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Subcutaneous Fat Necrosis

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41. Prediction of Skin Necrosis after Mastectomy for Breast Cancer Using Indocyanine Green Angiography Imaging Full Text available with Trip Pro

rate of grade III necrosis (reaching the subcutaneous fat layer) was significantly lower in the ICGA group (4.8%) than in the non-ICGA group (17.8%; P < 0.05). The specificity of RP for the diagnosis of skin necrosis was high (98.5%; cutoff value, 34). However, the sensitivities of slope parameters were higher than RP.ICGA-guided trimming decreased the rate of deep skin necrosis requiring additional surgical treatment. Region of interest analysis indicated that a relatively low percentage (...) Prediction of Skin Necrosis after Mastectomy for Breast Cancer Using Indocyanine Green Angiography Imaging In immediate tissue expander reconstruction following total mastectomy for breast cancer, indocyanine green angiography (ICGA)-guided skin trimming is useful for the prevention of complications. However, instances of unclear ICGA contrast can occur with this method, which are difficult to judge as to whether preventive trimming is warranted. To further improve the mastectomy flap necrosis

2017 Plastic and Reconstructive Surgery Global Open

42. IL-11, IL-1α, IL-6, and TNF-α are induced by solar radiation in vitro and may be involved in facial subcutaneous fat loss in vivo. (Abstract)

IL-11, IL-1α, IL-6, and TNF-α are induced by solar radiation in vitro and may be involved in facial subcutaneous fat loss in vivo. The loss of subcutaneous (sc) fat is associated with aging. Inflammatory cytokines, such as interleukin-1 α (IL-1α), interleukin-11 (IL-11) and tumor necrosis factor-α (TNF-α), are known to inhibit the differentiation of preadipocytes.This study investigated the potential role of inflammatory cytokines in solar-radiation-induced facial fat loss.Cultured fibroblasts (...) , conditioned medium from sunscreen-pretreated, solar-irradiated equivalents did not inhibit differentiation of preadipocytes. A cocktail of neutralizing antibodies to IL-11, IL-1α, IL-6 and TNF-α significantly reduced the SSR-induced inhibition of preadipocyte differentiation.These results support the hypothesis that SSR-induced inflammatory cytokine may be involved in the photoaging-induced loss of facial subcutaneous fat. Inhibition of this process, e.g. by sunscreens, might slow or prevent photoaging

2013 Journal of dermatological science

43. Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, Controlled Trial. Full Text available with Trip Pro

Metabolic and Structural Effects of Phosphatidylcholine and Deoxycholate Injections on Subcutaneous Fat: A Randomized, Controlled Trial. Phosphatidylcholine and deoxycholate (PC-DC) injections are a popular nonsurgical method to eliminate unwanted fat. The safety and efficacy of this approach is uncertain.The authors evaluate the effects of PC-DC treatments on body composition, adipocyte function, and mechanisms responsible for fat loss.This randomized, open-label study enrolled 13 women (...) with a body mass index (BMI) ≤30 kg/m(2) and lower abdominal subcutaneous fat suitable for small-volume liposuction. Patients were randomized by the final digit of their Social Security numbers and received between 2 and 4 PC-DC treatments, spaced 8 weeks apart. One side below the umbilicus was injected with PC-DC. The contralateral, control side received no treatment. Adipose tissue biopsies were performed on the treated side at baseline, 1 week after the first treatment, and 8 weeks after the final

2013 Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery Controlled trial quality: uncertain

44. Adipose stromal/stem cells assist fat transplantation reducing necrosis and increasing graft performance Full Text available with Trip Pro

Adipose stromal/stem cells assist fat transplantation reducing necrosis and increasing graft performance Autologous fat transfer (AFT) is a procedure for adipose tissue (AT) repair after trauma, burns, post-tumor resections and lipodystrophies still negatively impacted by the lack of graft persistence. The reasons behind this poor outcome are unclear and seem to involve damages in either harvested/transplanted mature adipocytes or on their mesenchymal progenitors, namely adipose stromal/stem (...) cells (ASC), and due to post-transplant AT apoptosis and involution. A rabbit subcutaneous AT regeneration model was here developed to first evaluate graft quality at different times after implant focusing on related parameters, such as necrosis and vasculogenesis. Standard AFT was compared with a strategy where purified autologous ASC, combined with hyaluronic acid (HA), assisted AFT. Five million of autologous ex vivo isolated CD29+, CD90+, CD49e+ ASC, loaded into HA, enriched 1 ml

2013 Apoptosis

45. Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women

Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cellular Dynamics (...) of Subcutaneous Fat Distribution in Obese Women (Apple/Pear) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01748994 Recruitment Status : Completed First Posted : December 13, 2012 Last Update Posted : August 29, 2018 Sponsor: Pennington Biomedical Research Center Collaborator: National Institute of Diabetes

2012 Clinical Trials

46. Combination of Increased Visceral Fat and Long Segment Involvement: Development and Validation of an updated imaging marker for differentiating Crohn's Disease from Intestinal Tuberculosis. (Abstract)

Combination of Increased Visceral Fat and Long Segment Involvement: Development and Validation of an updated imaging marker for differentiating Crohn's Disease from Intestinal Tuberculosis. Computed tomographic (CT) features (long segment, ileocaecal area involvement, and lymph nodes > 1 cm) have demonstrated good specificity but poor sensitivity, while visceral to subcutaneous fat ratio on CT (VF/SC > 0.63) has moderate sensitivity and specificity in differentiating Crohn's disease (CD (...) significantly different between CD/ITB were incorporated into a model.In both the cohorts, necrotic lymph nodes were exclusive for ITB (23.1% vs 0% and 43.3% vs 0%), while long segment involvement (57.6% vs 7.7%, P < 0.001, and 52.6% vs 16.1%, P < 0.001) and VF/SC ratio > 0.63 (72.7% vs 19.2%, P < 0.001, and 81.6% vs 25.8%, P < 0.001) were significantly more common in CD. A risk score of 2, based upon long segment involvement and VF/SC ratio > 0.63, had an excellent specificity of 100% and 100

2017 Journal of gastroenterology and hepatology

47. Pedicled buccal fat pad for the augmentation of facial depression deformity: A case report. Full Text available with Trip Pro

unabsorbed and soft 43 months postoperatively. The patient did not have any complications.This novel procedure has 2 advantages. First, the pedicled BFP is a vascularized tissue and is not absorbed postoperatively; control of contour is easy, and only 1 treatment session is required. Complications associated with fat necrosis can be avoided. Second, only a single intraoral incision is required; the risk of donor-site morbidity is very low, and scar formation does not occur on exposed skin. Third (...) Pedicled buccal fat pad for the augmentation of facial depression deformity: A case report. Tissue augmentation of facial depression deformities can be achieved by volume replacement with autologous fat injection, dermal filler injection, etc. Here, we report a case of tissue augmentation of a facial depression deformity using a pedicled buccal fat pad (BFP).A 64-year-old woman was referred with a chief complaint of facial depression deformity.Her molars had been removed at another hospital 12

2017 Medicine

48. Impact of pioglitazone and bradykinin type 1 receptor antagonist on type 2 diabetes in high‐fat diet‐fed C57BL/6J mice Full Text available with Trip Pro

the antidiabetic and anti-inflammatory effects of the B1R antagonist SSR240612 (SSR) in adipose tissue with those of pioglitazone (TZD), an activator of peroxisome proliferator-activated receptor gamma.C57BL/6J mice were fed with high-fat diet (HFD) or standard diet (control) for 20 weeks. Yet, during the last 4 weeks, HFD-fed mice were administered SSR and TZD (10 mg kg-1 d-1 each) as monotherapy or combined therapy subcutaneously. The impact of treatments was measured on metabolic hormones levels (ELISA (...) Impact of pioglitazone and bradykinin type 1 receptor antagonist on type 2 diabetes in high‐fat diet‐fed C57BL/6J mice Type 2 diabetes (T2D) is a major complication of obesity and a leading cause of morbidity and mortality. Antagonizing bradykinin type 1 receptor (B1R) improved body and tissue fat mass and reversed vascular and adipose tissue inflammation in a rat model of insulin resistance. This study aimed at evaluating further the role of B1R in a mouse model of T2D by comparing

2017 Obesity science & practice

49. Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial. Full Text available with Trip Pro

Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial. Background: Dietary fat composition can affect ectopic lipid accumulation and, thereby, insulin resistance. Diets that are high in saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs) have different metabolic responses.Objective: We investigated whether the epigenome of human adipose tissue is affected differently by dietary fat (...) composition and general overfeeding in a randomized trial.Design: We studied the effects of 7 wk of excessive SFA (n = 17) or PUFA (n = 14) intake (+750 kcal/d) on the DNA methylation of ∼450,000 sites in human subcutaneous adipose tissue. Both diets resulted in similar body weight increases. We also combined the data from the 2 groups to examine the overall effect of overfeeding on the DNA methylation in adipose tissue.Results: The DNA methylation of 4875 Cytosine-phosphate-guanine (CpG) sites

2017 American Journal of Clinical Nutrition Controlled trial quality: uncertain

50. Multi-country Study- Effect of Dietary Fats on Fat Deposition

Analyzer Change of serum Lp (a) [ Time Frame: week 0 (baseline), week 4, week 8, week 12 and week 16 ] measured by Siemens Advia 2400 Chemistry Analyzer Faecal fatty acid composition (FAC) [ Time Frame: week 0 (baseline), week 4, week 8, week 12 and week 16 ] FAC of faecal extracted fat measured by gas chromatography (GC) Change of visceral adipose tissue [ Time Frame: week 0 (baseline) and week 16 ] measured by MRI Change of subcutaneous adipose tissue [ Time Frame: week 0 (baseline) and week 16 (...) Multi-country Study- Effect of Dietary Fats on Fat Deposition Multi-country Study- Effect of Dietary Fats on Fat Deposition - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Multi-country Study- Effect

2016 Clinical Trials

51. Systemic lupus erythematosus with widespread subcutaneous fat calcification. Full Text available with Trip Pro

Systemic lupus erythematosus with widespread subcutaneous fat calcification. 4820822 1974 06 05 2018 11 13 0035-9157 67 3 1974 Mar Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Systemic lupus erythematosus with widespread subcutaneous fat calcification. 215-7 Powell R J RJ eng Journal Article England Proc R Soc Med 7505890 0035-9157 886U3H6UFF Chloroquine VB0R961HZT Prednisone IM Adipose Tissue pathology Adult Calcinosis complications Chloroquine therapeutic use Female Fever (...) Humans Lupus Erythematosus, Systemic complications Necrosis Prednisone therapeutic use Splenomegaly 1974 3 1 1974 3 1 0 1 1974 3 1 0 0 ppublish 4820822 PMC1645348 Arch Dermatol. 1969 Jul;100(1):17-22 5822350 Proc R Soc Med. 1972 Jul;65(7):591 5085931

1974 Proceedings of the Royal Society of Medicine

52. Successful Deep Inferior Epigastric Perforator Flap Harvest despite Preoperative Therapeutic Subcutaneous Heparin Administration into the Abdominal Pannus Full Text available with Trip Pro

Successful Deep Inferior Epigastric Perforator Flap Harvest despite Preoperative Therapeutic Subcutaneous Heparin Administration into the Abdominal Pannus Abdominal free flaps for microsurgical breast reconstruction are most commonly harvested based on the deep inferior epigastric vessels that supply skin and fat via perforators through the rectus muscle and sheath. Intact perforator anatomy and connections are vital for subsequent optimal flap perfusion and avoidance of necrosis, be it partial

2016 Case reports in surgery

53. Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study Full Text available with Trip Pro

between VDAT and MS (OR of 8.359 in men and 3.183 in women, p < 0.001) were higher than those of VAT (OR of 7.941 in men and 2.570 in women, p < 0.05) and dSAT (OR of 2.954 in men and 1.856 in women, p < 0.05).We demonstrated that dSAT was associated with increased inflammation and oxidative stress, suggesting that dSAT is an important determinant of MS. Therefore, abdominal subcutaneous fat should be considered as two functionally distinct compartments rather than a single entity. (...) Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study The deep subcutaneous adipose tissue (dSAT) is closely related to the obesity-associated complications similarly to the characteristics of visceral adipose tissue (VAT). However, the association between dSAT and metabolic syndrome (MS) is unclear. The purpose of our study was to evaluate the association of distinct abdominal adipose tissue with the cardiometabolic risk factors

2016 Diabetology & metabolic syndrome

54. Secretory activity of subcutaneous abdominal adipose tissue in male patients with rheumatoid arthritis and osteoarthritis – association with clinical and laboratory data Full Text available with Trip Pro

Secretory activity of subcutaneous abdominal adipose tissue in male patients with rheumatoid arthritis and osteoarthritis – association with clinical and laboratory data Adipose tissue exerts widespread effects on the metabolism and immune system, but its activity differs between the genders. In the general population low-grade adipose tissue inflammation contributes to development of diseases of affluence. Little is known about the systemic impact of peripheral fat tissue in osteoarthritis (...) (OA) and rheumatoid arthritis (RA), characterized by chronic, low- and high-grade systemic inflammation, respectively. To clarify this we evaluated the secretory activity of subcutaneous abdominal adipose tissue (SAAT) obtained from male patients affected with RA (n = 21) and OA (n = 13), and assessed its association with body mass and composition, demographic, clinical and laboratory data.Basal and interleukin (IL)-1β-triggered secretion of selected adipocytokines from SAAT explants was measured

2016 Reumatologia

55. Relations of Visceral and Abdominal Subcutaneous Adipose Tissue, Body Mass Index, and Waist Circumference to Serum Concentrations of Parameters of Chronic Inflammation Full Text available with Trip Pro

Relations of Visceral and Abdominal Subcutaneous Adipose Tissue, Body Mass Index, and Waist Circumference to Serum Concentrations of Parameters of Chronic Inflammation Different measures of body fat composition may vary in their relations to parameters of chronic inflammation.We assessed the relations of visceral (VAT) and subcutaneous adipose tissue (SAT), BMI, and waist circumference (WC) to serum concentrations of high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α

2016 Obesity facts

56. Subcutaneous Tissue Expander Placement with Synthetic Titanium-Coated Mesh in Breast Reconstruction: Long-term Results Full Text available with Trip Pro

and March 2014, 25 cases were enrolled in the study. Expander/implant loss rate was 0%. Skin/nipple necrosis rate was 4%. Infections rate was 12% after first-stage and 4% after second-stage procedure. Seromas rate was 0%. Five (20%) fat graft procedures were performed over the expander before second-stage reconstruction, and no reinterventions were required after second stage. Patients mean score was 99 for cosmetic outcome satisfaction, in a 0-100 scale. Subcutaneous 2-stage reconstruction (...) Subcutaneous Tissue Expander Placement with Synthetic Titanium-Coated Mesh in Breast Reconstruction: Long-term Results A subcutaneous, prepectoral, muscle-sparing approach has been recently described for implant-based breast reconstruction. This is a preliminary series of 2-stage breast reconstructions by means of tissue expander placed subcutaneously with the support of a titanium-coated polypropylene mesh. A pilot series of cases was started in 2012. Inclusion criteria were informed consent

2016 Plastic and Reconstructive Surgery Global Open

57. Closure Versus Non Closure of Subcutaneous Tissue After Cesarean Section in Diabetic Patients

spectrum penicillin (after clamping of the umbilical cord and 12 hours postoperatively. Oral antibiotic of the same group was then started for 3-5 days. 5.In group A (closure group)the subcutaneous fat will be closed with three to five interrupted sutures. The sutures were tied until the tissue was adequately re-approximated, but not as hard as possible to avoid necrosis. In group B (non closure group) the subcutaneous fat will not sutured. 6.In all participants Skin to be closed by subcuticular (...) interrupted sutures. The sutures were tied until the tissue was adequately re-approximated, but not as hard as possible to avoid necrosis after cesarean section. Other: closure of subcutaneous tissue the subcutaneous fat will be closed with three to five interrupted sutures. The sutures were tied until the tissue was adequately re-approximated, but not as hard as possible to avoid necrosis after cesarean section in diabetic patients. No closure of subcutaneous tissue in diabetic patients, the subcutaneous

2016 Clinical Trials

58. Subcutaneous Fat Necrosis After Moderate Therapeutic Hypothermia in Neonates. (Abstract)

Subcutaneous Fat Necrosis After Moderate Therapeutic Hypothermia in Neonates. Therapeutic moderate hypothermia in newborns with hypoxic-ischemic encephalopathy is rapidly becoming standard clinical practice. We report here 12 cases of subcutaneous fat necrosis among 1239 cases registered with a national registry of newborns treated with moderate whole-body hypothermia. All the infants suffered from perinatal asphyxia and hypoxic-ischemic encephalopathy. Moderate-to-severe hypercalcemia (...) was identified in 8 of 10 infants with blood calcium measurements. In all cases the skin lesions appeared after completion of the cooling treatment. Our data suggest that prolonged moderate hypothermia is an actual risk factor for subcutaneous fat necrosis. Because the lesions often develop several days after birth, physicians need to be aware of this condition as a possible complication in infants treated with moderate hypothermia after asphyxia. Blood calcium levels need to be monitored in affected infants.

2011 Pediatrics

59. Involvement of Brown Adipose Tissue in Subcutaneous Fat Necrosis of the Newborn. (Abstract)

Involvement of Brown Adipose Tissue in Subcutaneous Fat Necrosis of the Newborn. Subcutaneous fat necrosis (SCFN) of the newborn is a rare condition that manifests within days after birth. The interscapular region, axillae and shoulders are the most commonly affected sites, corresponding to anatomic sites of brown adipose tissue (BAT) in newborns.We postulated a specific involvement of BAT in SCFN and searched for brown adipocytes at affected sites.Biopsy specimens were immunostained

2011 Dermatology

60. An unusual complication of subcutaneous fat necrosis of the newborn Full Text available with Trip Pro

An unusual complication of subcutaneous fat necrosis of the newborn Subcutaneous fat necrosis (SCFN) is a well-described cause of subcutaneous calcification occurring in a young infant. Calcification of areas of fat necrosis in the neonate is a rare condition. In this case, the radiographic demonstration of soft-tissue calcification revealed the skin calcification in the absence of clinical signs of SCFN and without hypercalcaemia in the first 48 h of life.

2011 BMJ case reports

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