted fat. (PubMed)

SVFs and surrounding fat graft.Fat tissue and SVF separated from luciferase (Luc)-transgenic rats were applied for bioimaging analysis. The Luc-fat (0.2 mL) was subcutaneously injected into the back of nude mice with or without SVFs from 0.2 mL wild type rat fat, with bioimaging at 63 days. Immunohistochemical staining was performed to evaluate the structural integrity. Moreover, to evaluate the influence of surrounding fat tissue to transplanted SVFs, Luc-SVFs separated from 0.2 mL luciferase fat (...) were transplanted to evaluate the influence of surrounding fat tissue to transplanted SVFs.The bioimaging results showed that fat tissues transplanted with SVFs had higher survival ratio than those transplanted without SVFs (49.99(5.38)% vs. 32.78(3.32)%; P < 0.001). Stromal vascular fraction-assisted fat grafts had more integral structure and less necrosis cysts. The results showed that, with the existence of grafted fat, transplanted SVF survived for a significantly longer time and could

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2014 Transplantation

64. Impact of pioglitazone and bradykinin type 1 receptor antagonist on type 2 diabetes in high‐fat diet‐fed C57BL/6J mice (PubMed)

the antidiabetic and anti-inflammatory effects of the B1R antagonist SSR240612 (SSR) in adipose tissue with those of pioglitazone (TZD), an activator of peroxisome proliferator-activated receptor gamma.C57BL/6J mice were fed with high-fat diet (HFD) or standard diet (control) for 20 weeks. Yet, during the last 4 weeks, HFD-fed mice were administered SSR and TZD (10 mg kg-1 d-1 each) as monotherapy or combined therapy subcutaneously. The impact of treatments was measured on metabolic hormones levels (ELISA (...) Impact of pioglitazone and bradykinin type 1 receptor antagonist on type 2 diabetes in high‐fat diet‐fed C57BL/6J mice Type 2 diabetes (T2D) is a major complication of obesity and a leading cause of morbidity and mortality. Antagonizing bradykinin type 1 receptor (B1R) improved body and tissue fat mass and reversed vascular and adipose tissue inflammation in a rat model of insulin resistance. This study aimed at evaluating further the role of B1R in a mouse model of T2D by comparing

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2017 Obesity science & practice

65. Subcutaneous fat necrosis as a complication of whole-body cooling for birth asphyxia. (PubMed)

Subcutaneous fat necrosis as a complication of whole-body cooling for birth asphyxia. Subcutaneous fat necrosis (SCFN) of the newborn is a form of panniculitis that affects full-term neonates who often have suffered either birth asphyxia or hypothermia. The induction of hypothermia in newborns is becoming frequently used to reduce the neurologic sequelae associated with birth asphyxia. The risk of SCFN in neonates undergoing this therapy is unknown. Observation We describe a neonate who

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2010 Archives of Dermatology

66. Autologous fat transfer for breast augmentation: A systematic review (update)

using prostheses or autologous tissue transfers compared with fat injections alone. Fat necrosis, calcification and cysts were the most commonly reported complications associated with autologous fat transfer; however, these complications only occurred - ASERNIP-S REVIEW OF AUTOLOGOUS FAT TRANSFER FOR COSMETIC AND RECONSTRUCTIVE BREAST AUGMENTATION - v in a small proportion of patients. There was no data linking the presence of these complications with long-term mammographic and cancer-related (...) outcomes; therefore, the safety of autologous fat transfer in regards to interference with cancer detection could not be determined by this review. Complications, such as skin/flap necrosis, occurred at a similar frequency in patients undergoing breast reconstruction with gluteal and abdominal flaps. In addition, there were a variety of serious complications related to some of the comparator procedures that were not associated with autologous fat transfer (including hernia and capsular contracture

2010 ASERNIP-S

67. Autologous fat transfer for breast augmentation: a systematic review

compared with fat injections alone. Fat necrosis, calcification and cysts were the most commonly reported complications associated with autologous fat transfer; however, these complications only occurred - ASERNIP-S REVIEW OF AUTOLOGOUS FAT TRANSFER FOR COSMETIC AND RECONSTRUCTIVE BREAST AUGMENTATION - v in a small proportion of patients. There was no data linking the presence of these complications with long-term mammographic and cancer-related outcomes; therefore, the safety of autologous fat (...) transfer in regards to interference with cancer detection could not be determined by this review. Complications, such as skin/flap necrosis, occurred at a similar frequency in patients undergoing breast reconstruction with gluteal and abdominal flaps. In addition, there were a variety of serious complications related to some of the comparator procedures that were not associated with autologous fat transfer (including hernia and capsular contracture). The efficacy of autologous fat transfer could

2010 ASERNIP-S

68. Body Fat Composition Assessment Using Analytic Morphomics Predicts Infectious Complications After Bowel Resection in Crohn's Disease. (PubMed)

, or reoperation within 30 days. Bivariate and multivariate analyses using logistic regression were used to generate a prediction model of infectious complications.A total of 269 subjects met selection criteria; 27% incurred postoperative infectious complications. Bivariate analysis showed hemoglobin, albumin, surgical urgency, high-dose prednisone use, and subcutaneous-to-visceral fat volume distribution as predictors of complications. Body mass index, anti-tumor necrosis factor alpha therapies (...) , and immunomodulator use were not predictors of complication. Multivariate modeling demonstrated a c-statistic of 0.77 and a negative predictive value of 81.1% with surgical urgency (odds ratio = 2.78; 95% confidence interval, 1.46-6.02; P = 0.004), subcutaneous-to-visceral fat distribution (odds ratio = 2.01; 95% confidence interval, 1.20-3.19; P = 0.006), and hemoglobin (odds ratio = 0.69; 95% confidence interval, 0.55-0.85; P = 0.001) as predictors of infectious complication.Fat subtype and distribution

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2015 Inflammatory Bowel Diseases

69. Changes in fat distribution in children following severe burn injury. (PubMed)

changes in children with severe burn injury up to 6 months from discharge. Sixty-two boys and 35 girls (burn ≥30% of total body surface area) were included.We found a decrease in total body fat and subcutaneous peripheral fat at 6 months (6% and 2%, respectively; P<0.05 each). An inverse correlation between the decrease in peripheral fat content at 6 months and the extent of burn injury (r=-041, P=0.02) was also observed. In addition, there was a 12% increase in serum tumor necrosis factor-α (TNF-α (...) Changes in fat distribution in children following severe burn injury. Children with severe cutaneous burn injury show persistent metabolic abnormalities, including inflammation and insulin resistance. Such abnormalities could potentially increase their future risk for developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). This could be related to changes in body composition and fat distribution.We studied body composition, fat distribution, and inflammatory cytokines

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2014 Metabolic syndrome and related disorders

70. Fat Metabolism in OSA and COPD

and COPD is unclear, but OSA and COPD may be linked to other comorbid conditions such as obesity and type II diabetes. Upon onset of OSA and COPD, metabolic disturbances associated with obesity and type II diabetes can be exacerbated. Obesity is a condition characterized by an increase in visceral fat, elevated plasma levels of free fatty acids, inflammation, and insulin resistance. Although the effects of body fat distribution have not been studied in these patients, an increase in both subcutaneous (...) and abdominal fat mass in non-OSA older women was shown to increase morbidity and mortality. Fat/adipose tissue is an active tissue capable of secreting proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, reactive oxygen species and adipokines. Particularly, abdominal fat is a prominent source of pro-inflammatory cytokines, which contributes to a low grade, chronic inflammatory state in these patients. Additionally, an increased inflammatory state is associated

2014 Clinical Trials

71. IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFα expression in human subcutaneous preadipocytes. (PubMed)

IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFα expression in human subcutaneous preadipocytes. Free fatty acids (FFAs) are increased in visceral fat and contribute to insulin resistance through multiple mechanisms, including c-Jun N-terminal kinase (JNK) activation and expression of TNFα. Given that insulin-like growth factor-1 (IGF-1)-mediated proliferation is impaired in omental compared to subcutaneous (SC) preadipocytes, we investigated IGF-I anti-inflammatory (...) action in preadipocytes from SC and omental adipose tissue.Preadipocytes isolated from abdominal SC and omental fat of obese subjects were studied in primary culture. Cells were exposed to FFAs with or without IGF-I pretreatment followed by analysis of cytokine expression and JNK phosphorylation. Lentivirus infection was used to express a constitutively active AKT (myr-AKT) in omental preadipocytes.FFAs increased the expression of tumor necrosis factor (TNF)α, interleukin (IL)-6, and monocyte

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2013 Obesity

72. Subcutaneous Sweet syndrome in the setting of myeloid disorders: A case series and review of the literature. (PubMed)

demonstrated lobular or, less frequently, septal patterns with minimal dermal involvement. Leukocytoclasis, fat necrosis, reactive stromal fibroblasts, and mild reticular dermal edema were each seen in at least 3 of our 5 biopsy specimens. No myeloid blasts, vascular changes, or non-Miescher granulomas were observed. No micro-organisms were identified in the skin nodules.This study is limited by the small number of cases.Based on the fairly consistent clinical and histologic findings, neutrophilic (...) Subcutaneous Sweet syndrome in the setting of myeloid disorders: A case series and review of the literature. The association of neutrophilic dermatoses with myeloid disorders is well known, but neutrophilic panniculitis in the same setting has only been reported infrequently.We aimed to better characterize these lesions clinically and histologically, and to provide a comprehensive differential diagnosis and appropriate diagnostic approach.The pathology archives were searched for cases

2013 Journal of American Academy of Dermatology

73. Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer. (PubMed)

characteristics including necrosis and the extent of the inflammatory cell infiltrate. Body composition was examined using body mass index (BMI), total body fat, subcutaneous body fat, visceral fat, and skeletal muscle mass.Circulating IL-6 concentrations were significantly associated with increased T stage (P<0.05), tumour necrosis (P<0.001), IL-10 (P<0.001), VEGF (P<0.001), modified Glasgow Prognostic Score (mGPS; P<0.001), white cell (P<0.01) and platelet (P<0.01) counts, and low skeletal muscle index (P (...) Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer. Cancer-associated inflammation, in the form of local and systemic inflammatory responses, appear to be linked to tumour necrosis and have prognostic value in patients with colorectal cancer. However, their relationship with circulating biochemical mediators is unclear. The aim of the present study was to examine the interrelationships between

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2013 British Journal of Cancer

74. Intradural Extramedullary and Subcutaneous Tumors in Neonate : Atypical Myxoid Spindle Cell Neoplasm (PubMed)

clinical presentation, pathogenesis, and treatment. A male infant was delivered normally, with uneventful development. At 16 days post-delivery, his family took him to a pediatrician because of a mass on his upper back. Magnetic resonance imaging of the thoracic spine revealed a well-demarcated soft-tissue mass with central cystic change or necrosis at the subcutaneous layer of the posterior back (T2-7 level). Another mass was found with a fat component at the spinal canal of the T1-3 level, which (...) Intradural Extramedullary and Subcutaneous Tumors in Neonate : Atypical Myxoid Spindle Cell Neoplasm Tumors of the central nervous system are common in the pediatric population and constitute the second most prevalent tumor type in children. Within this group, spinal cord tumors are relatively rare and account for 1 to 10% of all pediatric central nervous system tumors. We describe a very rare case of an intradural extramedullary spinal cord tumor with a subcutaneous mass and discuss its

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2012 Journal of Korean Neurosurgical Society

75. New waves for fat reduction: high-intensity focused ultrasound. (PubMed)

subcutaneous adipose tissue and causing molecular vibrations that increase the temperature of local tissue and induce rapid cell necrosis. Several studies reveal the safety and efficacy of HIFU for fat reduction in the abdomen and the flanks. These studies indicate consistent reduction in abdominal circumference > 2 cm after a single treatment. The adverse events are limited to transient tenderness, bruising, and edema. Increased utility of HIFU for fat reduction will likely increase over time. (...) New waves for fat reduction: high-intensity focused ultrasound. With the rising demand for body contouring, noninvasive devices for fat reduction have become increasingly popular and have grown dramatically over the past decade. High-intensity focused ultrasound (HIFU) has been used for nearly half a century for the noninvasive treatment of tumors of various organs, but has only recently been evaluated as a method for the selective destruction of adipose tissue. HIFU works by ablating

2013 Seminars in Cutaneous Medicine and Surgery

76. Mesotherapy for local fat reduction. (PubMed)

Mesotherapy for local fat reduction. Mesotherapy, which is the injection of substances locally into mesodermally derived subcutaneous tissue, developed from empirical observations of a French physician in the 1950s. Although popular in Europe for many medical purposes, it is used for local cosmetic fat reduction in the United States. This paper reviews manuscripts indexed in PubMed/MEDLINE under 'mesotherapy', which pertains to local fat reduction. The history of lipolytic mesotherapy (...) , the physiology of body fat distribution, the mechanism of action of different lipolytic stimulators and their increased efficacy in combination are reviewed. Mesotherapy falls into two categories. Lipolytic mesotherapy using lipolytic stimulators requires more frequent treatments as the fat cells are not destroyed and can refill over time. Ablative mesotherapy destroys fat cells with a detergent, causes inflammation and scarring from the fat necrosis, but requires fewer treatments. The historic and empiric

2013 Obesity Reviews

77. Immunophenotyping of Fresh Stromal Vascular Fraction From Adipose Derived Stem Cells (ADSC) Enriched Fat Grafts

Study Completion Date : May 2015 Arms and Interventions Go to Arm Intervention/treatment Sham Comparator: centrifuged fat graft female patients who underwent breast reconstruction and present with volume insufficiency will undergo centrifuged fat graft for contour and volume refinements. Genetic: centrifuged fat graft fat from the abdominal subcutaneous tissue will be taken by vacuum assisted lipectomy and immediately prepared to be grafted in the reconstructed breast that presents contour (...) irregularities and/or volume insufficiency. No adipose derived stem cells will enrich the fat grafts in this group. Active Comparator: ADSCs enriched centrifuged fat graft female patients who underwent breast reconstruction and present volume insufficiency will undergo ADSCs enriched fat grafting for volume and irregularity contour improvement Genetic: ADSCs enriched fat graft fat from the abdominal subcutaneous tissue will be taken by suction assisted lipectomy and stromal vascular fraction will be isolated

2013 Clinical Trials

78. Composite breast augmentation: soft-tissue planning using implants and fat. (PubMed)

the overlying soft tissue was thin or insufficient to adequately cover the underlying prosthesis, in both breast implant revision and primary breast augmentation. In a subset of cases, quantitative three-dimensional breast imaging evaluated transplanted fat volume in the subcutaneous space of the breast. In primary cosmetic augmentation cases, preexpansion was not performed. In revision cases, preexpansion was performed to support the desired volume of fat required to achieve the aesthetic result (...) . In a second subset of patients, preoperative and 1-year postoperative mammograms were evaluated by breast radiologists.Fifty-seven percent of the volume of graft injected persisted at 1 year. Because fat provided soft-tissue implant coverage, there was less need to place the prosthesis beneath the muscle; many implants were placed in the subfascial plane. Evaluation revealed no cysts, masses, or fat necrosis, presumably because the recipient site was not overloaded with fat.Breast augmentation

2013 Plastic and reconstructive surgery

79. Epicardial fat, abdominal adiposity and insulin resistance in obese pre-pubertal and early pubertal children. (PubMed)

], visceral (VAT), subcutaneous (SAT), epicardial adipose tissues (EAT) and hepatic fat fraction (HFF) were estimated. Lipid profile, liver function tests, circulating adipokines and markers of inflammation [leptin, adiponectin, tumor necrosis factors-alpha (TNF-alpha), C-reactive protein (CRP), interleukins 6 and 10 (IL-6, IL-10)] were assayed. Insulin resistance was estimated by the homeostasis model assessment of insulin resistance (HOMA-IR). Body composition was measured by dual-energy X-ray (...) Epicardial fat, abdominal adiposity and insulin resistance in obese pre-pubertal and early pubertal children. To assess the cross-sectional association of epicardial fat with insulin resistance, major abdominal adipose depots, and cardiovascular disease (CVD) risk factors in obese pre-pubertal and early pubertal children.By using magnetic resonance imaging in 30 pre-pubertal and early pubertal patients [21 males, Tanner Stage I-II, median age 11.2 (2.95) y, BMI z-score 2.56 ± 0.11 SDS

2012 Atherosclerosis

80. Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir. (PubMed)

tNRTI to tenofovir (TDF) or added uridine (continuing tNRTI). End points were changes in limb fat (DEXA), subcutaneous abdominal fat mitochondrial DNA (mtDNA) and mitochondrial RNA (mtRNA), inflammation markers (soluble tumour necrosis factor receptors, high-sensitivity C reactive protein [hsCRP], interleukin-6 [IL-6], soluble vascular cell adhesion molecule 1), bone mineral density (BMD) of the hip and spine, HIV-1 RNA, CD4(+) T-cells and fasting metabolic parameters.Fifty patients were enrolled (n (...) Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir. Lipoatrophy modestly improves when the thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI) is removed. In vitro, uridine (NucleomaxX(®); Pharma Nord, Vojens, Denmark) reversed tNRTI mitochondrial toxicity.All patients had lipoatrophy on a tNRTI-containing regimen with HIV RNA<400 copies/ml. A randomized 48-week study switched patients from

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2012 Antiviral therapy

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