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Subcutaneous Fat Necrosis

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61. Follow-Up During Early Infancy of Newborns Diagnosed with Subcutaneous Fat Necrosis Full Text available with Trip Pro

Follow-Up During Early Infancy of Newborns Diagnosed with Subcutaneous Fat Necrosis Subcutaneous fat necrosis of the newborn (ScFN) is an uncommon condition caused by generalized and/or local tissue hypoperfusion. The skin lesions of ScFN tend to improve spontaneously. However, ScFN may also lead to complications which cause serious problems. The severity of the etiologic factors contributing to the development of the disease determines the severity of complications. Therefore, these patients

2011 Journal of clinical research in pediatric endocrinology

62. Intratumoral Heterogeneity of Subcutaneous Nodules in a Never-Smoker Woman of Lung Squamous Cell Carcinoma Detected on 18F-Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography: A Case Report. Full Text available with Trip Pro

with complaints of dry coughing, in which three positive subcutaneous nodules were found on ¹⁸F-FDG positron emission tomography and computed tomography (PET/CT). Pathologic examination confirmed that each of the nodules contained 1) necrotic fat, 2) small amounts of blood cells and glandular epithelium, and 3) subcutaneous metastasis of moderately differentiated lung squamous cell carcinoma, respectively. Although PET/CT is useful for the detection of subcutaneous metastasis of primary lung cancer, we noted (...) Intratumoral Heterogeneity of Subcutaneous Nodules in a Never-Smoker Woman of Lung Squamous Cell Carcinoma Detected on 18F-Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography: A Case Report. Subcutaneous tissue is a rare site of metastasis, accounting for only 1-2% of all lung neoplasms. Positron emission tomography (PET) using ¹⁸F-fluorodeoxyglucose (FDG) has been reported to increase the diagnostic accuracy of subcutaneous metastasis. A 58-year-old woman presented

2015 Medicine

63. In vivo bioimaging analysis of stromal vascular fraction-assisted fat grafting: the interaction and mutualism of cells and grafted fat. (Abstract)

SVFs and surrounding fat graft.Fat tissue and SVF separated from luciferase (Luc)-transgenic rats were applied for bioimaging analysis. The Luc-fat (0.2 mL) was subcutaneously injected into the back of nude mice with or without SVFs from 0.2 mL wild type rat fat, with bioimaging at 63 days. Immunohistochemical staining was performed to evaluate the structural integrity. Moreover, to evaluate the influence of surrounding fat tissue to transplanted SVFs, Luc-SVFs separated from 0.2 mL luciferase fat (...) were transplanted to evaluate the influence of surrounding fat tissue to transplanted SVFs.The bioimaging results showed that fat tissues transplanted with SVFs had higher survival ratio than those transplanted without SVFs (49.99(5.38)% vs. 32.78(3.32)%; P < 0.001). Stromal vascular fraction-assisted fat grafts had more integral structure and less necrosis cysts. The results showed that, with the existence of grafted fat, transplanted SVF survived for a significantly longer time and could

2014 Transplantation

64. Effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in drug-naive subjects with type 2 diabetes. (Abstract)

index 24.5 ± 0.5 kg/m(2)) were randomized into exenatide, insulin, or pioglitazone for 6 months. Intrahepatic fat (IHF), visceral fat (VF), and subcutaneous fat (SF) were measured using proton nuclear magnetic resonance spectroscopy. Plasma tumor necrosis factor α (TNFα) and adiponectin were assayed by ELISA. HbA1c declined significantly in all three groups. Body weight, waist, and serum triglycerides decreased with exenatide. After interventions, IHF significantly reduced with three treatments (...) Effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in drug-naive subjects with type 2 diabetes. Ectopic accumulation of lipids in nonadipose tissues plays a primary role in the pathogenesis of type 2 diabetes mellitus (T2DM). This study was to examine the effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in T2DM. Thirty-three drug-naive T2DM patients (age 52.7 ± 1.7 years, HbA1c 8.7 ± 0.2 %, body mass

2014 Acta diabetologica Controlled trial quality: uncertain

65. Sarcolipin knockout mice fed a high-fat diet exhibit altered indices of adipose tissue inflammation and remodeling. (Abstract)

. Catecholamines and fatty acids play a role in the pathology of adipose tissue inflammation.Male mice (wild type and SLN(-) (/-) ) were fed a HFD (42% kcal from fat) for 8 weeks.SLN(-) (/-) mice displayed greater obesity and glucose intolerance. This was accompanied by higher circulating epinephrine and nonesterified fatty acids. Epididymal but not inguinal subcutaneous adipose tissue from SLN(-) (/-) mice displayed higher interleukin-6, suppressor of cytokine signaling 3, interleukin-1β, and tumor necrosis (...) Sarcolipin knockout mice fed a high-fat diet exhibit altered indices of adipose tissue inflammation and remodeling. To investigate indices of adipose tissue inflammation and remodeling in high-fat diet (HFD) sarcolipin-knockout (SLN(-) (/-) ) mice. SLN regulates muscle-based nonshivering thermogenesis and is up-regulated with HFD. SLN(-) (/-) mice develop greater diet-induced obesity and glucose intolerance. This is accompanied by increases in circulating catecholamines and fatty acids

2016 Obesity

66. Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials. (Abstract)

Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials. Several meta-analyses have confirmed the positive metabolic effects of telmisartan, an angiotensin II receptor blocker that can also act as a partial peroxisome proliferator-activated receptor-γ agonist, compared to those of other angiotensin II receptor blockers. These effects include decreased fasting glucose, glycosylated hemoglobin, interleukin-6, and tumor necrosis factor-α levels. However (...) participants with overweight/obesity, metabolic syndrome, or glucose intolerance to telmisartan or control therapy group.Of 651 potentially relevant reports, 15 satisfied the inclusion criterion. While visceral fat area was significantly lower in the telmisartan group than in the control group (weighted mean difference = -18.13 cm(2), 95% C.I. = -27.16 to -9.11, Pχ(2) = 0.19, I(2) = 41%), subcutaneous fat area was similar (weighted mean difference =2.94 cm(2), 95% C.I. = -13.01 to 18.89, Pχ(2) = 0.30, I(2

2016 Current medical research and opinion

67. Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects

control group with non-calorie sweetener erythritol 5 g 3 times a day before meal to right after meal (with any liquid) Total number: n = 60 Either males or females, non-diabetic, aged > 18 years old with BMI ≥ 25 kg/m2 Primary objectives Efficacy 1. Compare the efficacy of pure D-allulose (psicose) plus conventional therapy on 1.1 visceral fat area (VFA), subcutaneous fat area (SFA), total fat area (TFA) change 1.2 body weight, BMI and body fat percentage (with impedance method) change after 24 weeks (...) Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2016 Clinical Trials

68. The Effects of Autologous Fat Transfer on Preventing Expanded Skin From Expansion Failure

to overcome these complications by therapeutic fat grafting to prevent skin necrosis and enable continuation of the expansion procedure. Patients undergoing soft tissue expansion treatment for resurfacing skin lesions including scars and nevi that required therapeutic intervention due to early complication signs were included in this study. Patients were randomly divided into treatment group using autologous fat grafting and control group with discontinued expansion and expectant management. The treatment (...) ; Significant medical diseases or infection (including but not limited to the carrier of hepatitis B virus or HIV); BMI less than 17 or insufficient subcutaneous fat; History of any hematological disease, including leukopenia , thrombocytopenia, or thrombocytosis; History of allogenic bone marrow transplantation; Pregnant or lactating woman; Long history of smoking; Evidence of malignant diseases or unwillingness to participate Contacts and Locations Go to Information from the National Library of Medicine

2016 Clinical Trials

69. Body Fat Composition Assessment Using Analytic Morphomics Predicts Infectious Complications After Bowel Resection in Crohn's Disease. Full Text available with Trip Pro

, or reoperation within 30 days. Bivariate and multivariate analyses using logistic regression were used to generate a prediction model of infectious complications.A total of 269 subjects met selection criteria; 27% incurred postoperative infectious complications. Bivariate analysis showed hemoglobin, albumin, surgical urgency, high-dose prednisone use, and subcutaneous-to-visceral fat volume distribution as predictors of complications. Body mass index, anti-tumor necrosis factor alpha therapies (...) , and immunomodulator use were not predictors of complication. Multivariate modeling demonstrated a c-statistic of 0.77 and a negative predictive value of 81.1% with surgical urgency (odds ratio = 2.78; 95% confidence interval, 1.46-6.02; P = 0.004), subcutaneous-to-visceral fat distribution (odds ratio = 2.01; 95% confidence interval, 1.20-3.19; P = 0.006), and hemoglobin (odds ratio = 0.69; 95% confidence interval, 0.55-0.85; P = 0.001) as predictors of infectious complication.Fat subtype and distribution

2015 Inflammatory Bowel Diseases

70. Necrotizing Fasciitis (Diagnosis)

an aggressive infection of subcutaneous tissue and the superficial fascia. Histologically, the necrosis of the fascia can manifest with or without polymorphonuclear infiltrates or bacteria. Surgical findings include presence of foul-smelling “dishwater” pus and gray, friable necrotic fascia that does not resist blunt dissection. [ ] The infection primarily does not affect musculature, but the prolongations of the deep fascia reach the surroundings of the skeletal muscle; progression to intermuscular fascia (...) ), to predict the likelihood of mortality. [ ] Myonecrosis is a rare, potentially lethal condition that refers to necrotic infection of the muscle. The terms gas gangrene and clostridial myonecrosis have been used to refer to necrosis of the muscle tissue caused by toxin-producing Clostridia . Other bacteria are also capable of producing gas, and nonclostridial organisms have been isolated in 60%-85% cases of NSTIs with subcutaneous gas, and the term gas gangrene has been used to describe any gas-forming

2014 eMedicine Emergency Medicine

71. Necrotizing Fasciitis (Follow-up)

an aggressive infection of subcutaneous tissue and the superficial fascia. Histologically, the necrosis of the fascia can manifest with or without polymorphonuclear infiltrates or bacteria. Surgical findings include presence of foul-smelling “dishwater” pus and gray, friable necrotic fascia that does not resist blunt dissection. [ ] The infection primarily does not affect musculature, but the prolongations of the deep fascia reach the surroundings of the skeletal muscle; progression to intermuscular fascia (...) ), to predict the likelihood of mortality. [ ] Myonecrosis is a rare, potentially lethal condition that refers to necrotic infection of the muscle. The terms gas gangrene and clostridial myonecrosis have been used to refer to necrosis of the muscle tissue caused by toxin-producing Clostridia . Other bacteria are also capable of producing gas, and nonclostridial organisms have been isolated in 60%-85% cases of NSTIs with subcutaneous gas, and the term gas gangrene has been used to describe any gas-forming

2014 eMedicine Emergency Medicine

72. Necrotizing Fasciitis (Treatment)

an aggressive infection of subcutaneous tissue and the superficial fascia. Histologically, the necrosis of the fascia can manifest with or without polymorphonuclear infiltrates or bacteria. Surgical findings include presence of foul-smelling “dishwater” pus and gray, friable necrotic fascia that does not resist blunt dissection. [ ] The infection primarily does not affect musculature, but the prolongations of the deep fascia reach the surroundings of the skeletal muscle; progression to intermuscular fascia (...) ), to predict the likelihood of mortality. [ ] Myonecrosis is a rare, potentially lethal condition that refers to necrotic infection of the muscle. The terms gas gangrene and clostridial myonecrosis have been used to refer to necrosis of the muscle tissue caused by toxin-producing Clostridia . Other bacteria are also capable of producing gas, and nonclostridial organisms have been isolated in 60%-85% cases of NSTIs with subcutaneous gas, and the term gas gangrene has been used to describe any gas-forming

2014 eMedicine Emergency Medicine

73. Necrotizing Fasciitis (Overview)

an aggressive infection of subcutaneous tissue and the superficial fascia. Histologically, the necrosis of the fascia can manifest with or without polymorphonuclear infiltrates or bacteria. Surgical findings include presence of foul-smelling “dishwater” pus and gray, friable necrotic fascia that does not resist blunt dissection. [ ] The infection primarily does not affect musculature, but the prolongations of the deep fascia reach the surroundings of the skeletal muscle; progression to intermuscular fascia (...) ), to predict the likelihood of mortality. [ ] Myonecrosis is a rare, potentially lethal condition that refers to necrotic infection of the muscle. The terms gas gangrene and clostridial myonecrosis have been used to refer to necrosis of the muscle tissue caused by toxin-producing Clostridia . Other bacteria are also capable of producing gas, and nonclostridial organisms have been isolated in 60%-85% cases of NSTIs with subcutaneous gas, and the term gas gangrene has been used to describe any gas-forming

2014 eMedicine Emergency Medicine

74. Autologous fat transfer for breast augmentation: A systematic review (update)

using prostheses or autologous tissue transfers compared with fat injections alone. Fat necrosis, calcification and cysts were the most commonly reported complications associated with autologous fat transfer; however, these complications only occurred - ASERNIP-S REVIEW OF AUTOLOGOUS FAT TRANSFER FOR COSMETIC AND RECONSTRUCTIVE BREAST AUGMENTATION - v in a small proportion of patients. There was no data linking the presence of these complications with long-term mammographic and cancer-related (...) outcomes; therefore, the safety of autologous fat transfer in regards to interference with cancer detection could not be determined by this review. Complications, such as skin/flap necrosis, occurred at a similar frequency in patients undergoing breast reconstruction with gluteal and abdominal flaps. In addition, there were a variety of serious complications related to some of the comparator procedures that were not associated with autologous fat transfer (including hernia and capsular contracture

2010 ASERNIP-S

75. Autologous fat transfer for breast augmentation: a systematic review

compared with fat injections alone. Fat necrosis, calcification and cysts were the most commonly reported complications associated with autologous fat transfer; however, these complications only occurred - ASERNIP-S REVIEW OF AUTOLOGOUS FAT TRANSFER FOR COSMETIC AND RECONSTRUCTIVE BREAST AUGMENTATION - v in a small proportion of patients. There was no data linking the presence of these complications with long-term mammographic and cancer-related outcomes; therefore, the safety of autologous fat (...) transfer in regards to interference with cancer detection could not be determined by this review. Complications, such as skin/flap necrosis, occurred at a similar frequency in patients undergoing breast reconstruction with gluteal and abdominal flaps. In addition, there were a variety of serious complications related to some of the comparator procedures that were not associated with autologous fat transfer (including hernia and capsular contracture). The efficacy of autologous fat transfer could

2010 ASERNIP-S

76. Subcutaneous Sweet syndrome in the setting of myeloid disorders: A case series and review of the literature. (Abstract)

demonstrated lobular or, less frequently, septal patterns with minimal dermal involvement. Leukocytoclasis, fat necrosis, reactive stromal fibroblasts, and mild reticular dermal edema were each seen in at least 3 of our 5 biopsy specimens. No myeloid blasts, vascular changes, or non-Miescher granulomas were observed. No micro-organisms were identified in the skin nodules.This study is limited by the small number of cases.Based on the fairly consistent clinical and histologic findings, neutrophilic (...) Subcutaneous Sweet syndrome in the setting of myeloid disorders: A case series and review of the literature. The association of neutrophilic dermatoses with myeloid disorders is well known, but neutrophilic panniculitis in the same setting has only been reported infrequently.We aimed to better characterize these lesions clinically and histologically, and to provide a comprehensive differential diagnosis and appropriate diagnostic approach.The pathology archives were searched for cases

2013 Journal of American Academy of Dermatology

77. IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFα expression in human subcutaneous preadipocytes. Full Text available with Trip Pro

IGF-I attenuates FFA-induced activation of JNK1 phosphorylation and TNFα expression in human subcutaneous preadipocytes. Free fatty acids (FFAs) are increased in visceral fat and contribute to insulin resistance through multiple mechanisms, including c-Jun N-terminal kinase (JNK) activation and expression of TNFα. Given that insulin-like growth factor-1 (IGF-1)-mediated proliferation is impaired in omental compared to subcutaneous (SC) preadipocytes, we investigated IGF-I anti-inflammatory (...) action in preadipocytes from SC and omental adipose tissue.Preadipocytes isolated from abdominal SC and omental fat of obese subjects were studied in primary culture. Cells were exposed to FFAs with or without IGF-I pretreatment followed by analysis of cytokine expression and JNK phosphorylation. Lentivirus infection was used to express a constitutively active AKT (myr-AKT) in omental preadipocytes.FFAs increased the expression of tumor necrosis factor (TNF)α, interleukin (IL)-6, and monocyte

2013 Obesity

78. Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer. Full Text available with Trip Pro

characteristics including necrosis and the extent of the inflammatory cell infiltrate. Body composition was examined using body mass index (BMI), total body fat, subcutaneous body fat, visceral fat, and skeletal muscle mass.Circulating IL-6 concentrations were significantly associated with increased T stage (P<0.05), tumour necrosis (P<0.001), IL-10 (P<0.001), VEGF (P<0.001), modified Glasgow Prognostic Score (mGPS; P<0.001), white cell (P<0.01) and platelet (P<0.01) counts, and low skeletal muscle index (P (...) Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer. Cancer-associated inflammation, in the form of local and systemic inflammatory responses, appear to be linked to tumour necrosis and have prognostic value in patients with colorectal cancer. However, their relationship with circulating biochemical mediators is unclear. The aim of the present study was to examine the interrelationships between

2013 British Journal of Cancer

79. Changes in fat distribution in children following severe burn injury. Full Text available with Trip Pro

changes in children with severe burn injury up to 6 months from discharge. Sixty-two boys and 35 girls (burn ≥30% of total body surface area) were included.We found a decrease in total body fat and subcutaneous peripheral fat at 6 months (6% and 2%, respectively; P<0.05 each). An inverse correlation between the decrease in peripheral fat content at 6 months and the extent of burn injury (r=-041, P=0.02) was also observed. In addition, there was a 12% increase in serum tumor necrosis factor-α (TNF-α (...) Changes in fat distribution in children following severe burn injury. Children with severe cutaneous burn injury show persistent metabolic abnormalities, including inflammation and insulin resistance. Such abnormalities could potentially increase their future risk for developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). This could be related to changes in body composition and fat distribution.We studied body composition, fat distribution, and inflammatory cytokines

2014 Metabolic syndrome and related disorders Controlled trial quality: uncertain

80. Fat Metabolism in OSA and COPD

and COPD is unclear, but OSA and COPD may be linked to other comorbid conditions such as obesity and type II diabetes. Upon onset of OSA and COPD, metabolic disturbances associated with obesity and type II diabetes can be exacerbated. Obesity is a condition characterized by an increase in visceral fat, elevated plasma levels of free fatty acids, inflammation, and insulin resistance. Although the effects of body fat distribution have not been studied in these patients, an increase in both subcutaneous (...) and abdominal fat mass in non-OSA older women was shown to increase morbidity and mortality. Fat/adipose tissue is an active tissue capable of secreting proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, reactive oxygen species and adipokines. Particularly, abdominal fat is a prominent source of pro-inflammatory cytokines, which contributes to a low grade, chronic inflammatory state in these patients. Additionally, an increased inflammatory state is associated

2014 Clinical Trials

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